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1. 发明授权

US5610200A Anhydroretinol and derivatives thereof as antagonists of immune responses and inhibitors of cancer cell growth 失效
标题翻译：作为免疫反应的拮抗剂和癌细胞生长抑制剂的脱氢解蛋白及其衍生物
公开(公告)号：US5610200A
公开(公告)日：1997-03-11
申请号：US420435
申请日：1995-04-10
申请人： Ulrich Hammerling , Jochen Buck , Fadila Derguini , Koji Nakanishi
发明人： Ulrich Hammerling , Jochen Buck , Fadila Derguini , Koji Nakanishi
IPC分类号： A61K31/015 , A61K31/045 , A61K31/07 , A61K31/075 , A61K31/22 , A61K31/23
CPC分类号： A61K31/07 , A61K31/015 , A61K31/045 , A61K31/075 , A61K31/22 , A61K31/23
摘要： This invention provides methods of inhibiting the growth of cells, of treating a subject having a disease characterized by an uncontrolled growth of cells and of blocking an immune response as well as related inflammatory responses in a subject which comprises administering a compound having the structure: ##STR1##
摘要翻译：本发明提供了抑制细胞生长的方法，该方法包括给予具有以下结构的化合物：治疗患有特征在于细胞不受控生长并且阻断免疫应答以及相关炎症反应的疾病的受试者，图像>

2. 发明授权

US5358972A Retro-alpha-retinol(4-14-retro-retinol) derivatives and uses of retro-.alpha.-retinol 失效
标题翻译：复方α-视黄醇（4-14-视黄醇）衍生物及其用途
公开(公告)号：US5358972A
公开(公告)日：1994-10-25
申请号：US104491
申请日：1993-08-09
申请人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
发明人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
IPC分类号： A01N37/18 , A01N37/34 , A61K31/07 , A61K31/23 , A61K31/70 , C07C403/08 , C07D303/14 , C07D317/20 , C07F7/18 , C12N1/38 , C12N5/078 , C12N5/0783 , C12N15/67 , C12P17/02 , C12P23/00
CPC分类号： C12P23/00 , C07C403/08 , C07C403/10 , C07C403/12 , C07D303/14 , C07F7/184 , C12N15/67 , C12N5/065 , C07B2200/09 , C07C2101/14 , C07C2101/16 , C12N2501/385
摘要： This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma. Further provided are a method for enhancing transcription of a gone regulated by retinoid in a cell, or a method for enhancing an immune response in a subject.
摘要翻译：本发明提供了一种以分子质量为约302道尔顿为特征的纯化的后视色素化合物。本发明还提供了增强维生素A还原环境中细胞生长的方法，其包括使细胞与有效生长增加量的具有以下结构的化合物接触：其中C6，C8的构型，C10和C12双键独立地为Z或E，C-14的绝对构型独立地为R或S; 其中R1是烷基，烷基卤，醇，酯，醚，醛，酮，羧酸，羧酸酯，酰卤，酰胺，腈或胺; 烷基，醇，醚，醛，酮，羧酸，羧酸酯，腈，胺，叠氮化物，烷基卤，酰卤，叠氮化物或酰胺; 或其中R 1和R 2被14,15-环氧乙烷基团取代; 并且其中所述复古结构是α或γ。还提供了增强细胞中类视黄醇调节的转录的方法，或增强受试者的免疫应答的方法。

3. 发明授权

US5883136A Anhydroretinol and derivatives thereof as antagonists of immune responses and inhibitors of cancer cell growth 失效
标题翻译：作为免疫反应的拮抗剂和癌细胞生长抑制剂的脱氢解蛋白及其衍生物
公开(公告)号：US5883136A
公开(公告)日：1999-03-16
申请号：US478411
申请日：1995-06-07
申请人： Ulrich Hammerling , Jochen Buck , Fadila Derguini , Koji Nakanishi
发明人： Ulrich Hammerling , Jochen Buck , Fadila Derguini , Koji Nakanishi
IPC分类号： A61K31/015 , A61K31/045 , A61K31/07 , A61K31/075 , A61K31/22 , A61K31/23
CPC分类号： A61K31/07 , A61K31/015 , A61K31/045 , A61K31/075 , A61K31/22 , A61K31/23
摘要： This invention provides methods of inhibiting the growth of cells, of treating a subject having a disease characterized by an uncontrolled growth of cells and of blocking an immune response as well as related inflammatory responses in a subject which comprises administering a compound having the structure: ##STR1##
摘要翻译：本发明提供了抑制细胞生长的方法，该方法包括给予具有以下结构的化合物：治疗患有特征在于细胞不受控生长并且阻断免疫应答以及相关炎症反应的疾病的受试者，图像>

