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1. 发明授权

US08696564B2 Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth 有权
标题翻译：具有生物相容性涂层的植入式传感器，用于控制或抑制组织生长
公开(公告)号：US08696564B2
公开(公告)日：2014-04-15
申请号：US10888340
申请日：2004-07-09
申请人： Abhi Chavan , Jeffrey Ross , Cynthia Morrissey , Scott Mazar , Donald Palme
发明人： Abhi Chavan , Jeffrey Ross , Cynthia Morrissey , Scott Mazar , Donald Palme
IPC分类号： A61B5/04
CPC分类号： B82Y30/00 , A61B5/00 , A61B5/0031 , B82Y15/00
摘要： All or a portion of a surface of an implantable sensor is covered with a biocompatible coating formed at least partially of a biomaterial matrix having properties that promote a substantially even growth of tissue cells over the surface of the coating. Additional materials, such as growth factors, agents that recruit endogenous stem cells, and cell adhesion motif arginine, glycine, aspartic acid may be included in the coating. Autologous cells may be added to the coating prior to implantation. The sensor surface may also be textured, by etching or abrading, in order to promote even tissue growth. Alternatively, the sensor surface may be covered with a coating having properties that inhibit the growth of tissue. These coatings may include a biomaterial, a biomaterial matrix having a drug, such as a sirolimus or a steroid, an active component, or a self assembled monolayer.
摘要翻译：可植入传感器的表面的全部或一部分被至少部分地由具有促进组织细胞在涂层表面上的基本均匀生长的特性的生物材料基质形成的生物相容性涂层覆盖。另外的材料，例如生长因子，招募内源性干细胞的药剂，细胞粘附基序精氨酸，甘氨酸，天冬氨酸可以包括在涂层中。自体细胞可以在植入之前加入到涂层中。为了促进均匀的组织生长，传感器表面也可以通过蚀刻或研磨进行纹理化。或者，传感器表面可以被具有抑制组织生长的性质的涂层覆盖。这些涂层可以包括生物材料，具有药物的生物材料基质，例如西罗莫司或类固醇，活性成分或自组装单层。

2. 发明申请

US20060008500A1 Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth 有权
标题翻译：具有生物相容性涂层的植入式传感器，用于控制或抑制组织生长
公开(公告)号：US20060008500A1
公开(公告)日：2006-01-12
申请号：US10888340
申请日：2004-07-09
申请人： Abhi Chavan , Jeffrey Ross , Cynthia Morrissey , Scott Mazar , Donald Palme
发明人： Abhi Chavan , Jeffrey Ross , Cynthia Morrissey , Scott Mazar , Donald Palme
IPC分类号： A61N1/00 , A61F2/00
CPC分类号： B82Y30/00 , A61B5/00 , A61B5/0031 , B82Y15/00
摘要： All or a portion of a surface of an implantable sensor is covered with a biocompatible coating formed at least partially of a biomaterial matrix having properties that promote a substantially even growth of tissue cells over the surface of the coating. Additional materials, such as growth factors, agents that recruit endogenous stem cells, and cell adhesion motif arginine, glycine, aspartic acid may be included in the coating. Autologous cells may be added to the coating prior to implantation. The sensor surface may also be textured, by etching or abrading, in order to promote even tissue growth. Alternatively, the sensor surface may be covered with a coating having properties that inhibit the growth of tissue. These coatings may include a biomaterial, a biomaterial matrix having a drug, such as a sirolimus or a steroid, an active component, or a self assembled monolayer.
摘要翻译：可植入传感器的表面的全部或一部分被至少部分地由具有促进组织细胞在涂层表面上的基本均匀生长的特性的生物材料基质形成的生物相容性涂层覆盖。另外的材料，例如生长因子，招募内源性干细胞的药剂，细胞粘附基序精氨酸，甘氨酸，天冬氨酸可以包括在涂层中。自体细胞可以在植入之前加入到涂层中。为了促进均匀的组织生长，传感器表面也可以通过蚀刻或研磨进行纹理化。或者，传感器表面可以被具有抑制组织生长的性质的涂层覆盖。这些涂层可以包括生物材料，具有药物的生物材料基质，例如西罗莫司或类固醇，活性成分或自组装单层。

