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1. 发明授权

US09192707B2 Electrolyte and pH monitoring for fluid removal processes 有权
标题翻译：电解液和pH监测用于流体清除过程
公开(公告)号：US09192707B2
公开(公告)日：2015-11-24
申请号：US13424479
申请日：2012-03-20
申请人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKatesh , Bryant Pudil
发明人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKatesh , Bryant Pudil
IPC分类号： B01D61/32 , B01D61/26 , A61M1/16 , A61B5/00 , A61B5/026 , A61B5/053 , A61B5/145 , A61M1/34 , B01D65/02 , A61M1/00 , A61B5/0295 , A61M1/14 , B01D61/00 , A61M1/36
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
摘要翻译：方法包括监测血液流体清除过程中血液pH值或血液电解质水平的指标，并根据监测的指标调整会话期间使用的透析液或替代液体中pH缓冲液或电解质的浓度。血液清除系统可以使用监测血液pH值或电解质水平的传感器，以在血液清除期间调整流体参数。

2. 发明授权

US08831748B2 Medical electrical electrodes with conductive polymer 有权
标题翻译：带导电聚合物的医用电极
公开(公告)号：US08831748B2
公开(公告)日：2014-09-09
申请号：US12414265
申请日：2009-03-30
申请人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
发明人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.
摘要翻译：医疗电极包括位于引线主体上方的细长导电线圈和与引线主体接触并位于细长导电线圈的各个线圈之间的导电聚合物材料。在某些实施方案中，导电聚合物是注入导电填料（例如炭黑）的聚合物（例如硅酮）。在某些实施例中，导电聚合物材料通常是等距的，细长导电线圈的各个线圈的外径。通过在引线体的长度上滑动细长导电线圈来制造医用电极，将导电聚合物分散在螺旋线圈上，将管插入细长导电线圈上，将聚合物材料分布在细长导电线圈，加热管道，使管道围绕细长的导电线圈收缩，并取出管道。

3. 发明申请

US20130199998A1 HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
标题翻译：具有控制合格体积的流路的血液透析系统
公开(公告)号：US20130199998A1
公开(公告)日：2013-08-08
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。透析电路和用于循环血液的体外循环通过透析膜流体连通。在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

4. 发明申请

US20120289881A1 System and Implantable Device for Treating Chronic Kidney Disease 审中-公开
标题翻译：用于治疗慢性肾脏疾病的系统和植入装置
公开(公告)号：US20120289881A1
公开(公告)日：2012-11-15
申请号：US13462190
申请日：2012-05-02
申请人： SuPing Lyu , Thomas Edward Meyer , Mark Fredrick Daniels , Bryant J. Pudil
发明人： SuPing Lyu , Thomas Edward Meyer , Mark Fredrick Daniels , Bryant J. Pudil
IPC分类号： A61M1/16
CPC分类号： A61M1/1678 , B01D61/18 , B01D61/28 , B01D63/084 , B01D2313/105
摘要： An implantable dialysis device with a related medical system for intracorporeal dialysis and ultrafiltration of blood, and methods of use are described. The medical system includes an extracorporeal module, a cutaneous module, and an implantable module. Features of the implantable module facilitate delivery and flow of blood and dialysate through the medical system. A filter pack within the implantable module performs dialysis and ultrafiltration of blood. System cleansing is also described.
摘要翻译：描述了具有用于体内透析和血液超滤的相关医疗系统的植入式透析装置及其使用方法。医疗系统包括体外模块，皮肤模块和可植入模块。可植入模块的特征便于血液和透析液通过医疗系统的输送和流动。可植入模块内的过滤器组件执行血液的透析和超滤。还描述了系统清洁。

5. 发明申请

US20080069856A1 Compression molding method for making biomaterial composites 有权
标题翻译：制备生物材料复合材料的压制成型方法
公开(公告)号：US20080069856A1
公开(公告)日：2008-03-20
申请号：US11523841
申请日：2006-09-20
申请人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
发明人： SuPing Lyu , Christopher M. Hobot , Sean M. Haddock , Brian Loy , Randall V. Sparer , K. Matthew Kinnane , Jeffrey M. Gross
IPC分类号： A61K35/12 , A61F2/02 , B27N3/00
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/3683 , A61L27/58 , C08L67/04
摘要： A process for making an implantable material comprising a composite of a biocompatible polymer and a bioactive agent. The composite combines desirable mechanical properties of polymers and the bioactivity of tissue or one or more component of tissue. More particularly, but not exclusively, the invention relates to methods for the manufacture of implantable materials, devices and components via a powder molding process.
摘要翻译：一种用于制造可植入材料的方法，其包括生物相容性聚合物和生物活性剂的复合物。该复合物结合聚合物的所需机械性能和组织的生物活性或组织的一种或多种组分。更具体地但不排他地，本发明涉及通过粉末成型工艺制造可植入材料，装置和部件的方法。

