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1. 发明授权

US10745370B2 Farnesyl transferase inhibitors and uses thereof 有权
公开(公告)号：US10745370B2
公开(公告)日：2020-08-18
申请号：US16087103
申请日：2017-03-20
申请人： Yu-Jen Chen
发明人： Yu-Jen Chen , Lie-Chwen Lin
IPC分类号： C07D311/22 , A61P37/06 , A61P25/28 , A61P35/00
摘要： Disclosed herein are novel compounds and uses thereof. The present compounds may suppress the activity of farnesyl transferase and thus, may act as modulators of immune cells; therefor, they are useful for the development of a medicament for treating diseases that are associated with or caused by excessive levels of farnesyl transferase or immune response. Also disclosed herein are pharmaceutical compositions containing the present compounds.

2. 发明授权

US09572545B2 Radiotherapy system adapted to monitor a target location in real time 有权
标题翻译：适用于实时监控目标位置的放射治疗系统
公开(公告)号：US09572545B2
公开(公告)日：2017-02-21
申请号：US13466142
申请日：2012-05-08
申请人： Yu-Jen Chen , Chia-Yuan Liu , Wen-Chung Chang , Chin-Sheng Chen
发明人： Yu-Jen Chen , Chia-Yuan Liu , Wen-Chung Chang , Chin-Sheng Chen
IPC分类号： A61B8/08 , A61B8/00 , A61N5/10
CPC分类号： A61B8/085 , A61B8/4218 , A61B8/4263 , A61B8/523 , A61B8/5261 , A61B8/565 , A61B8/587 , A61N5/1037 , A61N5/1067 , A61N2005/1058 , G06T7/187 , G06T7/33 , G06T2207/10081 , G06T2207/10132 , G06T2207/20032 , G06T2207/20061 , G06T2207/30056
摘要： The present invention provides a radiotherapy system that can monitor a target location in real time. The radiotherapy system includes a remote control system operable to actuate a real-time image capturing device to acquire images in real time for monitoring the target location. The system also includes an image registration system that can register the acquired image with an image previously captured for the treatment plan, whereby it can be determined whether the patient's tumor is in the beam's eye view of the treatment plan. By confirming that the tumor is in the range of the beam's eye view, the accuracy of the treatment can be improved, and the irradiated area can be reduced, which makes the radiation treatment safer.
摘要翻译：本发明提供了可以实时监视目标位置的放射治疗系统。放射治疗系统包括可操作以致动实时图像捕获装置以实时获取图像的遥控系统，用于监视目标位置。该系统还包括一个图像配准系统，其可以用先前为治疗计划拍摄的图像来注册所获取的图像，从而可以确定患者的肿瘤是否处于治疗计划的眼睛视图中。通过确认肿瘤在眼睛的视野范围内，可以提高治疗的准确性，并且可以减少照射面积，这使得放射治疗更安全。

3. 发明授权

US08846768B2 Use of compounds isolated from Euphorbia neriifolia for treating cancer and/or thrombocytopenia 有权
标题翻译：使用从大戟属分离的化合物治疗癌症和/或血小板减少症
公开(公告)号：US08846768B2
公开(公告)日：2014-09-30
申请号：US13595170
申请日：2012-08-27
申请人： Yu-Jen Chen , Lie-Chwn Lin , Ching-Pin Lin
发明人： Yu-Jen Chen , Lie-Chwn Lin , Ching-Pin Lin
IPC分类号： A61K31/015 , A61K33/24 , A61K31/336 , A61K31/045
CPC分类号： A61K31/336 , A61K31/045 , A61K31/575 , A61K33/24 , A61K2300/00
摘要： Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.
摘要翻译：本文公开了小分子特别是分离自大戟属的三萜类化合物和多糖二萜类的新型用途。三萜类化合物可用作制备用于治疗癌症的药物或药物组合物的铅化合物; 而二醇二萜可用作制备用于治疗血小板减少症的药物或药物组合物的铅化合物。

