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    • 1. 发明授权
    • Arrangement for on-line measurements on cells
    • 细胞上在线测量的安排
    • US08921093B2
    • 2014-12-30
    • US12309572
    • 2007-07-23
    • Daniel SeitzHelmar MayrGuenter ZieglerWinfried VonauFrank GerlachSigrun Herrmann
    • Daniel SeitzHelmar MayrGuenter ZieglerWinfried VonauFrank GerlachSigrun Herrmann
    • C12Q1/02G01N27/26C12M1/34G01N33/543B01L3/00
    • G01N33/5438B01L3/502707B01L2200/02B01L2300/0627B01L2300/0645B01L2300/163C12M41/32C12M41/34
    • The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area.The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.
    • 本发明涉及用于在细胞上在线测量的装置(测量装置),特别是用于在样品区域中的样品上测量可溶性分析物和溶解气体。 本发明的目的是为了调查和监测活细胞的新陈代谢来规定用于在线测量的装置,其避免了现有技术的缺点并且可以集成在该过程中的微流体系统中。 该装置包括基板,至少一个传感器,样品分析空间和具有保持传感器或传感器和膜的基板的膜,使得在传感器或传感器与膜之间产生样品分析空间 ,其中膜具有以生物相容性形式连接的能力和细胞培养空间,传感器或传感器是电化学传感器,其中样品分析空间可以填充有转移介质并且可以集成在流体系统中 ,并且传感器传感器安装有操作电路,下游电子器件可以通过该电路耦合。
    • 6. 发明申请
    • Arrangement For On-Line Measurements on Cells
    • 细胞在线测量的安排
    • US20100015656A1
    • 2010-01-21
    • US12309572
    • 2007-07-23
    • Daniel SeitzHelmar MayrGuenter ZieglerWinfried VonauFrank GerlachSigrun Herrmann
    • Daniel SeitzHelmar MayrGuenter ZieglerWinfried VonauFrank GerlachSigrun Herrmann
    • C12Q1/02G01N27/26C12M1/34
    • G01N33/5438B01L3/502707B01L2200/02B01L2300/0627B01L2300/0645B01L2300/163C12M41/32C12M41/34
    • The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area.The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.
    • 本发明涉及用于在细胞上在线测量的装置(测量装置),特别是用于在样品区域中的样品上测量可溶性分析物和溶解气体。 本发明的目的是为了调查和监测活细胞的新陈代谢来规定用于在线测量的装置,其避免了现有技术的缺点并且可以集成在该过程中的微流体系统中。 该装置包括基板,至少一个传感器,样品分析空间和具有保持传感器或传感器和膜的基板的膜,使得在传感器或传感器与膜之间产生样品分析空间 ,其中膜具有以生物相容性形式连接的能力和细胞培养空间,传感器或传感器是电化学传感器,其中样品分析空间可以填充有转移介质并且可以集成在流体系统中 ,并且传感器传感器安装有操作电路,下游电子器件可以通过该电路耦合。
    • 7. 发明申请
    • MEDICAL SURGICAL SPONGE AND INSTRUMENT DETECTION SYSTEM AND METHOD
    • 医用手术海绵和仪器检测系统及方法
    • US20090012418A1
    • 2009-01-08
    • US11772976
    • 2007-07-03
    • Frank Gerlach
    • Frank Gerlach
    • A61B5/06
    • A61B5/06A61B5/062A61B5/412
    • A magnetic detector locates magnetically tagged items, such as surgical sponges or instruments, introduced to and remaining in the body cavity of a surgical patient. The magnetic detector is a wand or probe that is manually handleable, and spatially manipulable and moveable, by an operator, such as a medical professional. The detector is moved about at a spatial location of an ambient magnetic field at the patient and operating table. A characteristic of the ambient magnetic field at the spatial location is saved by the detector. The detector is subsequently moved about at the same spatial location. If any magnetically tagged item is present in the vicinity of the detector during this subsequent movement at the spatial location, an anomalous magnetic effect is detected by comparison of the prior detection reading absent the tagged item to the detection reading in presence of the tagged item in the patient. The anomalous magnetic effect, and thus the tagged item, is locatable spatially in the patient, by three-dimensional sensor(s), arrays of sensors, and pluralities of arrays of sensors of the detector. The different detection readings with and without presence of the anomalous magnetic effect caused by presence of the tagged item in the patient are calculable as scalar, vector array, and/or gradient array determinations, according to the particular number and configuration of sensors in the detector.