3. 发明申请

US20060122522A1 Devices and methods for positioning and anchoring implantable sensor devices 审中-公开
标题翻译：用于定位和固定植入式传感器装置的装置和方法
公开(公告)号：US20060122522A1
公开(公告)日：2006-06-08
申请号：US11216738
申请日：2005-08-31
申请人： Abhi Chavan , Jeffrey Von Arx , Bruce Tockman , Donald Palme
发明人： Abhi Chavan , Jeffrey Von Arx , Bruce Tockman , Donald Palme
IPC分类号： A61B5/02
CPC分类号： A61F2/86 , A61B5/0215 , A61B5/076 , A61B5/6862 , A61B5/6876 , A61B5/6882 , A61B17/0057 , A61B2017/00022 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00889 , A61F2/01 , A61F2002/016 , A61F2230/0019 , A61F2230/0021 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2230/008 , A61F2230/0093 , A61N1/36514
摘要： Methods and systems provide for anchoring implantable medical device inside a bodily vessel. An anchoring structure can include a stent-like structure to which the IMD is attached. The stent-like structure is positioned at a desired location in the bodily vessel. The stent-like structure can be repositioned based on a measurement from the IMD. The IMD can include outwardly extending fins over which tissue can fibrose to affix the IMD to a wall of the bodily vessel. The stent-like structure can be made of a bio-absorbable material. The IMD can be attached to a stent-like structure by leads, by being lodged in a recessed diaphragm, by being embedded in mesh of the stent-like structure, or other methods. The stent-like structure can be balloon deployable to allow for controlled positioning and anchoring. The anchoring structure can include a vena cava filter.
摘要翻译：方法和系统提供将可植入医疗器械固定在体内血管内。锚定结构可以包括IMD附接到的支架状结构。支架状结构位于身体容器中的期望位置。可以基于来自IMD的测量重新定位支架样结构。 IMD可以包括向外延伸的翅片，组织可以在其上成纤维，以将IMD固定到身体血管的壁上。支架状结构可以由生物吸收材料制成。 IMD可以通过引线附着到具有支架的结构，通过嵌入在凹入的隔膜中，通过嵌入支架状结构的网状物或其它方法中。支架状结构可以是气囊展开以允许受控的定位和锚固。锚定结构可以包括腔静脉过滤器。

4. 发明申请

US20050085688A1 Cardiac support device 审中-公开
公开(公告)号：US20050085688A1
公开(公告)日：2005-04-21
申请号：US10984459
申请日：2004-11-08
申请人： Michael Girard , J. Shapland , Donald Palme
发明人： Michael Girard , J. Shapland , Donald Palme
IPC分类号： A61B17/00 , A61F2/00 , A61F2/24 , A61F9/00 , A61F11/00 , A61F13/00 , A61M1/10
CPC分类号： A61F2/2481
摘要： A highly compliant and elastic cardiac support device is provided. The device is constructed from a biocompatible material is applied to an external surface of a heart. The device can be used to resist dilatation of the heart, to provide acute wall support, or to enhance reduction in the size of the heart using stored potential energy, without interfering with systolic contraction.

