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1. 发明申请

US20100215648A1 Detecting Agent and Therapeutic Agent for Highly Malignant Breast Cancer 失效
标题翻译：高恶性乳腺癌检测剂和治疗剂
公开(公告)号：US20100215648A1
公开(公告)日：2010-08-26
申请号：US11993103
申请日：2006-12-08
申请人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
发明人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
IPC分类号： A61K39/395 , C07H21/04 , C12Q1/68 , G01N33/567 , C07K16/18 , A61P35/00
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6855 , C07K16/3015 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： The detection agent for high malignancy breast cancer of the present invention includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. The therapeutic agent for high malignancy breast cancer of the present invention includes a conjugate of an anticancer drug and an antibody against that protein, or a variant or derivative or fragment thereof. According to the present invention, it is possible to easily and accurately detect and diagnose high malignancy breast cancer.
摘要翻译：本发明的高恶性肿瘤乳腺癌检测剂包括针对胶原XIV的抗体或抗体的变体或衍生物或片段。本发明的高恶性肿瘤乳腺癌治疗剂包括抗癌药物和针对该蛋白质的抗体的缀合物，或其变体或衍生物或片段。根据本发明，可以容易且准确地检测和诊断高恶性乳腺癌。

2. 发明授权

US4973699A Cephem compounds and processes for preparation thereof 失效
标题翻译：头孢烯化合物及其制备方法
公开(公告)号：US4973699A
公开(公告)日：1990-11-27
申请号：US352989
申请日：1989-05-17
申请人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Shintaro Nishimura
发明人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Shintaro Nishimura
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C67/00 , C07C239/00 , C07C251/32 , C07C251/50 , C07D277/20 , C07D277/40 , C07D277/46 , C07D285/08 , C07D317/30 , C07D501/20 , C07D501/36 , C07D501/59 , C07D521/00
CPC分类号： C07D277/587 , C07D285/08 , C07D317/30
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, lower alkanoyl, aryl, ar(lower)alkyl or a heterocyclic group, each of which may have suitable substituent(s),R.sup.2 is carboxy or protected carboxy,R.sup.3 is hydrogen, halogen, hydroxy, lower alkoxy, acyloxy, lower alkylthio, lower alkenyl, lower alkenylthio, lower alkynyl, heterocycliothio or a heterocyclic group, in which lower alkylthio, lower alkenyl, lower alkenylthio, heterocyclicthio and a heterocyclic group may have suitable substituent(s),R.sup.4 and R.sup.5 are each hydrogen, halogen or arylthio,A is lower alkylene, andn is an integer of 0 or 1,and a pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical composition comprising the same.

3. 发明授权

US4350693A 3,7-Disubstituted-3-cephem-4-carboxylic acid compound and processes for the preparation thereof 失效
标题翻译： 3,7-二取代-3-头孢烯-4-羧酸化合物及其制备方法
公开(公告)号：US4350693A
公开(公告)日：1982-09-21
申请号：US206299
申请日：1980-11-12
申请人： Takao Takaya , Hisashi Takasugi , Toshiyuki Chiba , Zenzaburo Tozuka
发明人： Takao Takaya , Hisashi Takasugi , Toshiyuki Chiba , Zenzaburo Tozuka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D275/02 , C07D285/06 , C07D285/10 , C07D285/12 , C07D501/20 , C07D501/34 , C07D501/36 , C07D501/56
CPC分类号： C07D275/02 , C07D285/06 , C07D285/10 , C07D285/12 , Y02P20/55
摘要： 3,7-disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.
摘要翻译：具有抑菌性质的3,7-二取代-3-头孢烯-4-羧酸化合物和下式：其中R 1是噻二唑基或异噻唑基，其各自可以具有合适的取代基或噻唑基; R2是氢或低级烷基; R3是羧基或被保护的羧基; R4是氢，酰氧基或可具有合适取代基的杂环硫基; R5为氢或低级烷氧基，其制备方法和治疗感染性疾病。

