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1. 发明授权

US08831748B2 Medical electrical electrodes with conductive polymer 有权
标题翻译：带导电聚合物的医用电极
公开(公告)号：US08831748B2
公开(公告)日：2014-09-09
申请号：US12414265
申请日：2009-03-30
申请人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
发明人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.
摘要翻译：医疗电极包括位于引线主体上方的细长导电线圈和与引线主体接触并位于细长导电线圈的各个线圈之间的导电聚合物材料。在某些实施方案中，导电聚合物是注入导电填料（例如炭黑）的聚合物（例如硅酮）。在某些实施例中，导电聚合物材料通常是等距的，细长导电线圈的各个线圈的外径。通过在引线体的长度上滑动细长导电线圈来制造医用电极，将导电聚合物分散在螺旋线圈上，将管插入细长导电线圈上，将聚合物材料分布在细长导电线圈，加热管道，使管道围绕细长的导电线圈收缩，并取出管道。

2. 发明申请

US20090187236A1 MEDICAL ELECTRICAL ELECTRODES WITH CONDUCTIVE POLYMER 有权
标题翻译：具有导电聚合物的医用电极
公开(公告)号：US20090187236A1
公开(公告)日：2009-07-23
申请号：US12414265
申请日：2009-03-30
申请人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
发明人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.
摘要翻译：医疗电极包括位于引线主体上方的细长导电线圈和与引线主体接触并位于细长导电线圈的各个线圈之间的导电聚合物材料。在某些实施方案中，导电聚合物是注入导电填料（例如炭黑）的聚合物（例如硅酮）。在某些实施例中，导电聚合物材料通常是等距的，细长导电线圈的各个线圈的外径。通过在引线体的长度上滑动细长导电线圈来制造医用电极，将导电聚合物分散在螺旋线圈上，将管插入细长导电线圈上，将聚合物材料分布在细长导电线圈，加热管道，使管道围绕细长的导电线圈收缩，并取出管道。

3. 发明授权

US07512447B2 Medical electrical electrodes with conductive polymer 有权
标题翻译：带导电聚合物的医用电极
公开(公告)号：US07512447B2
公开(公告)日：2009-03-31
申请号：US11113867
申请日：2005-04-25
申请人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
发明人： Mark T. Marshall , Teresa A. Whitman , Suping Lyu , Elizabeth K. Nagy , David S. Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.
摘要翻译：医疗电极包括位于引线主体上方的细长导电线圈和与引线主体接触并位于细长导电线圈的各个线圈之间的导电聚合物材料。在某些实施方案中，导电聚合物是注入导电填料（例如炭黑）的聚合物（例如硅酮）。在某些实施例中，导电聚合物材料通常是等距的，细长导电线圈的各个线圈的外径。通过在引线体的长度上滑动细长导电线圈来制造医用电极，将导电聚合物分散在螺旋线圈上，将管插入细长导电线圈上，将聚合物材料分布在细长导电线圈，加热管道，使管道围绕细长的导电线圈收缩，并取出管道。

4. 发明授权

US09192707B2 Electrolyte and pH monitoring for fluid removal processes 有权
标题翻译：电解液和pH监测用于流体清除过程
公开(公告)号：US09192707B2
公开(公告)日：2015-11-24
申请号：US13424479
申请日：2012-03-20
申请人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKatesh , Bryant Pudil
发明人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKatesh , Bryant Pudil
IPC分类号： B01D61/32 , B01D61/26 , A61M1/16 , A61B5/00 , A61B5/026 , A61B5/053 , A61B5/145 , A61M1/34 , B01D65/02 , A61M1/00 , A61B5/0295 , A61M1/14 , B01D61/00 , A61M1/36
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.
摘要翻译：方法包括监测血液流体清除过程中血液pH值或血液电解质水平的指标，并根据监测的指标调整会话期间使用的透析液或替代液体中pH缓冲液或电解质的浓度。血液清除系统可以使用监测血液pH值或电解质水平的传感器，以在血液清除期间调整流体参数。

