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1. 发明授权

US06992202B1 Single-source precursors for ternary chalcopyrite materials, and methods of making and using the same 失效
标题翻译：三元黄铜矿材料的单源前体及其制备和使用方法
公开(公告)号：US06992202B1
公开(公告)日：2006-01-31
申请号：US10698118
申请日：2003-10-31
申请人： Kulbinder K. Banger , Aloysius F. Hepp , Jerry D. Harris , Michael Hyun-Chul Jin , Stephanie L. Castro
发明人： Kulbinder K. Banger , Aloysius F. Hepp , Jerry D. Harris , Michael Hyun-Chul Jin , Stephanie L. Castro
IPC分类号： C07F19/00 , C23C16/00 , C30B23/00
CPC分类号： C07F5/003 , B82Y10/00 , B82Y30/00 , C23C16/305
摘要： A single source precursor for depositing ternary I-III-VI2 chalcopyrite materials useful as semiconductors. The single source precursor has the I-III-VI2 stoichiometry “built into” a single precursor molecular structure which degrades on heating or pyrolysis to yield the desired I-III-VI2 ternary chalcopyrite. The single source precursors effectively degrade to yield the ternary chalcopyrite at low temperature, e.g. below 500° C., and are useful to deposit thin film ternary chalcopyrite layers via a spray CVD technique. The ternary single source precursors according to the invention can be used to provide nanocrystallite structures useful as quantum dots. A method of making the ternary single source precursors is also provided.
摘要翻译：用于沉积可用作半导体的三元I-III-VI 2黄铜矿材料的单一源前体。单源前体具有“内置于”单个前体分子结构中的I-III-VI'2化学计量，其在加热或热解时降解以产生所需的I-III-VI 2 三级黄铜矿。单一来源前体有效降解以在低温下产生三元黄铜矿，例如。低于500℃，并且可用于通过喷雾CVD技术沉积薄膜三元黄铜矿层。根据本发明的三元单源前体可用于提供可用作量子点的纳米晶体结构。还提供了制备三元单源前体的方法。

2. 发明授权

US06319607B1 Purification of functionalized fluorescent nanocrystals 有权
标题翻译：功能化荧光纳米晶体的纯化
公开(公告)号：US06319607B1
公开(公告)日：2001-11-20
申请号：US09590421
申请日：2000-06-08
申请人： Emilio Barbera-Guillem , Stephanie L. Castro
发明人： Emilio Barbera-Guillem , Stephanie L. Castro
IPC分类号： A61K4900
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , G01N33/588 , Y10T428/2989 , Y10T428/2993
摘要： Provided are methods for purifying functionalized fluorescent nanocrystals having affinity ligand operably bound thereto by using a solid support matrix in a reactor through which solutions are circulated, and by using an immobilized solid phase formed by operably binding functionalized fluorescent nanocrystals to the solid support matrix. Also provided are purified functionalized fluorescent nanocrystals having affinity ligand operably bound thereto which are purified using the methods according to the present invention to be substantially free of free affinity ligand.
摘要翻译：提供了通过在溶液循环的反应器中使用固体支持基质和通过使用通过可操作地将官能化荧光纳米晶体结合到固体支持基质上形成的固定化固相来纯化具有可操作地结合到其上的亲和配体的官能化荧光纳米晶体的方法。还提供了具有可操作地结合到其上的亲和配体的纯化的官能化荧光纳米晶体，其使用根据本发明的方法纯化为基本上不含游离亲和配体。

