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1. 发明授权

US08541585B2 N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof 有权
标题翻译： N-酰基环胺衍生物或其药学上可接受的盐
公开(公告)号：US08541585B2
公开(公告)日：2013-09-24
申请号：US13505161
申请日：2011-03-11
申请人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
发明人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar1 and Ar2 are aryl or heteroaryl; V is nitrogen, or CR3; W1 is a single bond, —C(O)—, etc.; W2 is C1-alkylene; W3 is a single bond, methylene, —NH—, —CR4═CR5—, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R1a, R1b and R1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C1-6 alkyl, etc.; or pharmaceutically acceptable salts thereof are provided.
摘要翻译：本发明提供对精神分裂症中的阳性症状，阴性症状和认知功能障碍具有高效力并降低常规副作用风险的化合物，并且对与精神分裂症以外的认知功能障碍相关的中枢神经系统疾病具有显着作用。式（1）的N-酰基环胺衍生物：其中Ar1和Ar2是芳基或杂芳基; V是氮，或CR 3; W1是单键，-C（O） - 等; W2是C1-亚烷基; W3是单键，亚甲基，-NH-，-CR4 = CR5-等; 环Q是式（a）的基团，其中n为0或1; m为0〜2; k为1〜3; Z是单键，亚甲基，氧等。 R 1a，R 1b和R 1c各自相同或不同，氢，羟基，卤素，氰基，C 1-6烷基等; 或其药学上可接受的盐。

2. 发明申请

US20090198056A1 Beta secretase inhibitor 失效
标题翻译： β分泌酶抑制剂
公开(公告)号：US20090198056A1
公开(公告)日：2009-08-06
申请号：US11991426
申请日：2006-08-31
申请人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
发明人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
IPC分类号： C07D403/12 , C07D405/12 , C07D233/88 , C07D235/30 , C07D257/06
CPC分类号： C07D233/88 , C07C279/22 , C07D235/30 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to a compound of the formula (1): wherein R1 is group of the formula (2): (wherein X is nitrogen atom or C(R5), Y is nitrogen atom or C(R6), R5 and R6 are each independently hydrogen atom, etc.) etc., m is 1 to 6, L1 is single bond, etc., R2 is hydrogen atom, substituted or unsubstituted alkyl group, etc., R3 is hydrogen atom, etc., L2 is single bond, etc., R4 is hydrogen atom, substituted or unsubstituted aryl group, etc., or pharmaceutically acceptable salt thereof, being useful for preventing or treating Alzheimer's disease.
摘要翻译：本发明涉及式（1）的化合物：其中R1是式（2）的基团：其中X是氮原子或C（R5），Y是氮原子或C（R6），R5和R6 各自独立地为氢原子等）等，m为1〜6，L1为单键等，R2为氢原子，取代或未取代的烷基等，R3为氢原子等，L2为单键等，R4为氢原子，取代或未取代的芳基等，或其药学上可接受的盐，可用于预防或治疗阿尔茨海默病。

3. 发明授权

US07197014B2 Recording medium, fault analysis device and fault analysis method 有权
标题翻译：记录介质，故障分析装置和故障分析方法
公开(公告)号：US07197014B2
公开(公告)日：2007-03-27
申请号：US11019547
申请日：2004-12-23
申请人： Tsuneo Katsuyama , Masanobu Morinaga , Hideaki Miyazaki , Yuji Nomura , Takeshi Yasuie , Noriyuki Fukuyama , Masaaki Wakamoto , Satoshi Nojima
发明人： Tsuneo Katsuyama , Masanobu Morinaga , Hideaki Miyazaki , Yuji Nomura , Takeshi Yasuie , Noriyuki Fukuyama , Masaaki Wakamoto , Satoshi Nojima
IPC分类号： H04J3/14
CPC分类号： H04L47/10 , H04L41/0631 , H04L43/0829 , H04L43/0864 , H04L43/0888 , H04L47/12 , H04L47/22 , H04L47/25
摘要： A computer-readable recording medium recording a program capable of accurately analyzing the cause of a performance fault at the very end point of a client system, server system, etc. Outgoing and incoming packets are captured during execution of a communication application to measure a round trip time, and a communication window size of the transmitting source is estimated based on the captured incoming packets. A throughput estimate is calculated from the round trip time and the communication window size, and the estimated value and actual measured value of the throughput are displayed on, for example, a display, together with various other communication parameters including the communication window size and the round trip time, whereby the cause of a performance fault can be accurately located by quantitative analysis.
摘要翻译：记录能够准确地分析客户端系统，服务器系统等的终点处的性能故障的原因的程序的计算机可读记录介质。在执行通信应用期间捕获出去的和进入的分组以测量一轮跳闸时间，并且基于所捕获的传入分组来估计发送源的通信窗口大小。从往返时间和通信窗口大小计算吞吐量估计，并且将吞吐量的估计值和实际测量值与各种其他通信参数一起显示在例如显示器上，包括通信窗口大小和往返时间，通过定量分析可以准确定位性能故障的原因。

