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1. 发明申请

US20100311080A1 WATER-SOLUBLE NANOCRYSTALS THROUGH DUAL-INTERACTION LIGANDS 有权
标题翻译：通过双相互联系的水溶性纳米晶体
公开(公告)号：US20100311080A1
公开(公告)日：2010-12-09
申请号：US12865056
申请日：2009-01-28
申请人： Y. Charles Cao , Huimeng Wu
发明人： Y. Charles Cao , Huimeng Wu
IPC分类号： G01N33/53 , C07D307/20 , C07K17/14 , C07F1/12
CPC分类号： G01N33/54353 , C01B19/007 , G01N33/54313
摘要： A dual-interaction ligand for rendering otherwise hydrophobic nanoparticles water soluble or suspendable has a hydrophilic base with a plurality of hydrophilic segments extending from a core of the base, where at least one segment or the core contains a hydrophobic groups capable of forming van der Waal interaction between hydrophobic groups of the dual-interaction ligand and other hydrophobic ligands, and at least one complexing functionality to complex a metal atom or ion of a nanoparticle. The dual-interaction ligands can be combined with hydrophobic nanoparticles, where the dual-interaction ligands can displace some or all of the hydrophobic ligands of the hydrophobic nanoparticles, to form a nanoparticle-dual interaction ligand complex that can be dissolved or dispersed readily in an aqueous solution. The dual interaction ligand can be functionalized to attach an antibody or other biomolecules such that the nanoparticle dual-interaction ligands complexes can contain biomolecules. Such biomolecules modified nanoparticle dual-interaction ligands can be used for sensing, labeling, optical imaging, magnetic resonance imaging, cell separation, and treatment of diseases.
摘要翻译：用于使另外的疏水性纳米颗粒水溶性或悬浮的双相互作用配体具有亲水性碱基，其具有从碱的核心延伸的多个亲水链段，其中至少一个链段或核心包含能够形成范德瓦尔双相互作用配体和其它疏水性配体的疏水基团之间的相互作用以及与金属原子或纳米颗粒的离子络合的至少一种络合官能团。双相互作用配体可以与疏水性纳米颗粒结合，其中双相互作用配体可以置换疏水性纳米颗粒的一些或全部疏水性配体，形成纳米颗粒 - 双相互作用配体配合物，其可以容易地溶解或分散在水溶液。双相互作用配体可以被官能化以附着抗体或其他生物分子，使得纳米颗粒双重相互作用配体复合物可以含有生物分子。这种生物分子修饰的纳米颗粒双相互作用配体可用于感测，标记，光学成像，磁共振成像，细胞分离和疾病的治疗。

2. 发明授权

US09174186B2 Supercrystalline colloidal particles and method of production 有权
标题翻译：超结晶胶体颗粒及其生产方法
公开(公告)号：US09174186B2
公开(公告)日：2015-11-03
申请号：US12672447
申请日：2008-08-15
申请人： Y. Charles Cao , Jiaqi Zhuang , Huimeng Wu , Yongan Yang
发明人： Y. Charles Cao , Jiaqi Zhuang , Huimeng Wu , Yongan Yang
IPC分类号： B01J13/00 , A61K9/16 , A61K47/02
CPC分类号： B01J13/0026 , B01J13/0043
摘要： The present invention concerns size- and shape-controlled, colloidal superparticles (SPs) and methods for synthesizing the same. Ligand-functionalized nanoparticles such as nonpolar-solvent-dispersible nanoparticles, are used, and the solvophobic interactions can be controlled. Advantageously, supercrystalline SPs having a superlattice structure, such as a face-centered cubic structure, can be produced. Further, the methods of the invention can provide SPs that self-assemble and are monodisperse. The SPs can be doped with organic dyes and further assembled into more complex structures.
摘要翻译：本发明涉及尺寸和形状控制的胶体超微粒（SPs）及其合成方法。使用配体官能化的纳米粒子，如非极性溶剂分散纳米粒子，可以控制溶剂渗透相互作用。有利地，可以生产具有超晶格结构的超晶体SP，例如面心立方结构。此外，本发明的方法可以提供自组装和单分散的SP。 SP可以掺杂有机染料并进一步组装成更复杂的结构。