3. 发明授权

US06680211B2 Fluorescent nanocrystal-embedded microspheres for fluorescence analysis 有权
标题翻译：荧光纳米晶体微球用于荧光分析
公开(公告)号：US06680211B2
公开(公告)日：2004-01-20
申请号：US10367063
申请日：2003-02-14
申请人： Emilio Barbera-Guillem , Stephanie L. Castro
发明人： Emilio Barbera-Guillem , Stephanie L. Castro
IPC分类号： G01N33546
CPC分类号： G07F7/086 , A61K9/167 , B82Y10/00 , B82Y15/00 , B82Y30/00 , G01N33/588 , G06K19/06 , G07D7/1205 , Y10S428/916 , Y10T428/24802 , Y10T428/24893 , Y10T428/24901 , Y10T428/25 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of producing the fluorescent microspheres comprising swelling the polymeric microsphere so that into its pores can enter fluorescent nanocrystals, and then unswelling the polymeric micropsheres so that the fluorescent nanocrystals become physically entrapped in the pores of the unswelled polymeric microsphere. Also provided is a method of using the fluorescent microspheres comprising affinity ligand for determining the presence or absence of a predetermined number of analytes in a sample by contacting the sample with the fluorescent microspheres, and detecting the fluorescence signal pattern of excited fluorescent microspheres bound to one or more analytes of the predetermined number of analytes, if present in the sample.
摘要翻译：提供一种荧光微球，其由嵌入聚合物微球中的多个荧光纳米晶体组成; 由荧光微球制备的试剂盒; 以及制备荧光微球的方法，其包括使聚合物微球溶胀，使得其进入其孔可以进入荧光纳米晶体，然后使聚合物微球不通溶，使得荧光纳米晶体物理地截留在未密封的聚合物微球的孔中。还提供了使用包含亲和配体的荧光微球的方法，用于通过使样品与荧光微球接触来检测样品中是否存在预定数量的分析物，并且检测结合到一个的激发的荧光微球的荧光信号图案或更多分析物，如果存在于样品中。

4. 发明授权

US06548171B1 Fluorescent nanocrystal-embedded microspheres for fluorescence analyses 有权
标题翻译：荧光纳米晶体微球用于荧光分析
公开(公告)号：US06548171B1
公开(公告)日：2003-04-15
申请号：US09633953
申请日：2000-08-08
申请人： Emilio Barbera-Guillem , Stephanie L. Castro
发明人： Emilio Barbera-Guillem , Stephanie L. Castro
IPC分类号： B32B1502
CPC分类号： G07F7/086 , A61K9/167 , B82Y10/00 , B82Y15/00 , B82Y30/00 , G01N33/588 , G06K19/06 , G07D7/1205 , Y10S428/916 , Y10T428/24802 , Y10T428/24893 , Y10T428/24901 , Y10T428/25 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： Provided are a fluorescent microsphere comprised of a plurality of fluorescent nanocrystals embedded in a polymeric microsphere; a kit prepared from the fluorescent microspheres; and a method of producing the fluorescent microspheres comprising swelling the polymeric microsphere so that into its pores can enter fluorescent nanocrystals, and then unswelling the polymeric micropsheres so that the fluorescent nanocrystals become physically entrapped in the pores of the unswelled polymeric microsphere. Also provided is a method of using the fluorescent microspheres comprising affinity ligand for determining the presence or absence of a predetermined number of analytes in a sample by contacting the sample with the fluorescent microspheres, and detecting the fluorescence signal pattern of excited fluorescent microspheres bound to one or more analytes of the predetermined number of analytes, if present in the sample.
摘要翻译：提供一种荧光微球，其由嵌入聚合物微球中的多个荧光纳米晶体组成; 由荧光微球制备的试剂盒; 以及制备荧光微球的方法，其包括使聚合物微球溶胀，使得其进入其孔可以进入荧光纳米晶体，然后使聚合物微球不通溶，使得荧光纳米晶体物理地截留在未密封的聚合物微球的孔中。还提供了使用包含亲和配体的荧光微球的方法，用于通过使样品与荧光微球接触来检测样品中是否存在预定数量的分析物，并且检测结合到一个的激发的荧光微球的荧光信号图案或更多分析物，如果存在于样品中。

