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1. 发明授权

US5223508A Pyridyl carboximidamide compounds useful in treating blood pressure 失效
标题翻译：用于治疗血压的吡啶基亚甲基酰胺化合物
公开(公告)号：US5223508A
公开(公告)日：1993-06-29
申请号：US843847
申请日：1992-02-28
申请人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
发明人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
IPC分类号： C07C257/18 , C07C335/32 , C07D213/78 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12
CPC分类号： C07D213/78 , C07C257/18 , C07C335/32 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12
摘要： Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboxyimidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: ##STR2## wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.
摘要翻译：公开了由下式（A）表示的新型甲脒类衍生物及其酸加成盐：其中全部取代基具有与上述相同的含义。还公开了作为制备上述式（A）中的取代基B为吡啶的N-氰基-N'-取代的吡啶甲酰胺衍生物的中间体的下式（II）表示的N-氰基 - 吡啶羧酰亚胺酸酯化合物：（II）其中所有取代基具有与上述相同的含义。还公开了制备该化合物的方法，包含具有血管舒张作用的化合物的药剂，以及将该化合物给予患者治疗的治疗方法。

2. 发明授权

US5166347A Carboximidamide derivatives 失效
标题翻译：羧甲酰胺衍生物
公开(公告)号：US5166347A
公开(公告)日：1992-11-24
申请号：US455973
申请日：1989-12-22
申请人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
发明人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
IPC分类号： C07D213/53 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4433 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/08 , C07C257/18 , C07C335/32 , C07D213/61 , C07D213/78 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12
CPC分类号： C07D213/78 , C07C257/18 , C07C335/32 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12
摘要： Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine is also disclosed: ##STR2## wherein all the substitutents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.
摘要翻译：公开了由下式（A）表示的新型甲脒类衍生物及其酸加成盐：其中全部取代基具有与上述相同的含义。还公开了作为上述式（A）中的取代基B为吡啶的N-氰基-N'-取代的吡啶甲酰胺衍生物的制造中间体的下述式（II）表示的N-氰基 - 吡啶甲脒化合物：（II）其中所有取代基具有与上述相同的含义。还公开了制备该化合物的方法，包含具有血管舒张作用的化合物的药剂，以及将该化合物给予患者治疗的治疗方法。

3. 发明授权

US5272164A Carboximidamide derivatives 失效
标题翻译：羧甲酰胺衍生物
公开(公告)号：US5272164A
公开(公告)日：1993-12-21
申请号：US843816
申请日：1992-02-28
申请人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
发明人： Toshio Izawa , Tomoko Kashiwabara , Shohachi Nakajima , Nobuyuki Ogawa
IPC分类号： C07C257/18 , C07C335/32 , C07D213/78 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12 , A01N43/40 , C07D24/00
CPC分类号： C07D213/78 , C07C257/18 , C07C335/32 , C07D213/81 , C07D215/54 , C07D241/24 , C07D307/68 , C07D333/38 , C07D409/12
摘要： Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: ##STR2## wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.
摘要翻译：公开了由下式（A）表示的新型甲脒类衍生物及其酸加成盐：其中全部取代基具有与上述相同的含义。还公开了作为用于制备上述式（A）中的取代基B为吡啶的N-氰基-N'-取代的吡啶甲酰胺衍生物的中间体的下式（II）表示的N-氰基 - 吡啶甲脒化合物：（II）其中所有取代基具有与上述相同的含义。还公开了制备该化合物的方法，包含具有血管舒张作用的化合物的药剂，以及将该化合物给予患者治疗的治疗方法。

4. 发明授权

US5508293A Pyridinecarboxyimidamide compounds and the use thereof 失效
标题翻译：吡啶甲脒类化合物及其用途
公开(公告)号：US5508293A
公开(公告)日：1996-04-16
申请号：US256625
申请日：1994-09-27
申请人： Hideki Okawara , Tatsuo Nakajima , Nobuyuki Ogawa , Tomoko Kashiwabara , Soichiro Kaneta
发明人： Hideki Okawara , Tatsuo Nakajima , Nobuyuki Ogawa , Tomoko Kashiwabara , Soichiro Kaneta
IPC分类号： A61K31/44 , C07D213/78 , C07D213/82
CPC分类号： C07D213/78
摘要： Disclosed are pyridinecarboximidamides having a vasodilating effect (hypotensive activity or antianginal activity), and acid adduct salts thereof. ##STR1## wherein when R.sup.1 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group, R.sup.2 represents a hydrogen atom and R.sup.3 represents a nitroxyl, 2-chlorophenyl or phenyl group; andwhen R.sup.1 represents a hydrogen atom, R.sup.2 represents an alkyl, hydroxyalkyl, carboxyl, amino, acylamino, alkylamino, dialkylamino, aralkylamino, alkylsulfonamide, bisalkylsulfonylamino or hydroxyl group and R.sup.3 represents a nitroxyl, 2-chlorophenyl or phenyl group.There is also disclosed the use of the compounds represented by the formula (I) for antihypertensive or antianginal purpose.
摘要翻译： PCT No.PCT / JP93 / 00103 Sec。 371日期：1994年9月27日 102（e）1994年9月27日PCT 1993年1月28日PCT公布。第WO93 / 15057号公报日期：1993年8月5日。公开的是具有血管扩张作用（降血压活性或抗血管活性）的吡啶甲脒和其酸加成盐。（I）其中当R 1表示烷基，羟烷基，羧基，氨基，酰氨基，烷基氨基，二烷基氨基，芳烷基氨基，烷基磺酰胺，双烷基磺酰基氨基或羟基时，R 2表示氢原子，R 3表示硝酰基，2-氯苯基或苯基组; 当R 1表示氢原子时，R 2表示烷基，羟烷基，羧基，氨基，酰氨基，烷基氨基，二烷基氨基，芳烷基氨基，烷基磺酰胺，双烷基磺酰基氨基或羟基，R 3表示硝酰基，2-氯苯基或苯基。还公开了由式（I）表示的化合物用于抗高血压或抗血管功能的用途。

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