专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06673772B2 Dipeptide compounds and their use as antiviral agents 失效
标题翻译：二肽化合物及其作为抗病毒剂的用途
公开(公告)号：US06673772B2
公开(公告)日：2004-01-06
申请号：US09939858
申请日：2001-08-27
申请人： Tsutomu Mimoto , Keisuke Terashima , Haruso Takaku , Shinji Matsumoto , Makoto Shintani , Satoshi Nojima
发明人： Tsutomu Mimoto , Keisuke Terashima , Haruso Takaku , Shinji Matsumoto , Makoto Shintani , Satoshi Nojima
IPC分类号： C07K506
CPC分类号： C07D207/16 , C07D277/06
摘要： A novel dipeptide compound inhibiting the enzymatic activity of HIV protease and an anti-AIDS medicine comprising this dipeptide compound as an effective component represented by formula (I) wherein R1, R2, and R3 independently represent C1-4 alkyl, alkoxyl, hydrogen etc . . . (provided that not all of the R1, R2, and R3 are hydrogen), R2 and R3 may form a ring together, R4 represents C1-4 alkyl or hydrogen; X is a methylene group or a sulfur atom; Y represents e.g., a five or six member monocycle or aryloxyalkyl having up to 12 carbon atoms (provided that the aromatic ring may be substituted by alkyl etc . . . ); and Z represents a C1-6 aliphatic hydrocarbon or an aromatic hydrocarbon having up to 12 carbon atoms (provided that this aromatic ring may be substituted by alkyl etc . . . , or at least one carbon atom in the aromatic hydrocarbon may be replaced by a hereto atom).
摘要翻译：抑制HIV蛋白酶的酶活性的新型二肽化合物和包含该二肽化合物作为由式（I）表示的有效成分的抗艾滋病药物，其中R 1，R 2和R 3独立地表示C1 -4烷基，烷氧基，氢等。。。（条件是不是全部R 1，R 2和R 3都是氢），R 2和R 3可以一起形成一个环，R 4表示C 1-4烷基或氢; X是亚甲基或硫原子; Y表示例如具有至多12个碳原子的5或6元单环或芳氧基烷基（条件是芳环可被烷基等取代）; Z表示碳原子数1〜6的脂肪烃或碳原子数最多为12的芳香族烃（前提是该芳香环可以被烷基等取代，或者芳香族烃中的至少一个碳原子可以被原子）。

2. 发明授权

US06291432B1 Tripeptide compounds and anti-AIDS medicine 失效
标题翻译：三肽化合物和抗艾滋病药物
公开(公告)号：US06291432B1
公开(公告)日：2001-09-18
申请号：US09155773
申请日：1999-02-16
申请人： Haruo Takaku , Satoshi Nojima , Tsutomu Mimoto , Keisuke Terashima , Yoshiaki Kiso
发明人： Haruo Takaku , Satoshi Nojima , Tsutomu Mimoto , Keisuke Terashima , Yoshiaki Kiso
IPC分类号： A61K3806
CPC分类号： C07D263/04 , C07D277/06 , C07D417/12 , C07K5/0202
摘要： A novel tripeptide compound represented by the following general formula (I) exhibiting superior HIV protease inhibition activity, and an anti-AIDS medicine comprising this compound as an effective component and a pharmaceutically acceptable salt thereof. (R)-N-(2-methylbenzyl)-3-{(2S,3S)-3-[N-(2-chromonecarbonyl)-L-asparaginyl]amino-2-hydroxy-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide can be given as a typical example of this compound.
摘要翻译：由下述通式（I）表示的具有优异的HIV蛋白酶抑制活性的新型三肽化合物和包含该化合物作为有效成分的抗艾滋病药物，（R）-N-（2-甲基苄基）-3 - {（2S，3S）-3- [N-（2-色烯羰基）-L-天冬酰胺基]氨基-2-羟基-4-苯基丁酰基} -5,5-二甲基-1,3-噻唑烷-4 甲酰胺可以作为该化合物的典型实例给出。

3. 发明申请

US20090198056A1 Beta secretase inhibitor 失效
标题翻译： β分泌酶抑制剂
公开(公告)号：US20090198056A1
公开(公告)日：2009-08-06
申请号：US11991426
申请日：2006-08-31
申请人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
发明人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
IPC分类号： C07D403/12 , C07D405/12 , C07D233/88 , C07D235/30 , C07D257/06
CPC分类号： C07D233/88 , C07C279/22 , C07D235/30 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to a compound of the formula (1): wherein R1 is group of the formula (2): (wherein X is nitrogen atom or C(R5), Y is nitrogen atom or C(R6), R5 and R6 are each independently hydrogen atom, etc.) etc., m is 1 to 6, L1 is single bond, etc., R2 is hydrogen atom, substituted or unsubstituted alkyl group, etc., R3 is hydrogen atom, etc., L2 is single bond, etc., R4 is hydrogen atom, substituted or unsubstituted aryl group, etc., or pharmaceutically acceptable salt thereof, being useful for preventing or treating Alzheimer's disease.
摘要翻译：本发明涉及式（1）的化合物：其中R1是式（2）的基团：其中X是氮原子或C（R5），Y是氮原子或C（R6），R5和R6 各自独立地为氢原子等）等，m为1〜6，L1为单键等，R2为氢原子，取代或未取代的烷基等，R3为氢原子等，L2为单键等，R4为氢原子，取代或未取代的芳基等，或其药学上可接受的盐，可用于预防或治疗阿尔茨海默病。

