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1. 发明授权

US08637090B2 Gallium formulation for the treatment and prevention of infectious diseases 有权
标题翻译：用于治疗和预防传染病的镓制剂
公开(公告)号：US08637090B2
公开(公告)日：2014-01-28
申请号：US13318774
申请日：2010-05-04
申请人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V Pham , Russell Martin , Atul Saxena
发明人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V Pham , Russell Martin , Atul Saxena
IPC分类号： A61K33/24
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译：用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。

2. 发明申请

US20130302425A1 HIGHLY DISPERSIBLE POWDERS, COMPOSITIONS AND METHODS FOR PREPARATION 有权
标题翻译：高度分散的粉末，组合物和制备方法
公开(公告)号：US20130302425A1
公开(公告)日：2013-11-14
申请号：US13988248
申请日：2010-11-18
申请人： Satoshi Ohtake , Atul Saxena , Vu Truong-Le
发明人： Satoshi Ohtake , Atul Saxena , Vu Truong-Le
IPC分类号： A61K47/18 , A61K33/24
CPC分类号： A61K47/183 , A61K9/1617 , A61K33/24
摘要： A method for the selection of pharmaceutically acceptable excipients that allow for the production of highly dispersible powders produced by spray drying.
摘要翻译：用于选择允许生产通过喷雾干燥生产的高度分散性粉末的药学上可接受的赋形剂的方法。

3. 发明申请

US20120308526A1 Sonic Low Pressure Spray Drying 有权
标题翻译：声波低压喷雾干燥
公开(公告)号：US20120308526A1
公开(公告)日：2012-12-06
申请号：US13585096
申请日：2012-08-14
申请人： Satoshi Ohtake , Russell Andrew Martin , Binh Pham , Luisa Yee
发明人： Satoshi Ohtake , Russell Andrew Martin , Binh Pham , Luisa Yee
IPC分类号： B29B9/12 , A61K35/74 , A61K38/44 , A61K35/76
CPC分类号： B01D1/18
摘要： This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
摘要翻译：本发明提供了在低压下从振动喷嘴喷雾干燥药物粉末的方法。该方法可以有效地喷洒干燥的稠粘或粘稠溶液或悬浮液以提供小的均匀颗粒。本发明包括通过从振动喷嘴进行低压喷射的方法制备的干燥颗粒组合物。

4. 发明授权

US08241886B2 Formulations for preservation of rotavirus 有权
标题翻译：轮状病毒保存制剂
公开(公告)号：US08241886B2
公开(公告)日：2012-08-14
申请号：US12733920
申请日：2008-09-24
申请人： Vu Truong-Le , Luisa Yee , David Lechuga-Ballesteros , Satoshi Ohtake
发明人： Vu Truong-Le , Luisa Yee , David Lechuga-Ballesteros , Satoshi Ohtake
IPC分类号： C12N7/00 , A61K39/15
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/542 , C12N2720/12334
摘要： This invention provides formulations and methods for stabilizing viruses in liquid and dried formulations. In particular, formulations are provided including Zn2+ cations that stabilize the viability of Rotaviruses. Methods of vaccination include neutralization of gastric contents and administration of the vaccine formulations of the invention.
摘要翻译：本发明提供用于在液体和干燥制剂中稳定病毒的制剂和方法。特别地，提供了包括稳定轮状病毒活力的Zn 2+阳离子的制剂。接种疫苗的方法包括中和胃内容物和施用本发明的疫苗制剂。

5. 发明申请

US20120128729A1 Gallium Formulation For The Treatment And Prevention of Infectious Diseases 有权
标题翻译：用于治疗和预防传染病的镓配方
公开(公告)号：US20120128729A1
公开(公告)日：2012-05-24
申请号：US12772854
申请日：2010-05-03
申请人： Satoshi Ohtake , David Lechuga-Ballesteros , Vu Truong-Le , Luisa Yee , Binh V. Pham , Russell Martin , Atul Saxena
发明人： Satoshi Ohtake , David Lechuga-Ballesteros , Vu Truong-Le , Luisa Yee , Binh V. Pham , Russell Martin , Atul Saxena
IPC分类号： A61K9/14 , A61K31/28 , A61P31/00 , B32B5/16 , A61P31/12 , A61P31/10 , A61P33/02 , A61K33/24 , C07F5/00 , A61P31/04
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译：用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。

6. 发明授权

US06735730B1 Integrated circuit with design for testability and method for designing the same 失效
标题翻译：具有可测试性设计的集成电路及其设计方法
公开(公告)号：US06735730B1
公开(公告)日：2004-05-11
申请号：US09699478
申请日：2000-10-31
申请人： Hideo Fujiwara , Toshimitsu Masuzawa , Satoshi Ohtake
发明人： Hideo Fujiwara , Toshimitsu Masuzawa , Satoshi Ohtake
IPC分类号： G01R3128
CPC分类号： G01R31/3183 , G01R31/31724
摘要： A test controller 4 has a test plan generating unit 11 for generating a test plan of a data path 2 which is formed to have a fixed control testability in which a test plan constituted by three phases, that is, the propagation of a test vector to a data input, the execution of a test and the propagation of an output response is present for each test object module. Thus, an integrated circuit is capable of supplying a test plan as a time series of a control signal to a control input of a data path, shortening a test execution time and generating the test plan at the normal operation speed of the circuit, thereby carrying out a test at an actual operation speed and an integrated circuit designing method.
摘要翻译：测试控制器4具有测试计划生成单元11，用于生成数据路径2的测试计划，数据路径2形成为具有固定控制可测试性，其中由三个阶段构成的测试计划，即测试向量的传播到对于每个测试对象模块，存在数据输入，测试的执行和输出响应的传播。因此，集成电路能够将作为控制信号的时间序列的测试计划提供给数据路径的控制输入，缩短测试执行时间，并以电路的正常操作速度生成测试计划，从而携带以实际运行速度进行测试和集成电路设计方法。

