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1. 发明授权

US07200434B2 Control of arbitrary waveforms for constant delivered energy 有权
标题翻译：控制任意波形的恒定传送能量
公开(公告)号：US07200434B2
公开(公告)日：2007-04-03
申请号：US11089798
申请日：2005-03-25
申请人： William J. Havel , Paul J. Degroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. Degroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrarywaveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.
摘要翻译：本发明概述了通过自动补偿由可植入式心律转复除颤器（ICD）检测的负载阻抗来向患者传送可控量的能量的结构和方法。本发明采用高速，开关电源转换器技术，有效地生成高能量，任意波形。与线性放大器不同，开关电源转换器提供高能量波形，效率与所需波形的大小和幅度无关。使用开关功率转换器将期望的能量递送到患者的ICD存储要在存储电容器中传递的能量。然后，转换器通过以高速率切换存储电容器输入和输出输出电路，将该能量转换成任意形状的输出电压控制或电流控制波形。优选地，波形包括斜坡型波形。

2. 发明授权

US07151963B2 Control of arbitrary waveforms for constant delivered energy 有权
公开(公告)号：US07151963B2
公开(公告)日：2006-12-19
申请号：US10308832
申请日：2002-12-03
申请人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
发明人： William J. Havel , Paul J. DeGroot , Thomas W. Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren W. Wold
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.

3. 发明申请

US20050228453A1 Control of arbitrary waveforms for constant delivered energy 有权
标题翻译：控制任意波形的恒定传送能量
公开(公告)号：US20050228453A1
公开(公告)日：2005-10-13
申请号：US11089798
申请日：2005-03-25
申请人： William Havel , Paul Degroot , Thomas Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren Wold
发明人： William Havel , Paul Degroot , Thomas Sinner , Kevin Kuehn , Gary Kemmetmueller , Warren Wold
IPC分类号： A61B5/05 , A61N1/04 , A61N1/08 , A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrarywaveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.
摘要翻译：本发明概述了通过自动补偿由可植入式心律转复除颤器（ICD）检测的负载阻抗来向患者传送可控量的能量的结构和方法。本发明采用高速，开关电源转换器技术，有效地生成高能量，任意波形。与线性放大器不同，开关电源转换器提供高能量波形，效率与所需波形的大小和幅度无关。使用开关功率转换器将期望的能量递送到患者的ICD存储要在存储电容器中传递的能量。然后，转换器通过以高速率切换存储电容器输入和输出输出电路，将该能量转换成任意形状的输出电压控制或电流控制波形。优选地，波形包括斜坡型波形。

4. 发明申请

US20080183230A1 Methods and Apparatus for Selectively Shunting Energy in an Implantable Extra-Cardiac Defibrillation Device 审中-公开
标题翻译：在可植入心脏除颤装置中选择性分流能量的方法和装置
公开(公告)号：US20080183230A1
公开(公告)日：2008-07-31
申请号：US11554873
申请日：2007-01-26
申请人： Gary Kemmetmueller , W. William Wold
发明人： Gary Kemmetmueller , W. William Wold
IPC分类号： A61N1/05
CPC分类号： A61N1/3931 , A61N1/0504 , A61N1/3756 , A61N1/3956
摘要： The disclosure provides methods and apparatus for simultaneously providing protection to an implantable medical device, such as an extra-cardiac implantable defibrillator (EID), while allowing efficacious therapy delivery via an external defibrillator (e.g., an automated external defibrillator, or AED). Due to the orientation of the electrodes upon application of therapy via, for example, via an AED the structure of the EID essentially blocks therapy delivery. In addition, but for the teaching of this disclosure sensitive circuitry of an EID can be damaged during application of external high voltage therapy thus rendering the EID inoperable. EIDs are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. Configurations include one hermetically sealed housing with one or, optionally, two subcutaneous sensing and cardioversion-defibrillation therapy delivery leads or alternatively, two hermetically sealed housings interconnected by a power/signal cable. The housings are generally dynamically configurable to adjust to varying rib structure and associated articulation of the thoracic cavity and muscles. Further the housings may optionally be flexibly adjusted for ease of implant and patient comfort. One aspect includes partially insulating a surface of an EID that faces away from a heart while maintaining a major conductive surface facing the heart.
摘要翻译：本公开提供了用于同时向诸如心脏外植入性除颤器（EID）的可植入医疗装置提供保护的方法和装置，同时允许通过外部去纤颤器（例如，自动外部除颤器或AED）进行有效的治疗递送。由于通过例如经由AED施加治疗时电极的取向，EID的结构基本上阻止治疗递送。此外，但是为了教导本公开，在应用外部高电压治疗期间，EID的敏感电路可能被损坏，从而使得EID不可操作。公开了完全可植入皮下的EID，其中最少的外科手术侵入患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中递送心脏复律除颤休克和起搏疗法。配置包括一个密封的壳体，其具有一个或任选的两个皮下感测和心脏复律除颤治疗递送线，或者两个通过电力/信号电缆互连的气密密封的壳体。这些外壳通常是可动态配置的，以适应胸部结构和胸腔和肌肉关联的变化。此外，为了便于植入和患者舒适，还可以灵活地调整这些外壳。一个方面包括将面向远离心脏的EID的表面部分地绝缘，同时保持面向心脏的主导电表面。

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