4. 发明授权

US06625658B1 End equipment and router 失效
标题翻译：终端设备和路由器
公开(公告)号：US06625658B1
公开(公告)日：2003-09-23
申请号：US09211153
申请日：1998-12-14
申请人： Naoki Oguchi , Satoshi Nojima
发明人： Naoki Oguchi , Satoshi Nojima
IPC分类号： G06F15173
CPC分类号： H04L29/06 , H04L69/32
摘要： An end equipment (including a terminal equipment and a router) executes a destination address resolution of a data packet. In a network layer, when a packet transmitter detects that a direct route of an input packet is not registered in a routing table a path manager transmits an inquiry packet, demands a preparation of a point-to-point logical interface of the direct route based on a data link layer address of the destination included in the received response packet, and registers the prepared logical interface in the routing table.
摘要翻译：终端设备（包括终端设备和路由器）执行数据包的目的地地址解析。在网络层中，当分组发送器检测到输入分组的直接路由未被登记在路由表中时，路径管理器发送查询分组，需要准备基于直接路由的点对点逻辑接口在接收到的响应分组中包括的目的地的数据链路层地址上，并将准备的逻辑接口注册在路由表中。

5. 发明申请

US20120214790A1 N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 有权
标题翻译： N-乙酰氨基胺衍生物或其药学上可接受的盐
公开(公告)号：US20120214790A1
公开(公告)日：2012-08-23
申请号：US13505161
申请日：2011-03-11
申请人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
发明人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
IPC分类号： A61K31/454 , A61K31/496 , C07D417/14 , C07D413/14 , A61K31/4545 , A61K31/55 , A61K31/553 , C07D471/04 , A61P25/18 , C07D405/14 , C07D401/14 , A61K31/5377
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar1 and Ar2 are aryl or heteroaryl; V is nitrogen, or CR3; W1 is a single bond, —C(O)—, etc.; W2 is C1-alkylene; W3 is a single bond, methylene, —NH—, —CR4═CR5—, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R1a, R1b and R1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C1-6 alkyl, etc.; or pharmaceutically acceptable salts thereof are provided.
摘要翻译：本发明提供对精神分裂症中的阳性症状，阴性症状和认知功能障碍具有高效力并降低常规副作用风险的化合物，并且对与精神分裂症以外的认知功能障碍相关的中枢神经系统疾病具有显着作用。式（1）的N-酰基环胺衍生物：其中Ar1和Ar2是芳基或杂芳基; V是氮，或CR 3; W1是单键，-C（O） - 等; W2是C1-亚烷基; W3是单键，亚甲基，-NH-，-CR 4 = CR 5 - 等; 环Q是式（a）的基团，其中n为0或1; m为0〜2; k为1〜3; Z是单键，亚甲基，氧等。 R 1a，R 1b和R 1c各自相同或不同，氢，羟基，卤素，氰基，C 1-6烷基等; 或其药学上可接受的盐。

