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1. 发明授权

US10080797B2 Oncolytic heterologous recombinant newcastle disease virus, preparation method and application thereof 有权
公开(公告)号：US10080797B2
公开(公告)日：2018-09-25
申请号：US15244006
申请日：2016-08-23
申请人： Yongxiang Zhao
发明人： Xia Peng , Yi Peng
IPC分类号： A61K31/702 , A61K31/715 , A61K35/18 , A61K38/00 , A61K38/14 , A61K39/17 , C12N7/00 , C12N9/10
CPC分类号： A61K39/17 , A61K35/768 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N9/1051 , C12N15/86 , C12N2760/18121 , C12N2760/18132 , C12N2760/18134 , C12N2760/18143 , C12Y204/01087
摘要： Provided are an oncolytic heterologous recombinant Newcastle disease virus (NDV), preparation method and application thereof. The heterologous recombinant NDV can express alpha (1,3) galactosyltransferase (α1,3GT). The α1,3GT is the protein represented by the flowing B1) and B2): B1) the protein has an amino acid sequence of SEQ ID No.1; and B2) the protein is derived from B1) and has a function of α1,3GT obtained by substituting and/or deleting and/or adding one or more amino acid residue(s) in the amino acid sequence represented by SEQ ID No.1. The recombination NDV can be used for tumor treatment.

2. 发明申请

US20150252331A1 METHOD FOR INDUCING FUSION OF DENDRITIC CELL WITH TUMOUR CELL 有权
标题翻译：用于诱导具有肿瘤细胞的细胞融合的方法
公开(公告)号：US20150252331A1
公开(公告)日：2015-09-10
申请号：US14426163
申请日：2013-03-07
申请人： Yongxiang Zhao
发明人： Xiaoling Lu , Yi Peng
IPC分类号： C12N5/16
CPC分类号： C12N5/16 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , C12N2500/50 , C12N2502/1121 , C12N2502/30
摘要： Disclosed in the present invention is a method for inducing the fusion of a dendritic cell with a tumour cell, in the fusion process, successively adding an amount of polyethylene glycol and collagen to induce cell fusion highly efficiently, wherein polyethylene glycol can make the lipid molecules of the plasma membrane at the contact point between the two cells disperse and recombine, and then the cells fuse due to the mutual affinity between the bilayer membranes at the interface of the two cells and the surface tension between each other. The collagen can retrench the cell membrane and repair the cell membrane after fusion, thereby forming stable fusion cells highly efficiently, so it is suitable for the production of specific biological products such as tumour vaccines and monoclonal antibodies etc.
摘要翻译：在本发明中公开了一种用于诱导树突状细胞与肿瘤细胞融合的方法，在融合过程中，依次加入一定量的聚乙二醇和胶原来高效诱导细胞融合，其中聚乙二醇可制成脂质分子在两个细胞之间的接触点处的质膜分散和重组，然后由于在两个电池的界面处的双层膜之间的相互亲和力和彼此之间的表面张力而使细胞融合。胶原蛋白可以缩短细胞膜并融合后修复细胞膜，从而高效形成稳定的融合细胞，适用于生产特定的生物制品，如肿瘤疫苗和单克隆抗体等。

