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1. 发明授权

US08546544B2 Antibody specifically binding to c-Met and methods of use 有权
标题翻译：抗体特异性结合c-Met和使用方法
公开(公告)号：US08546544B2
公开(公告)日：2013-10-01
申请号：US12807191
申请日：2010-08-30
申请人： Kwang-ho Cheong , Sung-young Jeong , Sang-hyun Paek
发明人： Kwang-ho Cheong , Sung-young Jeong , Sang-hyun Paek
IPC分类号： C07K16/26 , C07K16/00 , C12N5/20 , C12N15/00 , C12N15/87 , C07H21/04
CPC分类号： G01N33/57407 , C07K16/2863 , C07K2317/33 , G01N33/57492
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.
摘要翻译：本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。还公开了制备和使用抗体和组合物的方法。

2. 发明授权

US08524059B2 Apparatus and method for adjusting pH of solution 有权
标题翻译：调节溶液pH值的装置和方法
公开(公告)号：US08524059B2
公开(公告)日：2013-09-03
申请号：US13495342
申请日：2012-06-13
申请人： Hun joo Lee , Jin tae Kim , Sung-young Jeong , Joon-ho Kim , Hee-kyun Lim
发明人： Hun joo Lee , Jin tae Kim , Sung-young Jeong , Joon-ho Kim , Hee-kyun Lim
IPC分类号： G01N27/44
CPC分类号： G05D21/02
摘要： A pH adjusting apparatus includes an electrolytic chip receiving a solution, an electrolytic chip loading station receiving the electrolytic chip, an input unit inputting electrolysis conditions, a control unit receiving the electrolysis conditions and controlling electrolysis performed in the electrolytic chip, and a display unit displaying the electrolysis conditions and a progress of the electrolysis. Thus, the pH of a solution can be adjusted easily and accurately, by precisely controlling a constant current, a constant voltage, and current and voltage application times, thereby enabling useful application in various biological assays such as cell lysis. Furthermore, the pH adjusting apparatus has small size and weight and can be operated for a long time after charging once due to low power consumption.
摘要翻译： pH调节装置包括：接收溶液的电解芯片，接收电解芯片的电解芯片装载站，输入电解条件的输入单元，接收电解条件的控制单元以及控制电解芯片中进行的电解;以及显示单元，电解条件和电解进度。因此，通过精确地控制恒定电流，恒定电压，电流和电压施加时间，可以容易且精确地调节溶液的pH，从而可用于各种生物测定如细胞裂解中的有用应用。此外，pH调节装置的体积小，重量轻，能够在低功耗的情况下一次充电后长时间运转。

3. 发明授权

US08481689B2 Antibody specifically binding to c-Met and methods of use 有权
公开(公告)号：US08481689B2
公开(公告)日：2013-07-09
申请号：US12807191
申请日：2010-08-30
申请人： Kwang-ho Cheong , Sung-young Jeong , Sang-hyun Paek
发明人： Kwang-ho Cheong , Sung-young Jeong , Sang-hyun Paek
IPC分类号： C07K16/26 , C07K16/00 , C12N5/20 , C12N15/00 , C12N15/87 , C07H21/04
摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

4. 发明授权

US08153085B2 Microfluidic chip and method of fabricating the same 有权
标题翻译：微流控芯片及其制造方法
公开(公告)号：US08153085B2
公开(公告)日：2012-04-10
申请号：US12949981
申请日：2010-11-19
申请人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
发明人： Kyu-youn Hwang , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502753 , B01L2200/12 , B01L2300/16 , Y10T428/14
摘要： Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other.
摘要翻译：提供了一种微流控芯片及其制造方法。微流体芯片包括：下基板; 由硅树脂形成的上基板，其中所述下基板和所述上基板接合在一起，提供流体可以流过的通道和容纳所述流体的室; 以及形成在下基板的上表面上的有机薄膜，除了下基板和上基板彼此附接的部分之外。

5. 发明申请

US20100160585A1 METHOD AND APPARATUS FOR ISOLATING AND PURIFYING NUCLEIC ACID USING A SINGLE SURFACE 有权
标题翻译：使用单面表面分离和纯化核酸的方法和装置
公开(公告)号：US20100160585A1
公开(公告)日：2010-06-24
申请号：US12716695
申请日：2010-03-03
申请人： Chang eun YOO , Sung-young JEONG , Young-rok KIM
发明人： Chang eun YOO , Sung-young JEONG , Young-rok KIM
IPC分类号： C08F226/06
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.
摘要翻译：提供了使用单个表面从细胞中分离核酸的方法，其中由式1表示的化合物结合到表面。还提供了用于分离核酸的装置和用于分离核酸的珠粒。

6. 发明授权

US07718371B2 Method and apparatus for isolating and purifying nucleic acid using a single surface 有权
标题翻译：使用单个表面分离和纯化核酸的方法和设备
公开(公告)号：US07718371B2
公开(公告)日：2010-05-18
申请号：US11693259
申请日：2007-03-29
申请人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
发明人： Chang eun Yoo , Sung-young Jeong , Young-rok Kim
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , C07H21/04 , B01L3/00 , G01N15/06 , A61K9/14
CPC分类号： B01J20/28009 , B01D15/1807 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/327 , C08F20/02 , C08F26/06 , C12N1/066 , C12N13/00
摘要： Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.
摘要翻译：提供了使用单个表面从细胞中分离核酸的方法，其中由式1表示的化合物结合到表面。还提供了用于分离核酸的装置和用于分离核酸的珠粒。