5. 发明申请

US20060241734A1 Medical electrical electrodes with conductive polymer 有权
公开(公告)号：US20060241734A1
公开(公告)日：2006-10-26
申请号：US11113867
申请日：2005-04-25
申请人： Mark Marshall , Teresa Whitman , Suping Lyu , Elizabeth Nagy , David Olson
发明人： Mark Marshall , Teresa Whitman , Suping Lyu , Elizabeth Nagy , David Olson
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , Y10T29/49117
摘要： A medical electrical electrode includes an elongated conductive coil located over a lead body, and a conductive polymer material in contact with the lead body and located between individual coils of the elongated conductive coil. In certain embodiments, the conductive polymer is a polymer (e.g., silicone) implanted with a conductive filler (e.g., carbon black). In certain embodiments, the conductive polymer material is generally isodiametric with an outer diameter of the individual coils of the elongated conductive coil. A medical electrical electrode is fabricated by sliding an elongated conductive coil over a length of a lead body, dispersing a conductive polymer on the helical coil, inserting a tubing over the elongated conductive coil, distributing the polymer material between individual turns of the elongated conductive coil, heating the tubing so the tubing shrinks around the elongated conductive coil, and removing the tubing.

6. 发明授权

US09700661B2 Chronic pH or electrolyte monitoring 有权
公开(公告)号：US09700661B2
公开(公告)日：2017-07-11
申请号：US13424525
申请日：2012-03-20
申请人： Martin Gerber , Suping Lyu , Bryant Pudil
发明人： Martin Gerber , Suping Lyu , Bryant Pudil
IPC分类号： A61M1/00 , A61M31/00 , A61M37/00 , A61B5/00 , B01D61/00 , A61M1/16 , A61B5/145 , A61B5/026 , A61B5/053 , A61M1/34 , B01D65/02 , A61B5/0295 , A61M1/14 , B01D61/32 , A61M1/36 , A61M1/28 , B01D11/00
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods include monitoring blood pH or electrolyte levels and setting initial fluid parameters, such as dialysate fluid parameters or replacement fluid parameters, for a blood fluid removal session based the monitored data. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.

7. 发明授权

US09005634B2 Shelf stable pharmaceutical depot 有权
标题翻译：货架稳定药厂
公开(公告)号：US09005634B2
公开(公告)日：2015-04-14
申请号：US13282532
申请日：2011-10-27
申请人： Phillip E. McDonald , Suping Lyu
发明人： Phillip E. McDonald , Suping Lyu
IPC分类号： A61K9/14 , A61K9/00 , A61K47/10 , A61K47/32 , A61K47/38 , A61K9/70 , A61K31/4168 , A61K31/445
CPC分类号： A61K9/0024 , A61K9/7007 , A61K31/4168 , A61K31/445 , A61K47/10 , A61K47/32 , A61K47/38
摘要： A pharmaceutical depot includes a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less and at least 25% wt solid particles suspended in the biodegradable polymer. The pharmaceutical depot also includes a post-operative pain relieving therapeutic agent.
摘要翻译：药物贮库包括玻璃化转变温度为20摄氏度或更低的可生物降解的聚合物和悬浮在可生物降解聚合物中的至少25重量％的固体颗粒。药剂库还包括术后止痛治疗剂。