4. 发明授权

US07816387B2 β secretase inhibitor 失效
标题翻译：＆bgr 分泌酶抑制剂
公开(公告)号：US07816387B2
公开(公告)日：2010-10-19
申请号：US11991426
申请日：2006-08-31
申请人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
发明人： Tsutomu Mimoto , Satoshi Nojima , Naoya Kinomura , Yoshiaki Kiso
IPC分类号： A61K31/4168 , A61K31/4196 , A61K31/41 , C07D233/88 , C07D249/14 , C07D257/06
CPC分类号： C07D233/88 , C07C279/22 , C07D235/30 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to a compound of the formula (1): wherein R1 is group of the formula (2): (wherein X is nitrogen atom or C(R5), Y is nitrogen atom or C(R6), R5 and R6 are each independently hydrogen atom, etc.) etc., m is 1 to 6, L1 is single bond, etc., R2 is hydrogen atom, substituted or unsubstituted alkyl group, etc., R3 is hydrogen atom, etc., L2 is single bond, etc., R4 is hydrogen atom, substituted or unsubstituted aryl group, etc., or pharmaceutically acceptable salt thereof, being useful for preventing or treating Alzheimer's disease.
摘要翻译：本发明涉及式（1）的化合物：其中R1是式（2）的基团：其中X是氮原子或C（R5），Y是氮原子或C（R6），R5和R6 各自独立地为氢原子等）等，m为1〜6，L1为单键等，R2为氢原子，取代或未取代的烷基等，R3为氢原子等，L2为单键等，R4为氢原子，取代或未取代的芳基等，或其药学上可接受的盐，可用于预防或治疗阿尔茨海默病。

5. 发明授权

US08541585B2 N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof 有权
标题翻译： N-酰基环胺衍生物或其药学上可接受的盐
公开(公告)号：US08541585B2
公开(公告)日：2013-09-24
申请号：US13505161
申请日：2011-03-11
申请人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
发明人： Megumi Maruyama , Naoya Kinomura , Satoshi Nojima , Masahiro Takamura , Keisuke Kakiguchi , Hiroto Tatamidani
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar1 and Ar2 are aryl or heteroaryl; V is nitrogen, or CR3; W1 is a single bond, —C(O)—, etc.; W2 is C1-alkylene; W3 is a single bond, methylene, —NH—, —CR4═CR5—, etc.; Ring Q is a group of formula (a) in which n is 0 or 1; m is 0 to 2; k is 1 to 3; Z is a single bond, methylene, oxygen, etc.; R1a, R1b and R1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C1-6 alkyl, etc.; or pharmaceutically acceptable salts thereof are provided.
摘要翻译：本发明提供对精神分裂症中的阳性症状，阴性症状和认知功能障碍具有高效力并降低常规副作用风险的化合物，并且对与精神分裂症以外的认知功能障碍相关的中枢神经系统疾病具有显着作用。式（1）的N-酰基环胺衍生物：其中Ar1和Ar2是芳基或杂芳基; V是氮，或CR 3; W1是单键，-C（O） - 等; W2是C1-亚烷基; W3是单键，亚甲基，-NH-，-CR4 = CR5-等; 环Q是式（a）的基团，其中n为0或1; m为0〜2; k为1〜3; Z是单键，亚甲基，氧等。 R 1a，R 1b和R 1c各自相同或不同，氢，羟基，卤素，氰基，C 1-6烷基等; 或其药学上可接受的盐。