5. 发明申请

US20100317918A1 Septum attached ventricular support 审中-公开
标题翻译：隔垫附着心室支持
公开(公告)号：US20100317918A1
公开(公告)日：2010-12-16
申请号：US12806646
申请日：2010-08-18
申请人： J. Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
发明人： J. Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
IPC分类号： A61F2/04
CPC分类号： A61F2/2481
摘要： A method and device are disclosed for treating congestive heart disease. The material of the device is secured to the heart proximate the septal wall. The material covering the ventricles may or may not have the same tension and or compliance. The device can be constructed as a unitary “jacket” that is slipped over the apex of the heart. Alternately, the device implanted as one, two or more separate components. In one embodiment, the material covers both the left and right ventricles. In another embodiment, the material covers only one ventricle. The device may include at least one adjustment mechanism configured to adjust the tension of the material. Preferably, the device includes a first adjustment mechanism configured to adjust a tension of the material covering the right ventricle and a second adjustment mechanism configured to adjust the tension of the material covering the left ventricle such that the tension of the material covering the left ventricle can be different than the tension of the material covering the right ventricle.
摘要翻译：公开了治疗充血性心脏病的方法和装置。该装置的材料固定在靠近隔壁的心脏上。覆盖心室的材料可能具有或不具有相同的张力和/或顺应性。该装置可以被构造成整体的“夹克”，其被滑过心脏的顶点。或者，该装置作为一个，两个或更多个分离的部件植入。在一个实施例中，材料覆盖左心室和右心室。在另一个实施例中，材料仅覆盖一个心室。该装置可以包括被配置为调节材料张力的至少一个调节机构。优选地，该装置包括被配置为调节覆盖右心室的材料的张力的第一调节机构和被配置为调节覆盖左心室的材料的张力的第二调节机构，使得覆盖左心室的材料的张力可以与覆盖右心室的材料的张力不同。

6. 发明申请

US20050131528A1 Biodegradable drug delivery vascular stent 有权
公开(公告)号：US20050131528A1
公开(公告)日：2005-06-16
申请号：US11041027
申请日：2005-01-21
申请人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
发明人： Paul Buscemi , Elizabeth Stejskal , Donald Palme , Lixiao Wang
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06
CPC分类号： A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要： A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.

7. 发明申请

US20070208211A1 SEPTUM ATTACHED VENTRICULAR SUPPORT 审中-公开
标题翻译： SEPTUM附着的心脏支持
公开(公告)号：US20070208211A1
公开(公告)日：2007-09-06
申请号：US11745260
申请日：2007-05-07
申请人： James Shapland , Clifton Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
发明人： James Shapland , Clifton Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
IPC分类号： A61B17/00
CPC分类号： A61F2/2481
摘要： A method and device are disclosed for treating congestive heart disease. The material of the device is secured to the heart proximate the septal wall. The material covering the ventricles may or may not have the same tension and or compliance. The device can be constructed as a unitary “jacket” that is slipped over the apex of the heart. Alternately, the device implanted as one, two or more separate components. In one embodiment, the material covers both the left and right ventricles. In another embodiment, the material covers only one ventricle. The device may include at least one adjustment mechanism configured to adjust the tension of the material. Preferably, the device includes a first adjustment mechanism configured to adjust a tension of the material covering the right ventricle and a second adjustment mechanism configured to adjust the tension of the material covering the left ventricle such that the tension of the material covering the left ventricle can be different than the tension of the material covering the right ventricle.
摘要翻译：公开了治疗充血性心脏病的方法和装置。该装置的材料固定在靠近隔壁的心脏上。覆盖心室的材料可能具有或不具有相同的张力和/或顺应性。该装置可以被构造成整体的“夹克”，其被滑过心脏的顶点。或者，该装置作为一个，两个或更多个分离的部件植入。在一个实施例中，材料覆盖左心室和右心室。在另一个实施例中，材料仅覆盖一个心室。该装置可以包括被配置为调节材料张力的至少一个调节机构。优选地，该装置包括被配置为调节覆盖右心室的材料的张力的第一调节机构和被配置为调节覆盖左心室的材料的张力的第二调节机构，使得覆盖左心室的材料的张力可以与覆盖右心室的材料的张力不同。