    • 磁性检测器定位被引入并保留在手术患者的体腔中的磁性标记的物品,例如手术海绵或器械。 磁性检测器是由操作人员(例如医疗专业人员)可手动操作并且可空间操作和移动的魔棒或探针。 检测器在患者和手术台处的环境磁场的空间位置移动。 检测器可节省空间位置环境磁场的特性。 检测器随后在相同的空间位置移动。 如果在空间位置的随后移动期间在检测器附近存在任何磁性标记的物品,则通过将不存在标记物品的先前检测读数与存在标记物品的检测读数进行比较来检测异常磁效应 患者。 通过三维传感器,传感器阵列和检测器的多个传感器阵列,异常磁效应以及因此标记的物体在空间上可定位在患者体内。 根据检测器中的传感器的具体数量和配置,不同检测读数的差异和不存在由患者中标记物品的存在引起的异常磁效应可计算为标量,矢量阵列和/或梯度阵列确定 。
    • 8. 发明授权
    • Single receiver wireless tracking system
    • 单接收机无线跟踪系统
    • US06437740B1
    • 2002-08-20
    • US09618483
    • 2000-07-18
    • Brian De ChamplainFrank Gerlach
    • Brian De ChamplainFrank Gerlach
    • G01S502
    • H01Q21/245G01S7/292G01S7/4004G01S13/4418G01S13/765G01S13/825H01Q1/125H01Q1/22H01Q1/2225H01Q1/246H01Q19/28H01Q21/067H01Q21/10H01Q21/12H01Q21/24H01Q21/29H01Q25/00H01R13/6273
    • A wireless tracking system consists of a wireless target including a wireless communication system for transmitting a data packet over a communication path, and a locating station for determining a position of the target. The data packet transmitted from the target includes an identification code uniquely associated with the target. The locating station includes a configurable directional antenna, a communication interval processing system, a direction processing system, and a position processing system. The communication interval processing system is in communication with the directional antenna and determines the transmission interval of the transmitted data packet over the communication path. The direction processing system determines the transmission angle of the communication path, and is in communication with the directional antenna for controlling the configuration of the directional antenna so as to facilitate the determination of the transmission angle. The position processing system is in communication with the interval processing system and the direction processing system, and determines the target position from the identification code, the transmission interval and the transmission angle.
    • 无线跟踪系统由包括用于通过通信路径发送数据分组的无线通信系统的无线目标以及用于确定目标位置的定位站组成。 从目标发送的数据分组包括与目标唯一相关联的识别码。 定位站包括可配置定向天线,通信间隔处理系统,方向处理系统和位置处理系统。 通信间隔处理系统与定向天线通信,并且确定通过通信路径发送的数据分组的传输间隔。 方向处理系统确定通信路径的传输角度,并且与用于控制定向天线的配置的定向天线通信,以便于确定传输角度。 位置处理系统与间隔处理系统和方向处理系统通信,并且从识别码,发送间隔和发送角度确定目标位置。
    • 10. 发明授权
    • Single receiver wireless tracking system
    • 单接收机无线跟踪系统
    • US06683567B2
    • 2004-01-27
    • US10316860
    • 2002-12-12
    • Brian De ChamplainFrank Gerlach
    • Brian De ChamplainFrank Gerlach
    • G01S100
    • H01R13/6273G01S3/18G01S13/767G01S13/785G01S13/788H01Q3/242H01Q9/32H01Q21/205
    • A wireless tracking system consists of a wireless target including a wireless communication system for transmitting a data packet over a communication path, and a locating station for determining a position of the target. The data packet transmitted from the target includes an identification code uniquely associated with the target. The locating station includes a configurable directional antenna, a communication interval processing system, a direction processing system, and a position processing system. The communication interval processing system is in communication with the directional antenna and determines the transmission interval of the transmitted data packet over the communication path. The direction processing system determines the transmission angle of the communication path, and is in communication with the directional antenna for controlling the configuration of the directional antenna so as to facilitate the determination of the transmission angle. The position processing system is in communication with the interval processing system and the direction processing system, and determines the target position from the identification code, the transmission interval and the transmission angle.
    • 无线跟踪系统由包括用于通过通信路径发送数据分组的无线通信系统的无线目标以及用于确定目标位置的定位站组成。 从目标发送的数据分组包括与目标唯一相关联的识别码。 定位站包括可配置定向天线,通信间隔处理系统,方向处理系统和位置处理系统。 通信间隔处理系统与定向天线通信,并且确定通过通信路径发送的数据分组的传输间隔。 方向处理系统确定通信路径的传输角度,并且与用于控制定向天线的配置的定向天线通信,以便于确定传输角度。 位置处理系统与间隔处理系统和方向处理系统通信,并且从识别码,发送间隔和发送角度确定目标位置。