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1. 发明申请

US20090132171A1 Screening Method for Specific Protein in Proteome Comprehensive Analysis 审中-公开
标题翻译：蛋白质组学综合分析中特异性蛋白质的筛选方法
公开(公告)号：US20090132171A1
公开(公告)日：2009-05-21
申请号：US11915981
申请日：2006-02-08
申请人： Rieko Goto , Shohei Shioyama , Zenzaburo Tozuka , Kunio Momiyama , Yasushi Nakamura , Kennichi Kakudo
发明人： Rieko Goto , Shohei Shioyama , Zenzaburo Tozuka , Kunio Momiyama , Yasushi Nakamura , Kennichi Kakudo
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N33/6848
摘要： A screening method for a specific protein in a proteome analysis comprises: (a) obtaining samples containing a protein or protein digest from a cell or tissue in a specific group and a control group; (b) analyzing the samples obtained in the step (a) with a mass spectrometer, thereby obtaining mass spectrometry data; (c) analyzing the mass spectrometry data obtained in the step (b) using an arbitrary database searching software, thereby acquiring a protein list containing items for specifying proteins and indexes for identifying the proteins, for each of the samples; (d) averaging values of the indexes for each of the items in all of the protein lists acquired in the step (c), and acquiring protein list models of the specific group and the control group, containing the average values of the indexes; (e) calculating a difference between the average values for each of the items, between the protein list models of the specific group and the control group obtained in the step (d), and acquiring one protein list in which the items are rearranged in the order of the difference between the average values; and (f) selecting a protein with a large difference between the average values, from the protein list acquired in the step (e).
摘要翻译：蛋白质组分析中特定蛋白质的筛选方法包括：（a）从特定组和对照组的细胞或组织中获得含有蛋白质或蛋白质消化物的样品; （b）用质谱仪分析步骤（a）中获得的样品，从而获得质谱数据; （c）使用任意的数据库搜索软件分析步骤（b）中获得的质谱数据，从而获得每个样品获得含有用于指定蛋白质的项目和用于识别蛋白质的指标的蛋白质列表; （d）对步骤（c）中获得的所有蛋白质列表中的每个项目的指标平均值，并获取包含指标的平均值的特定组和对照组的蛋白质表型模型; （e）计算特定组的蛋白质列表模型与步骤（d）中获得的对照组之间的每个项目的平均值之间的差异，并且获取在其中重新排列项目的一个蛋白质列表平均值之间的差异顺序; 和（f）从步骤（e）中获得的蛋白质列表中选择平均值差异大的蛋白质。

2. 发明申请

US20100215648A1 Detecting Agent and Therapeutic Agent for Highly Malignant Breast Cancer 失效
标题翻译：高恶性乳腺癌检测剂和治疗剂
公开(公告)号：US20100215648A1
公开(公告)日：2010-08-26
申请号：US11993103
申请日：2006-12-08
申请人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
发明人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
IPC分类号： A61K39/395 , C07H21/04 , C12Q1/68 , G01N33/567 , C07K16/18 , A61P35/00
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6855 , C07K16/3015 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： The detection agent for high malignancy breast cancer of the present invention includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. The therapeutic agent for high malignancy breast cancer of the present invention includes a conjugate of an anticancer drug and an antibody against that protein, or a variant or derivative or fragment thereof. According to the present invention, it is possible to easily and accurately detect and diagnose high malignancy breast cancer.
摘要翻译：本发明的高恶性肿瘤乳腺癌检测剂包括针对胶原XIV的抗体或抗体的变体或衍生物或片段。本发明的高恶性肿瘤乳腺癌治疗剂包括抗癌药物和针对该蛋白质的抗体的缀合物，或其变体或衍生物或片段。根据本发明，可以容易且准确地检测和诊断高恶性乳腺癌。

3. 发明申请

US20080160542A1 METHOD FOR ACTIVATING AN ANTIGEN, METHOD FOR DETECTING A CELL, AND SOLUTION FOR ACTIVATING AN ANTIGEN 有权
标题翻译：用于激活抗原的方法，用于检测细胞的方法和用于激活抗原的解决方案
公开(公告)号：US20080160542A1
公开(公告)日：2008-07-03
申请号：US11966318
申请日：2007-12-28
申请人： Yuichi YASUDA , Masakatsu Morita , Junyi Ding , Rieko Goto , Kazuki Kishi
发明人： Yuichi YASUDA , Masakatsu Morita , Junyi Ding , Rieko Goto , Kazuki Kishi
IPC分类号： G01N33/53 , C12N5/02 , C07C275/00
CPC分类号： G01N33/54393
摘要： A method of activating an antigen is herein described. The method comprises providing an antigen activation solution and contacting the cell with the solution to activate the antigen. A method of detecting a cell fixed by a nonbridging fixation solution is also described. The method comprises providing an antigen activation solution, contacting the cell with the solution, immunostaining the cell, and detecting the stained cell. The solution used for these methods comprises an agent for breaking a hydrogen bond, and is also described herein.
摘要翻译：本文描述了激活抗原的方法。该方法包括提供抗原活化溶液并使细胞与溶液接触以活化抗原。还描述了检测由非桥接固定液固定的细胞的方法。该方法包括提供抗原活化溶液，使细胞与溶液接触，免疫染色细胞，检测染色的细胞。用于这些方法的溶液包括用于破坏氢键的试剂，并且在本文中也描述。