4. 发明授权

US5648563A Retro-alpha-retinol derivative and uses of retro-alpha-retinol 失效
标题翻译：复方α-视黄醇衍生物和复方α-视黄醇的应用
公开(公告)号：US5648563A
公开(公告)日：1997-07-15
申请号：US481913
申请日：1995-06-07
申请人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
发明人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
IPC分类号： A01N37/18 , A01N37/34 , A61K31/07 , A61K31/23 , A61K31/70 , C07C403/08 , C07D303/14 , C07D317/20 , C07F7/18 , C12N1/38 , C12N5/078 , C12N5/0783 , C12N15/67 , C12P17/02 , C12P23/00 , C07C35/18 , C07C37/68
CPC分类号： C07D303/14 , C07C403/08 , C07C403/10 , C07C403/12 , C07F7/184 , C12N15/67 , C12N5/0636 , C12N5/065 , C12P23/00 , C07B2200/09 , C07C2101/14 , C07C2101/16 , C12N2501/385
摘要： This invention provides a homogeneous retro-retinoid compound, a method of enhancing the growth of a cell in a vitamin A reduced environment, a method for enhancing transcription of a gene regulated by retinoid in a cell, and a method for enhancing an immune response in a subject, wherein the compound has the structure: ##STR1##
摘要翻译：本发明提供均匀的类维生素A化合物，增强维生素A还原环境中细胞生长的方法，增强细胞中类视黄醇调节基因转录的方法和增强免疫应答的方法对象，其中化合物具有以下结构：

5. 发明授权

US5521221A Retro-.alpha.-retinol (4,14-retro-retinol) derivatives and uses of retro-.alpha.-retinol 失效
标题翻译：复方α-吗啉醇（4,14-反 - 视黄醇）衍生物及其用途
公开(公告)号：US5521221A
公开(公告)日：1996-05-28
申请号：US682909
申请日：1991-04-09
申请人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
发明人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
IPC分类号： A01N37/18 , A01N37/34 , A61K31/07 , A61K31/23 , A61K31/70 , C07C403/08 , C07D303/14 , C07D317/20 , C07F7/18 , C12N1/38 , C12N5/078 , C12N5/0783 , C12N15/67 , C12P17/02 , C12P23/00 , C07C35/18 , C07C37/68
CPC分类号： C12P23/00 , C07C403/08 , C07C403/10 , C07C403/12 , C07D303/14 , C07F7/184 , C12N15/67 , C12N5/065 , C07B2200/09 , C07C2101/14 , C07C2101/16 , C12N2501/385
摘要： This invention provides a purified retro-retinoid compound characterized by a molecular mass of about 302 daltons. Also provided by this invention is a method of enhancing the growth of a cell in a vitamin A reduced environment which comprises contacting the cell with an effective growth enhancing amount of a compound having a structure: ##STR1## wherein the configuration of the C6, C8, C10 and C12 double bond independently is Z or E and the absolute configuration at C-14 is independently R or S; wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acid halide, amide, nitrile, or amine; and wherein R.sub.2 is hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R.sub.1 and R.sub.2 are replaced by a 14, 15-oxirane group; and wherein the retro structure is alpha or gamma. Further provided are a method for enhancing transcription of a gene regulated by retinoid in a cell, or a method for enhancing an immune response in a subject.
摘要翻译：本发明提供了一种以分子质量为约302道尔顿为特征的纯化的后视色素化合物。本发明还提供了增强维生素A还原环境中细胞生长的方法，其包括使细胞与有效生长增加量的具有以下结构的化合物接触：其中C6，C8的构型，C10和C12双键独立地为Z或E，C-14的绝对构型独立地为R或S; 其中R1是烷基，烷基卤，醇，酯，醚，醛，酮，羧酸，羧酸酯，酰卤，酰胺，腈或胺; 烷基，醇，醚，醛，酮，羧酸，羧酸酯，腈，胺，叠氮化物，烷基卤，酰卤，叠氮化物或酰胺; 或其中R 1和R 2被14,15-环氧乙烷基团取代; 并且其中所述复古结构是α或γ。还提供了增强细胞中类视黄醇调节基因转录的方法，或增强受试者的免疫应答的方法。

