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1. 发明授权

US09920356B2 Amplified nucleic acid detection method and detection device 有权
公开(公告)号：US09920356B2
公开(公告)日：2018-03-20
申请号：US13989207
申请日：2011-11-24
申请人： Koji Takahashi , Shigehiko Miyamoto , Takaaki Jikihara , Jun Tomono
发明人： Koji Takahashi , Shigehiko Miyamoto , Takaaki Jikihara , Jun Tomono
IPC分类号： C12P19/34 , C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00 , G01N33/543
CPC分类号： C12Q1/6834 , C12Q1/6832 , C12Q1/686 , G01N33/54313 , C12Q2525/155 , C12Q2525/161 , C12Q2565/519 , C12Q2525/186 , C12Q2531/113 , C12Q2565/625
摘要： An object of the invention is to provide a nucleic acid detection method which takes advantage of the high specificity of hybridization techniques, reduces the time length and the number of steps required for detection of PCR products, and allows for easy and highly accurate detection by visual observation without the need of special equipment; and a nucleic acid detection device or kit. The invention provides a method for detecting a target nucleic acid in a sample, which includes performing amplification of the target nucleic acid sequence to synthesize an amplification product having a partially double-stranded structure where a single-stranded region is added to each end of the target sequence, and hybridizing a nucleic acid sequence bound to a development medium and a nucleic acid sequence labeled with a labeling compound with the single-stranded regions of the amplification product to form a sandwich hybridization complex; and a detection device thereof.

2. 发明授权

US09040747B2 Method for producing reduced coenzyme Q10, method for stabilizing same, and composition comprising same 有权
标题翻译：还原型辅酶Q10的制造方法，其稳定化方法及其组合物
公开(公告)号：US09040747B2
公开(公告)日：2015-05-26
申请号：US13501692
申请日：2010-10-15
申请人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A23L1/30 , A23L1/00 , A23L1/305 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46
CPC分类号： A23L1/30 , A23L33/10 , A23L33/175 , A23P10/30 , A23V2002/00 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/314
摘要： An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.
摘要翻译：本发明的目的是提供一种特征在于能够减少氧化型辅酶Q10和使含有营养成分的还原型辅酶Q10稳定，具有良好的味道，通用性优异的能力的物质及其使用方法。本发明涉及还原型辅酶Q10的制备方法，其包括用特定氨基酸还原氧化型辅酶Q10。本发明还涉及在特定氨基酸和通过该方法稳定的组合物存在下稳定还原型辅酶Q10的方法。

3. 发明申请

US20130252341A1 METHOD AND DEVICE FOR DETECTING NUCLEIC ACID, AND KIT 有权
标题翻译：用于检测核酸和方法的方法和装置
公开(公告)号：US20130252341A1
公开(公告)日：2013-09-26
申请号：US13823946
申请日：2011-09-21
申请人： Shigehiko Miyamoto , Takaaki Jikihara , Sotaro Sano , Koji Takahashi , Jun Tomono
发明人： Shigehiko Miyamoto , Takaaki Jikihara , Sotaro Sano , Koji Takahashi , Jun Tomono
IPC分类号： G01N33/58
CPC分类号： G01N33/583 , C12Q1/6816 , C12Q1/6846 , C12Q1/686 , G01N21/78 , Y10T436/143333 , C12Q2563/173
摘要： The present invention provides a method for detecting a nucleic acid, by which a multi-stranded nucleic acid amplified by a nucleic acid amplification method is detected easily and with a high degree of accuracy without the need for specialized equipment, and also provides a nucleic acid detection device. Provided are a method for detecting a nucleic acid under visible light via a color reaction produced by contact between a chromogenic leuco dye and the multi-stranded nucleic acid, as well as a nucleic acid detection device using this method.
摘要翻译：本发明提供一种检测核酸的方法，通过该方法可以容易地且高精度地检测通过核酸扩增方法扩增的多链核酸而不需要专门的设备，并且还提供核酸检测装置提供了通过由显色无色染料和多链核酸之间的接触产生的显色反应以及使用该方法的核酸检测装置在可见光下检测核酸的方法。

4. 发明授权

US09097718B2 Method and device for detecting nucleic acid, and kit 有权
标题翻译：用于检测核酸的方法和装置，以及试剂盒
公开(公告)号：US09097718B2
公开(公告)日：2015-08-04
申请号：US13823946
申请日：2011-09-21
申请人： Shigehiko Miyamoto , Takaaki Jikihara , Sotaro Sano , Koji Takahashi , Jun Tomono
发明人： Shigehiko Miyamoto , Takaaki Jikihara , Sotaro Sano , Koji Takahashi , Jun Tomono
IPC分类号： G01N33/58 , G01N21/78 , C12Q1/68
CPC分类号： G01N33/583 , C12Q1/6816 , C12Q1/6846 , C12Q1/686 , G01N21/78 , Y10T436/143333 , C12Q2563/173
摘要： The present invention provides a method for detecting a nucleic acid, by which a multi-stranded nucleic acid amplified by a nucleic acid amplification method is detected easily and with a high degree of accuracy without the need for specialized equipment, and also provides a nucleic acid detection device. Provided are a method for detecting a nucleic acid under visible light via a color reaction produced by contact between a chromogenic leuco dye and the multi-stranded nucleic acid, as well as a nucleic acid detection device using this method.
摘要翻译：本发明提供一种检测核酸的方法，通过该方法可以容易地且高精度地检测通过核酸扩增方法扩增的多链核酸而不需要专门的设备，并且还提供核酸检测装置提供了通过由显色无色染料和多链核酸之间的接触产生的显色反应以及使用该方法的核酸检测装置在可见光下检测核酸的方法。

