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1. 发明授权

US07785717B2 Fluorescent ink compositions comprising functionalized fluorescent nanocrystals 有权
标题翻译：包含官能化荧光纳米晶体的荧光墨水组合物
公开(公告)号：US07785717B2
公开(公告)日：2010-08-31
申请号：US10884528
申请日：2004-07-02
申请人： Emilio Barbera-Guillem
发明人： Emilio Barbera-Guillem
IPC分类号： B32B19/00 , B32B9/00
CPC分类号： C09D11/50 , A61K9/167 , B82Y15/00 , C09K11/02 , C09K11/025 , C09K11/0805 , G07F7/086 , Y10T428/24802 , Y10T428/253
摘要： A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate.
摘要翻译：包含官能化荧光纳米晶体的荧光墨水组合物，包含水或水基溶液的水基墨水载体和粘合剂。还提供了在衬底上提供图像或安全标记以便随后通过将荧光墨水组合物施加到基底上的方法。

2. 发明申请

US20090202400A1 BIOREACTOR FOR SELECTIVELY CONTROLLING THE MOLECULAR DIFFUSION BETWEEN FLUIDS 有权
标题翻译：用于选择性地控制流体之间的分子扩散的生物反应器
公开(公告)号：US20090202400A1
公开(公告)日：2009-08-13
申请号：US12389523
申请日：2009-02-20
申请人： Emilio Barbera-Guillem
发明人： Emilio Barbera-Guillem
IPC分类号： B01J19/00
CPC分类号： C12M23/16 , B01L3/50273 , B01L2200/0684 , B01L2200/16 , B01L2300/0867 , B01L2400/0472 , B01L2400/086 , C12M29/04
摘要： A diffusion controlling bioreactor that selectively controls the molecular diffusion between fluids through at least one microchannel in fluid communication with a reaction reservoir. Length and cross-sectional area of the microchannel may be selected to obtain a predetermined rate of molecular diffusion between fluids. When the fluids are liquids, flow through the microchannel is laminar and the capillary action of the microchannel and fluid is such that the fluid flow is regulated, and may have a structure configured to minimize the chances of fluid leakage from the bioreactor, even if the bioreactor is turned in various directions. In certain embodiments, one or more diffusion control chambers regulate fluid flow and diffusion between a reaction reservoir and an outside atmosphere.
摘要翻译：扩散控制生物反应器，其选择性地控制流体之间的分子扩散通过与反应储存器流体连通的至少一个微通道。可以选择微通道的长度和横截面面积以获得流体之间的预定分子扩散速率。当流体是液体时，流过微通道的流动是层流的，并且微通道和流体的毛细管作用使得流体流动被调节，并且可以具有构造成使得从生物反应器泄漏的机会最小化的结构，即使生物反应器在各个方向转动。在某些实施例中，一个或多个扩散控制室调节反应容器和外部气氛之间的流体流动和扩散。

3. 发明申请

US20080020937A1 Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system 审中-公开
标题翻译：具有多核苷酸链的纳米晶体及其在信号放大系统中形成树枝状大分子的用途
公开(公告)号：US20080020937A1
公开(公告)日：2008-01-24
申请号：US10975642
申请日：2004-10-28
申请人： Emilio Barbera-Guillem , M. Nelson , Stephanie Castro
发明人： Emilio Barbera-Guillem , M. Nelson , Stephanie Castro
IPC分类号： C40B20/04 , C07H21/04
CPC分类号： B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/682 , G01N33/54306 , G01N33/588 , Y10T436/143333 , C12Q2563/149 , C12Q2563/131 , C12Q2563/107
摘要： Provided are compositions and assay kits comprising functionalized nanocrystals having extending therefrom a plurality of polynucleotide strands of known sequence; wherein primary dots are used to operably link to a molecular probe, and secondary dots comprise a plurality of polynucleotide strands which are complementary to the plurality of polynucleotide strands of the primary dots. Also provided is a method for detecting the presence or absence of target molecule in a sample comprising operably linking primary dots to molecular probe, contacting the complex formed with the sample, contacting the sample with successive additions of secondary dots and primary dots. If target molecule is present in the sample, the primary dots and secondary dots will form dendrimers that can be detected by fluorescence emission.
摘要翻译：提供了包含官能化纳米晶体的组合物和测定试剂盒，其具有从其延伸的多个已知序列的多核苷酸链; 其中主要点用于可操作地连接到分子探针，并且次要点包括与主要点的多个多核苷酸链互补的多个多核苷酸链。还提供了用于检测样品中靶分子存在或不存在的方法，其包括可操作地将原始点与分子探针连接，使与样品形成的复合物接触，使样品与次要点和原始点的连续添加接触。如果样品中存在靶分子，则主要点和次要点将形成可通过荧光发射检测的树枝状大分子。

