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1. 发明授权

US06635045B2 Electrodes and method for manufacturing electrodes for electrically assisted drug delivery 失效
公开(公告)号：US06635045B2
公开(公告)日：2003-10-21
申请号：US09897698
申请日：2001-06-29
申请人： Preston Keusch , Uday K. Jain , Vilambi Nrk Reddy , Bruce M. Eliash , Kevin John Carey , Vitaly Falevich
发明人： Preston Keusch , Uday K. Jain , Vilambi Nrk Reddy , Bruce M. Eliash , Kevin John Carey , Vitaly Falevich
IPC分类号： A61M3100
CPC分类号： A61N1/0448 , A61N1/0436
摘要： Provided is a method for loading electrode-corroding ingredients into an un-loaded donor gel reservoir of an electrode for an electrically assisted drug delivery system. The method provides that a salt, such as sodium chloride or an organic salt, is provided in the un-loaded donor gel reservoir, contrary to convention. Related electrically assisted drug delivery electrode assemblies also are provided.

2. 发明授权

US06629968B1 Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode 失效
标题翻译：储存稳定的离子电渗储库电极和结合储层电极的离子电渗系统
公开(公告)号：US06629968B1
公开(公告)日：2003-10-07
申请号：US09610563
申请日：2000-06-30
申请人： Uday K. Jain , Vilambi N R K Reddy , Bruce M. Eliash , Kevin John Carey , Vitaly Falevich , Preston Keusch
发明人： Uday K. Jain , Vilambi N R K Reddy , Bruce M. Eliash , Kevin John Carey , Vitaly Falevich , Preston Keusch
IPC分类号： A61M3100
CPC分类号： A61N1/0448 , A61N1/0436
摘要： A reservoir-electrode for an iontophoretic delivery device of the present invention includes an electrode; and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a substantially uniform concentration of an alkali metal chloride salt therein thereby substantially eliminating concentration gradients of the salt with respect to the electrode. The polymeric material has a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesive to an applied area of a patient's skin. The polymeric material has a cohesive strength, wherein a bond strength of an adhesive bond between the second surface of the polymeric material to the electrode is greater than the cohesive strength of the polymeric material and an adhesive bond strength of the first surface of the polymeric material to the applied area of the patient is less than the cohesive strength of the polymeric material so that upon removal of the reservoir-electrode from the applied area of the patient, substantially no polymeric material remains on the applied area and the reservoir remains substantially intact and adhesively adherent to the electrode.
摘要翻译：本发明的用于离子电渗疗法输送装置的储液器电极包括电极; 以及位于与电极导电关系的亲水性储存器。储存器由其中碱金属氯化物盐基本均匀的亲水性交联聚合物材料形成，从而基本上消除了盐相对于电极的浓度梯度。聚合物材料具有粘附到电极上的第一表面和第二表面。聚合物材料的第一表面可剥离地粘附到患者皮肤的施加区域。聚合物材料具有内聚强度，其中聚合物材料的第二表面与电极之间的粘合剂粘结的粘合强度大于聚合物材料的内聚强度和聚合物材料的第一表面的粘结粘合强度对于患者的施用区域小于聚合物材料的内聚强度，使得当从患者的施用区域移除储存器电极时，基本上没有聚合物材料保留在施用区域上，并且储存器基本保持完整，并且粘附到电极上。

3. 发明授权

US06394994B1 Method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament 失效
标题翻译：用于测试离子电渗储器电极递送药物的能力的方法
公开(公告)号：US06394994B1
公开(公告)日：2002-05-28
申请号：US09384765
申请日：1999-08-27
申请人： Nrk Vilambi , Bruce M. Eliash , Preston Keusch , Lue Huai Li , Elena N. Chabala , Uday K. Jain , Louis J. Mestichelli
发明人： Nrk Vilambi , Bruce M. Eliash , Preston Keusch , Lue Huai Li , Elena N. Chabala , Uday K. Jain , Louis J. Mestichelli
IPC分类号： A61M3100
CPC分类号： A61N1/0428
摘要： A method for testing the ability of an iontophoretic reservoir-electrode to deliver a medicament includes providing an iontophoretic reservoir-electrode with a contact surface having a shape, a suitable electrical connection and a hydrated bibulous reservoir containing an ionized medicament. The method further includes providing another electrode operating a at preselected polarity opposite to the preselected polarity of the medicament reservoir-electrode. The method further includes providing a separation medium having the property of allowing passage therein to of ions of one charge. The separation medium is positioned between the reservoir electrode with the ionized medicament and the another electrode. The method also includes applying a sufficient electrical potential between the iontophoretic reservoir-electrode containing the ionized medicament and the another iontophoretic reservoir-electrode so that a current flows through the separation medium for a preselected time thereby transporting a quantity of the ionized medicament into the separation medium. The method then includes determining an amount of the ionizable medicament in the separation medium.
摘要翻译：用于测试离子电渗储存器电极递送药物的能力的方法包括提供具有形状，合适的电连接的接触表面和含有电离药物的水合吸水性储存器的离子电渗储器电极。该方法还包括提供另外的电极，其操作的预选极性与药物储存器电极的预选极性相反。该方法还包括提供一种分离介质，该分离介质具有允许通过一次电荷的离子的性质。分离介质位于储存器电极与电离药物和另一电极之间。该方法还包括在包含电离药物的离子电渗储存器电极和另一离子电渗储存器电极之间施加足够的电势，使得电流流过分离介质预选的时间，从而将一定量的离子化药物输送到分离中。该方法然后包括确定分离介质中的可离子化药物的量。

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