5. 发明申请

US20140065725A1 AMPLIFIED NUCLEIC ACID DETECTION METHOD AND DETECTION DEVICE 有权
标题翻译：放大核酸检测方法和检测装置
公开(公告)号：US20140065725A1
公开(公告)日：2014-03-06
申请号：US13989207
申请日：2011-11-24
申请人： Koji Takahashi , Shigehiko Miyamoto , Takaaki Jikihara , Jun Tomono
发明人： Koji Takahashi , Shigehiko Miyamoto , Takaaki Jikihara , Jun Tomono
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6832 , C12Q1/686 , G01N33/54313 , C12Q2525/155 , C12Q2525/161 , C12Q2565/519 , C12Q2525/186 , C12Q2531/113 , C12Q2565/625
摘要： An object of the invention is to provide a nucleic acid detection method which takes advantage of the high specificity of hybridization techniques, reduces the time length and the number of steps required for detection of PCR products, and allows for easy and highly accurate detection by visual observation without the need of special equipment; and a nucleic acid detection device or kit. The invention provides a method for detecting a target nucleic acid in a sample, which includes performing amplification of the target nucleic acid sequence to synthesize an amplification product having a partially double-stranded structure where a single-stranded region is added to each end of the target sequence, and hybridizing a nucleic acid sequence bound to a development medium and a nucleic acid sequence labeled with a labeling compound with the single-stranded regions of the amplification product to form a sandwich hybridization complex; and a detection device thereof.
摘要翻译：本发明的目的是提供一种核酸检测方法，其利用杂交技术的高特异性，减少检测PCR产物所需的时间长度和数量，并且允许通过视觉方便和高度准确的检测观察无需特殊设备; 和核酸检测装置或试剂盒。本发明提供了一种用于检测样品中靶核酸的方法，其包括进行目标核酸序列的扩增以合成具有部分双链结构的扩增产物，其中单链区域被添加到靶序列，并将与显影培养基结合的核酸序列与标记化合物标记的核酸序列与扩增产物的单链区域杂交以形成夹心杂交复合物; 及其检测装置。

6. 发明申请

US20120201802A1 METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME 审中-公开
标题翻译：用于生产降低的聚苯乙烯的方法Q10，其稳定化方法和包含其的组合物
公开(公告)号：US20120201802A1
公开(公告)日：2012-08-09
申请号：US13502181
申请日：2010-10-14
申请人： Takao Yamaguchi , Takaaki Jikihara , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takao Yamaguchi , Takaaki Jikihara , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , A61K31/122 , A23L1/30 , C07C50/28
CPC分类号： A61K36/53 , A23L33/10 , A23L33/105 , A23L33/15 , A23P10/30 , A23V2002/00 , A61K9/4875 , A61K31/09 , A61K31/122 , A61K36/15 , A61K36/736 , A61K36/82 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/21 , A23V2250/314
摘要： The present invention aims to provide a component having not only an ability to reduce oxidized coenzyme Q10 and an ability to stabilize reduced coenzyme Q10, but also nutrient, flavor, broad utility and the like, and a utilization method thereof. The present invention relates to a safe and convenient method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 by using, as a component derived from a naturally-occurring substance, which is safe for the body, any one or more components selected from the group consisting of an acerola extract, a tea extract, a rosemary extract, a pine bark extract and a Vaccinium vitis-idaea extract. In addition, the present invention also relates to a method of stabilizing reduced coenzyme Q10 in the co-presence of a component derived from a naturally-occurring substance, and a stabilized composition. Since the above-mentioned components derived from a naturally-occurring substance can also be expected to function as nutrients, the composition of the present invention is particularly useful as a pharmaceutical product, a supplement, a food with nutrient function claims, a food for specified health use, a nutritional supplement, a nutritional product, an animal drug, a cosmetic, a therapeutic drug and the like, which are required to show various effects.
摘要翻译：本发明的目的在于提供一种不仅具有减少氧化型辅酶Q10的能力和稳定还原型辅酶Q10的能力，而且还具有养分，风味，广泛用途等的成分及其利用方法。本发明涉及一种生产还原型辅酶Q10的安全且方便的方法，其包括使用作为对身体安全的天然存在物质的成分的还原氧化型辅酶Q10，任何一种或多种选自一组由槭树提取物，茶提取物，迷迭香提取物，松树皮提取物和痘苗提取物组成。此外，本发明还涉及在衍生自天然存在物质的成分的共存下稳定还原型辅酶Q10的稳定化组合物的方法。由于上述衍生自天然物质的组分也可以预期作为营养物质使用，所以本发明的组合物特别可用作药物产品，补充剂，具有营养功能要求的食品，特定食品健康用品，营养补充剂，营养产品，动物药物，化妆品，治疗药物等，需要显示各种效果。

