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    • 5. 发明授权
    • Novel bisphenoxy carboxylic acid derivatives and their salts
    • US4008265A
    • 1977-02-15
    • US491033
    • 1974-07-23
    • Yoshio SuzukiMasayoshi MinaiNoritaka HammaEiichi MurayamaShunji Aono
    • Yoshio SuzukiMasayoshi MinaiNoritaka HammaEiichi MurayamaShunji Aono
    • C07D211/46C07D213/30C07D213/75C07D295/185C07C69/66
    • C07D213/30C07D211/46C07D213/75C07D295/185Y10S514/824
    • Bisphenoxy carboxylic acid derivatives useful as an antiarteriosclerosis agent with good absorbability and low toxicity, which are novel compounds represented by the general formula, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atoms or lower alkyl groups and A represents ##STR2## (wherein in case R.sub.3 is a hydrogen atom, R.sub.4 represents an amino-lower-alkyl group, an N-lower-alkylaminoalkyl group, a heterocyclic group, or a heterocyclic group-substituted alkyl group; or R.sub.3 and R.sub.4 may join through an intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent) or ##STR3## (wherein R.sub.5 represents a hydrogen atom, a hydroxyalkyl group or a derivative thereof, and R.sub.6 represents a hydroxyalkyl group or a heterocyclic group; or R.sub.5 and R.sub.6 may join to form a cyclic group, or may join through another intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent), are prepared by reacting a bisphenoxy acid represented by the general formula, ##STR4## wherein R.sub.1 and R.sub.2 have the same meanings as defined above, or a reactive derivative thereof with a hetero atom-containing alcohol compound represented by the general formula, ##STR5## wherein R.sub.3 and R.sub.4 have the same meanings as defined above, an amine derivative represented by the general formula, ##STR6## wherein R.sub.5 and R.sub.6 have the same meanings as defined above, or a salt thereof. Alternatively, the bisphenoxy carboxylic acid derivatives represented by the said general formula (I), wherein A is ##STR7## R.sub.5 is hydrogen and R.sub.6 is a hydroxyalkyl group, are prepared by heating a bisphenoxy acid derivative represented by the general formula, ##STR8## wherein R.sub.1 and R.sub.2 have the same meanings as defined above and X represents an alkylene chain.
    • 6. 发明授权
    • Diheterocyclic esters of 4-(1,1-bis-(phenoxy-propionic or -butoyric
acid)-cyclohexane).alpha.-methyl substituted
    • 4-(1,1-双 - (苯氧基 - 丙酸) - 环己烷)(60-甲基取代的)的二杂环酯
    • US4092324A
    • 1978-05-30
    • US716666
    • 1976-08-23
    • Yoshio SuzukiMasayoshi MinaiNoritaka HammaEiichi MurayamaShunji Aono
    • Yoshio SuzukiMasayoshi MinaiNoritaka HammaEiichi MurayamaShunji Aono
    • C07D211/46C07D213/30C07D213/75C07D213/55
    • C07D213/30C07D211/46C07D213/75
    • Bisphenoxy carboxylic acid derivatives useful as an antiarteriosclerosis agent with good absorbability and low toxicity, which are novel compounds represented by the general formula, ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atoms or lower alkyl groups and A preresents ##STR2## (wherein in case R.sub.3 is a hydrogen atom, R.sub.4 represents an amino-lower-alkyl group, an N-lower-alkylaminoalkyl group, a heterocyclic group, or a heterocyclic group-substituted alkyl group; or R.sub.3 and R.sub.4 may join through an intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent) or ##STR3## (wherein R.sub.5 represents a hydrogen atom, a hydroxyalkyl group or a derivative thereof, and R.sub.6 represents a hydroxyalkyl group or a heterocyclic group; or R.sub.5 and R.sub.6 may join to form a cyclic group, or may join through another intermediary hetero atom to form a heterocyclic group and if said hetero atom is a nitrogen atom, this nitrogen atom can bear a lower alkyl group as a substituent).
    • 作为具有良好吸收性和低毒性的抗动脉硬化剂的双苯氧基羧酸衍生物,它们是由通式表示的新化合物,其中R 1和R 2表示氢原子或低级烷基,并且A表示( 其中,在R 3为氢原子的情况下,R 4表示氨基 - 低级烷基,N-低级烷基氨基烷基,杂环基或杂环基取代的烷基;或者,R 3和R 4可以通过中间杂原子 原子形成杂环基,如果所述杂原子是氮原子,则该氮原子可以具有作为取代基的低级烷基)或者其中R5表示氢原子,羟烷基或其衍生物,和 R6表示羟基烷基或杂环基;或者R5和R6可以连接形成环状基团,或者可以通过另一个中间杂原子连接形成杂环基,如果所述杂原子是氮原子 ,该氮原子可以具有低级烷基作为取代基)。