8. 发明授权

US08951219B2 Fluid volume monitoring for patients with renal disease 有权
标题翻译：肾脏病患者的体液监测
公开(公告)号：US08951219B2
公开(公告)日：2015-02-10
申请号：US13424454
申请日：2012-03-20
申请人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKalesh , Bryant Pudil
发明人： Martin Gerber , John Burnes , Suping Lyu , Manda R. VenKalesh , Bryant Pudil
IPC分类号： A61M37/00 , C02F1/44 , A61B5/053 , A61M1/36 , A61M1/16 , A61M1/00 , A61B5/145 , A61B5/00 , A61B5/026 , A61B5/0295 , B01D61/00 , A61M1/34 , B01D65/02 , A61M1/14 , B01D61/32
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： A method includes initiating a blood fluid removal session of a patient; monitoring an indicator of tissue fluid volume of the patient, or a portion thereof, during the blood fluid removal session; monitoring an indicator of blood fluid volume of the patient during the blood fluid removal session; determining whether a ratio of the indicator of tissue fluid volume to indicator of blood fluid volume is outside of a predetermined range; and altering the rate of fluid removal during the blood fluid removal session if the ratio is determined to be outside of the predetermined range. A blood fluid removal system may be configured to carry out the method.
摘要翻译：一种方法包括启动患者的血液流体清除会话; 在血液清除会话期间监测患者或其部分的组织液体体积的指标; 在血液清除期间监测患者的血液体积的指标; 确定组织液体体积指标与血液体积指标之间的比率是否超出预定范围; 以及如果所述比例被确定为在所述预定范围之外，则改变在所述血液流体清除会话期间的流体去除速率。血液清除系统可以被配置为执行该方法。

9. 发明申请

US20120263761A1 SHELF STABLE PHARMACEUTICAL DEPOT 有权
标题翻译：保存稳定的药用剂
公开(公告)号：US20120263761A1
公开(公告)日：2012-10-18
申请号：US13282532
申请日：2011-10-27
申请人： PHILLIP E. MCDONALD , Suping Lyu
发明人： PHILLIP E. MCDONALD , Suping Lyu
IPC分类号： A61K31/4174 , A61P25/00 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/7007 , A61K31/4168 , A61K31/445 , A61K47/10 , A61K47/32 , A61K47/38
摘要： A pharmaceutical depot includes a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less and at least 25% wt solid particles suspended in the biodegradable polymer. The pharmaceutical depot also includes a post-operative pain relieving therapeutic agent.
摘要翻译：药物贮库包括玻璃化转变温度为20摄氏度或更低的可生物降解的聚合物和悬浮在可生物降解的聚合物中的至少25重量％的固体颗粒。药剂库还包括术后止痛治疗剂。

10. 发明授权

US09750862B2 Adaptive system for blood fluid removal 有权
公开(公告)号：US09750862B2
公开(公告)日：2017-09-05
申请号：US13424533
申请日：2012-03-20
申请人： Martin Gerber , John Burnes , Suping Lyu , VenKatesh R. Manda , Bryant Pudil
发明人： Martin Gerber , John Burnes , Suping Lyu , VenKatesh R. Manda , Bryant Pudil
IPC分类号： A61M1/16 , A61B5/145 , A61B5/00 , A61B5/026 , A61B5/053 , A61M1/34 , B01D65/02 , A61M1/00 , A61B5/0295 , A61M1/14 , B01D61/00 , B01D61/32 , A61M1/36 , A61M1/28
CPC分类号： A61M1/1603 , A61B5/0031 , A61B5/026 , A61B5/0295 , A61B5/053 , A61B5/0537 , A61B5/145 , A61B5/14503 , A61B5/14535 , A61B5/14539 , A61B5/14546 , A61B5/4836 , A61B5/4848 , A61B5/4875 , A61B5/6866 , A61B5/7282 , A61B2560/0223 , A61M1/00 , A61M1/14 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/1607 , A61M1/1613 , A61M1/28 , A61M1/34 , A61M1/3403 , A61M1/342 , A61M1/3607 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3672 , A61M2202/0498 , A61M2205/04 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3306 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3375 , A61M2205/3523 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/60 , A61M2205/70 , A61M2230/00 , A61M2230/005 , A61M2230/06 , A61M2230/20 , A61M2230/207 , A61M2230/208 , A61M2230/65 , B01D61/00 , B01D61/32 , B01D65/02 , B01D2321/12 , B01D2321/40 , G06F19/00
摘要： Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

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