4. 发明授权

US08691870B2 Use of isothiocyanates for treating cancer 有权
标题翻译：使用异硫氰酸酯治疗癌症
公开(公告)号：US08691870B2
公开(公告)日：2014-04-08
申请号：US13243128
申请日：2011-09-23
申请人： Yu-Jen Chen , Hui-Fen Liao
发明人： Yu-Jen Chen , Hui-Fen Liao
IPC分类号： A61K31/26 , C07C331/00
CPC分类号： A61K31/26
摘要： Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
摘要翻译：本文公开了小分子，特别是异硫氰酸6-甲基亚磺酰基己酯和异硫氰酸6-甲基磺酰基己酯的新用途。两种异硫氰酸酯可用作制造用于治疗患者中的癌症，特别是耐药性癌症的药物或药物组合物的铅化合物。

5. 发明申请

US20140056995A1 USE OF COMPOUNDS ISOLATED FROM EUPHORBIA NERIIFOLIA FOR TREATING CANCER AND/OR THROMBOCYTOPENIA 有权
标题翻译：用于治疗癌症和/或血栓形成的化合物从欧盟内镜分离的用途
公开(公告)号：US20140056995A1
公开(公告)日：2014-02-27
申请号：US13595170
申请日：2012-08-27
申请人： YU-JEN CHEN , Lie-Chwn Lin , Ching-Pin Lin
发明人： YU-JEN CHEN , Lie-Chwn Lin , Ching-Pin Lin
IPC分类号： A61K31/336 , A61K33/24 , A61K31/045
CPC分类号： A61K31/336 , A61K31/045 , A61K31/575 , A61K33/24 , A61K2300/00
摘要： Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.
摘要翻译：本文公开了小分子特别是分离自大戟属的三萜类化合物和多糖二萜类的新型用途。三萜类化合物可用作制备用于治疗癌症的药物或药物组合物的铅化合物; 而二醇二萜可用作制备用于治疗血小板减少症的药物或药物组合物的铅化合物。

6. 发明授权

US08546366B2 Method for inhibition of tumor cell growth using (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol 有权
标题翻译：（22R）-5alpha-lanosta-8,24-二烯-3β，15α，21-三醇抑制肿瘤细胞生长的方法
公开(公告)号：US08546366B2
公开(公告)日：2013-10-01
申请号：US13483620
申请日：2012-05-30
申请人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
发明人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
IPC分类号： A61K31/56 , A61K38/00 , A61P35/00
CPC分类号： A61K31/575
摘要： In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.
摘要翻译：在这项专利中，我们从番茄子实体中分离出一种新的化合物，即（22R）-5α-羊毛甾-8,24-二烯-3β，15α，21-三醇。该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

7. 发明申请

US20130141061A1 BUCK COVERTER WITH OVERCURRENT PROTECTION FUNCTION 有权
标题翻译：带过流保护功能的保险丝罩
公开(公告)号：US20130141061A1
公开(公告)日：2013-06-06
申请号：US13655401
申请日：2012-10-18
申请人： YU-JEN CHEN , CHUN-YUAN TIEN , FAN-CHIN KUNG , CHUN-PO CHEN , CHIA-MING YEH
发明人： YU-JEN CHEN , CHUN-YUAN TIEN , FAN-CHIN KUNG , CHUN-PO CHEN , CHIA-MING YEH
IPC分类号： G05F1/10
CPC分类号： H02M1/32 , H02M3/1588 , Y02B70/1466
摘要： A buck converter configured for converting a voltage output from a power supply to a load includes a first switch, a second switch, an inductor, three compensators and a control microchip. The first switch and the second switch are connected in series between two ends of the power supply. A first end of the inductor is connected to a node between the first switch and the second switch; a second end of the inductor serves as an output terminal connected to the load. The compensators are correspondingly connected to the first switch, the second switch and the inductor. The control microchip is electrically connected to the first and second switches and the node. The control microchip controls the first and second switches to turn on or off, and executes a current protective process when output current of the output terminal exceeds a current protective threshold of the load.
摘要翻译：被配置为将从电源输出的电压转换为负载的降压转换器包括第一开关，第二开关，电感器，三个补偿器和控制微芯片。第一开关和第二开关串联在电源的两端之间。电感器的第一端连接到第一开关和第二开关之间的节点; 电感器的第二端用作连接到负载的输出端子。补偿器相应地连接到第一开关，第二开关和电感器。控制微芯片电连接到第一和第二开关和节点。控制微芯片控制第一和第二开关导通或关断，并且当输出端子的输出电流超过负载的当前保护阈值时执行当前的保护处理。

