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1. 发明申请

US20090280527A1 Amylase variants 审中-公开
公开(公告)号：US20090280527A1
公开(公告)日：2009-11-12
申请号：US11235738
申请日：2005-09-21
申请人： Henrik Bisgard-Frantzen , Allan Svendsen , Torben Borchert
发明人： Henrik Bisgard-Frantzen , Allan Svendsen , Torben Borchert
IPC分类号： C12P21/06 , C13K1/06 , C12P7/08 , C12N9/26 , C12N1/21 , C12N1/19 , C12N15/63 , C07H21/04
CPC分类号： C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/2417 , C12Y302/01001 , D06L1/14
摘要： The present invention relates to variants of a parent α-amylase, which parent α-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an α-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an α-amylase having one of these amino acid sequences; in which variant:(a) at least one amino acid residue of the parent α-amylase has been deleted; and/or (b) at least one amino acid residue of the parent α-amylase has been replaced by a different amino acid residue; and/or (c) at least one amino acid residue has been inserted relative to the parent α-amylase; the variant having α-amylase activity and exhibiting at least one of the following properties relative to the parent α-amylase: increased thermostability; increased stability towards oxidation; and reduced Ca2+ dependency; with the proviso that the amino acid sequence of the variant is not identical to any of the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 7, respectively.

2. 发明申请

US20050170487A1 Alpha-amylase mutants 失效
标题翻译： α-淀粉酶突变体
公开(公告)号：US20050170487A1
公开(公告)日：2005-08-04
申请号：US11064196
申请日：2005-02-22
申请人： Allan Svendsen , Henrik Bisgard-Frantzen , Torben Borchert
发明人： Allan Svendsen , Henrik Bisgard-Frantzen , Torben Borchert
IPC分类号： C11D3/386 , C12N9/28
CPC分类号： C11D3/386 , C12N9/2417
摘要： The present invention relates to a method of constructing a variant of a parent Termamyl-like α-amylase, which variant has α-amylase activity and at least one altered property as compared to the parent α-amylase, comprises i) analysing the structure of the parent Termamyl-like α-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like α-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like α-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like α-amylase variant, which as compared to the parent Termamyl-like α-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and, optionally, iii) testing the resulting Termamyl-like α-amylase variant with respect to the property in question.
摘要翻译：本发明涉及一种构建母体类戊酰样α-淀粉酶的变体的方法，该变体具有与母体α-淀粉酶相比具有α-淀粉酶活性和至少一种改变的性质，包括：i）分析鉴定至少一个氨基酸残基或类甲酰样α-淀粉酶结构的至少一个结构部分，所述氨基酸残基或结构部分被认为与改变其性质有关的相关性母体类戊酰样α-淀粉酶（根据结构或功能考虑进行评估），ii）构建与母体类戊酰样α-淀粉酶相比的类戊酰样α-淀粉酶变体，已经在在i）中鉴定的氨基酸残基或结构部分，以改变其性质，以及任选地，iii）相对于所讨论的性质测试所得的类戊酰样α-淀粉酶变体。

3. 发明申请

US20080083406A1 Alpha-Amylase Mutants 有权
标题翻译： α-淀粉酶突变体
公开(公告)号：US20080083406A1
公开(公告)日：2008-04-10
申请号：US11862580
申请日：2007-09-27
申请人： Allan Svendsen , Torben Borchert , Henrik Bisgard-Frantzen
发明人： Allan Svendsen , Torben Borchert , Henrik Bisgard-Frantzen
IPC分类号： C12N9/26 , C08B30/00 , C12N1/21 , C12N15/52 , C12N15/63
CPC分类号： C12N9/2417 , C11D3/386 , C12P19/02 , C12P19/14
摘要： The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has a-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent a-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency and specific activity.
摘要翻译：本发明涉及母体类戊酰样α-淀粉酶的变体，该变体具有α-淀粉酶活性并相对于所述亲本α-淀粉酶在下列特性中表现出至少一个变化：底物特异性，底物结合，底物裂解模式，热稳定性，pH /活性曲线，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性和比活性。

4. 发明申请

US20070270574A1 SUBTILISIN VARIANTS 失效
公开(公告)号：US20070270574A1
公开(公告)日：2007-11-22
申请号：US11736322
申请日：2007-04-17
申请人： Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
发明人： Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
IPC分类号： C07K14/00
CPC分类号： C12N9/6408 , C12N9/54
摘要： New subtilisin homologues (both nucleic acids and proteins) are provided. Compositions which include these new proteins, recombinant cells, shuffling methods involving the new homologues, antibodies to the new homologues, and methods of using the homologues are also provided.
摘要翻译：提供了新的枯草杆菌蛋白酶同源物（核酸和蛋白质）。还提供了包括这些新蛋白质，重组细胞，涉及新同系物的洗牌方法，新同系物的抗体以及使用同源物的方法的组合物。