3. 发明授权

US08889429B2 Water-soluble nanocrystals through dual-interaction ligands 有权
标题翻译：水溶性纳米晶体通过双相互作用配体
公开(公告)号：US08889429B2
公开(公告)日：2014-11-18
申请号：US12865056
申请日：2009-01-28
申请人： Y. Charles Cao , Huimeng Wu
发明人： Y. Charles Cao , Huimeng Wu
IPC分类号： G01N33/553 , G01N33/543 , C01B19/00
CPC分类号： G01N33/54353 , C01B19/007 , G01N33/54313
摘要： A dual-interaction ligand for rendering otherwise hydrophobic nanoparticles water soluble or suspendable has a hydrophilic base with a plurality of hydrophilic segments extending from a core of the base, where at least one segment or the core contains a hydrophobic groups capable of forming van der Waal interaction between hydrophobic groups of the dual-interaction ligand and other hydrophobic ligands, and at least one complexing functionality to complex a metal atom or ion of a nanoparticle. The dual-interaction ligands can be combined with hydrophobic nanoparticles, where the dual-interaction ligands can displace some or all of the hydrophobic ligands of the hydrophobic nanoparticles, to form a nanoparticle-dual interaction ligand complex that can be dissolved or dispersed readily in an aqueous solution. The dual interaction ligand can be functionalized to attach an antibody or other biomolecules such that the nanoparticle dual-interaction ligands complexes can contain biomolecules. Such biomolecules modified nanoparticle dual-interaction ligands can be used for sensing, labeling, optical imaging, magnetic resonance imaging, cell separation, and treatment of diseases.
摘要翻译：用于使另外的疏水性纳米颗粒水溶性或悬浮的双相互作用配体具有亲水性碱基，其具有从碱的核心延伸的多个亲水链段，其中至少一个链段或核心包含能够形成范德瓦尔双相互作用配体和其它疏水性配体的疏水基团之间的相互作用以及与金属原子或纳米颗粒的离子络合的至少一种络合官能团。双相互作用配体可以与疏水性纳米颗粒结合，其中双相互作用配体可以置换疏水性纳米颗粒的一些或全部疏水性配体，形成纳米颗粒 - 双相互作用配体配合物，其可以容易地溶解或分散在水溶液。双相互作用配体可以被官能化以附着抗体或其他生物分子，使得纳米颗粒双重相互作用配体复合物可以含有生物分子。这种生物分子修饰的纳米颗粒双相互作用配体可用于感测，标记，光学成像，磁共振成像，细胞分离和疾病的治疗。

4. 发明申请

US20110031430A1 SYNTHESIS OF WATER-SOLUBLE ORGANIC NANOPARTICLES AS EPR STANDARD 审中-公开
标题翻译：作为EPR标准的水溶性有机纳米颗粒的合成
公开(公告)号：US20110031430A1
公开(公告)日：2011-02-10
申请号：US12850088
申请日：2010-08-04
申请人： Y. CHARLES CAO , Ou Chen , Alexander Angerhofer
发明人： Y. CHARLES CAO , Ou Chen , Alexander Angerhofer
IPC分类号： H01F1/00 , C07C241/02 , B32B5/16
CPC分类号： C07C243/22 , B82Y25/00 , G01F1/716 , H01F1/0054 , Y10T428/2982 , Y10T428/2989
摘要： Novel water soluble paramagnetic organic nanoparticles are formed by a novel method where an organic solution of an organic compound is injected into water under agitation that is maintained for a desired period of time for nanoparticle growth followed by termination of the growth by the addition of an aqueous surfactant solution. The size of the nanoparticles depends on the time between injection and addition of the surfactant solution. In embodiments of the invention, the water soluble paramagnetic organic nanoparticles can be DPPH nanoparticles, DPPH nanoparticles doped with DPPH-H, or core/shell nanoparticles where a DPPH core is covered by a DPPH-H shell.
摘要翻译：通过一种新的方法形成新的水溶性顺磁性有机纳米颗粒，其中将有机化合物的有机溶液在搅拌下注入水中，将其维持在纳米颗粒生长所需的时间段，然后通过加入水溶液终止生长表面活性剂溶液。纳米颗粒的尺寸取决于注射和添加表面活性剂溶液之间的时间。在本发明的实施方案中，水溶性顺磁性有机纳米颗粒可以是DPPH纳米颗粒，掺有DPPH-H的DPPH纳米颗粒或其中DPPH核被DPPH-H壳覆盖的核/壳纳米颗粒。

