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1. 发明授权

US07615370B2 System having device for preventing air bubbles in a hybridization chamber and corresponding method 有权
标题翻译：具有用于在杂交室中防止气泡的装置的系统和相应的方法
公开(公告)号：US07615370B2
公开(公告)日：2009-11-10
申请号：US10931432
申请日：2004-09-01
申请人： Wolfgang Streit , Gyoergy Wenczel , Waltraud Lamprecht , Heribert Eglauer
发明人： Wolfgang Streit , Gyoergy Wenczel , Waltraud Lamprecht , Heribert Eglauer
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/502723 , B01L3/50855 , B01L2200/0684 , B01L2300/0822 , B01L2300/14
摘要： The present invention relates to a system (1) having hybridization chambers (5) for hybridizing nucleic acid samples, proteins, or tissue sections immobilized on slides (27), each hybridization chamber (5) being defined as an essentially gap-shaped chamber, which is essentially fillable with a liquid, between one of these slides (27) and a cover (26), and the cover (26) being positioned in relation to the slide (27) in such a way that the hybridization chamber (5) is sealed to the surrounding air, the system (1) including a device for preventing air bubbles in the hybridization chambers (5). The system according to the present invention is distinguished in that this device for preventing air bubbles in the hybridization chambers (5) is implemented as a pressure device to build up a chamber pressure in the hybridization chambers (5), this chamber pressure lying above the normal atmospheric pressure existing in the surrounding air. The present invention additionally relates to a method for preventing air bubbles in the hybridization chambers (5) of such a system (1) and is distinguished in that, using a pressure device of this system (1), a chamber pressure is implemented in the hybridization chambers (5) which lies above the normal atmospheric pressure existing in the surrounding air.
摘要翻译：本发明涉及一种具有杂交室（5）的系统（1），用于将固定在载片（27）上的核酸样品，蛋白质或组织切片进行杂交，每个杂交室（5）被定义为基本间隙形的室，其基本上可用液体填充，在这些滑动件（27）中的一个和盖（26）之间，并且盖（26）相对于载玻片（27）定位成使得杂交室（5）密封到周围空气，系统（1）包括用于防止杂交室（5）中的气泡的装置。根据本发明的系统的特征在于，用于防止杂交室（5）中的气泡的装置被实施为用于在杂交室（5）中建立室压力的压力装置，该室压力位于周围空气中存在正常的大气压力。本发明还涉及一种用于防止这种系统（1）的杂交室（5）中的气泡的方法，其区别在于，使用该系统（1）的压力装置，在位于周围空气中存在的正常大气压力之上的杂交室（5）。

2. 发明授权

US07425311B2 Holding device 有权
标题翻译：保持装置
公开(公告)号：US07425311B2
公开(公告)日：2008-09-16
申请号：US10465429
申请日：2003-06-18
申请人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
发明人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
IPC分类号： B01L9/00 , B01L3/00 , G01N21/00 , A47G1/06
CPC分类号： B01L3/50855 , B01F5/10 , B01F11/0071 , B01F13/0059 , B01F15/00123 , B01F15/00318 , B01F15/00396 , B01F15/0244 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L9/06 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B33Y80/00
摘要： A holding device for at least one object carrier, the object carrier being suitable to receive one or more organic and/or inorganic samples and comprising materials such as glass, plastic, silicon, pyrolytic graphite, and/or metal, this holding device being configured to be gripped by grippers of a robot. The holding device comprising two essentially parallel lengthwise walls and two essentially parallel transverse walls which extend substantially at right angles from the lengthwise walls. Holding devices according to preferred embodiments are constructed in a frame shape, wherein the lengthwise and transverse walls define a frame surrounding at least one opening which completely transverses the device. Holding devices according to further embodiments are constructed a plate shape, in that the region between the lengthwise walls and transverse walls is implemented as a carrying surface. All embodiments comprising gripping surfaces on the external surface profile of the lengthwise and transverse walls.
摘要翻译：一种用于至少一个物体载体的保持装置，所述物体载体适于接收一种或多种有机和/或无机样品并且包括诸如玻璃，塑料，硅，热解石墨和/或金属的材料，该保持装置被配置被机器人的夹具夹住。保持装置包括两个基本上平行的纵向壁和两个基本上平行的横向壁，其从纵向壁基本上以直角延伸。根据优选实施例的保持装置被构造成框架形状，其中纵向和横向壁限定围绕完全横穿装置的至少一个开口的框架。根据其他实施例的保持装置被构造为板形，其中纵向壁和横向壁之间的区域被实现为承载表面。所有实施例包括在纵向和横向壁的外表面轮廓上抓握表面。