4. 发明申请

US20090132171A1 Screening Method for Specific Protein in Proteome Comprehensive Analysis 审中-公开
标题翻译：蛋白质组学综合分析中特异性蛋白质的筛选方法
公开(公告)号：US20090132171A1
公开(公告)日：2009-05-21
申请号：US11915981
申请日：2006-02-08
申请人： Rieko Goto , Shohei Shioyama , Zenzaburo Tozuka , Kunio Momiyama , Yasushi Nakamura , Kennichi Kakudo
发明人： Rieko Goto , Shohei Shioyama , Zenzaburo Tozuka , Kunio Momiyama , Yasushi Nakamura , Kennichi Kakudo
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N33/6848
摘要： A screening method for a specific protein in a proteome analysis comprises: (a) obtaining samples containing a protein or protein digest from a cell or tissue in a specific group and a control group; (b) analyzing the samples obtained in the step (a) with a mass spectrometer, thereby obtaining mass spectrometry data; (c) analyzing the mass spectrometry data obtained in the step (b) using an arbitrary database searching software, thereby acquiring a protein list containing items for specifying proteins and indexes for identifying the proteins, for each of the samples; (d) averaging values of the indexes for each of the items in all of the protein lists acquired in the step (c), and acquiring protein list models of the specific group and the control group, containing the average values of the indexes; (e) calculating a difference between the average values for each of the items, between the protein list models of the specific group and the control group obtained in the step (d), and acquiring one protein list in which the items are rearranged in the order of the difference between the average values; and (f) selecting a protein with a large difference between the average values, from the protein list acquired in the step (e).
摘要翻译：蛋白质组分析中特定蛋白质的筛选方法包括：（a）从特定组和对照组的细胞或组织中获得含有蛋白质或蛋白质消化物的样品; （b）用质谱仪分析步骤（a）中获得的样品，从而获得质谱数据; （c）使用任意的数据库搜索软件分析步骤（b）中获得的质谱数据，从而获得每个样品获得含有用于指定蛋白质的项目和用于识别蛋白质的指标的蛋白质列表; （d）对步骤（c）中获得的所有蛋白质列表中的每个项目的指标平均值，并获取包含指标的平均值的特定组和对照组的蛋白质表型模型; （e）计算特定组的蛋白质列表模型与步骤（d）中获得的对照组之间的每个项目的平均值之间的差异，并且获取在其中重新排列项目的一个蛋白质列表平均值之间的差异顺序; 和（f）从步骤（e）中获得的蛋白质列表中选择平均值差异大的蛋白质。

5. 发明授权

US4985555A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4985555A
公开(公告)日：1991-01-15
申请号：US385542
申请日：1989-07-27
申请人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Kohji Kawabata
发明人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Kohji Kawabata
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D213/32 , C07D501/18 , C07D501/22 , C07D501/59
CPC分类号： C07D213/32
摘要： The invention relates to a cephem compound of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino, R.sup.2 is hydrogen, phenyl, pyridyl which may have a lower alkyl group, or cyano, and R.sup.3 is carboxy or protected carboxy, or a salt thereof.

6. 发明授权

US4558047A 3,5-Di hydroxy morpholine derivatives and pharmaceutical compositions 失效
标题翻译： 3,5-二羟基吗啉衍生物和药物组合物
公开(公告)号：US4558047A
公开(公告)日：1985-12-10
申请号：US598581
申请日：1984-04-10
申请人： Takao Takaya , Zenzaburo Tozuka
发明人： Takao Takaya , Zenzaburo Tozuka
IPC分类号： A61K31/535 , A61P35/00 , C07D265/32 , C07D413/14 , C07D417/14 , C07D473/00 , C07D473/30 , C07D473/34 , C07D519/00 , C07H19/04
CPC分类号： C07D473/00 , C07D265/32 , C07D413/14 , C07D417/14 , C07H19/04
摘要： 3,5-Di hydroxy morpholine derivatives having antitumor activity and methods of preparation thereof, are disclosed.
摘要翻译：公开了具有抗肿瘤活性的3,5-二羟基吗啉衍生物及其制备方法。

7. 发明授权

US4349552A 5-Fluorouracil derivatives, and their pharmaceutical compositions 失效
标题翻译： 5-氟尿嘧啶衍生物及其药物组合物
公开(公告)号：US4349552A
公开(公告)日：1982-09-14
申请号：US111643
申请日：1980-01-14
申请人： Takao Takaya , Zenzaburo Tozuka
发明人： Takao Takaya , Zenzaburo Tozuka
IPC分类号： C07D239/54 , C07D239/553 , C07D317/70 , C07D333/38 , C07D239/30
CPC分类号： C07D239/553 , C07C265/00 , C07D317/70 , C07D333/38 , Y10S514/908
摘要： A compound of the formula: ##STR1## wherein R is a bridged alicyclic group selected from the group consisting of norbornyl, norbornenyl, bicyclo[2,2,2]-heptyl and adamantyl optionally substituted by at least one substituent selected from the group consisting of lower alkyl, carboxy, lower alkoxycarbonyl, alkylidenedioxy, N,N-di(lower)alkylcarbamoyl, amino, loweralkoxycarbonylamino and halogen. The present compound is useful in the therapeutic treatment of cancer in human beings and animals.
摘要翻译：下式的化合物，其中R是选自降冰片基，降冰片烯基，降冰片烯基，双环[2,2,2] - 庚基和金刚烷基的桥连脂环基，任选被至少一个选自以下的取代基取代的金刚烷基：低级烷基，羧基，低级烷氧基羰基，亚烷基二氧基，N，N-二（低级）烷基氨基甲酰基，氨基，低级烷氧基羰基氨基和卤素。本发明化合物可用于治疗人类和动物中的癌症。