3. 发明申请

US20120230282A1 BASE STATION, NETWORK SYSTEM, AND IMPLEMENTATION METHOD 有权
标题翻译：基站，网络系统和实现方法
公开(公告)号：US20120230282A1
公开(公告)日：2012-09-13
申请号：US13478812
申请日：2012-05-23
申请人： Wangjun WU , Jun ZHOU , Peng LAN , Ziqiang WANG , Jun XIA , Yongxiang ZHAO , Jingyu WANG , Nengwu XIANG , Ni MA
发明人： Wangjun WU , Jun ZHOU , Peng LAN , Ziqiang WANG , Jun XIA , Yongxiang ZHAO , Jingyu WANG , Nengwu XIANG , Ni MA
IPC分类号： H04W72/04 , H04W4/00
CPC分类号： H04W28/16 , H04B7/024 , H04L5/0037 , H04W88/085 , H04W88/10
摘要： A base station includes multiple edge nodes and a central node. The edge nodes are configured to perform communication with a user equipment, and execute baseband processing and mutual conversion between baseband data and radio data, in which the multiple edge nodes belong to one or more edge node groups, and each edge node group includes at least one edge node. The central node is configured to perform communication with the multiple edge nodes, manage the multiple edge nodes, and perform resource sharing so that resources are shared by the multiple edge nodes. The base station is divided into two levels of architecture, namely, a central node and an edge node, and the central node implements resource sharing so that resources are shared by the edge nodes, so that a resource sharing degree in the base station is enhanced.
摘要翻译：基站包括多个边缘节点和中心节点。边缘节点被配置为执行与用户设备的通信，并且执行基带数据和无线电数据之间的基带处理和相互转换，其中多个边缘节点属于一个或多个边缘节点组，并且每个边缘节点组至少包括一个边缘节点。中心节点被配置为执行与多个边缘节点的通信，管理多个边缘节点，并执行资源共享，使得资源由多个边缘节点共享。基站分为两个级别的架构，即中心节点和边缘节点，中心节点实现资源共享，使资源由边缘节点共享，从而提高基站资源共享度。

4. 发明授权

US09615402B2 Base station, network system, and implementation method 有权
公开(公告)号：US09615402B2
公开(公告)日：2017-04-04
申请号：US13478812
申请日：2012-05-23
申请人： Wangjun Wu , Jun Zhou , Peng Lan , Ziqiang Wang , Jun Xia , Yongxiang Zhao , Jingyu Wang , Nengwu Xiang , Ni Ma
发明人： Wangjun Wu , Jun Zhou , Peng Lan , Ziqiang Wang , Jun Xia , Yongxiang Zhao , Jingyu Wang , Nengwu Xiang , Ni Ma
IPC分类号： H04W72/04 , H04W88/08 , H04L5/00 , H04W28/16 , H04B7/024
CPC分类号： H04W28/16 , H04B7/024 , H04L5/0037 , H04W88/085 , H04W88/10
摘要： A base station includes multiple edge nodes and a central node. The edge nodes are configured to perform communication with a user equipment, and execute baseband processing and mutual conversion between baseband data and radio data, in which the multiple edge nodes belong to one or more edge node groups, and each edge node group includes at least one edge node. The central node is configured to perform communication with the multiple edge nodes, manage the multiple edge nodes, and perform resource sharing so that resources are shared by the multiple edge nodes. The base station is divided into two levels of architecture, namely, a central node and an edge node, and the central node implements resource sharing so that resources are shared by the edge nodes, so that a resource sharing degree in the base station is enhanced.

5. 发明授权

US08854968B2 Communication network, device, and method 有权
标题翻译：通信网络，设备和方法
公开(公告)号：US08854968B2
公开(公告)日：2014-10-07
申请号：US13150979
申请日：2011-06-01
申请人： Yongxiang Zhao , Lian Yang , Wenyuan Yong
发明人： Yongxiang Zhao , Lian Yang , Wenyuan Yong
IPC分类号： G06F11/00 , H04J1/16 , H04L1/00 , H04L12/26 , H04W28/08 , H04W76/02 , H04W28/06 , H04W8/24
CPC分类号： H04W28/08 , H04W8/24 , H04W28/06 , H04W76/10
摘要： The present invention discloses a communication network, device and method. The communication method includes the following steps: a Mobile Broadband Edge (MBB-Edge) node sends a traffic offloading indication to a NodeB according to a traffic offloading policy; and the NodeB directs User Plane (UP) data of a Packet Switched (PS) service to a Public Data Network (PDN) through a fixed broadband bearer network of an offloading path according to the traffic offloading indication. The present invention increases the transmission efficiency of PS services.
摘要翻译：本发明公开了一种通信网络，装置和方法。通信方法包括以下步骤：移动宽带边缘（MBB-Edge）节点根据流量卸载策略向节点B发送流量卸载指示; 并且NodeB根据流量卸载指示，通过卸载路径的固定宽带承载网络将分组交换（PS）业务的用户平面（UP）数据指向公共数据网络（PDN）。本发明提高了PS业务的传输效率。

