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1. 发明授权

US08232285B2 Quinazolinone compounds and methods of use thereof 有权
标题翻译：喹唑啉酮化合物及其使用方法
公开(公告)号：US08232285B2
公开(公告)日：2012-07-31
申请号：US12142762
申请日：2008-06-19
申请人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
发明人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/72
CPC分类号： C07D239/90
摘要： The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention.
摘要翻译：本发明涉及喹唑啉酮化合物及其制备方法。本发明还涉及包含喹唑啉酮化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明的喹唑啉酮化合物来治疗细胞增殖性疾病如癌症的方法。

2. 发明申请

US20110166038A1 SCREENING METHODS FOR HEAT-SHOCK RESPONSE MODULATORS 审中-公开
标题翻译：用于热冲击响应调制器的筛选方法
公开(公告)号：US20110166038A1
公开(公告)日：2011-07-07
申请号：US12994703
申请日：2009-06-03
申请人： Bin Zhang , Shi Chung Ng , Qingyan Au
发明人： Bin Zhang , Shi Chung Ng , Qingyan Au
IPC分类号： C40B30/06 , C40B60/00 , C07C61/29
CPC分类号： G01N33/5035
摘要： High-throughput methods are provided for quantitatively measuring the modulation of heat shock protein (HSP) expression in a cell by exposing the cell to at least one stress and measuring cellular stress responses. High-throughput methods for identifying modulators (activators or inhibitors) of HSP or HSF expression in a cell by treating the cell with an agent, such as a compound or composition, exposing the cell to a stress, and measuring responses of the cell to the stress in the presence or absence of the agent are also provided. Devices useful in performing high-throughput methods of the invention, and modulators identified using such methods, are also provided.
摘要翻译：提供了高通量方法，用于通过将细胞暴露于至少一种应激和测量细胞应激反应来定量测量细胞中热休克蛋白（HSP）表达的调节。通过用试剂（例如化合物或组合物）将细胞暴露于应激来测定细胞中的HSP或HSF表达的调节剂（激活剂或抑制剂）的高通量方法，以及测量细胞对还提供在存在或不存在试剂的情况下的压力。还提供了可用于执行本发明的高通量方法的装置，以及使用这些方法识别的调制器。

3. 发明申请

US20110217300A1 Quinazolinone Compounds and Methods of Use Thereof 审中-公开
标题翻译：喹唑啉酮化合物及其使用方法
公开(公告)号：US20110217300A1
公开(公告)日：2011-09-08
申请号：US13080785
申请日：2011-04-06
申请人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
发明人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
IPC分类号： A61K31/517 , C07D239/92 , C07D403/12 , C07D401/12 , C07D409/12 , C07D471/04 , A61K31/566 , A61K33/24 , A61K31/664 , A61K31/7068 , A61K38/09 , A61K31/7048 , A61K31/5377 , A61K39/395 , A61P35/00 , A61P35/02 , A61P35/04
CPC分类号： A61K31/517 , A61K31/5377 , A61K31/566 , A61K31/664 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K38/09 , A61K39/395 , C07D239/92 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/04
摘要： The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention
摘要翻译：本发明涉及喹唑啉酮化合物及其制备方法。本发明还涉及包含喹唑啉酮化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明的喹唑啉酮化合物来治疗细胞增殖性疾病如癌症的方法

4. 发明申请

US20090227572A1 TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES 审中-公开
标题翻译：治疗糖尿病和外周神经病变
公开(公告)号：US20090227572A1
公开(公告)日：2009-09-10
申请号：US12405915
申请日：2009-03-17
申请人： Jack R. Barber , Shi Chung Ng
发明人： Jack R. Barber , Shi Chung Ng
IPC分类号： A61K31/5395 , A61K31/4545 , A61K31/15 , C07D413/14 , C07D401/12 , C07C251/16
CPC分类号： A61K31/165 , A61K31/4545 , A61K31/5395
摘要： The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provides methods of treating or preventing peripheral nervous system neuropathies. Peripheral nervous system neuropathies may but need not be diabetic neuropathies, and may but need not be associated with a diabetic wound. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions and methods, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供增强与糖尿病相关的伤口愈合的方法，包括向有需要的受试者施用有效量的一种或多种某些羟胺衍生物。另一方面，本发明提供治疗或预防周围神经系统神经病的方法。外周神经系统神经病可能不需要是糖尿病性神经病，并且可能不需要与糖尿病伤口相关联。本发明还提供药物组合物，其包含某些羟胺衍生物或其药学上可接受的盐，任选地与一种或多种另外的治疗剂组合。在某些组合物和方法中，另外的治疗剂是第二羟胺衍生物或其药学上可接受的盐。

5. 发明申请

US20090130097A1 Quinazolinone Compounds and Methods of Use Thereof 有权
标题翻译：喹唑啉酮化合物及其使用方法
公开(公告)号：US20090130097A1
公开(公告)日：2009-05-21
申请号：US12142762
申请日：2008-06-19
申请人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
发明人： Jifeng Liu , Syed M. Ali , Mark A. Ashwell , Ping Ye , Yousheng Guan , Shi-Chung Ng , Rocio Palma , Dan Yohannes
IPC分类号： A61K39/395 , C07D471/04 , A61K31/519 , C07D239/95 , A61K31/517 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/56 , A61K33/24 , A61K31/675 , A61K31/7068 , A61K31/4985 , A61K38/10 , A61K31/704 , A61K38/12 , A61K31/496 , A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号： C07D239/90
摘要： The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention
摘要翻译：本发明涉及喹唑啉酮化合物及其制备方法。本发明还涉及包含喹唑啉酮化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明的喹唑啉酮化合物来治疗细胞增殖性疾病如癌症的方法

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