4. 发明授权

US07041362B2 Methods for identification and verification 有权
标题翻译：识别和验证方法
公开(公告)号：US07041362B2
公开(公告)日：2006-05-09
申请号：US10842327
申请日：2004-05-10
申请人： Emilio Barbera-Guillem
发明人： Emilio Barbera-Guillem
IPC分类号： B32B5/16 , B32B9/00 , B32B31/00 , B32B33/00
CPC分类号： G07F7/086 , A61K9/167 , B82Y10/00 , B82Y15/00 , B82Y30/00 , G01N33/588 , G06K19/06 , G07D7/1205 , Y10S428/916 , Y10T428/24802 , Y10T428/24893 , Y10T428/24901 , Y10T428/25 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2998
摘要： An identifiable code pattern, a method of providing a carrier material with an identifiable code pattern, and a method for detecting an identifiable code pattern are based on applying water-soluble nanocrystals to carrier materials in a spatially arranged format that can be detected by exposing the identifiable code pattern to an excitation light source in exciting the water-soluble nanocrystals, and detecting any fluorescence peaks emitted from the excited water-soluble nanocrystals using a detection system.
摘要翻译：可识别的代码模式，提供具有可识别代码模式的载体材料的方法和用于检测可识别代码模式的方法基于将水溶性纳米晶体以空间排列的格式应用于载体材料，该格式可以通过将在激发水溶性纳米晶体中激发光源的可识别代码图案，以及使用检测系统检测从激发的水溶性纳米晶体发射的任何荧光峰。

5. 发明授权

US06835326B2 Fluorescent ink compositions comprising functionalized fluorescent nanocrystals 有权
标题翻译：包含官能化荧光纳米晶体的荧光墨水组合物
公开(公告)号：US06835326B2
公开(公告)日：2004-12-28
申请号：US10417303
申请日：2003-04-16
申请人： Emilio Barbera-Guillem
发明人： Emilio Barbera-Guillem
IPC分类号： G06K714
CPC分类号： C09D11/50 , A61K9/167 , B82Y15/00 , C09K11/02 , C09K11/025 , C09K11/0805 , G07F7/086 , Y10T428/24802 , Y10T428/253
摘要： A fluorescent ink composition comprising functionalized fluorescent nanocrystals, an aqueous-based ink carrier comprising water or a water-based solution, and a binder. Also provided are methods of providing an image or a security mark on a substrate for subsequent identification by applying a fluorescent ink composition onto the substrate

6. 发明授权

US06762032B1 Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response 失效
标题翻译：组合物，测定试剂盒和与包含多发性硬化和/或原-MS免疫应答的疾病状态相关的使用方法
公开(公告)号：US06762032B1
公开(公告)日：2004-07-13
申请号：US09643277
申请日：2000-08-22
申请人： M. Bud Nelson , Emilio Barbera-Guillem
发明人： M. Bud Nelson , Emilio Barbera-Guillem
IPC分类号： G01N33543
CPC分类号： G01N33/56972 , A61K39/39541 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K16/2896 , C07K16/42 , G01N2333/70596 , G01N2800/52 , Y10S436/813 , Y10S436/827 , A61K2300/00
摘要： Provided are methods, and assay kits, and compositions useful for generating an indicator of a disease condition selected from the group consisting of multiple sclerosis (MS), a pro-MS immune response, and a combination thereof. A method for assaying a sample of an individual for an indicator of the disease condition comprises contacting the sample with a combination of two or more affinity ligands, at least one of which comprises a detection reagent; measuring an amount of the detection reagent which is bound to the sample in determining a value of a marker in the sample; wherein a difference in the value of the marker determined in the sample, when compared to the reference value, comprises an indicator of the presence of the disease condition.
摘要翻译：提供了可用于产生选自多发性硬化（MS），原-MS免疫应答及其组合的疾病状态指标的方法和测定试剂盒和组合物。用于测定个体样品作为疾病状况指标的方法包括使样品与两种或更多种亲和配体的组合接触，其中至少一种包含检测试剂; 在确定样品中的标记物的值时测量与样品结合的检测试剂的量; 其中当与所述参考值相比时，在所述样品中确定的所述标记物的值的差异包括所述疾病状况的存在的指标。