5. 发明申请

US20050158839A1 Hybrid enzymes 有权
标题翻译：杂交酶
公开(公告)号：US20050158839A1
公开(公告)日：2005-07-21
申请号：US10974508
申请日：2004-10-27
申请人： Torben Borchert , Steffen Danielsen , Eric Allain
发明人： Torben Borchert , Steffen Danielsen , Eric Allain
IPC分类号： C07K14/32 , C07K14/37 , C07K14/375 , C07K14/38 , C07K14/385 , C12N9/34 , C12N9/32 , C07H21/04 , C12N1/16 , C12N15/74
CPC分类号： C07K14/32 , C07K14/37 , C07K14/375 , C07K14/38 , C07K14/385 , C07K2319/00 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a hybrid enzyme comprising at least one carbohydrate-binding module amino acid sequence and at least the catalytic module of a glucoamylase amino acid sequence. The invention also relates to the use of the hybrid enzyme in starch processing and especially ethanol production.
摘要翻译：本发明涉及包含至少一种碳水化合物结合组件氨基酸序列和至少葡糖淀粉酶氨基酸序列的催化组件的杂合酶。本发明还涉及杂交酶在淀粉加工中尤其是乙醇生产中的应用。

6. 发明申请

US20050019886A1 Alpha-amylase variants 失效
标题翻译： α-淀粉酶变体
公开(公告)号：US20050019886A1
公开(公告)日：2005-01-27
申请号：US10926720
申请日：2004-08-26
申请人： Allan Svendsen , Henrik Bisgard-Frantzen , Torben Borchert
发明人： Allan Svendsen , Henrik Bisgard-Frantzen , Torben Borchert
IPC分类号： C12N15/09 , C11D3/386 , C12N1/21 , C12N9/28 , C12N15/00 , C12N15/56 , C12R1/07
CPC分类号： C12N9/2417 , C11D3/386
摘要： The present invention relates to a method of constructing a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and at least one altered property as compared to the parent alpha-amylase, comprising i) analyzing the structure of the parent Termamyl-like alpha-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like alpha-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like alpha-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like alpha-amylase variant, which as compared to the parent Termamyl-like alpha-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and iii) testing the resulting Termamyl-like alpha-amylase variant for the property in question.
摘要翻译：本发明涉及一种构建母体类戊酰样α-淀粉酶的变体的方法，该变体具有与母体α-淀粉酶相比具有α-淀粉酶活性和至少一种改变的性质，其包括：i）分析鉴定至少一个氨基酸残基或类甲酰样α-淀粉酶结构的至少一个结构部分，所述氨基酸残基或结构部分被认为与改变其性质有关的相关性母体类戊酰样α-淀粉酶（根据结构或功能考虑进行评估），ii）构建与母体类戊酰样α-淀粉酶相比的类戊酰样α-淀粉酶变体，已经在在i）中鉴定的氨基酸残基或结构部分，以便改变性质，和iii）测试所得到的类戊酰样α-淀粉酶变体的性质。

7. 发明申请

US20050118695A1 Alpha-amylase mutants 失效
标题翻译： α-淀粉酶突变体
公开(公告)号：US20050118695A1
公开(公告)日：2005-06-02
申请号：US10980759
申请日：2004-11-03
申请人： Allan Svendsen , Torben Borchert , Henrik Bisgard-Frantzen
发明人： Allan Svendsen , Torben Borchert , Henrik Bisgard-Frantzen
IPC分类号： C12N15/09 , C11D3/386 , C12N1/21 , C12N9/28 , C12R1/07 , C12N9/94
CPC分类号： C12N9/2417 , C11D3/386 , C12P19/02 , C12P19/14
摘要： The invention relates to a variant of a parent Termamyl-like a-amylase, which variant has a-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent a-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards oxidation, Ca2+ dependency and specific activity.
摘要翻译：本发明涉及母体类戊酰样α-淀粉酶的变体，该变体具有α-淀粉酶活性，并且相对于所述亲本α-淀粉酶表现出至少一种以下特性的改变：底物特异性，底物结合，底物裂解模式，热稳定性，pH /活性分布，pH /稳定性分布，对氧化的稳定性，Ca 2+依赖性和比活性。