8. 发明授权

US4263291A 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof 失效
标题翻译： 3,7-二取代-3-头孢烯-4-羧酸化合物及其制备方法
公开(公告)号：US4263291A
公开(公告)日：1981-04-21
申请号：US26779
申请日：1979-04-03
申请人： Takao Takaya , Hisashi Takasugi , Toshiyuki Chiba , Zenzaburo Tozuka
发明人： Takao Takaya , Hisashi Takasugi , Toshiyuki Chiba , Zenzaburo Tozuka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D275/02 , C07D285/06 , C07D285/10 , C07D285/12 , C07D501/20 , C07D501/34 , C07D501/36 , C07D501/56
CPC分类号： C07D275/02 , C07D285/06 , C07D285/10 , C07D285/12 , Y02P20/55
摘要： 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.
摘要翻译：具有抑菌性质的3,7-二取代-3-头孢烯-4-羧酸化合物和下式：其中R 1是噻二唑基或异噻唑基，其各自可以具有合适的取代基或噻唑基; R2是氢或低级烷基; R3是羧基或被保护的羧基; R4是氢，酰氧基或可具有合适取代基的杂环硫基; R5为氢或低级烷氧基，其制备方法和治疗感染性疾病。

9. 发明授权

US4861769A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4861769A
公开(公告)日：1989-08-29
申请号：US828527
申请日：1986-02-12
申请人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Shintaro Nishimura
发明人： Takao Takaya , Zenzaburo Tozuka , Nobuyoshi Yasuda , Shintaro Nishimura
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C67/00 , C07C239/00 , C07C251/32 , C07C251/50 , C07D277/20 , C07D277/40 , C07D277/46 , C07D285/08 , C07D317/30 , C07D501/20 , C07D501/36 , C07D501/59 , C07D521/00
CPC分类号： C07D277/587 , C07D285/08 , C07D317/30
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl, lower alkanoyl, aryl, ar(lower)alkyl or a heterocyclic group, each of which may have suitable substituent(s),R.sup.2 is carboxy or protected carboxy,R.sup.3 is hydrogen, halogen, hydroxy, lower alkoxy, acyloxy, lower alkylthio, lower alkenyl, lower alkenylthio, lower alkynyl, heterocyclicthio or a heterocyclic group, in which lower alkylthio, lower alkenyl, lower alkenylthio, heterocyclicthio and a heterocyclic group may have suitable substituent(s),R.sup.4 and R.sup.5 are each hydrogen, halogen or arylthio,A is lower alkylene, andn is an integer of 0 or 1,and a pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical composition comprising the same.
摘要翻译：下式的化合物，其中R 1是低级烷基，低级烷酰基，芳基，芳（低级）烷基或杂环基，其各自可以具有合适的取代基，R 2是羧基或被保护的羧基，R 3是氢，卤素，羟基，低级烷氧基，酰氧基，低级烷硫基，低级烯基，低级链烯硫基，低级炔基，杂环硫基或杂环基，其中低级烷硫基，低级烯基，低级链烯硫基，杂环硫基和杂环基可具有合适的取代基 s）中，R 4和R 5各自为氢，卤素或芳硫基，A为低级亚烷基，n为0或1的整数，及其药学上可接受的盐，其制备方法和包含其的药物组合物。

10. 发明授权

US08030014B2 Detecting agent and therapeutic agent for highly malignant breast cancer 失效
标题翻译：高恶性乳腺癌检测剂和治疗剂
公开(公告)号：US08030014B2
公开(公告)日：2011-10-04
申请号：US11993103
申请日：2006-12-08
申请人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
发明人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
IPC分类号： G01N33/574
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6855 , C07K16/3015 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： A detection agent for high malignancy breast cancer includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. A therapeutic agent for high malignancy breast cancer includes a conjugate of an anticancer drug and an antibody against that protein, or a variant or derivative or fragment thereof. Accordingly, it is possible to easily and accurately detect and diagnose high malignancy breast cancer.
摘要翻译：用于高恶性乳腺癌的检测剂包括针对胶原XIV的抗体或抗体的变体或衍生物或片段。高恶性乳腺癌的治疗剂包括抗癌药物和针对该蛋白质的抗体的缀合物，或其变体或衍生物或片段。因此，可以容易且准确地检测和诊断高恶性乳腺癌。

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