5. 发明申请

US20100184230A1 NANOCRYSTALS HAVING POLYNUCLEOTIDE STRANDS AND THEIR USE TO FORM DENDRIMERS IN A SIGNAL AMPLIFICATION SYSTEM 审中-公开
标题翻译：具有多核结构的纳米晶体及其在信号放大系统中的形式使用
公开(公告)号：US20100184230A1
公开(公告)日：2010-07-22
申请号：US12606114
申请日：2009-10-26
申请人： Emilio BARBERA-GUILLEM , M. Bud Nelson , Stephanie L. Castro
发明人： Emilio BARBERA-GUILLEM , M. Bud Nelson , Stephanie L. Castro
IPC分类号： G01N33/48 , C07H21/00 , C07K14/00
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/682 , G01N33/54306 , G01N33/588 , Y10T436/143333 , C12Q2563/149 , C12Q2563/131 , C12Q2563/107
摘要： Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands which are complementary to the plurality of polynucleotide strands of the primary dots. Also provided is a method for detecting the presence or absence of target molecule in a sample comprising operably linking primary dots to molecular probe, contacting the complex formed with the sample, contacting the sample with successive additions of secondary dots and primary dots. If target molecule is present in the sample, the primary dots and secondary dots will form dendrimers that can be detected by fluorescence emission.
摘要翻译：提供了包含官能化纳米晶体的组合物和测定试剂盒，其具有从其延伸的多个已知序列的多核苷酸链; 其中主要点用于可操作地连接到分子探针，并且次要点包括与主要点的多个多核苷酸链互补的多个多核苷酸链。还提供了用于检测样品中靶分子存在或不存在的方法，其包括可操作地将原始点与分子探针连接，使与样品形成的复合物接触，使样品与次要点和原始点的连续添加接触。如果样品中存在靶分子，则主要点和次要点将形成可通过荧光发射检测的树枝状大分子。

6. 发明授权

US06261779B1 Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system 有权
标题翻译：具有多核苷酸链的纳米晶体及其在信号放大系统中形成树枝状大分子的用途
公开(公告)号：US06261779B1
公开(公告)日：2001-07-17
申请号：US09437076
申请日：1999-11-09
申请人： Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
发明人： Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
IPC分类号： C12P1934
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/682 , G01N33/54306 , G01N33/588 , Y10T436/143333 , C12Q2563/149 , C12Q2563/131 , C12Q2563/107
摘要： Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands which are complemetary to the plurality of polynucleotide strands of the primary dots. Also provided is a method for detecting the presence or absence of target molecule in a sample comprising operably linking primary dots to molecular probe, contacting the complex formed with the sample, contacting the sample with successive additions of secondary dots and primary dots. If target molecule is present in the sample, the primary dots and secondary dots will form dendrimers that can be detected by fluorescence emission.
摘要翻译：提供了包含官能化纳米晶体的组合物和测定试剂盒，其具有从其延伸的多个已知序列的多核苷酸链; 其中主要点被用于可操作地连接到分子探针，并且次要点包括与主要点的多个多核苷酸链互补的多个多核苷酸链。还提供了用于检测样品中靶分子存在或不存在的方法，其包括可操作地将原始点与分子探针连接，使与样品形成的复合物接触，使样品与次要点和原始点的连续添加接触。如果样品中存在靶分子，则主要点和次要点将形成可通过荧光发射检测的树枝状大分子。

7. 发明授权

US06828142B2 Polynucleotide strands operably linked to nanocrystals functionalized to be water soluble 有权
标题翻译：可操作地连接到功能化为水溶性的纳米晶体的多核苷酸链
公开(公告)号：US06828142B2
公开(公告)日：2004-12-07
申请号：US09904744
申请日：2001-07-13
申请人： Emillo Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
发明人： Emillo Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
IPC分类号： C12M134
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/682 , G01N33/54306 , G01N33/588 , Y10T436/143333 , C12Q2563/149 , C12Q2563/131 , C12Q2563/107
摘要： Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands which are complementary to the plurality of polynucleotide strands of the primary dots. Also provided is a method for detecting the presence or absence of target molecule in a sample comprising operably linking primary dots to molecular probe, contacting the complex formed with the sample, contacting the sample with successive additions of secondary dots and primary dots. If target molecule is present in the sample, the primary dots and secondary dots will form dendrimers that can be detected by fluorescence emission.
摘要翻译：提供了包含官能化纳米晶体的组合物和测定试剂盒，其具有从其延伸的多个已知序列的多核苷酸链; 其中主要点用于可操作地连接到分子探针，并且次要点包括与主要点的多个多核苷酸链互补的多个多核苷酸链。还提供了用于检测样品中靶分子存在或不存在的方法，其包括可操作地将原始点与分子探针连接，使与样品形成的复合物接触，使样品与次要点和原始点的连续添加接触。如果样品中存在靶分子，则主要点和次要点将形成可通过荧光发射检测的树枝状大分子。