6. 发明授权

US5928931A Isolation, purification and cloning of retinol dehydratase 失效
标题翻译：视黄醇脱水酶的分离，纯化和克隆
公开(公告)号：US5928931A
公开(公告)日：1999-07-27
申请号：US852481
申请日：1997-05-07
申请人： Felix Grun , Jochen Buck , Ulrich Hammerling
发明人： Felix Grun , Jochen Buck , Ulrich Hammerling
IPC分类号： A61K38/00 , C12N1/21 , C12N9/88 , C12N15/60 , C12N15/63
CPC分类号： C12N9/88 , A61K38/00
摘要： The present invention relates to retinol dehydratase, the enzyme which synthesizes the retro-retinoid anhydroretinol in the Spodoptera frugiperda insect cell line Sf-21, as well as the DNA molecule encoding that enzyme. The DNA molecule can be incorporated in a DNA expression system and a host for recombinant production of anhydroretinol dehydratase. The isolated retinol dehydratase protein or polypeptide of the present invention can be combined with a pharmaceutically-acceptable carrier or used alone for administration to mammals, particularly humans, for preventing cell growth and/or uncontrolled cell growth in cells which are growth dependent on retinol and/or 14 hydroxy-4, 14-retro-retinol.
摘要翻译：本发明涉及视黄醇脱水酶，该酶是在草地夜蛾（Fododoptera frugiperda）昆虫细胞系Sf-21中合成后视黄醇脱水解蛋白的酶，以及编码该酶的DNA分子。 DNA分子可以并入DNA表达系统和用于重组生产脱氢赖氨醇脱水酶的宿主。本发明的分离的视黄醇脱水酶蛋白或多肽可以与药学上可接受的载体组合，或者单独使用用于哺乳动物，特别是人，用于预防细胞生长和/或不依赖视黄醇生长的细胞中的不受控制的细胞生长，以及 /或14羟基-4,14-复古视黄醇。

7. 发明授权

US4680258A Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen 失效
标题翻译：通过使用H-Y抗原的单克隆抗体在人中进行性别测定的方法
公开(公告)号：US4680258A
公开(公告)日：1987-07-14
申请号：US521635
申请日：1983-08-09
申请人： Ulrich Hammerling , Gloria C. Koo , Nobuhiko Tada
发明人： Ulrich Hammerling , Gloria C. Koo , Nobuhiko Tada
IPC分类号： C07K16/28 , G01N33/577 , A61K39/395 , C12N5/00 , C12P15/00
CPC分类号： C07K16/28 , Y10S435/948 , Y10S436/821 , Y10S436/828
摘要： Production of anti-H-Y hybridoma cell lines, and the use of the antibodies to determine the presence of H-Y antigen to indicate the sex of the proband inclusive of fetus, newborn and adult humans.
摘要翻译：生产抗H-Y杂交瘤细胞系，以及使用抗体确定H-Y抗原的存在，以指示包含胎儿，新生儿和成年人的先证者的性别。

8. 发明授权

US5908868A Retinol derivatives useful for enhancing immune response 失效
标题翻译：视黄醇衍生物可用于增强免疫反应
公开(公告)号：US5908868A
公开(公告)日：1999-06-01
申请号：US331627
申请日：1995-06-05
申请人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
发明人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
IPC分类号： A61K31/07 , C07D303/14 , C07F7/18 , C12N5/078 , C12N5/0783 , C12N15/67 , C12P23/00 , A61K31/045 , A61K31/075
CPC分类号： C12P23/00 , A61K31/045 , A61K31/07 , A61K31/075 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/20 , C07D303/14 , C07F7/184 , C12N15/67 , C12N5/0636 , C12N5/065 , C07B2200/07 , C07B2200/09 , C07C2101/16 , C12N2501/385
摘要： The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C.sub.20 H.sub.32 O.sub.3. The present invention also provides a purified retinoid compound having the following structure: ##STR1## wherein the configuration of C7, C9, and C11 double bond independently is Z or E and the absolute configuration at C13 and C14 is independently R or S; wherein R1 is hydroxyl, alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acyl halide, amide, nitrile, or amine; wherein R2 and R3 are independently hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R2 and R3, or R1 and R2 are replaced by a 13,14-oxirane or a 14,15-oxirane group, respectively. Also provided by this invention is a pharmaceutical composition which comprises the compound above and a pharmaceutically acceptable carrier. This invention further provides a growth medium comprising the compound above at a concentration effective to enhance cell growth. Additionally, the present invention provides a method of enhancing the growth of a cell, a method for enhancing an immune response in a subject, and a method for enhancing transcription of a gene regulated by a retinoid in a cell.
摘要翻译： PCT No.PCT / US93 / 04323 Sec。 371日期：1995年5月6日 102（e）日期1995年5月6日PCT提交1993年5月6日PCT公布。公开号WO93 / 22267 日期：1993年11月11日本发明提供一种纯化的类视黄醇化合物，其特征在于分子量为约320道尔顿，原子组成为C20H32O3。本发明还提供具有以下结构的纯化类视黄醇化合物：其中C7，C9和C11双键独立的构型是Z或E，C13和C14的绝对构型独立地是R或S; 其中R1是羟基，烷基，烷基卤，醇，酯，醚，醛，酮，羧酸，羧酸酯，酰基卤，酰胺，腈或胺; 其中R2和R3独立地是羟基，卤素，烷氧基，酯，烷基，醇，醚，醛，酮，羧酸，羧酸酯，腈，胺，叠氮化物，烷基卤，酰卤，叠氮化物或酰胺; 或其中R2和R3，或R1和R2分别被13,14-环氧乙烷或14,15-环氧乙烷基团取代。本发明还提供了包含上述化合物和药学上可接受的载体的药物组合物。本发明进一步提供包含上述化合物的生物培养基，其浓度有效地增强细胞生长。此外，本发明提供增强细胞生长的方法，增强受试者的免疫应答的方法，以及增强细胞中类视黄醇调节基因转录的方法。