6. 发明申请

US20060241734A1 Medical electrical electrodes with conductive polymer 有权
公开(公告)号：US20060241734A1
公开(公告)日：2006-10-26
申请号：US11113867
申请日：2005-04-25
申请人： Mark Marshall , Teresa Whitman , Suping Lyu , Elizabeth Nagy , David Olson
发明人： Mark Marshall , Teresa Whitman , Suping Lyu , Elizabeth Nagy , David Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.

7. 发明授权

US10695481B2 Hemodialysis system having a flow path with a controlled compliant volume 有权
公开(公告)号：US10695481B2
公开(公告)日：2020-06-30
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/34 , A61M1/16
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

8. 发明授权

US09700661B2 Chronic pH or electrolyte monitoring 有权
公开(公告)号：US09700661B2
公开(公告)日：2017-07-11
申请号：US13424525
申请日：2012-03-20
申请人： Martin Gerber , Suping Lyu , Bryant Pudil
发明人： Martin Gerber , Suping Lyu , Bryant Pudil
IPC分类号： A61M1/00 , A61M31/00 , A61M37/00 , A61B5/00 , B01D61/00 , A61M1/16 , A61B5/145 , A61B5/026 , A61B5/053 , A61M1/34 , B01D65/02 , A61B5/0295 , A61M1/14 , B01D61/32 , A61M1/36 , A61M1/28 , B01D11/00
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods include monitoring blood pH or electrolyte levels and setting initial fluid parameters, such as dialysate fluid parameters or replacement fluid parameters, for a blood fluid removal session based the monitored data. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.

9. 发明授权

US09005634B2 Shelf stable pharmaceutical depot 有权
标题翻译：货架稳定药厂
公开(公告)号：US09005634B2
公开(公告)日：2015-04-14
申请号：US13282532
申请日：2011-10-27
申请人： Phillip E. McDonald , Suping Lyu
发明人： Phillip E. McDonald , Suping Lyu
IPC分类号： A61K9/14 , A61K9/00 , A61K47/10 , A61K47/32 , A61K47/38 , A61K9/70 , A61K31/4168 , A61K31/445
CPC分类号： A61K9/0024 , A61K9/7007 , A61K31/4168 , A61K31/445 , A61K47/10 , A61K47/32 , A61K47/38
摘要： A pharmaceutical depot includes a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less and at least 25% wt solid particles suspended in the biodegradable polymer. The pharmaceutical depot also includes a post-operative pain relieving therapeutic agent.
摘要翻译：药物贮库包括玻璃化转变温度为20摄氏度或更低的可生物降解的聚合物和悬浮在可生物降解聚合物中的至少25重量％的固体颗粒。药剂库还包括术后止痛治疗剂。

10. 发明授权

US08951219B2 Fluid volume monitoring for patients with renal disease 有权
标题翻译：肾脏病患者的体液监测
公开(公告)号：US08951219B2
公开(公告)日：2015-02-10
申请号：US13424454
申请日：2012-03-20
申请人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKalesh , Bryant Pudil
发明人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKalesh , Bryant Pudil
IPC分类号： A61M37/00 , C02F1/44 , A61B5/053 , A61M1/36 , A61M1/16 , A61M1/00 , A61B5/145 , A61B5/00 , A61B5/026 , A61B5/0295 , B01D61/00 , A61M1/34 , B01D65/02 , A61M1/14 , B01D61/32
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.
摘要翻译：一种方法包括启动患者的血液流体清除会话; 在血液清除会话期间监测患者或其部分的组织液体体积的指标; 在血液清除期间监测患者的血液体积的指标; 确定组织液体体积指标与血液体积指标之间的比率是否超出预定范围; 以及如果所述比例被确定为在所述预定范围之外，则改变在所述血液流体清除会话期间的流体去除速率。血液清除系统可以被配置为执行该方法。

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