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1. 发明申请

US20070172444A1 Hair tonics and method of screening the same 审中-公开
标题翻译：发质和筛选方法相同
公开(公告)号：US20070172444A1
公开(公告)日：2007-07-26
申请号：US11649279
申请日：2007-01-04
申请人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
发明人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
IPC分类号： A61K8/97 , A61K36/82 , A61K36/899 , A61K36/48 , A61K36/87
CPC分类号： A61Q5/00 , A61K8/498 , A61K8/64 , A61K8/97 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/55 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： There is provided a hair tonic comprising at least two of an inhibitor against 5α reductase type 2, an inhibitor against transforming growth factor β2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5α reductase type 2, inhibition against transforming growth factor β2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.
摘要翻译：提供了包含至少两种抑制剂5型5α还原酶2型抑制剂，抗转化生长因子β2的抑制剂和抗半胱天冬酶-3抑制剂的滋补剂; 一种方法包括筛选至少两种对2型5α还原酶的抑制，对转化生长因子β2的抑制和对半胱天冬酶-3的抑制，或包括筛选对半胱天冬酶-3的抑制，然后筛选凋亡抑制，以及脱发抑制剂具有抑制半胱天冬酶-3的效果，以及具有抑制半胱天冬酶-3的作用并抑制细胞凋亡的脱发抑制剂。

2. 发明申请

US20060153794A1 Hair tonics and method of screening the same 审中-公开
标题翻译：发质和筛选方法相同
公开(公告)号：US20060153794A1
公开(公告)日：2006-07-13
申请号：US11312549
申请日：2005-12-21
申请人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
发明人： Toshihiko Hibino , Yumiko Tsuji , Tsutomu Soma , Sumiko Denda , Jotaro Nakanishi , Tadahito Takahashi , Kenichi Umishio , Koji Kobayashi
IPC分类号： A61K8/97 , A61K36/185
CPC分类号： A61Q5/00 , A61K8/498 , A61K8/64 , A61K8/97 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/55 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： There is provided a hair tonic comprising at least two of an inhibitor against 5α reductase type 2, an inhibitor against transforming growth factor β2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5α reductase type 2, inhibition against transforming growth factor β2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.
摘要翻译：提供了包含至少两种抑制剂5型5α还原酶2型抑制剂，抗转化生长因子β2的抑制剂和抗半胱天冬酶-3抑制剂的滋补剂; 一种方法包括筛选至少两种对2型5α还原酶的抑制，对转化生长因子β2的抑制和对半胱天冬酶-3的抑制，或包括筛选对半胱天冬酶-3的抑制，然后筛选凋亡抑制，以及脱发抑制剂具有抑制半胱天冬酶-3的效果，以及具有抑制半胱天冬酶-3的作用并抑制细胞凋亡的脱发抑制剂。

3. 发明授权

US3951998A Benzothiazole derivatives 失效
标题翻译：苯并噻唑衍生物
公开(公告)号：US3951998A
公开(公告)日：1976-04-20
申请号：US480311
申请日：1974-06-17
申请人： Toshihiko Hibino , Yoshio Suzuki , Shigeru Okano , Yoichi Hara , Etsuro Sato
发明人： Toshihiko Hibino , Yoshio Suzuki , Shigeru Okano , Yoichi Hara , Etsuro Sato
IPC分类号： C07D277/74 , C07D277/72 , C07D295/08
CPC分类号： C07D277/74
摘要： Novel benzothiazole derivatives of the formula ##SPC1##Wherein R.sub.1 and R.sub.2 are individually hydrogen, lower alkyl, nitro, halogen, optionally substituted amino, carboxyl, lower alkoxy-carbonyl or di-lower alkyl-carbamoyl; and R.sub.3 and R.sub.4 are individually hydrogen, lower alkyl or .alpha.-lower alkyl-benzyl or NR.sub.3 R.sub.4 is a saturated heterocyclic ring containing a nitrogen atom, and their salts. They are useful as antihypertensives.
摘要翻译：式WHEREIN R1和R2的新型苯并噻唑衍生物分别为氢，低级烷基，硝基，卤素，任选取代的氨基，羧基，低级烷氧基羰基或二低级烷基 - 氨基甲酰基; 并且R 3和R 4分别是氢，低级烷基或α-低级烷基 - 苄基或NR 3 R 4是含有氮原子的饱和杂环及其盐。它们可用作抗高血压药物。

4. 发明申请

US20110165607A1 METHOD FOR EVALUATING STATUS OF SKIN BARRIER FUNCTION OF NATURAL MOISTURIZING FACTOR USING BLEOMYCIN HYDROLASE ACTIVITY AS INDICATOR 审中-公开
标题翻译：使用溴霉素水解酶活性作为指示剂评价天然水分因子皮肤屏障功能状态的方法
公开(公告)号：US20110165607A1
公开(公告)日：2011-07-07
申请号：US12736918
申请日：2009-05-21
申请人： Atsushi Takeda , Toshihiko Hibino
发明人： Atsushi Takeda , Toshihiko Hibino
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37
摘要： The present invention provides a method for evaluating the status of the skin barrier function of natural moisturizing factor (NMF) using the activity of bleomycin hydrolase in skin tissue as an indicator.
摘要翻译：本发明提供了一种使用博来霉素水解酶在皮肤组织中的活性作为指标来评估天然保湿因子（NMF）的皮肤屏障功能的状态的方法。