6. 发明授权

US07816387B2 β secretase inhibitor 失效
标题翻译：＆bgr 分泌酶抑制剂
公开(公告)号：US07816387B2
公开(公告)日：2010-10-19
申请号：US11991426
申请日：2006-08-31
申请人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
发明人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
IPC分类号： A61K31/4168 , A61K31/4196 , A61K31/41 , C07D233/88 , C07D249/14 , C07D257/06
CPC分类号： C07D233/88 , C07C279/22 , C07D235/30 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to a compound of the formula (1): wherein R1 is group of the formula (2): (wherein X is nitrogen atom or C(R5), Y is nitrogen atom or C(R6), R5 and R6 are each independently hydrogen atom, etc.) etc., m is 1 to 6, L1 is single bond, etc., R2 is hydrogen atom, substituted or unsubstituted alkyl group, etc., R3 is hydrogen atom, etc., L2 is single bond, etc., R4 is hydrogen atom, substituted or unsubstituted aryl group, etc., or pharmaceutically acceptable salt thereof, being useful for preventing or treating Alzheimer's disease.
摘要翻译：本发明涉及式（1）的化合物：其中R1是式（2）的基团：其中X是氮原子或C（R5），Y是氮原子或C（R6），R5和R6 各自独立地为氢原子等）等，m为1〜6，L1为单键等，R2为氢原子，取代或未取代的烷基等，R3为氢原子等，L2为单键等，R4为氢原子，取代或未取代的芳基等，或其药学上可接受的盐，可用于预防或治疗阿尔茨海默病。

7. 发明授权

US06673772B2 Dipeptide compounds and their use as antiviral agents 失效
标题翻译：二肽化合物及其作为抗病毒剂的用途
公开(公告)号：US06673772B2
公开(公告)日：2004-01-06
申请号：US09939858
申请日：2001-08-27
申请人： Tsutomu Mimoto , Keisuke Terashima , Haruso Takaku , Shinji Matsumoto , Makoto Shintani , Satoshi Nojima
发明人： Tsutomu Mimoto , Keisuke Terashima , Haruso Takaku , Shinji Matsumoto , Makoto Shintani , Satoshi Nojima
IPC分类号： C07K506
CPC分类号： C07D207/16 , C07D277/06
摘要： A novel dipeptide compound inhibiting the enzymatic activity of HIV protease and an anti-AIDS medicine comprising this dipeptide compound as an effective component represented by formula (I) wherein R1, R2, and R3 independently represent C1-4 alkyl, alkoxyl, hydrogen etc . . . (provided that not all of the R1, R2, and R3 are hydrogen), R2 and R3 may form a ring together, R4 represents C1-4 alkyl or hydrogen; X is a methylene group or a sulfur atom; Y represents e.g., a five or six member monocycle or aryloxyalkyl having up to 12 carbon atoms (provided that the aromatic ring may be substituted by alkyl etc . . . ); and Z represents a C1-6 aliphatic hydrocarbon or an aromatic hydrocarbon having up to 12 carbon atoms (provided that this aromatic ring may be substituted by alkyl etc . . . , or at least one carbon atom in the aromatic hydrocarbon may be replaced by a hereto atom).
摘要翻译：抑制HIV蛋白酶的酶活性的新型二肽化合物和包含该二肽化合物作为由式（I）表示的有效成分的抗艾滋病药物，其中R 1，R 2和R 3独立地表示C1 -4烷基，烷氧基，氢等。。。（条件是不是全部R 1，R 2和R 3都是氢），R 2和R 3可以一起形成一个环，R 4表示C 1-4烷基或氢; X是亚甲基或硫原子; Y表示例如具有至多12个碳原子的5或6元单环或芳氧基烷基（条件是芳环可被烷基等取代）; Z表示碳原子数1〜6的脂肪烃或碳原子数最多为12的芳香族烃（前提是该芳香环可以被烷基等取代，或者芳香族烃中的至少一个碳原子可以被原子）。

8. 发明授权

US5325203A Adaptively controlled noise reduction device for producing a continuous output 失效
标题翻译：用于产生连续输出的自适应控制降噪装置
公开(公告)号：US5325203A
公开(公告)日：1994-06-28
申请号：US046578
申请日：1993-04-14
申请人： Satoshi Nojima , Toshitaka Senuma
发明人： Satoshi Nojima , Toshitaka Senuma
IPC分类号： H04N5/14 , H04N5/21
CPC分类号： H04N5/21 , H04N5/144
摘要： An adaptively controlled noise reduction device in which an input video signal is supplied to first, second, and third adders and in which an output of the first adder is supplied to the second adder via a memory responsive to a controller whereby the memory provides a controllable delay. An output of the second adder is supplied via a first coefficient multiplication unit having variable attenuation that is controlled by the controller to the first adder as well as via a second coefficient multiplication unit having variable attenuation that is controlled by the controller to the third adder. A change-over switch responsive to the controller outputs either a signal from the third adder or from the memory. Therefore, a signal is output even during the delay period produced by the memory when the signal is delayed between the first and second adders.
摘要翻译：一种自适应控制的降噪装置，其中输入视频信号被提供给第一，第二和第三加法器，并且其中第一加法器的输出经由响应于控制器的存储器提供给第二加法器，由此存储器提供可控制的延迟。第二加法器的输出经由具有由控制器控制的可变衰减的第一系数乘法单元提供给第一加法器，以及经由具有由控制器控制到第三加法器的可变衰减的第二系数乘法单元提供。响应于控制器的转换开关输出来自第三加法器或存储器的信号。因此，当信号在第一和第二加法器之间被延迟时，甚至在由存储器产生的延迟时间期间也输出信号。

