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    • 3. 发明授权
    • Brachytherapy devices and methods of using them
    • 近距离放射治疗装置及其使用方法
    • US07070554B2
    • 2006-07-04
    • US10342536
    • 2003-01-15
    • Jack WhiteStephen N. CarrKyle Millage
    • Jack WhiteStephen N. CarrKyle Millage
    • A61N5/00
    • A61N5/1017A61B2090/0445A61B2090/0481A61F9/00A61N5/103A61N2005/1094
    • Brachytherapy devices are provided for delivering a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. The devices include a holder defining a cavity, and a radioactive material located within the cavity. The holder comprises radiation-shielding material therein. The holder and the radioactive material are positioned to cooperatively provide a substantially uniform dose rate of radiation to a treatment area at a predetermined treatment depth. Also disclosed are methods for treating macular degeneration or ocular melanoma. The methods involve positioning a brachytherapy device in contact with or in close proximity to tissue located in a treatment area and exposing the tissue located in the treatment area to a therapeutic dose of radiation, which is delivered at a substantially uniform dose rate over the treatment area at a predetermined treatment depth. The devices and methods of the invention also ensure that the radiation delivered outside the treatment area is substantially reduced relative to the radiation delivered within the treatment area to minimize exposure of healthy tissue to radiation. The provision of a substantially uniform dose rate in the treatment area prevents substantial over- and under-exposure to radiation of different portions of the tissue in the treatment area.
    • 近距离放射治疗装置被提供用于在预定处理深度处将治疗区域的辐射基本上均匀地传送给辐射。 这些装置包括限定空腔的保持器和位于空腔内的放射性物质。 支架包括其中的辐射屏蔽材料。 保持器和放射性材料被定位成在预定处理深度处协同地向处理区域提供基本均匀的辐射剂量率。 还公开了治疗黄斑变性或眼黑素瘤的方法。 所述方法涉及将近距离放射治疗装置定位为接触处于与治疗区域中的组织接触或接近于位于治疗区域中的组织,并将位于治疗区域中的组织暴露于治疗剂量的辐射,所述治疗剂量的辐射以基本均匀的剂量率在治疗区域 在预定处理深度。 本发明的装置和方法还确保了相对于处理区域内传送的辐射,在处理区域外部传送的辐射大大降低,以使健康组织对辐射的暴露最小化。 在治疗区域中提供基本上均匀的剂量率可防止处理区域中组织的不同部分的辐射显着过度暴露和暴露于暴露。