9. 发明授权

US5814612A Retinol derivatives and uses thereof 失效
标题翻译：视黄醇衍生物及其用途
公开(公告)号：US5814612A
公开(公告)日：1998-09-29
申请号：US880041
申请日：1992-05-06
申请人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
发明人： Jochen Buck , Ulrich Hammerling , Fadila Derguini , Koji Nakanishi
IPC分类号： A01N37/18 , A01N37/34 , A61K31/07 , A61K31/16 , A61K31/23 , A61K31/70 , C07C43/15 , C07C47/21 , C07C49/203 , C07C233/09 , C07C235/28 , C07C403/00 , C07C403/08 , C07D303/12 , C07D303/14 , C07D317/20 , C07F7/18 , C07F9/06 , C12N1/38 , C12N5/078 , C12N5/0783 , C12N15/67 , C12P17/02 , C12P23/00 , A61K37/22 , C07D317/74
CPC分类号： C07F7/184 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/20 , C07D303/14 , C12N15/67 , C12N5/065 , C12P23/00 , C07B2200/09 , C07C2101/14 , C07C2101/16 , C12N2501/385
摘要： The present invention provides a purified retinoid compound characterized by a molecular mass of about 320 daltons and an atomic composition of C.sub.20 H.sub.32 O.sub.3. The present invention also provides a purified retinoid compound having the structure: ##STR1## wherein the configuration of the C7, C9, and C11 double bond independently is Z or E and the absolute configuration at C13 and C14 is independently R or S; wherein R1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, acyl halide, amide, nitrile, or amine; R2 and R3 are independently hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, carboxylic ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide, or amide; or wherein R2 and R3, or R1 and R2 are replaced by a 13,14-oxirane or a 14,15-oxirane group, respectively.
摘要翻译：本发明提供一种纯化的类视色素化合物，其特征在于分子量为约320道尔顿，原子组成为C20H32O3。本发明还提供了具有以下结构的纯化的类视黄醇化合物：单独的独立地为Z或E，且C13和C14的绝对构型独立地为R或S; 其中R1是烷基，烷基卤，醇，酯，醚，醛，酮，羧酸，羧酸酯，酰卤，酰胺，腈或胺; R2和R3独立地是羟基，卤素，烷氧基，酯，烷基，醇，醚，醛，酮，羧酸，羧酸酯，腈，胺，叠氮化物，烷基卤，酰卤，酸叠氮化物或酰胺; 或其中R2和R3，或R1和R2分别被13,14-环氧乙烷或14,15-环氧乙烷基团取代。

10. 发明授权

US4804627A Method for cloning lymphoblastoid cells 失效
标题翻译：克隆淋巴母细胞样细胞的方法
公开(公告)号：US4804627A
公开(公告)日：1989-02-14
申请号：US732370
申请日：1985-05-09
申请人： Ulrich Hammerling , Slawomir Kosinski
发明人： Ulrich Hammerling , Slawomir Kosinski
IPC分类号： C12N5/02 , C12N5/0781 , C12M3/00 , C12N5/00
CPC分类号： C12N5/0635 , C12N2502/1323 , C12N2510/02
摘要： A method of growing cells, particularly cells transformed by Epstein Barr Virus, in agarose is disclosed. At least one of the agarose layers has human fibroblast cells suspended therein and another layer has irradiated fibroblasts and the particular growing cells suspended therein.
摘要翻译：公开了一种在琼脂糖中培养细胞，特别是由爱泼斯坦巴尔病毒转化的细胞的方法。至少一个琼脂糖层具有悬浮在其中的人成纤维细胞，另一层已经照射成纤维细胞，并且特定的生长细胞悬浮在其中。

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