4. 发明授权

US08030014B2 Detecting agent and therapeutic agent for highly malignant breast cancer 失效
标题翻译：高恶性乳腺癌检测剂和治疗剂
公开(公告)号：US08030014B2
公开(公告)日：2011-10-04
申请号：US11993103
申请日：2006-12-08
申请人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
发明人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
IPC分类号： G01N33/574
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6855 , C07K16/3015 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： A detection agent for high malignancy breast cancer includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. A therapeutic agent for high malignancy breast cancer includes a conjugate of an anticancer drug and an antibody against that protein, or a variant or derivative or fragment thereof. Accordingly, it is possible to easily and accurately detect and diagnose high malignancy breast cancer.
摘要翻译：用于高恶性乳腺癌的检测剂包括针对胶原XIV的抗体或抗体的变体或衍生物或片段。高恶性乳腺癌的治疗剂包括抗癌药物和针对该蛋白质的抗体的缀合物，或其变体或衍生物或片段。因此，可以容易且准确地检测和诊断高恶性乳腺癌。

5. 发明申请

US20110111414A1 Detecting Agent and Therapeutic Agent for Highly Malignant Breast Cancer 审中-公开
标题翻译：高恶性乳腺癌检测剂和治疗剂
公开(公告)号：US20110111414A1
公开(公告)日：2011-05-12
申请号：US12954968
申请日：2010-11-29
申请人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
发明人： Yasushi Nakamura , Hironao Yasuoka , Masahiko Tsujimoto , Rieko Goto , Zenzaburo Tozuka , Kunio Momiyama , Kennichi Kakudo , Tomonori Takami
IPC分类号： C12Q1/68
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6855 , C07K16/3015 , C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： A detection agent for high malignancy breast cancer includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. A therapeutic agent for high malignancy breast cancer includes a conjugate of an anticancer drug and an antibody against that protein, or a variant or derivative or fragment thereof. Accordingly, it is possible to easily and accurately detect and diagnose high malignancy breast cancer.
摘要翻译：用于高恶性乳腺癌的检测剂包括针对胶原XIV的抗体或抗体的变体或衍生物或片段。高恶性乳腺癌的治疗剂包括抗癌药物和针对该蛋白质的抗体的缀合物，或其变体或衍生物或片段。因此，可以容易且准确地检测和诊断高恶性乳腺癌。

6. 发明授权

US07871783B2 Method for activating an antigen, method for detecting a cell, and solution for activating an antigen 有权
标题翻译：激活抗原的方法，检测细胞的方法和激活抗原的溶液
公开(公告)号：US07871783B2
公开(公告)日：2011-01-18
申请号：US11966318
申请日：2007-12-28
申请人： Yuichi Yasuda , Masakatsu Morita , Junyi Ding , Rieko Goto , Kazuki Kishi
发明人： Yuichi Yasuda , Masakatsu Morita , Junyi Ding , Rieko Goto , Kazuki Kishi
IPC分类号： G01N33/53
CPC分类号： G01N33/54393
摘要： A method of activating an antigen is herein described. The method comprises providing an antigen activation solution and contacting the cell with the solution to activate the antigen. A method of detecting a cell fixed by a nonbridging fixation solution is also described. The method comprises providing an antigen activation solution, contacting the cell with the solution, immunostaining the cell, and detecting the stained cell. The solution used for these methods comprises an agent for breaking a hydrogen bond, and is also described herein.
摘要翻译：本文描述了激活抗原的方法。该方法包括提供抗原活化溶液并使细胞与溶液接触以活化抗原。还描述了检测由非桥接固定液固定的细胞的方法。该方法包括提供抗原活化溶液，使细胞与溶液接触，免疫染色细胞，检测染色的细胞。用于这些方法的溶液包括用于破坏氢键的试剂，并且在本文中也描述。

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