8. 发明授权

US08456433B2 Signal processing apparatus, signal processing method and selection method of user interface icon for multi-touch panel 有权
标题翻译：信号处理装置，信号处理方法和多点触控面板用户界面图标选择方法
公开(公告)号：US08456433B2
公开(公告)日：2013-06-04
申请号：US12632931
申请日：2009-12-08
申请人： Yu Jen Chen
发明人： Yu Jen Chen
IPC分类号： G06F3/041
CPC分类号： G06F3/04886 , G06F3/0488 , G06F2203/04808
摘要： The present invention provides a signal processing apparatus and a signal processing method of a man-machine interface. The signal processing method comprises steps of: receiving a first touch signal; recognizing an object corresponding to the first touch signal; determining whether a second touch signal is received while receiving the first touch signal; and selecting the object corresponding to the first touch signal when receiving the second touch signal.
摘要翻译：本发明提供一种人机接口的信号处理装置和信号处理方法。信号处理方法包括以下步骤：接收第一触摸信号; 识别与第一触摸信号对应的对象; 确定在接收到所述第一触摸信号的同时是否接收到第二触摸信号; 以及当接收到第二触摸信号时选择与第一触摸信号对应的对象。

9. 发明申请

US20120309732A1 METHOD FOR INHIBITION OF TUMOR CELL GROWTH USING (22R)-5alpha-LANOSTA-8,24-DIEN-3Beta,15alpha,21-TRIOL 有权
标题翻译：使用（22R）-5alpha-LANOSTA-8,24-DIEN-3Beta，15α，21-TRIOL抑制肿瘤细胞生长的方法
公开(公告)号：US20120309732A1
公开(公告)日：2012-12-06
申请号：US13483620
申请日：2012-05-30
申请人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
发明人： Yu-Jen Chen , Cheng-Jen Chou , Tun-Tschu Chang
IPC分类号： A61K31/56 , A61P35/04 , A61P35/02 , C12N5/09
CPC分类号： A61K31/575
摘要： In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.
摘要翻译：在该专利中，我们分离出了一种新型的化合物，即，（22R）-5α-lanosta-8,24-二烯-3和bgr，15α，21-三醇的子实体。该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

10. 发明授权

US08310215B2 Linear modulation voltage transformer circuitry 有权
标题翻译：线性调制电压互感器电路
公开(公告)号：US08310215B2
公开(公告)日：2012-11-13
申请号：US12777437
申请日：2010-05-11
申请人： Chen-Kun Chou , Zhan-Yi Lin , Ting-Kuan Li , Yu-Jen Chen , Chi-Bin Wu
发明人： Chen-Kun Chou , Zhan-Yi Lin , Ting-Kuan Li , Yu-Jen Chen , Chi-Bin Wu
IPC分类号： G05F1/70
CPC分类号： G05F1/575
摘要： A linear modulation voltage transformer circuitry includes a power stage unit, a voltage division unit, a linear modulation unit, an error amplifier, and a recursive controller. The power stage unit adapts an input voltage and outputs a first voltage to the voltage division unit, which outputs a divided voltage. The linear modulation unit receives the divided voltage, compares it with a control voltage, and outputs an error voltage signal to the error amplifier, which amplifies the error voltage signal as an error gain control signal. The recursive controller receives and modulates the error gain control signal and outputs the modulation error gain control signal to the power stage unit as a reference signal so as for the power stage unit to modulate the first voltage. Thus, the first voltage can be varied in real time via the linear modulation unit to meet load demands.
摘要翻译：线性调制电压互感器电路包括功率级单元，分压单元，线性调制单元，误差放大器和递归控制器。功率级单元适应输入电压，并向分压单元输出第一电压，分压单元输出分压。线性调制单元接收分压，将其与控制电压进行比较，并将误差电压信号输出到误差放大器，该误差放大器将误差电压信号放大为误差增益控制信号。递归控制器接收并调制误差增益控制信号，并将调制误差增益控制信号输出到功率级单元作为参考信号，以使功率级单元调制第一电压。因此，可以经由线性调制单元实时地改变第一电压以满足负载需求。

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