9. 发明授权

US5140582A Packet switching system having bus matrix switch 失效
标题翻译：具有总线矩阵开关的分组开关系统
公开(公告)号：US5140582A
公开(公告)日：1992-08-18
申请号：US516687
申请日：1991-04-30
申请人： Mitsuru Tsuboi , Susumu Tominaga , Akira Takeyama , Satoshi Nojima
发明人： Mitsuru Tsuboi , Susumu Tominaga , Akira Takeyama , Satoshi Nojima
IPC分类号： H04L12/933 , H04L12/935 , H04L12/937
CPC分类号： H04L49/102 , H04L49/101 , H04L49/254 , H04L49/3018
摘要： A packet switching system having a matrix switch including input packet transfer buses and output packet transfer buses. Transfer buffers or gates are provided at cross points of the input and output packet transfer buses. An input packet is supplied to the matrix switch through a transfer control circuit, and an output packet from the matrix switch is output through the transfer control circuit. The input packet is permitted to be applied to the matrix switch so that each of the output packet transfer buses has only one packet during one packet transfer cycle.
摘要翻译：具有包括输入分组传输总线和输出分组传输总线的矩阵切换的分组交换系统。在输入和输出分组传输总线的交叉点提供传送缓冲器或门。通过传送控制电路将输入分组提供给矩阵切换器，通过传送控制电路输出来自矩阵切换器的输出分组。允许将输入分组应用于矩阵切换器，使得每个输出分组传送总线在一个分组传送周期期间仅具有一个分组。

10. 发明授权

US4542496A Loop transmission system and method of controlling the loop-back condition thereof 失效
标题翻译：环路传输系统及其环回条件的控制方法
公开(公告)号：US4542496A
公开(公告)日：1985-09-17
申请号：US525464
申请日：1983-08-22
申请人： Akira Takeyama , Kenshi Tazaki , Satoshi Nojima , Norihiro Aritaka , Teruyoshi Mita
发明人： Akira Takeyama , Kenshi Tazaki , Satoshi Nojima , Norihiro Aritaka , Teruyoshi Mita
IPC分类号： H04J3/08 , H04B1/74 , H04B3/46 , H04L1/24 , H04L12/437
CPC分类号： H04B1/745 , H04L1/243 , H04L12/437
摘要： A loop transmission system and a method of controlling the loop-back condition thereof. The loop transmission system comprises a plurality of node stations, a supervisory station, and two duplicate loop transmission lines which transmit signals in opposite directions. In the loop transmission system, the supervisory station first sends out loop-back commands via both of the duplicate loop transmission lines when faults are detected on both of the duplicate loop transmission lines at the same time. Each of the node stations establishes a loop-back path while retaining a connection path to a succeeding node station upon the receipt of a loop-back command. The loop-back path is released only in the node stations which receive signals normally from both of the duplicate loop transmission lines when the supervisory station sends release commands to the node stations after sending the loopback commands.
摘要翻译：环路传输系统及其环回条件的控制方法。环路传输系统包括多个节点站，监控站和两个相反方向传输信号的重复环路传输线路。在环路传输系统中，当同时在两条重复环路传输线路上检测到故障时，监控站首先通过双重传输线路发送环回指令。每个节点站建立循环路径，同时在接收到回送命令时保留到后续节点站的连接路径。当发送回送命令后，当监控站向节点发送释放命令时，环回路径只能在从两个重复环路传输线路正常接收信号的节点站中释放。

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