3. 发明申请

US20060003440A1 Device and process unit for providing a hybridization chamber 有权
公开(公告)号：US20060003440A1
公开(公告)日：2006-01-05
申请号：US11191327
申请日：2005-07-28
申请人： Wolfgang Streit , Gyoergy Wenczel , Anton Mathes , Waltraud Lamprecht
发明人： Wolfgang Streit , Gyoergy Wenczel , Anton Mathes , Waltraud Lamprecht
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01F5/10 , B01F11/0071 , B01F13/0059 , B01F15/00123 , B01F15/00318 , B01F15/00396 , B01F15/0244 , B01F2015/00084 , B01F2215/0037 , B01F2215/0073 , B01J2219/00353 , B01J2219/00396 , B01J2219/00477 , B01J2219/00479 , B01J2219/00533 , B01J2219/00659 , B01L3/50273 , B01L3/502738 , B01L3/50855 , B01L9/06 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2400/0481 , C40B60/14
摘要： A device provides a hybridization chamber for hybridizing nucleic acid samples, proteins or tissue sections on a slide, and is an essentially rectangular body movable opposite the slide. The device includes a surface, lines for supplying and/or removing media, a specimen supply line and an agitating device. The agitation device includes at least one membrane which separates a pressure chamer to be fillable with a pressure fluid via one of the lines, from at least one agitation chamber connected via an agitation line to the hybridization chamber. The lines are continuously open so the media therein can permanently flow unhindered. Four such devices can be combined into a process unit for providing a hybridization chamber. Such unit is pivotable around an axis and has a holder with four seats, which is lockable in relation to a baseplate, one device being insertable into each one of the seats.

4. 发明申请

US20120198928A1 METHOD FOR REGISTERING THE FILLING POTENTIAL OF A WASTE CONTAINER OF MICROPLATE WASHING DEVICES 有权
标题翻译：注入微波炉洗涤装置废水容器填充电位的方法
公开(公告)号：US20120198928A1
公开(公告)日：2012-08-09
申请号：US13357773
申请日：2012-01-25
申请人： WOLFGANG STREIT , Juha Koota , Wolfgang Fuchs
发明人： WOLFGANG STREIT , Juha Koota , Wolfgang Fuchs
IPC分类号： G01F23/14
CPC分类号： G01N35/1004 , B01L99/00 , B01L2300/0829 , G01F17/00 , G01F23/14
摘要： Method for registering filling potential of a waste container of a microplate washing device has a needle for aspirating liquids, a waste container, a pump for generating a partial vacuum and a pressure sensor for determining air pressure in the container, a sensor controller, and a first valve for blocking the line between the needle and the waste container. The pump and needle are connected to the container and the method includes closing the first valve, generating a partial vacuum in a test range, closing a further valve between the container and the pump, opening the first valve, triggering a partial vacuum dissipation in the container, measuring a test time for the partial vacuum dissipation in the test range, comparing the test time to a known threshold time, and deciding that the waste container is fillable or not.
摘要翻译：用于记录微板清洗装置的废液容器的填充电位的方法具有用于吸液的针，废液容器，用于产生部分真空的泵和用于确定容器中的空气压力的压力传感器，传感器控制器和用于阻塞针和废物容器之间的线的第一阀。泵和针连接到容器，并且该方法包括关闭第一阀，在测试范围内产生部分真空，关闭容器和泵之间的另一阀，打开第一阀，触发第一阀中的部分真空耗散在测试范围内测量部分真空耗散的测试时间，将测试时间与已知阈值时间进行比较，并确定废物容器是否可填充。