7. 发明授权

US06555365B2 Microincubator comprising a cell culture apparatus and a transparent heater 有权
标题翻译：微培养器包括细胞培养装置和透明加热器
公开(公告)号：US06555365B2
公开(公告)日：2003-04-29
申请号：US09732162
申请日：2000-12-07
申请人： Emilio Barbera-Guillem , Rick D. Lucas
发明人： Emilio Barbera-Guillem , Rick D. Lucas
IPC分类号： C12M100
CPC分类号： C12M23/24 , B01L7/00 , C12M23/10 , C12M23/22 , C12M41/10 , C12M41/22
摘要： Provided for heating cultured cells is a controlled heater device comprising a cell culture apparatus, a transparent heater in thermal contact with the cell culture apparatus, and may further comprise one or more of a transparent filter provided to prevent a predetermined spectral range of light from passing through the transparent filter, and a power source for controlling the amount of heat generated by the transparent heater of the controlled heater device.
摘要翻译：提供用于培养细胞的加热是受控的加热器装置，其包括细胞培养装置，与细胞培养装置热接触的透明加热器，并且还可以包括一个或多个透明过滤器，用于防止预定光谱范围的光通过通过透明过滤器，以及用于控制由受控加热器装置的透明加热器产生的热量的电源。

8. 外观设计

USD473318S1 Cell management device 失效
标题翻译：电池管理装置
公开(公告)号：USD473318S1
公开(公告)日：2003-04-15
申请号：US29145630
申请日：2001-07-26
申请人： Emilio Barbera-Guillem
设计人： Emilio Barbera-Guillem

9. 发明授权

US06333110B1 Functionalized nanocrystals as visual tissue-specific imaging agents, and methods for fluorescence imaging 有权
标题翻译：功能化纳米晶体作为视觉组织特异性成像剂，以及用于荧光成像的方法
公开(公告)号：US06333110B1
公开(公告)日：2001-12-25
申请号：US09394635
申请日：1999-09-13
申请人： Emilio Barbera-Guillem
发明人： Emilio Barbera-Guillem
IPC分类号： A61K4900
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y10/00 , Y10T428/2989 , Y10T428/2993
摘要： Provided is a method of fluorescence imaging of living tissue using functionalized nanocrystals. The method comprises contacting an effective amount of functionalized nanocrystals with the living tissue; exposing the tissue to a spectrum of light suitable for exciting functionalized nanocrystals, present in fluorescently labeled tissue, to emit a emission spectrum comprising a fluorescence peak; and detecting any fluorescence peak emitted by the tissue exposed to the excitation spectrum of light, and obtaining a fluorescence image of the tissue. Also provided is a composition comprising a functionalized nanocrystal which is bound to a substrate in a living tissue.
摘要翻译：提供了使用官能化的纳米晶体进行活体组织的荧光成像的方法。该方法包括使有效量的官能化纳米晶体与活组织接触; 将组织暴露于存在于荧光标记组织中的适于激发功能化纳米晶体的光谱，以发射包含荧光峰的发射光谱; 并且检测由暴露于光的激发光谱的组织发射的任何荧光峰，并获得组织的荧光图像。还提供了包含与活组织中的底物结合的官能化纳米晶体的组合物。

10. 发明授权

US6126835A Device and method for magnetic separation of biological molecules 有权
标题翻译：用于分离生物分子的装置和方法
公开(公告)号：US6126835A
公开(公告)日：2000-10-03
申请号：US240811
申请日：1999-02-01
申请人： Emilio Barbera-Guillem , Marlin O. Thurston
发明人： Emilio Barbera-Guillem , Marlin O. Thurston
IPC分类号： B01D35/06 , B03C1/00 , B03C1/28 , C12N13/00 , G01N33/543
CPC分类号： A61M1/0056 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/22 , Y10S435/803 , Y10S436/824
摘要： Provided is a magnetic separation device comprising a container having one or more outer surfaces; at least one magnetic sheet; and a physical coupler that is used to detachably secure the container to the magnetic sheet. A method of using the magnetic separation device according to the present invention comprises obtaining a fluid containing a mixed population of biological molecules, from which it is desired to separate at least one subpopulation of biological molecules; mixing the fluid with a magnetic separation reagent; contacting the mixture with the fluid holding chamber of the magnetic separation device; incubating the mixture for a sufficient time to allow for complexes to form between the subpopulation of biological molecules and the magnetic separation reagent; positioning the magnetic separation device in a position that magnetically attracts the complexes towards the magnetic sheet, and thereby holds them in position in the container; and removing the remainder of the fluid from the magnetic separation device.
摘要翻译：提供一种磁分离装置，其包括具有一个或多个外表面的容器; 至少一个磁性片; 以及用于将容器可拆卸地固定到磁性片的物理耦合器。使用根据本发明的磁分离装置的方法包括获得含有生物分子的混合群体的流体，期望从其分离至少一个生物分子亚群; 将流体与磁性分离试剂混合; 使混合物与磁选机的流体保持室接触; 将混合物温育足够的时间以允许在生物分子的亚群与磁分离试剂之间形成复合物; 将磁分离装置定位在磁性吸引复合体朝向磁性片的位置，从而将它们保持在容器中的适当位置; 以及从磁分离装置中除去剩余的流体。

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