7. 发明授权

US08268354B2 Sonic low pressure spray drying 有权
标题翻译：声波低压喷雾干燥
公开(公告)号：US08268354B2
公开(公告)日：2012-09-18
申请号：US12266493
申请日：2008-11-06
申请人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
发明人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh V. Pham , Luisa Yee
IPC分类号： A61K9/14 , F26B5/06
CPC分类号： B01D1/18
摘要： This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
摘要翻译：本发明提供了在低压下从振动喷嘴喷雾干燥药物粉末的方法。该方法可以有效地喷洒干燥的稠粘或粘稠溶液或悬浮液以提供小的均匀颗粒。本发明包括通过从振动喷嘴进行低压喷射的方法制备的干燥颗粒组合物。

8. 发明申请

US20120148635A1 GALLIUM FORMULATION FOR THE TREATMENT AND PREVENTION OF INFECTIOUS DISEASES 有权
标题翻译：用于治疗和预防感染性疾病的GALLIUM配方
公开(公告)号：US20120148635A1
公开(公告)日：2012-06-14
申请号：US13318774
申请日：2010-05-04
申请人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V. Pham , Russel Martin , Atul Saxena
发明人： Satoshi Ohtake , Vu Truong-Le , David Lechuga-Ballesteros , Luisa Yee , Binh V. Pham , Russel Martin , Atul Saxena
IPC分类号： A61K31/28 , A61K31/555 , A61P31/04 , A61P31/00 , A61P11/00 , C07F5/00 , A61K9/14
CPC分类号： A61K31/28 , A61K9/0078 , A61K9/08 , A61K9/14 , A61K9/1617 , A61K9/1623 , A61K33/24 , A61K47/12 , Y02A50/473 , Y10T428/2982
摘要： A method and composition for treatment of bacterial infections caused by gram negative or gram positive bacteria such as Staphylococcus aureus, Rhodococcus equi, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a formulation containing gallium (III), in a pharmaceutically acceptable salt or complex thereof.
摘要翻译：用于治疗由革兰氏阴性或革兰氏阳性细菌如金黄色葡萄球菌，马氏体球菌，结核分枝杆菌，大肠杆菌，肺炎克雷伯菌，克雷伯杆菌，铜绿假单胞菌，流感嗜血杆菌，奇异变形杆菌，肠杆菌属，沙雷氏菌属引起的细菌感染的方法和组合物粘膜结肠炎以及由伯克霍克伯克伯克霍尔德氏菌，嗜麦芽寡养单胞菌，产碱杆菌xylosoxidans和多药耐药铜绿假单胞菌引起的那些，其使用含有镓（III）的制剂在其药学上可接受的盐或复合物中。

9. 发明申请

US20110064723A1 Formulation for room temperature stabilization of a live attenuated bacterial vaccine 审中-公开
标题翻译：活减毒细菌疫苗的室温稳定化配方
公开(公告)号：US20110064723A1
公开(公告)日：2011-03-17
申请号：US12880213
申请日：2010-09-13
申请人： Vu Truong-Le , Satoshi Ohtake , Gary Chiueh , Russell A. Martin , Atul Saxena , Binh V. Pham , David Lechuga-Ballesteros
发明人： Vu Truong-Le , Satoshi Ohtake , Gary Chiueh , Russell A. Martin , Atul Saxena , Binh V. Pham , David Lechuga-Ballesteros
IPC分类号： A61K39/395 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/085 , A61K39/09 , A61K39/112 , A61K39/108 , A61K39/04 , A61K39/104 , A61K39/07 , A61P37/04
CPC分类号： A61K39/07 , A61K39/0208 , A61K39/0275 , A61K39/0283 , A61K39/12 , A61K39/165 , A61K47/183 , A61K47/26 , A61K47/42 , A61K2039/522 , A61K2039/523 , A61K2039/5254 , A61K2039/55505 , A61K2039/55561 , C12N7/00 , C12N2760/18411 , C12N2760/18434 , C12N2760/18451 , Y02A50/476 , Y02A50/482
摘要： This invention provides methods and compositions for stabilizing proteins and vaccines in dried formulations. In particular, a cavitation method and compositions of preparing a dried vaccine are provided that stabilize the viability of live bacteria and live virus vaccines at room temperature.
摘要翻译：本发明提供用于在干燥制剂中稳定蛋白质和疫苗的方法和组合物。特别地，提供空化方法和制备干燥疫苗的组合物，其在室温下稳定活细菌和活病毒疫苗的活力。

10. 发明申请

US20100331428A1 Sonic Low Pressure Spray Drying 有权
标题翻译：声波低压喷雾干燥
公开(公告)号：US20100331428A1
公开(公告)日：2010-12-30
申请号：US12266493
申请日：2008-11-06
申请人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh Pham , Luisa Yee
发明人： Vu Truong-Le , Satoshi Ohtake , Russell Andrew Martin , Binh Pham , Luisa Yee
IPC分类号： A61K47/26 , B29B9/00
CPC分类号： B01D1/18
摘要： This invention provides methods of spray drying pharmaceutical powders from a vibrating nozzle at low pressures. The method can effectively spray dry thick or viscous solutions or suspensions to provide small uniform particles. The invention includes dry particle compositions prepared by methods of low pressure spraying from vibrating nozzles.
摘要翻译：本发明提供了在低压下从振动喷嘴喷雾干燥药物粉末的方法。该方法可以有效地喷洒干燥的稠粘或粘稠溶液或悬浮液以提供小的均匀颗粒。本发明包括通过从振动喷嘴进行低压喷射的方法制备的干燥颗粒组合物。

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