5. 发明授权

US4153610A Process for producing 5-carboxy-2-acetylthiophene 失效
标题翻译： 5-羧基-2-乙酰基噻吩的制备方法
公开(公告)号：US4153610A
公开(公告)日：1979-05-08
申请号：US847617
申请日：1977-11-01
申请人： Toshihiko Hibino , Eiichi Murayama
发明人： Toshihiko Hibino , Eiichi Murayama
IPC分类号： C07D333/24 , C07D333/38
CPC分类号： C07D333/38 , C07D333/24
摘要： 5-Carboxy-2-acetylthiophene, which is useful as an intermediate for the production of a therapeutic agent, can be prepared in a high yield by the selective oxidation of 5-acetyl-2-thienylacetic acid or its derivative with a particularly selected oxidizing agent, i.e. permanganate.
摘要翻译：可用作制备治疗剂的中间体的5-羧基-2-乙酰基噻吩可以通过选择性氧化5-乙酰基-2-噻吩基乙酸或其衍生物，以高产率通过特别选择的氧化代理，即高锰酸盐。

6. 发明申请

US20120302649A1 METHOD FOR SCREENING AMELIORANTS OF DRY SKIN CAUSED BY ATOPIC DERMATITIS USING BLEOMYCIN HYDROLASE ACTIVITY AS INDICATOR 有权
标题翻译：用作为指示剂的BLEOMYCIN水解酶活性筛选由原生质体引起的干性皮肤微生物的方法
公开(公告)号：US20120302649A1
公开(公告)日：2012-11-29
申请号：US13513537
申请日：2010-12-02
申请人： Toshihiko Hibino , Yayoi Kamata , Mami Yamamoto
发明人： Toshihiko Hibino , Yayoi Kamata , Mami Yamamoto
IPC分类号： C12Q1/68 , C12Q1/37 , C12Q1/66 , A61K45/00 , A61P17/00 , G01N33/53 , G01N33/573 , C12N5/071
CPC分类号： C12Q1/6883 , C12Q1/37 , C12Q2600/158 , G01N33/573 , G01N33/6881 , G01N2333/914 , G01N2333/96466 , G01N2500/04 , G01N2500/10 , G01N2800/202
摘要： The present invention provides a method for screening and evaluating ameliorants of dry skin caused by atopic dermatitis, comprising: evaluating a candidate drug as being an ameliorant of dry skin caused by atopic dermatitis in the case the candidate drug significantly increases expression and/or activity of bleomycin hydrolase in comparison with a control drug.
摘要翻译：本发明提供了筛选和评价由特应性皮炎引起的干性皮肤变性的方法，其包括：在候选药物显着增加表型和/或活性的情况下，将候选药物评估为由特应性皮炎引起的干性皮肤的改善剂博来霉素水解酶与对照药相比。

7. 发明申请

US20110305783A1 Method and pharmaceutical composition for treating psoriasis, squamous cell carcinoma and/or parakeratosis by inhibiting expression of squamous cell carcinoma-related antigen 审中-公开
标题翻译：通过抑制鳞状细胞癌相关抗原的表达来治疗牛皮癣，鳞状细胞癌和/或角化不全的方法和药物组合物
公开(公告)号：US20110305783A1
公开(公告)日：2011-12-15
申请号：US12907412
申请日：2010-10-19
申请人： Toshihiko Hibino , Jotaro Nakanishi , Chika Katagiri
发明人： Toshihiko Hibino , Jotaro Nakanishi , Chika Katagiri
IPC分类号： A61K36/42 , A61K36/81 , A61P17/00 , A61K36/725 , A61K36/88 , A61K36/87 , A61K36/185
CPC分类号： C12Q1/37 , A61K31/713 , A61K36/185 , A61K36/42 , A61K36/725 , A61K36/81 , A61K36/87 , A61K36/88 , G01N33/5044 , G01N2500/04 , G01N2800/20 , G01N2800/205
摘要： In a first aspect thereof, the present invention provides a method for treatment and/or prevention of a disease selected from the group consisting of psoriasis and squamous cell carcinoma by inhibiting the expression of squamous cell carcinoma antigen (SCCA) by cells. In another aspect thereof, the present invention provides a method for screening for substances that inhibit epidermal parakeratosis, wherein the activity of a candidate substance that inhibits cysteine protease inhibitory activity possessed by squamous cell carcinoma antigen 1 (SCCA-1) is used as an indicator.
摘要翻译：在其第一方面，本发明提供了通过抑制细胞对鳞状细胞癌抗原（SCCA）的表达来治疗和/或预防选自牛皮癣和鳞状细胞癌的疾病的方法。另一方面，本发明提供了筛选抑制表皮角化不全的物质的方法，其中抑制鳞状细胞癌抗原1（SCCA-1）具有的半胱氨酸蛋白酶抑制活性的候选物质的活性被用作指示剂。

