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1. 发明申请

US20140154286A1 MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS 有权
标题翻译：改性生物蛋白结合蛋白，其融合蛋白及其应用
公开(公告)号：US20140154286A1
公开(公告)日：2014-06-05
申请号：US14116492
申请日：2012-05-11
申请人： Richard Malley , Yingjie Lu , Fan Zhang
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： C07K14/195 , A61K47/48 , C07K14/31
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
摘要翻译：本公开提供修饰的生物素结合蛋白，其可以在细菌中以可高产率表达为可溶形式。还提供了包含修饰的生物素结合蛋白和抗原的融合蛋白。本公开还提供了来自金黄色葡萄球菌的α-溶血素的非溶血性变体和包含α-溶血素的非溶血性变体和生物素结合结构域的融合蛋白。还公开了包含蛋白质的免疫原性组合物，并且还公开了用于诱导免疫应答或接种受试者的这种免疫原性组合物的用途。

2. 发明申请

US20120251577A1 SELECTIVELY DISRUPTED WHOLE-CELL VACCINE 有权
标题翻译：选择性破坏全细胞疫苗
公开(公告)号：US20120251577A1
公开(公告)日：2012-10-04
申请号：US13500925
申请日：2010-10-12
申请人： Richard Malley , Porter Anderson , Yingjie Lu , George A. Robertson , Mark Alderson , Jean-Francois Lucien Maisonneuve , Andrea Maria Tate , Waldely de Oliveira Dias , Viviane Maimoni Gonçalves
发明人： Richard Malley , Porter Anderson , Yingjie Lu , George A. Robertson , Mark Alderson , Jean-Francois Lucien Maisonneuve , Andrea Maria Tate , Waldely de Oliveira Dias , Viviane Maimoni Gonçalves
IPC分类号： A61K39/02 , A61P37/04 , A61P31/04 , A61K39/09
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.
摘要翻译：本发明提供免疫原性组合物和方法，用于通过以诱导主要抗体应答的可溶性级分的方式选择性地破坏全细胞细菌制剂来产生具有杀死的全细胞肺炎链球菌的多种免疫诱导级分的免疫原性组合物，并且诱导主要抗体非依赖性应答的细胞部分保留在免疫原性组合物中。

3. 发明授权

US09827299B2 Selectively disrupted whole-cell vaccine 有权
公开(公告)号：US09827299B2
公开(公告)日：2017-11-28
申请号：US13500925
申请日：2010-10-12
申请人： Richard Malley , Porter Anderson , Yingjie Lu , George A. Robertson , Mark Alderson , Jean-Francois Lucien Maisonneuve , Andrea Maria Tate , Waldely de Oliveira Dias , Viviane Maimoni Gonçalves
发明人： Richard Malley , Porter Anderson , Yingjie Lu , George A. Robertson , Mark Alderson , Jean-Francois Lucien Maisonneuve , Andrea Maria Tate , Waldely de Oliveira Dias , Viviane Maimoni Gonçalves
IPC分类号： C12Q1/00 , A61K39/09 , A61K39/00
CPC分类号： A61K39/092 , A61K2039/521 , A61K2039/543 , A61K2039/55505 , A61K2039/55544
摘要： The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell Streptococcus pneumoniae by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.

4. 发明申请

US20110159040A1 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF 审中-公开
标题翻译：新型免疫调节剂及其发现和筛选方法
公开(公告)号：US20110159040A1
公开(公告)日：2011-06-30
申请号：US12981706
申请日：2010-12-30
申请人： Richard Malley , Yingjie Lu , Kristin L. Moffitt
发明人： Richard Malley , Yingjie Lu , Kristin L. Moffitt
IPC分类号： A61K39/09 , C07K1/14 , C07H1/06 , C07C51/42 , G01N33/68 , C12Q1/02 , A61P37/04 , A61P31/04
CPC分类号： A61K39/092 , A61K2039/521 , C07K1/14
摘要： An aspect of the present invention provides for methods for identifying novel immunogens that when administered as vaccines elicit a cellular or humoral immunogenic response. In a particular embodiment, a method identified pneumococcal T-cell immunogens that elicit systemic IL-17A responses, and reduce or protect against pneumococcal colonization.
摘要翻译：本发明的一个方面提供了用于鉴定新的免疫原的方法，所述新型免疫原当作为疫苗施用时引发细胞或体液免疫原性应答。在一个具体实施方案中，确定引起全身IL-17A应答的肺炎球菌T细胞免疫原的方法，并减少或防止肺炎球菌定植。

5. 发明申请

US20080017629A1 Steam oven 审中-公开
标题翻译：蒸汽烤箱
公开(公告)号：US20080017629A1
公开(公告)日：2008-01-24
申请号：US11825725
申请日：2007-07-09
申请人： Yaosheng Xu , Shengkai Lin , Yingjie Lu
发明人： Yaosheng Xu , Shengkai Lin , Yingjie Lu
IPC分类号： A47J39/00 , A21B1/08 , A47J36/24
CPC分类号： F24C15/327
摘要： A steam oven is disclosed. The steam oven includes an oven, a water storing element, a steam generating element, a first conveying element, a second conveying element and a heating element, herein the oven includes an orifice. Both of the water storing element and the steam generating element are disposed adjacent to the oven. The first conveying element used for conveying water from the water storing element to the steam generating element is disposed between the water storing element and the steam generating element. The second conveying element used for conveying steam from the steam generating element to the oven via the orifice connects the steam generating element and the oven. The heating element used for heating steam is disposed adjacent to the second conveying element.
摘要翻译：公开了一种蒸汽炉。蒸汽炉包括烤箱，储水元件，蒸汽发生元件，第一输送元件，第二输送元件和加热元件，这里，烤箱包括孔口。储水元件和蒸汽发生元件都设置在炉附近。用于将水从储水元件输送到蒸汽发生元件的第一输送元件设置在储水元件和蒸汽产生元件之间。用于将蒸汽从蒸汽发生元件经由孔口输送到烘箱的第二输送元件连接蒸汽产生元件和烘箱。用于加热蒸汽的加热元件邻近第二输送元件设置。