5. 发明申请

US20100167406A1 MEASURING APPARATUS AND METHOD FOR DETERMINING FLUID PARAMETERS PROVIDED BY A LABORATORY SYSTEM 审中-公开
标题翻译：用于确定实验室系统提供的流体参数的测量装置和方法
公开(公告)号：US20100167406A1
公开(公告)日：2010-07-01
申请号：US12617237
申请日：2009-11-12
申请人： WOLFGANG STREIT , Gerald Probst , Juha Koota , Gyoergy Wenczel
发明人： WOLFGANG STREIT , Gerald Probst , Juha Koota , Gyoergy Wenczel
IPC分类号： G01N31/00 , G01F1/00 , G01L7/00 , G01N33/00 , G01N7/00 , G01N1/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/028 , B01L2200/146 , B01L2200/147 , B01L2300/024 , B01L2300/043 , B01L2300/0636 , B01L2300/0663 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , Y10T436/25
摘要： Relates to a measuring apparatus (4) and corresponding methods carried out in e.g. hybridization systems for determining fluid parameters provided by a laboratory system (1). The measuring apparatus (4) comprises a measuring unit (5) and a processing unit (6) for determining the fluid parameters provided by the laboratory system (1) and the measuring unit (5) is accomplished to be able to be integrated into this laboratory system (1). The measuring apparatus (4) according to the invention is characterised in that the measuring unit (5) comprises a measuring block (15) without a reaction room (34) and at least one sensor (17). The measuring block (15) comprises hollow spaces (16) for receiving or guiding fluids (13) provided by the laboratory system (1). The at least one sensor (17) is arranged, for determining physical and/or chemical parameters of fluids (13) located in the hollow spaces (16), on or in fluidic operative connection with these hollow spaces (16) of the measuring block (15).
摘要翻译：关于测量装置（4）和相应的方法。用于确定由实验室系统（1）提供的流体参数的杂交系统。测量装置（4）包括测量单元（5）和用于确定由实验室系统（1）提供的流体参数的处理单元（6），并且测量单元（5）被实现为能够集成到该测量单元实验室系统（1）。根据本发明的测量装置（4）的特征在于，测量单元（5）包括没有反应室（34）和至少一个传感器（17）的测量块（15）。测量块（15）包括用于接收或引导由实验室系统（1）提供的流体（13）的中空空间（16）。布置所述至少一个传感器（17），用于确定位于所述中空空间（16）中的流体（13）的物理和/或化学参数，或者与所述测量块的这些中空空间（16）流体地操作连接（15）。

6. 发明授权

US07618812B2 Device and process unit for providing a hybridization chamber 有权
标题翻译：用于提供杂交室的装置和处理装置
公开(公告)号：US07618812B2
公开(公告)日：2009-11-17
申请号：US11191327
申请日：2005-07-28
申请人： Wolfgang Streit , Gyoergy Wenczel , Anton Mathes , Waltraud Lamprecht
发明人： Wolfgang Streit , Gyoergy Wenczel , Anton Mathes , Waltraud Lamprecht
IPC分类号： C12M1/34
CPC分类号： B01L3/502715 , B01F5/10 , B01F11/0071 , B01F13/0059 , B01F15/00123 , B01F15/00318 , B01F15/00396 , B01F15/0244 , B01F2015/00084 , B01F2215/0037 , B01F2215/0073 , B01J2219/00353 , B01J2219/00396 , B01J2219/00477 , B01J2219/00479 , B01J2219/00533 , B01J2219/00659 , B01L3/50273 , B01L3/502738 , B01L3/50855 , B01L9/06 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2400/0481 , C40B60/14
摘要： A device provides a hybridization chamber for hybridizing nucleic acid samples, proteins or tissue sections on a slide, and is an essentially rectangular body movable opposite the slide. The device includes a surface, lines for supplying and/or removing media, a specimen supply line and an agitating device. The agitation device includes at least one membrane which separates a pressure chamer to be fillable with a pressure fluid via one of the lines, from at least one agitation chamber connected via an agitation line to the hybridization chamber. The lines are continuously open so the media therein can permanently flow unhindered. Four such devices can be combined into a process unit for providing a hybridization chamber. Such unit is pivotable around an axis and has a holder with four seats, which is lockable in relation to a baseplate, one device being insertable into each one of the seats.
摘要翻译：一种装置提供用于将载体上的核酸样品，蛋白质或组织切片杂交的杂交室，并且是与载片相对移动的基本上矩形的主体。该装置包括表面，用于供应和/或移除介质的管线，试样供应管线和搅拌装置。所述搅拌装置包括至少一个膜，其通过所述管线将至少一个通过搅动管线连接的搅拌室与压力流体分离成压缩倒角，所述至少一个搅拌室通过所述杂交室。线路是连续打开的，因此其中的介质可以永久地不受阻碍地流动。四个这样的装置可以组合成用于提供杂交室的处理单元。这种单元可围绕轴线枢转并且具有具有四个座的保持器，该座具可相对于底板锁定，一个装置可插入每个座中。

7. 发明授权

US09333505B2 Setting method for microplate washing devices 有权
标题翻译：微孔板清洗装置的设定方法
公开(公告)号：US09333505B2
公开(公告)日：2016-05-10
申请号：US13357080
申请日：2012-01-24
申请人： Wolfgang Streit , Juha Koota , Wolfgang Fuchs
发明人： Wolfgang Streit , Juha Koota , Wolfgang Fuchs
IPC分类号： B08B7/04 , B08B7/00 , B01L99/00
CPC分类号： B01L99/00 , B01L2200/08 , B01L2200/14
摘要： Setting method for microplate washing devices has a receptacle for receiving a microplate and a washing head having washing cannulas. The cannulas are in an array corresponding to a well array with lowermost ends define a work plane. This work plane is parallel to a reference plane. In a first phase, the receptacle and/or washing head are moved together until the lowermost ends of the cannulas touch a surface defining the reference plane. A sensor device has a controller linked thereto and from the sensor device is registered using the controller and a relative altitude value is determined therewith, which indicates touching of the surface by the lowermost ends of the cannulas or for determining the position of this surface. Based on this, an active altitude of the lowermost ends of the washing cannulas in relation to an inner surface of the well bottoms of a microplate is determined.
摘要翻译：微孔板洗涤装置的设置方法具有容纳微孔板的容器和具有清洗插管的清洗头。插管是对应于具有最下端限定工作平面的井阵列的阵列。该工作平面与参考平面平行。在第一阶段，容器和/或洗涤头一起移动，直到插管的最下端接触限定参考平面的表面。传感器装置具有连接到其上的控制器，并且使用控制器登记传感器装置，并且由此确定相对高度值，其指示由插管的最下端接触表面或用于确定该表面的位置。基于此，确定相对于微板的井底的内表面的洗涤插管的最下端的主动高度。