8. 发明授权

US06221602B1 Functionalized nanocrystals and their use in labeling for strand synthesis or sequence determination 有权
标题翻译：官能化纳米晶体及其在链合成或序列测定标记中的应用
公开(公告)号：US06221602B1
公开(公告)日：2001-04-24
申请号：US09436159
申请日：1999-11-09
申请人： Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
发明人： Emilio Barbera-Guillem , M. Bud Nelson , Stephanie L. Castro
IPC分类号： C12P1934
CPC分类号： G01N33/588 , B82Y15/00 , G01N23/223 , G01N2223/076
摘要： Provided are compositions comprising functionalized nanocrystal-labeled nucleobases that are produced by operably linking a nucleobase to a functionalized nanocrystal via reactive functionalities. Also provided are kits comprising a plurality of species of functionalized nanocrystal-labeled nucleobases. The functionalized nanocrystal-labeled nucleobases may be added to a strand synthesis reaction under suitable conditions to be incorporated into one or more strands synthesized in the reaction.
摘要翻译：提供了包含功能化纳米晶体标记的核碱基的组合物，其通过可操作地通过反应性官能团将核碱基与功能化的纳米晶体连接而产生。还提供了包含多种官能化的纳米晶体标记的核碱基的试剂盒。官能化的纳米晶体标记的核碱基可以在合适的条件下加入到链合成反应中，以引入在反应中合成的一个或多个链中。

9. 发明授权

US6114038A Functionalized nanocrystals and their use in detection systems 有权
标题翻译：功能化纳米晶体及其在检测系统中的应用
公开(公告)号：US6114038A
公开(公告)日：2000-09-05
申请号：US372729
申请日：1999-08-11
申请人： Stephanie L. Castro , Emilio Barbera-Guillem
发明人： Stephanie L. Castro , Emilio Barbera-Guillem
IPC分类号： A61K49/00 , B05D7/00 , B32B9/00 , B32B9/04 , H01L29/04
CPC分类号： B82Y30/00 , B82Y10/00 , B82Y5/00 , Y10T428/2989 , Y10T428/2993
摘要： Provided are compositions comprising water-soluble, functionalized nanocrystals. The water-soluble functionalized nanocrystals comprise quantum dots capped with a layer of a capping compound, and further comprise, by operably linking and in a successive manner, one or more additional compounds. The one or more additional compounds is comprised of at least a diaminocarboxylic acid which is operatively linked to the capping compound, and may further comprise an amino acid, an affinity ligand, or a combination thereof. Also provided are methods of using the functionalized nanocrystals having an affinity ligand to detect the presence or absence of a target substrate in a sample. The method comprises contacting the functionalized nanocrystals with the sample so that complexes are formed between the functionalized nanocrystals and substrate, if the substrate is present; exposing the complexes in the detection system to a wavelength of light suitable for exciting the functionalized nanocrystals of the complexes to emit a luminescence peak; and detecting the emitted luminescence peak.
摘要翻译：提供了包含水溶性官能化纳米晶体的组合物。水溶性官能化纳米晶体包括用封端化合物层覆盖的量子点，并且还通过可操作地连接并以连续的方式包含一种或多种另外的化合物。一种或多种另外的化合物由至少一种与封端化合物有效连接的二氨基羧酸组成，并且还可包含氨基酸，亲和配体或其组合。还提供了使用具有亲和配体的功能化纳米晶体来检测样品中目标底物的存在或不存在的方法。该方法包括使官能化的纳米晶体与样品接触，使得如果存在底物，则在官能化的纳米晶体和衬底之间形成复合物; 将检测系统中的复合物暴露于适于激发复合物的官能化纳米晶体的光的波长以发射发光峰; 并检测发射的发光峰。

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