8. 发明申请

US20050059131A1 Detergent compositions containing amylase variants 审中-公开
标题翻译：含有淀粉酶变体的洗涤剂组合物
公开(公告)号：US20050059131A1
公开(公告)日：2005-03-17
申请号：US10778469
申请日：2004-02-12
申请人： Henrik Bisgard-Frantzen , Allan Svendsen , Torben Borchert
发明人： Henrik Bisgard-Frantzen , Allan Svendsen , Torben Borchert
IPC分类号： C11D3/386 , C12N9/28 , C12N15/56 , D06L1/14 , C12N9/32
CPC分类号： C11D3/38618 , C11D3/38609 , C11D3/38681 , C12N9/2417 , C12Y302/01001 , D06L1/14
摘要： The present invention relates to variants of a parent α-amylase, which parent α-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an α-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an α-amylase having one of these amino acid sequences; in which variant: (a) at least one amino acid residue of the parent α-amylase has been deleted; and/or (b) at least one amino acid residue of the parent α-amylase has been replaced by a different amino acid residue; and/or (c) at least one amino acid residue has been inserted relative to the parent α-amylase; the variant having α-amylase activity and exhibiting at least one of the following properties relative to the parent α-amylase: increased thermostability; increased stability towards oxidation; and reduced Ca2+ dependency; with the proviso that the amino acid sequence of the variant is not identical to any of the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and SEQ ID No. 7, respectively.
摘要翻译：本发明涉及母体α-淀粉酶的变体，其母体α-淀粉酶（i）具有选自SEQ ID No.1，SEQ ID No.2，SEQ ID No.2所示的氨基酸序列的氨基酸序列。 3和SEQ ID No.7; 或（ii）与这些氨基酸序列中的一个或多个显示至少80％的同源性; 和/或显示与针对具有这些氨基酸序列之一的α-淀粉酶产生的抗体的免疫交叉反应性; 和/或由与编码具有这些氨基酸序列之一的α-淀粉酶的DNA序列相同的探针杂交的DNA序列编码; 在该变体中：（a）母体α-淀粉酶的至少一个氨基酸残基已被缺失; 和/或（b）母体α-淀粉酶的至少一个氨基酸残基被不同的氨基酸残基替代; 和/或（c）相对于母体α-淀粉酶插入至少一个氨基酸残基; 该变体具有α-淀粉酶活性并且相对于母体α-淀粉酶表现出以下特性中的至少一个：增加的热稳定性; 提高氧化稳定性; 并减少Ca 2+依赖性; 条件是变体的氨基酸序列分别与SEQ ID No.1，SEQ ID No.2，SEQ ID No.3和SEQ ID No.7所示的任何氨基酸序列不同。

9. 发明申请

US20070015677A1 Variant subtilising enzymes (subtilases) 失效
标题翻译：变异的枯草芽孢杆菌（subtilases）
公开(公告)号：US20070015677A1
公开(公告)日：2007-01-18
申请号：US10555484
申请日：2004-05-06
申请人： Stefan Minning , Jurgen Carsten Franz Knotzel , Niels Sorensen , Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
发明人： Stefan Minning , Jurgen Carsten Franz Knotzel , Niels Sorensen , Jon Ness , Mark Welch , Lorraine Giver , Joel Cherry , Torben Borchert , Jeremy Minshull
IPC分类号： C11D3/386 , C07H21/04 , C12P21/06 , C12N9/54 , C12N15/74
CPC分类号： C11D3/38636 , C11D3/38681 , C12N9/52 , Y02P20/582
摘要： Novel subtilases having an improved wash performance on egg stains. These subtilases are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
摘要翻译：具有改进的蛋渍洗涤性能的新型枯草芽孢杆菌。当用于例如蛋白质时，这些脱水酶可用于在蛋渍上表现出优异或改善的洗涤性能。清洁剂或洗涤剂组合物，例如衣物洗涤剂组合物和洗碟组合物，包括自动洗碗组合物。

10. 发明授权

US07163816B2 Alpha-amylase variants 失效
标题翻译： α-淀粉酶变体
公开(公告)号：US07163816B2
公开(公告)日：2007-01-16
申请号：US10926720
申请日：2004-08-26
申请人： Allan Svendsen , Henrik Bisgaard-Frantzen , Torben Borchert
发明人： Allan Svendsen , Henrik Bisgaard-Frantzen , Torben Borchert
IPC分类号： C12N9/28 , G01N33/483 , C07H21/04 , C12N1/21 , C12Q1/40 , G06F19/00
CPC分类号： C12N9/2417 , C11D3/386
摘要： The present invention relates to a method of constructing a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and at least one altered property as compared to the parent alpha-amylase, comprising i) analyzing the structure of the parent Termamyl-like alpha-amylase to identify at least one amino acid residue or at least one structural part of the Termamyl-like alpha-amylase structure, which amino acid residue or structural part is believed to be of relevance for altering the property of the parent Termamyl-like alpha-amylase (as evaluated on the basis of structural or functional considerations), ii) constructing a Termamyl-like alpha-amylase variant, which as compared to the parent Termamyl-like alpha-amylase, has been modified in the amino acid residue or structural part identified in i) so as to alter the property, and iii) testing the resulting Termamyl-like alpha-amylase variant for the property in question.
摘要翻译：本发明涉及一种构建母体类戊酰样α-淀粉酶的变体的方法，该变体具有与母体α-淀粉酶相比具有α-淀粉酶活性和至少一种改变的性质，其包括：i）分析鉴定至少一个氨基酸残基或类甲酰样α-淀粉酶结构的至少一个结构部分，所述氨基酸残基或结构部分被认为与改变其性质有关的相关性母体类戊酰样α-淀粉酶（根据结构或功能考虑进行评估），ii）构建与母体类戊酰样α-淀粉酶相比的类戊酰样α-淀粉酶变体，已经在在i）中鉴定的氨基酸残基或结构部分，以便改变性质，和iii）测试所得到的类戊酰样α-淀粉酶变体的性质。

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