6. 发明申请

US20110228676A1 COMMUNICATION NETWORK, DEVICE, AND METHOD 有权
标题翻译：通信网络，设备和方法
公开(公告)号：US20110228676A1
公开(公告)日：2011-09-22
申请号：US13150979
申请日：2011-06-01
申请人： Yongxiang ZHAO , Lian Yang , Wenyuan Yong
发明人： Yongxiang ZHAO , Lian Yang , Wenyuan Yong
IPC分类号： H04W28/12
CPC分类号： H04W28/08 , H04W8/24 , H04W28/06 , H04W76/10
摘要： The present invention discloses a communication network, device and method. The communication method includes the following steps: a Mobile Broadband Edge (MBB-Edge) node sends a traffic offloading indication to a NodeB according to a traffic offloading policy; and the NodeB directs User Plane (UP) data of a Packet Switched (PS) service to a Public Data Network (PDN) through a fixed broadband bearer network of an offloading path according to the traffic offloading indication. The present invention increases the transmission efficiency of PS services.
摘要翻译：本发明公开了一种通信网络，装置和方法。通信方法包括以下步骤：移动宽带边缘（MBB-Edge）节点根据流量卸载策略向节点B发送流量卸载指示; 并且NodeB根据流量卸载指示，通过卸载路径的固定宽带承载网络将分组交换（PS）业务的用户平面（UP）数据指向公共数据网络（PDN）。本发明提高了PS业务的传输效率。

7. 发明授权

US09499798B2 Method for inducing fusion of dendritic cell with tumour cell 有权
标题翻译：诱导树突状细胞与肿瘤细胞融合的方法
公开(公告)号：US09499798B2
公开(公告)日：2016-11-22
申请号：US14426163
申请日：2013-03-07
申请人： Yongxiang Zhao
发明人： Xiaoling Lu , Yi Peng
IPC分类号： C12N5/16 , A61K39/00
CPC分类号： C12N5/16 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , C12N2500/50 , C12N2502/1121 , C12N2502/30
摘要： Disclosed in the present invention is a method for inducing the fusion of a dendritic cell with a tumour cell, in the fusion process, successively adding an amount of polyethylene glycol and collagen to induce cell fusion highly efficiently, wherein polyethylene glycol can make the lipid molecules of the plasma membrane at the contact point between the two cells disperse and recombine, and then the cells fuse due to the mutual affinity between the bilayer membranes at the interface of the two cells and the surface tension between each other. The collagen can retrench the cell membrane and repair the cell membrane after fusion, thereby forming stable fusion cells highly efficiently, so it is suitable for the production of specific biological products such as tumour vaccines and monoclonal antibodies etc.
摘要翻译：在本发明中公开了一种用于诱导树突状细胞与肿瘤细胞融合的方法，在融合过程中，依次加入一定量的聚乙二醇和胶原来高效诱导细胞融合，其中聚乙二醇可制成脂质分子在两个细胞之间的接触点处的质膜分散和重组，然后由于在两个电池的界面处的双层膜之间的相互亲和力和彼此之间的表面张力而使细胞融合。胶原蛋白可以缩短细胞膜并融合后修复细胞膜，从而高效形成稳定的融合细胞，适用于生产特定的生物制品，如肿瘤疫苗和单克隆抗体等。