6. 发明授权

US10766932B2 Multiple antigen presenting immunogenic composition, and methods and uses thereof 有权
公开(公告)号：US10766932B2
公开(公告)日：2020-09-08
申请号：US14116402
申请日：2012-05-11
申请人： Richard Malley , Yingjie Lu , Fan Zhang
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： C07K14/31 , A61K47/61 , A61K47/54 , A61P31/04 , A61K39/09 , A61K39/385 , A61K39/00
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.

7. 发明授权

US09499593B2 Modified biotin-binding protein, fusion proteins thereof and applications 有权
标题翻译：改良的生物素结合蛋白，其融合蛋白和应用
公开(公告)号：US09499593B2
公开(公告)日：2016-11-22
申请号：US14116492
申请日：2012-05-11
申请人： Richard Malley , Yingjie Lu , Fan Zhang
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： A61K39/00 , A61K39/02 , C07K14/31 , A61K47/48
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
摘要翻译：本公开提供修饰的生物素结合蛋白，其可以在细菌中以可高产率表达为可溶形式。还提供了包含修饰的生物素结合蛋白和抗原的融合蛋白。本公开还提供了来自金黄色葡萄球菌的α-溶血素的非溶血性变体和包含α-溶血素的非溶血性变体和生物素结合结构域的融合蛋白。还公开了包含蛋白质的免疫原性组合物，并且还公开了用于诱导免疫应答或接种受试者的这种免疫原性组合物的用途。

8. 发明申请

US20160090404A1 MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS 有权
标题翻译：改性生物蛋白结合蛋白，其融合蛋白及其应用
公开(公告)号：US20160090404A1
公开(公告)日：2016-03-31
申请号：US14946372
申请日：2015-11-19
申请人： Richard Malley , Yingjie Lu , Fan Zhang
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： C07K14/31 , C07K14/195
CPC分类号： C07K14/31 , A61K39/092 , A61K39/385 , A61K47/543 , A61K47/557 , A61K47/61 , A61K2039/55505 , A61K2039/6031 , A61K2039/6093 , A61K2039/625 , A61K2039/627 , A61K2039/645 , C07K2319/00 , C07K2319/20 , Y02A50/484
摘要： The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed.
摘要翻译：本公开提供修饰的生物素结合蛋白，其可以在细菌中以可高产率表达为可溶形式。还提供了包含修饰的生物素结合蛋白和抗原的融合蛋白。本公开还提供了来自金黄色葡萄球菌的α-溶血素的非溶血性变体和包含α-溶血素的非溶血性变体和生物素结合结构域的融合蛋白。还公开了包含蛋白质的免疫原性组合物，并且还公开了用于诱导免疫应答或接种受试者的这种免疫原性组合物的用途。

9. 发明申请

US20140154287A1 MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF 审中-公开
标题翻译：多种抗原呈递免疫组合物，其方法及用途
公开(公告)号：US20140154287A1
公开(公告)日：2014-06-05
申请号：US14116402
申请日：2012-05-11
申请人： Richard Malley , Yingjie Lu , Fan Zhang
发明人： Richard Malley , Yingjie Lu , Fan Zhang
IPC分类号： A61K47/48
摘要： The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.
摘要翻译：本实施方案提供了一种免疫原性多抗原呈递系统，其包含抗体通过互补亲和分子与之相关的聚合物。例如，聚合物可以是来自相同或不同病原体的蛋白质或肽抗原间接连接的多糖或抗原性多糖。本发明的免疫原性组合物可以同时引起对一种或多种抗原的体液和细胞免疫应答。

10. 发明申请

US20130039947A1 NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF 审中-公开
标题翻译：新型免疫调节剂及其发现和筛选方法
公开(公告)号：US20130039947A1
公开(公告)日：2013-02-14
申请号：US13634357
申请日：2011-03-11
申请人： Richard Malley , Yingjie Lu , Kristin L. Moffitt
发明人： Richard Malley , Yingjie Lu , Kristin L. Moffitt
IPC分类号： A61K39/09 , A61P31/04 , G01N33/53 , A61K39/02 , C07K14/315
CPC分类号： A61K39/092 , A61K2039/55544 , A61K2039/55583 , A61K2039/70 , C07K14/3156 , C07K2319/00
摘要： The present application is generally directed to methods for identifying immunogens from organisms and pathogens, and in particular for identifying immunogens which when administered as vaccines elicit a cellular and/or humoral immune response. The present application is also directed to pneumococcal T-cell immunogens, and vaccine compositions comprising one or a combination of pneumococcal immunogens and methods for treating or preventing pneumococcal infections using the vaccines thereof. The present invention also encompasses use of the pneumococcal immunogens for diagnostic purposes to identify a subject with a pneumococcal infection.
摘要翻译：本申请一般涉及从生物体和病原体鉴定免疫原的方法，特别是鉴定当作为疫苗引起细胞和/或体液免疫应答时的免疫原的鉴定方法。本申请还涉及肺炎球菌T细胞免疫原，以及包含肺炎球菌免疫原的一种或组合的疫苗组合物，以及使用其疫苗治疗或预防肺炎球菌感染的方法。本发明还包括用于诊断目的的肺炎球菌免疫原用于识别患有肺炎球菌感染的受试者的用途。

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