8. 发明申请

US20060149122A1 Septum attached ventricular support 有权
标题翻译：隔垫附着心室支持
公开(公告)号：US20060149122A1
公开(公告)日：2006-07-06
申请号：US11338571
申请日：2006-01-24
申请人： Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
发明人： Edward Shapland , Clif Alferness , Donald Palme , Michael Girard , Donald Rohrbaugh
IPC分类号： A61F2/00
CPC分类号： A61F2/2481
摘要： A method and device are disclosed for treating congestive heart disease. The material of the device is secured to the heart proximate the septal wall. The material covering the ventricles may or may not have the same tension and or compliance. The device can be constructed as a unitary “jacket” that is slipped over the apex of the heart. Alternately, the device implanted as one, two or more separate components. In one embodiment, the material covers both the left and right ventricles. In another embodiment, the material covers only one ventricle. The device may include at least one adjustment mechanism configured to adjust the tension of the material. Preferably, the device includes a first adjustment mechanism configured to adjust a tension of the material covering the right ventricle and a second adjustment mechanism configured to adjust the tension of the material covering the left ventricle such that the tension of the material covering the left ventricle can be different than the tension of the material covering the right ventricle.
摘要翻译：公开了治疗充血性心脏病的方法和装置。该装置的材料固定在靠近隔壁的心脏上。覆盖心室的材料可能具有或不具有相同的张力和/或顺应性。该装置可以被构造成整体的“夹克”，其被滑过心脏的顶点。或者，该装置作为一个，两个或更多个分离的部件植入。在一个实施例中，材料覆盖左心室和右心室。在另一个实施例中，材料仅覆盖一个心室。该装置可以包括被配置为调节材料张力的至少一个调节机构。优选地，该装置包括被配置为调节覆盖右心室的材料的张力的第一调节机构和被配置为调节覆盖左心室的材料的张力的第二调节机构，使得覆盖左心室的材料的张力可以与覆盖右心室的材料的张力不同。

9. 发明申请

US20050113901A1 Myocardial lead attachment system 审中-公开
标题翻译：心肌引导附件系统
公开(公告)号：US20050113901A1
公开(公告)日：2005-05-26
申请号：US10971551
申请日：2004-10-22
申请人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , Charles Gresl
发明人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme , Charles Gresl
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： The present invention is a myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes an anchor, a tether coupled to the anchor, and a delivery instrument for receiving and advancing the anchor through a tract in the heart from a proximal entrance site to a distal exit site in such a manner that the tether extends proximally from the anchor through the tract. The delivery instrument includes a needle having a distal tip and a nest. The nest is positioned proximal to the distal tip and is sized to receive the anchor. The delivery instrument further includes an ejection mechanism for ejecting the anchor from the nest.
摘要翻译：本发明是用于将铅的远端固定在患者心脏的心肌内的心肌引导附着系统。所述系统包括锚固件，联接到所述锚固件的系绳和用于接收并推进所述锚固件穿过所述心脏中的管道从近侧入口部位到远端出口部位的方式的系统，所述系绳以从所述锚固件的方式向近侧延伸锚通过道。递送器械包括具有远端和窝的针。巢定位在远侧末端附近，并且其尺寸被设计成接收锚。输送仪器还包括用于从座中弹出锚固件的弹出机构。

10. 发明申请

US20050228217A1 Compliant cardiac support device 审中-公开
标题翻译：符合心脏支持装置
公开(公告)号：US20050228217A1
公开(公告)日：2005-10-13
申请号：US11144353
申请日：2005-06-03
申请人： Clifton Alferness , Donald Rohrbaugh , J. Shapland , Michael Girard , Donald Palme , James Cox
发明人： Clifton Alferness , Donald Rohrbaugh , J. Shapland , Michael Girard , Donald Palme , James Cox
IPC分类号： A61B17/00 , A61F2/00 , A61F2/24 , A61F9/00 , A61F11/00 , A61F13/00 , A61M1/10
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

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