8. 发明申请

US20120057550A1 Method, Apparatus, and System for Transmitting Packet Service Data 审中-公开
标题翻译：用于发送分组业务数据的方法，装置和系统
公开(公告)号：US20120057550A1
公开(公告)日：2012-03-08
申请号：US13290674
申请日：2011-11-07
申请人： Yongxiang Zhao , Yu Shao , Shujuan Wang , Ming Li , Jiahong Wei , Wenyuan Yong , Shengyi Qin , Hua Qiu , Yaowen Zhang , Wei Gu , Guangwei Wang
发明人： Yongxiang Zhao , Yu Shao , Shujuan Wang , Ming Li , Jiahong Wei , Wenyuan Yong , Shengyi Qin , Hua Qiu , Yaowen Zhang , Wei Gu , Guangwei Wang
IPC分类号： H04W40/00 , H04W72/04
CPC分类号： H04W88/16 , H04L45/04 , H04W8/082 , H04W40/00
摘要： The present disclosure relates to the communications field and discloses a method, an apparatus, and a system for transmitting packet service data Packet service data is sent by a User Equipment (UE). It is determined whether the packet service data is Internet service data according to a pre-obtained Internet service offloading policy. If the packet service data is Internet service data, the packet service data is transmitted to a Public Data Network (PDN) via a Metropolitan Area Network (MAN) and an IP backbone. Embodiments of the present disclosure may be applied to wireless communication systems such as a WCDMA system.
摘要翻译：本公开涉及通信领域，并且公开了用于发送分组业务数据的方法，装置和系统。分组业务数据由用户设备（UE）发送。根据预先获得的因特网服务卸载策略，确定分组业务数据是否是因特网服务数据。如果分组业务数据是互联网业务数据，则分组业务数据经由城域网（MAN）和IP骨干网被发送到公共数据网络（PDN）。本公开的实施例可以应用于诸如WCDMA系统的无线通信系统。

9. 发明申请

US20050094629A1 Integrated mobile gateway device used in wireless communication network 有权
标题翻译：集成移动网关设备用于无线通信网络
公开(公告)号：US20050094629A1
公开(公告)日：2005-05-05
申请号：US10956674
申请日：2004-10-01
申请人： Yongxiang Zhao , Lian Yang , Tao Peng , Zhijun Zhang , Xingwang Huang , Zhi Zeng , Li Wenxian
发明人： Yongxiang Zhao , Lian Yang , Tao Peng , Zhijun Zhang , Xingwang Huang , Zhi Zeng , Li Wenxian
IPC分类号： H04W88/16 , H04L12/66
CPC分类号： H04W88/16
摘要： Embodiments of the invention include a universal integrated mobile gateway used in wireless communication networks to interconnect different networks, comprising: AMP for data collocation and state management for other modules, CCM for data switching network management (together with other modules) and control data frame switching between modules, CDP for storage and management of relay resource and global shared resources, SPCs for processing services in different networks, and network interface; CCM is connected with AMP, CDP, and SPCs through HDLC protocol; SPCs are connected to the network interface through TCP/IP protocol. The embodiments improve normalization and operability of network interconnection, facilitate unified settlement between different networks, and enhance overall resource utilization of the networks.
摘要翻译：本发明的实施例包括在无线通信网络中用于互连不同网络的通用集成移动网关，包括：用于其他模块的数据搭配和状态管理的AMP，用于数据交换网络管理的CCM（与其他模块一起）和控制数据帧切换模块之间，用于存储和管理中继资源和全局共享资源的CDP，用于在不同网络中处理业务的SPC和网络接口; CCM通过HDLC协议与AMP，CDP和SPC连接; SPC通过TCP / IP协议连接到网络接口。实现了网络互联的正常化和可操作性，促进了不同网络之间的统一定位，提高了网络的整体资源利用。

10. 发明申请

US20210348189A1 METHOD FOR FAST GENE EDITING AND CONSTRUCTING PRIMATE DISEASE MODEL 有权
公开(公告)号：US20210348189A1
公开(公告)日：2021-11-11
申请号：US17277731
申请日：2018-09-20
申请人： YONGXIANG ZHAO
发明人： YONGXIANG ZHAO , LIPING ZHONG
IPC分类号： C12N15/85 , C12N9/22 , C12N15/11 , A01K67/027 , C12N15/89
摘要： Provided is a primate disease model construction method based on fast gene edition, which including (a) constructing a sgRNA expression plasmid by using a gRNA oligonucleotide and a pX330 plasmid; (b) injecting the sgRNA expression plasmid prepared in step (a) into a hepatic portal vein of a primate animal by using a biopsy needle until liver cells become cancerous for obtaining a primate disease model. The sgRNA expression plasmid constructed by the gRNA oligonucleotide and pX330 plasmid can be directly injected into the primate liver tissue, so as to construct a tumor model rapidly.

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