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1. 发明授权

US08921093B2 Arrangement for on-line measurements on cells 有权
标题翻译：细胞上在线测量的安排
公开(公告)号：US08921093B2
公开(公告)日：2014-12-30
申请号：US12309572
申请日：2007-07-23
申请人： Daniel Seitz , Helmar Mayr , Guenter Ziegler , Winfried Vonau , Frank Gerlach , Sigrun Herrmann
发明人： Daniel Seitz , Helmar Mayr , Guenter Ziegler , Winfried Vonau , Frank Gerlach , Sigrun Herrmann
IPC分类号： C12Q1/02 , G01N27/26 , C12M1/34 , G01N33/543 , B01L3/00
CPC分类号： G01N33/5438 , B01L3/502707 , B01L2200/02 , B01L2300/0627 , B01L2300/0645 , B01L2300/163 , C12M41/32 , C12M41/34
摘要： The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area.The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.
摘要翻译：本发明涉及用于在细胞上在线测量的装置（测量装置），特别是用于在样品区域中的样品上测量可溶性分析物和溶解气体。本发明的目的是为了调查和监测活细胞的新陈代谢来规定用于在线测量的装置，其避免了现有技术的缺点并且可以集成在该过程中的微流体系统中。该装置包括基板，至少一个传感器，样品分析空间和具有保持传感器或传感器和膜的基板的膜，使得在传感器或传感器与膜之间产生样品分析空间，其中膜具有以生物相容性形式连接的能力和细胞培养空间，传感器或传感器是电化学传感器，其中样品分析空间可以填充有转移介质并且可以集成在流体系统中，并且传感器传感器安装有操作电路，下游电子器件可以通过该电路耦合。

2. 发明申请

US20100015656A1 Arrangement For On-Line Measurements on Cells 有权
标题翻译：细胞在线测量的安排
公开(公告)号：US20100015656A1
公开(公告)日：2010-01-21
申请号：US12309572
申请日：2007-07-23
申请人： Daniel Seitz , Helmar Mayr , Guenter Ziegler , Winfried Vonau , Frank Gerlach , Sigrun Herrmann
发明人： Daniel Seitz , Helmar Mayr , Guenter Ziegler , Winfried Vonau , Frank Gerlach , Sigrun Herrmann
IPC分类号： C12Q1/02 , G01N27/26 , C12M1/34
CPC分类号： G01N33/5438 , B01L3/502707 , B01L2200/02 , B01L2300/0627 , B01L2300/0645 , B01L2300/163 , C12M41/32 , C12M41/34
摘要： The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area.The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.
摘要翻译：本发明涉及用于在细胞上在线测量的装置（测量装置），特别是用于在样品区域中的样品上测量可溶性分析物和溶解气体。本发明的目的是为了调查和监测活细胞的新陈代谢来规定用于在线测量的装置，其避免了现有技术的缺点并且可以集成在该过程中的微流体系统中。该装置包括基板，至少一个传感器，样品分析空间和具有保持传感器或传感器和膜的基板的膜，使得在传感器或传感器与膜之间产生样品分析空间，其中膜具有以生物相容性形式连接的能力和细胞培养空间，传感器或传感器是电化学传感器，其中样品分析空间可以填充有转移介质并且可以集成在流体系统中，并且传感器传感器安装有操作电路，下游电子器件可以通过该电路耦合。

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