8. 发明申请

US20090221031A1 NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 有权
公开(公告)号：US20090221031A1
公开(公告)日：2009-09-03
申请号：US12298874
申请日：2007-04-27
申请人： Christian Elend , Karl-Erich Jaeger , Christian Leggewie , Christel Vollstedt , Wolfgang Streit
发明人： Christian Elend , Karl-Erich Jaeger , Christian Leggewie , Christel Vollstedt , Wolfgang Streit
IPC分类号： C12P21/00 , C12N9/18 , C12N15/11 , C12N15/00 , C12N1/21 , C12N15/63 , C07K16/18 , C07H21/04 , C12P7/02
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6 and 8; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5 and 7; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxyl esterase activity which polynucleotide is at least 65% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6 and 8; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (f) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host, genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a polypeptide comprising the amino acid sequence encoded by a polynucleotide of the present invention or which is obtainable by the process of the present invention. Moreover, the present invention relates to a process for producing said polypeptide and for producing bacteria expressing said polypeptide. Finally, the present invention relates to a composition comprising the polynucleotide of the present invention, the vector of the present invention, the host of the present invention, the polypeptide of the present invention, the antibody of the present invention and/or one or more primers of the present invention.

9. 发明授权

US08956838B2 Carboxyl esterase polypeptides 有权
标题翻译：羧基酯酶多肽
公开(公告)号：US08956838B2
公开(公告)日：2015-02-17
申请号：US12298874
申请日：2007-04-27
申请人： Christian Elend , Karl-Erich Jaeger , Christian Leggewie , Christel Vollstedt , Wolfgang Streit
发明人： Christian Elend , Karl-Erich Jaeger , Christian Leggewie , Christel Vollstedt , Wolfgang Streit
IPC分类号： C12P7/02 , C12N9/18 , C12N15/00 , C12N1/20 , C12N15/74 , C07H21/04
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 2.1.1.1] activity.
摘要翻译：本发明涉及编码具有羧基酯酶[E.C. 2.1.1.1]活动。

10. 发明申请

US20120199163A1 SETTING METHOD FOR MICROPLATE WASHING DEVICES 有权
标题翻译：微波清洗装置的设定方法
公开(公告)号：US20120199163A1
公开(公告)日：2012-08-09
申请号：US13357080
申请日：2012-01-24
申请人： Wolfgang Streit , Juha Koota , Wolfgang Fuchs
发明人： Wolfgang Streit , Juha Koota , Wolfgang Fuchs
IPC分类号： B08B7/04
CPC分类号： B01L99/00 , B01L2200/08 , B01L2200/14
摘要： Setting method for microplate washing devices has a receptacle for receiving a microplate and a washing head having washing cannulas. The cannulas are in an array corresponding to a well array with lowermost ends define a work plane. This work plane is parallel to a reference plane. In a first phase, the receptacle and/or washing head are moved together until the lowermost ends of the cannulas touch a surface defining the reference plane. A sensor device has a controller linked thereto and from the sensor device is registered using the controller and a relative altitude value is determined therewith, which indicates touching of the surface by the lowermost ends of the cannulas or for determining the position of this surface. Based on this, an active altitude of the lowermost ends of the washing cannulas in relation to an inner surface of the well bottoms of a microplate is determined.
摘要翻译：微孔板洗涤装置的设置方法具有容纳微孔板的容器和具有清洗插管的清洗头。插管是对应于具有最下端限定工作平面的井阵列的阵列。该工作平面与参考平面平行。在第一阶段，容器和/或洗涤头一起移动，直到插管的最下端接触限定参考平面的表面。传感器装置具有连接到其上的控制器，并且使用控制器登记传感器装置，并且由此确定相对高度值，其指示由插管的最下端接触表面或用于确定该表面的位置。基于此，确定相对于微板的井底的内表面的洗涤插管的最下端的主动高度。

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