7. 发明申请

US20140058043A1 NUCLEIC ACID DETECTION METHOD, AND DEVICE AND KIT FOR USE IN SAME 有权
标题翻译：核酸检测方法，以及用于其的装置和试剂盒
公开(公告)号：US20140058043A1
公开(公告)日：2014-02-27
申请号：US14002886
申请日：2012-03-05
申请人： Shigehiko Miyamoto , Jun Tomono , Koji Takahashi , Sotaro Sano , Takaaki Jikihara
发明人： Shigehiko Miyamoto , Jun Tomono , Koji Takahashi , Sotaro Sano , Takaaki Jikihara
IPC分类号： C08F222/10
CPC分类号： G01N21/78 , C08F222/10 , C12Q1/6806 , C12Q1/6846 , C12Q1/6848 , G01N21/03 , Y10T436/143333 , C12Q2547/101 , C12Q2563/103 , C12Q2563/173
摘要： The present invention aims to solve problems in the analysis of amplified nucleic acids, i.e., cost, workability, and contamination and pollution of samples. In the present invention, a sample containing a nucleic acid and a reagent for detecting the nucleic acid are mixed in a closed system. In this regard, the nucleic acid is amplified in the same closed system, and then mixed with the detecting reagent without opening the system. In order to carry out this method, for example, a device that includes the detecting reagent shielded by a coating material or the like is used.
摘要翻译：本发明旨在解决扩增核酸分析中的问题，即成本，可加工性以及样品的污染和污染。在本发明中，含有核酸和检测核酸的试剂的样品在封闭系统中混合。在这方面，核酸在相同的封闭系统中扩增，然后与检测试剂混合而不打开系统。为了实施该方法，例如，使用包含被涂料等遮蔽的检测试剂的装置。

8. 发明申请

US20120207731A1 METHOD FOR PRODUCING REDUCED COENZYME Q10, METHOD FOR STABILIZING SAME, AND COMPOSITION COMPRISING SAME 有权
标题翻译：用于生产降低的聚苯乙烯的方法Q10，其稳定化方法和包含其的组合物
公开(公告)号：US20120207731A1
公开(公告)日：2012-08-16
申请号：US13501692
申请日：2010-10-15
申请人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takaaki Jikihara , Takao Yamaguchi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K38/43 , C07C49/753 , A61K31/122 , C07C45/61
CPC分类号： A23L1/30 , A23L33/10 , A23L33/175 , A23P10/30 , A23V2002/00 , A61K9/10 , A61K31/122 , A61K47/10 , C07C41/26 , C07C41/46 , C07C43/23 , A23V2250/314
摘要： An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.
摘要翻译：本发明的目的是提供一种特征在于能够减少氧化型辅酶Q10和使含有营养成分的还原型辅酶Q10稳定，具有良好的味道，通用性优异的能力的物质及其使用方法。本发明涉及还原型辅酶Q10的制备方法，其包括用特定氨基酸还原氧化型辅酶Q10。本发明还涉及在特定氨基酸和通过该方法稳定的组合物存在下稳定还原型辅酶Q10的方法。

9. 发明授权

US09273174B2 Nucleic acid detection method, and device and kit for use in same 有权
标题翻译：核酸检测方法，以及用于其中的装置和试剂盒
公开(公告)号：US09273174B2
公开(公告)日：2016-03-01
申请号：US14002886
申请日：2012-03-05
申请人： Shigehiko Miyamoto , Jun Tomono , Koji Takahashi , Sotaro Sano , Takaaki Jikihara
发明人： Shigehiko Miyamoto , Jun Tomono , Koji Takahashi , Sotaro Sano , Takaaki Jikihara
IPC分类号： C12Q1/68 , G01N21/78 , C08F222/10 , G01N21/03
CPC分类号： G01N21/78 , C08F222/10 , C12Q1/6806 , C12Q1/6846 , C12Q1/6848 , G01N21/03 , Y10T436/143333 , C12Q2547/101 , C12Q2563/103 , C12Q2563/173
摘要： The present invention aims to solve problems in the analysis of amplified nucleic acids, i.e., cost, workability, and contamination and pollution of samples. In the present invention, a sample containing a nucleic acid and a reagent for detecting the nucleic acid are mixed in a closed system. In this regard, the nucleic acid is amplified in the same closed system, and then mixed with the detecting reagent without opening the system. In order to carry out this method, for example, a device that includes the detecting reagent shielded by a coating material or the like is used.
摘要翻译：本发明旨在解决扩增核酸分析中的问题，即成本，可加工性以及样品的污染和污染。在本发明中，含有核酸和检测核酸的试剂的样品在封闭系统中混合。在这方面，核酸在相同的封闭系统中扩增，然后与检测试剂混合而不打开系统。为了实施该方法，例如，使用包含被涂料等遮蔽的检测试剂的装置。

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