5. 发明申请

US20100264334A1 EXCITATION-INTENSITY-DEPENDENT, COLOR-TUNABLE, DUAL EMITTING NANOCRYSTALS 有权
标题翻译：激发依赖性，颜色可调，双重发光纳米晶体
公开(公告)号：US20100264334A1
公开(公告)日：2010-10-21
申请号：US12755820
申请日：2010-04-07
申请人： Y. CHARLES CAO , Ou Chen , Daniel Edward Shelby , Yongan Yang , Jiaqi Zhuang , Nicolo Omenetto
发明人： Y. CHARLES CAO , Ou Chen , Daniel Edward Shelby , Yongan Yang , Jiaqi Zhuang , Nicolo Omenetto
IPC分类号： F21V9/16 , H01L33/06
CPC分类号： C09K11/025 , C09K11/565
摘要： An embodiment of the invention is a device for photo-stimulated color emission having at least one plurally doped semiconducting nanoparticle comprising at least one semiconducting material and a plurality of at least one dopant coupled with an irradiation source such that the plurally doped semiconducting nanoparticle emit electromagnetic radiation at two or more wavelengths where the intensities of the emissions depend on the intensity of the irradiation. In an embodiment of the invention, the plurally doped semiconducting nanoparticle can be a doped core/shell nanoparticle where the plurality of dopants can reside in exclusively the core, exclusively the shell, or in both the core and shell.
摘要翻译：本发明的一个实施例是一种用于光刺激颜色发射的装置，其具有至少一个多掺杂的半导体纳米颗粒，其包含至少一种半导体材料和多个与辐射源耦合的至少一种掺杂剂，使得多个掺杂的半导体纳米颗粒发射电磁在两个或更多个波长处的辐射，其中发射强度取决于照射的强度。在本发明的一个实施方案中，多掺杂的半导体纳米颗粒可以是掺杂的核/壳纳米颗粒，其中多个掺杂剂可以仅存在于核心中，仅存在于壳中，或者位于核和壳两者中。

6. 发明申请

US20100055462A1 Doped Nanocrystals 有权
标题翻译：掺杂的纳米晶体
公开(公告)号：US20100055462A1
公开(公告)日：2010-03-04
申请号：US12376371
申请日：2007-08-30
申请人： Y. Charles Cao
发明人： Y. Charles Cao
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： H01L21/0257 , C09K11/02 , C09K11/565 , C09K11/574 , H01L21/02521 , H01L21/02601 , H01L21/242 , H01L21/40 , H01L29/225 , Y10T428/2991
摘要： A doping method using a three-step synthesis to make high-quality doped nanocrystals is provided. The first step includes synthesizing starting host particles. The second step includes dopant growth on the starting host particles. The third step includes final shell growth. In one embodiment, this method can be used to form Mn-doped CdS/ZnS core/shell nanocrystals. The Mn dopant can be formed inside the CdS core, at the core/shell interface, and/or in the ZnS shell. The subject method allows precisely controlling the impurity radial position and doping level in the nanocrystals.
摘要翻译：提供了使用三步合成制造高品质掺杂纳米晶体的掺杂方法。第一步包括合成起始的主体颗粒。第二步包括在起始主体颗粒上的掺杂剂生长。第三步包括最终的壳增长。在一个实施方案中，该方法可用于形成Mn掺杂的CdS / ZnS核/壳纳米晶体。 Mn掺杂剂可以形成在CdS芯内，核/壳界面和/或ZnS壳内。本方法允许精确控制纳米晶体中的杂质径向位置和掺杂水平。

7. 发明授权

US09406759B2 Methods for forming nanocrystals with position-controlled dopants 有权
标题翻译：用位置控制掺杂剂形成纳米晶体的方法
公开(公告)号：US09406759B2
公开(公告)日：2016-08-02
申请号：US12376371
申请日：2007-08-30
申请人： Y. Charles Cao
发明人： Y. Charles Cao
IPC分类号： C30B7/14 , H01L29/225 , C09K11/02 , C09K11/56 , C09K11/57 , H01L21/24 , H01L21/40 , H01L21/02
CPC分类号： H01L21/0257 , C09K11/02 , C09K11/565 , C09K11/574 , H01L21/02521 , H01L21/02601 , H01L21/242 , H01L21/40 , H01L29/225 , Y10T428/2991
摘要： A doping method using a three-step synthesis to make high-quality doped nanocrystals is provided. The first step includes synthesizing starting host particles. The second step includes dopant growth on the starting host particles. The third step includes final shell growth. In one embodiment, this method can be used to form Mn-doped CdS/ZnS core/shell nanocrystals. The Mn dopant can be formed inside the CdS core, at the core/shell interface, and/or in the ZnS shell. The subject method allows precisely controlling the impurity radial position and doping level in the nanocrystals.
摘要翻译：提供了使用三步合成制造高品质掺杂纳米晶体的掺杂方法。第一步包括合成起始的主体颗粒。第二步包括在起始主体颗粒上的掺杂剂生长。第三步包括最终的壳增长。在一个实施方案中，该方法可用于形成Mn掺杂的CdS / ZnS核/壳纳米晶体。 Mn掺杂剂可以形成在CdS芯内，核/壳界面和/或ZnS壳内。本方法允许精确控制纳米晶体中的杂质径向位置和掺杂水平。