7. 发明申请

US20100111770A1 Microfluidic Chip and Method of Fabricating The Same 审中-公开
标题翻译：微流控芯片及其制造方法
公开(公告)号：US20100111770A1
公开(公告)日：2010-05-06
申请号：US12613847
申请日：2009-11-06
申请人： Kyu-youn HWANG , Joon-ho KIM , Chin-sung PARK , Sung-young JEONG , Taeseok SIM
发明人： Kyu-youn HWANG , Joon-ho KIM , Chin-sung PARK , Sung-young JEONG , Taeseok SIM
IPC分类号： B81B3/00 , B32B37/14 , B32B3/02 , B32B9/00
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2300/16 , Y10T428/24612 , Y10T428/31507 , Y10T428/31544 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663
摘要： Provided are a microfluidic structure including a polysiloxane layer and a method of fabricating the microfluidic structure. The polysiloxane layer is coupled to substrates via a SiO2 layer.
摘要翻译：提供包括聚硅氧烷层的微流体结构和制造微流体结构的方法。聚硅氧烷层通过SiO 2层与基底相连。

8. 发明申请

US20090098291A1 METHOD OF PRODUCING SOLID SUPPORT FOR BIOLOGICAL ANALYSIS USING PLASTIC MATERIAL 审中-公开
标题翻译：使用塑料材料生产生物分析的固体支持方法
公开(公告)号：US20090098291A1
公开(公告)日：2009-04-16
申请号：US12100700
申请日：2008-04-10
申请人： Kyu-youn HWANG , Joon-ho Kim , Sung-young Jeong , Chin-sung Park
发明人： Kyu-youn HWANG , Joon-ho Kim , Sung-young Jeong , Chin-sung Park
IPC分类号： C23C16/44 , B05D1/36
CPC分类号： G01N33/54353 , C23C14/025 , C23C14/028 , C23C14/10 , G01N33/553
摘要： The present invention provides a method of manufacturing a solid support for biological analysis using a plastic material, the method including: depositing a metal film on a plastic substrate on which a microstructure is formed; depositing an inorganic oxide on the metal film; and anchoring a compound with an amino functional group or a compound with a water contact angle of 70 to 95 degrees on the inorganic oxide.
摘要翻译：本发明提供一种使用塑料材料制造用于生物分析的固体支持物的方法，所述方法包括：在形成微结构的塑料基板上沉积金属膜; 在金属膜上沉积无机氧化物; 并且将具有氨基官能团的化合物或具有70至95度的水接触角的化合物锚定在无机氧化物上。

9. 发明申请

US20090005265A1 METHOD OF ISOLATING NUCLEIC ACID USING MATERIAL POSITIVELY CHARGED AT FIRST PH AND CONTAINING AMINO GROUP AND CARBOXYL GROUP 有权
标题翻译：使用在第一个PH和含有氨基和羧基的正电荷充填材料分离核酸的方法
公开(公告)号：US20090005265A1
公开(公告)日：2009-01-01
申请号：US12141894
申请日：2008-06-18
申请人： Kyu-youn HWANG , Joon-ho KIM , Chang-eun YOO , Hun-joo LEE , Hee-kyun LIM , Sung-young JEONG , Jeo-young SHIM
发明人： Kyu-youn HWANG , Joon-ho KIM , Chang-eun YOO , Hun-joo LEE , Hee-kyun LIM , Sung-young JEONG , Jeo-young SHIM
IPC分类号： C40B40/04 , C07C63/26
CPC分类号： C12N15/1006 , B01D15/361 , B01D15/364 , B01J20/3285 , B01J43/00 , C12Q1/6806 , C12Q2527/119 , C12Q2523/308
摘要： A method of isolating nucleic acid from a sample containing nucleic acid is provided. The method includes contacting the sample with a bifunctional material that contains an amino group and a carboxyl group and is positively charged at a first pH to allow binding of the nucleic acid to the bifunctional material; and extracting the nucleic acid at a second pH higher than the first pH from the complex.
摘要翻译：提供了从含有核酸的样品中分离核酸的方法。该方法包括使样品与含有氨基和羧基的双官能材料接触并在第一pH下带正电荷以允许核酸与双功能材料的结合; 以及从所述络合物中提取比所述第一pH高的第二pH的所述核酸。

10. 发明申请

US20080305011A1 MICROFLUIDIC CHIP AND METHOD OF FABRICATING THE SAME 有权
标题翻译：微流控芯片及其制造方法
公开(公告)号：US20080305011A1
公开(公告)日：2008-12-11
申请号：US11934811
申请日：2007-11-05
申请人： Kyu-youn HWANG , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
发明人： Kyu-youn HWANG , Joon-ho Kim , Chin-sung Park , Sung-young Jeong
IPC分类号： B44C1/22 , B01L3/00 , G03C5/00
CPC分类号： B01L3/502707 , B01L3/502753 , B01L2200/12 , B01L2300/16 , Y10T428/14
摘要： Provided are a microfluidic chip and a method of fabricating the same. The microfluidic chip includes: a lower substrate; an upper substrate formed of a silicone resin, wherein the lower substrate and the upper substrate, bonded together, provide a channel through which a fluid can flow and a chamber to receive the fluid; and an organic thin film formed on the upper surface of the lower substrate except for portions on which the lower substrate and the upper substrate are attached to each other.
摘要翻译：提供了一种微流控芯片及其制造方法。微流体芯片包括：下基板; 由硅树脂形成的上基板，其中所述下基板和所述上基板接合在一起，提供流体可以流过的通道和容纳所述流体的室; 以及形成在下基板的上表面上的有机薄膜，除了下基板和上基板彼此附接的部分之外。

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