8. 发明授权

US07829547B2 Method and pharmaceutical composition for treating psoriasis, squamous cell carcinoma and/or parakeratosis by inhibiting expression of squamous cell carcinoma-related antigen 有权
标题翻译：通过抑制鳞状细胞癌相关抗原的表达来治疗牛皮癣，鳞状细胞癌和/或角化不全的方法和药物组合物
公开(公告)号：US07829547B2
公开(公告)日：2010-11-09
申请号：US11886475
申请日：2005-09-22
申请人： Toshihiko Hibino , Jotaro Nakanishi , Chika Katagiri
发明人： Toshihiko Hibino , Jotaro Nakanishi , Chika Katagiri
IPC分类号： A61K30/71 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/37 , A61K31/713 , A61K36/185 , A61K36/42 , A61K36/725 , A61K36/81 , A61K36/87 , A61K36/88 , G01N33/5044 , G01N2500/04 , G01N2800/20 , G01N2800/205
摘要： In a first aspect thereof, the present invention provides a method for treatment and/or prevention of a disease selected from the group consisting of psoriasis and squamous cell carcinoma by inhibiting the expression of squamous cell carcinoma antigen (SCCA) by cells. In another aspect thereof, the present invention provides a method for screening for substances that inhibit epidermal parakeratosis, wherein the activity of a candidate substance that inhibits cysteine protease inhibitory activity possessed by squamous cell carcinoma antigen 1 (SCCA-1) is used as an indicator.
摘要翻译：在其第一方面，本发明提供了通过抑制细胞对鳞状细胞癌抗原（SCCA）的表达来治疗和/或预防选自牛皮癣和鳞状细胞癌的疾病的方法。另一方面，本发明提供了筛选抑制表皮角化不全的物质的方法，其中抑制鳞状细胞癌抗原1（SCCA-1）具有的半胱氨酸蛋白酶抑制活性的候选物质的活性被用作指示剂。

9. 发明申请

US20070160545A1 Method for reducing ultraviolet light induced apoptosis 审中-公开
标题翻译：降低紫外光诱导细胞凋亡的方法
公开(公告)号：US20070160545A1
公开(公告)日：2007-07-12
申请号：US10593955
申请日：2005-03-18
申请人： Chika Katagiri , Toshihiko Hibino
发明人： Chika Katagiri , Toshihiko Hibino
IPC分类号： A61K8/49 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/47 , A61K8/606 , A61K48/00 , A61Q17/04 , G01N33/6893 , G01N2510/00 , G01N2800/20
摘要： The present invention provides a method for enhancing resistance to the onset of skin damage caused by irradiation of the skin with ultraviolet light by inhibiting ultraviolet irradiation-induced apoptosis of epidermal cells as a result of increasing expression of SCCA-1 and/or SCCA-2 in epidermal cells. Moreover, the present invention provides a skin testing method for evaluating resistance of the skin to skin damage caused by ultraviolet irradiation by measuring the expression of SCCA-1 and/or SCCA-2 in epidermal cells, and judging UV resistance of the epidermis to be weak in the case expression is decreased as compared with expression in epidermal cells. Moreover, the present invention provides a method for screening drugs which enhance resistance of the skin to skin damage by ultraviolet irradiation by selecting a drug that increases expression of SCCA-1 and/or SCCA-2 as a UV resistance enhancer.
摘要翻译：本发明提供一种通过抑制由于SCCA-1和/或SCCA-2的表达增加而导致的表皮细胞的紫外线照射诱导的细胞凋亡而增强由紫外线照射皮肤引起的皮肤损伤发作的抗性的方法在表皮细胞中。此外，本发明提供了一种皮肤测试方法，用于通过测量表皮细胞中SCCA-1和/或SCCA-2的表达并评估表皮的抗紫外线性来评估由紫外线照射引起的皮肤对皮肤损伤的抗性与表皮细胞中的表达相比，病例表达较弱。此外，本发明提供了通过选择增加作为抗紫外线增强剂的SCCA-1和/或SCCA-2的表达的药物来增强抗紫外线照射对皮肤的皮肤损伤的药物的方法。

10. 发明授权

US06818214B2 Two novel genes from psoriatic epidermis: psoriastatin type I and psoriastatin type II 失效
标题翻译：来自牛皮癣表皮的两种新型基因：I型和Psoriastatin II型
公开(公告)号：US06818214B2
公开(公告)日：2004-11-16
申请号：US08731566
申请日：1996-10-16
申请人： Toshihiko Hibino , Tadahito Takahashi , Peter C. Baciu , Paul F. Goetinck
发明人： Toshihiko Hibino , Tadahito Takahashi , Peter C. Baciu , Paul F. Goetinck
IPC分类号： A61K3940
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/57
摘要： A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.
摘要翻译：调节细胞增殖或细胞凋亡的方法，包括调节游离激素的活性。

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