8. 发明授权

US08410455B2 Excitation-intensity-dependent, color-tunable, dual emitting nanocrystals 有权
标题翻译：激发强度相关，颜色可调，双发射纳米晶体
公开(公告)号：US08410455B2
公开(公告)日：2013-04-02
申请号：US12755820
申请日：2010-04-07
申请人： Y. Charles Cao , Ou Chen , Daniel Edward Shelby , Yongan Yang , Jiaqi Zhuang , Nicolo Omenetto
发明人： Y. Charles Cao , Ou Chen , Daniel Edward Shelby , Yongan Yang , Jiaqi Zhuang , Nicolo Omenetto
IPC分类号： G01N21/64
CPC分类号： C09K11/025 , C09K11/565
摘要： An embodiment of the invention is a device for photo-stimulated color emission having at least one plurally doped semiconducting nanoparticle comprising at least one semiconducting material and a plurality of at least one dopant coupled with an irradiation source such that the plurally doped semiconducting nanoparticle emit electromagnetic radiation at two or more wavelengths where the intensities of the emissions depend on the intensity of the irradiation. In an embodiment of the invention, the plurally doped semiconducting nanoparticle can be a doped core/shell nanoparticle where the plurality of dopants can reside in exclusively the core, exclusively the shell, or in both the core and shell.
摘要翻译：本发明的一个实施例是一种用于光刺激颜色发射的装置，其具有至少一个多掺杂的半导体纳米颗粒，其包含至少一种半导体材料和多个与辐射源耦合的至少一种掺杂剂，使得多个掺杂的半导体纳米颗粒发射电磁在两个或更多个波长处的辐射，其中发射强度取决于照射的强度。在本发明的一个实施方案中，多掺杂的半导体纳米颗粒可以是掺杂的核/壳纳米颗粒，其中多个掺杂剂可以仅存在于核心中，仅存在于壳中，或者位于核和壳两者中。

9. 发明申请

US20110150938A1 Supercrystalline Colloidal Particles and Method of Production 有权
标题翻译：超结晶胶体颗粒和生产方法
公开(公告)号：US20110150938A1
公开(公告)日：2011-06-23
申请号：US12672447
申请日：2008-08-15
申请人： Y. Charles Cao , Jiaqi Zhuang , Huimeng Wu , Yongan Yang
发明人： Y. Charles Cao , Jiaqi Zhuang , Huimeng Wu , Yongan Yang
IPC分类号： A61K9/00 , A61K47/02 , A61K31/43 , A61K31/337 , A61K49/00 , A61K38/18 , A61K38/00 , A61K38/23 , A61K51/00 , A61K38/22 , A61K31/56 , A61K39/00 , A61K31/522 , A61K48/00 , A61K31/7052 , A61B5/055 , B82Y5/00
CPC分类号： B01J13/0026 , B01J13/0043
摘要： The present invention concerns size- and shape-controlled, colloidal superparticles (SPs) and methods for synthesizing the same. Ligand-functionalized nanoparticles such as nonpolar-solvent-dispersible nanoparticles, are used, and the solvophobic interactions can be controlled. Advantageously, supercrystalline SPs having a superlattice structure, such as a face-centered cubic structure, can be produced. Further, the methods of the invention can provide SPs that self-assemble and are monodisperse. The SPs can be doped with organic dyes and further assembled into more complex structures.
摘要翻译：本发明涉及尺寸和形状控制的胶体超微粒（SPs）及其合成方法。使用配体官能化的纳米粒子，如非极性溶剂分散纳米粒子，可以控制溶剂渗透相互作用。有利地，可以生产具有超晶格结构的超晶体SP，例如面心立方结构。此外，本发明的方法可以提供自组装和单分散的SP。 SP可以掺杂有机染料并进一步组装成更复杂的结构。

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