6. 发明授权

US07197014B2 Recording medium, fault analysis device and fault analysis method 有权
标题翻译：记录介质，故障分析装置和故障分析方法
公开(公告)号：US07197014B2
公开(公告)日：2007-03-27
申请号：US11019547
申请日：2004-12-23
申请人： Tsuneo Katsuyama , Masanobu Morinaga , Hideaki Miyazaki , Yuji Nomura , Takeshi Yasuie , Noriyuki Fukuyama , Masaaki Wakamoto , Satoshi Nojima
发明人： Tsuneo Katsuyama , Masanobu Morinaga , Hideaki Miyazaki , Yuji Nomura , Takeshi Yasuie , Noriyuki Fukuyama , Masaaki Wakamoto , Satoshi Nojima
IPC分类号： H04J3/14
CPC分类号： H04L47/10 , H04L41/0631 , H04L43/0829 , H04L43/0864 , H04L43/0888 , H04L47/12 , H04L47/22 , H04L47/25
摘要： A computer-readable recording medium recording a program capable of accurately analyzing the cause of a performance fault at the very end point of a client system, server system, etc. Outgoing and incoming packets are captured during execution of a communication application to measure a round trip time, and a communication window size of the transmitting source is estimated based on the captured incoming packets. A throughput estimate is calculated from the round trip time and the communication window size, and the estimated value and actual measured value of the throughput are displayed on, for example, a display, together with various other communication parameters including the communication window size and the round trip time, whereby the cause of a performance fault can be accurately located by quantitative analysis.
摘要翻译：记录能够准确地分析客户端系统，服务器系统等的终点处的性能故障的原因的程序的计算机可读记录介质。在执行通信应用期间捕获出去的和进入的分组以测量一轮跳闸时间，并且基于所捕获的传入分组来估计发送源的通信窗口大小。从往返时间和通信窗口大小计算吞吐量估计，并且将吞吐量的估计值和实际测量值与各种其他通信参数一起显示在例如显示器上，包括通信窗口大小和往返时间，通过定量分析可以准确定位性能故障的原因。

7. 发明授权

US06625658B1 End equipment and router 失效
标题翻译：终端设备和路由器
公开(公告)号：US06625658B1
公开(公告)日：2003-09-23
申请号：US09211153
申请日：1998-12-14
申请人： Naoki Oguchi , Satoshi Nojima
发明人： Naoki Oguchi , Satoshi Nojima
IPC分类号： G06F15173
CPC分类号： H04L29/06 , H04L69/32
摘要： An end equipment (including a terminal equipment and a router) executes a destination address resolution of a data packet. In a network layer, when a packet transmitter detects that a direct route of an input packet is not registered in a routing table a path manager transmits an inquiry packet, demands a preparation of a point-to-point logical interface of the direct route based on a data link layer address of the destination included in the received response packet, and registers the prepared logical interface in the routing table.
摘要翻译：终端设备（包括终端设备和路由器）执行数据包的目的地地址解析。在网络层中，当分组发送器检测到输入分组的直接路由未被登记在路由表中时，路径管理器发送查询分组，需要准备基于直接路由的点对点逻辑接口在接收到的响应分组中包括的目的地的数据链路层地址上，并将准备的逻辑接口注册在路由表中。

8. 发明授权

US07385930B2 Packet discard point probing method and device 有权
标题翻译：分组丢弃点探测方法和设备
公开(公告)号：US07385930B2
公开(公告)日：2008-06-10
申请号：US10974523
申请日：2004-10-27
申请人： Takeshi Yasuie , Yuji Nomura , Satoshi Nojima
发明人： Takeshi Yasuie , Yuji Nomura , Satoshi Nojima
IPC分类号： H04L12/26
CPC分类号： H04L47/10 , H04L47/13 , H04L47/22 , H04L2001/0097
摘要： In a relay device or the like in which a speed changes from a high speed to a low speed, a packet residence (packet transfer wait) occurs when a packet string in which packet intervals are shortened arrives. When a packet discard occurs before passing through the relay device or the like, a packet interval having been lengthened by the packet discard is shortened by the relay device or the like for transferring packets. When a packet discard occurs after passing through the relay device or the like, a packet interval having been lengthened by the packet discard remains unshortened for transferring packets. Therefore, by observing at terminals the packet discard and the packet interval on the occasion of the packet discard, whether the packet discard has occurred in the high speed section or the low speed section is specified.
摘要翻译：在速度从高速变化到低速的中继装置等中，当分组间隔被缩短的分组串到达时，发生分组驻留（分组传送等待）。当在通过中继装置等之前发生分组丢弃时，由分组丢弃延长的分组间隔由传送分组的中继装置等缩短。当在通过中继装置等之后发生分组丢弃时，已经被分组丢弃延长的分组间隔保持不被用于传送分组。因此，通过在终端观察分组丢弃和分组丢弃时的分组间隔，是否指定了在高速部分或低速部分中发生了分组丢弃。

9. 发明申请

US20060057101A1 German cockroach attractant 审中-公开
标题翻译：德国蟑螂引诱剂
公开(公告)号：US20060057101A1
公开(公告)日：2006-03-16
申请号：US11178833
申请日：2005-07-11
申请人： Wendell Roelofs , Coby Schal , Francis Webster , Satoshi Nojima
发明人： Wendell Roelofs , Coby Schal , Francis Webster , Satoshi Nojima
IPC分类号： A01N25/00 , C07C50/38
CPC分类号： A01N37/02 , C07C67/14 , C07C67/297 , C07C69/24 , C07C69/30
摘要： A compound of the formula I where R represents unsubstituted or substituted, alkyl, cycloalkyl, alkenyl, alkynyl, or aryl, and X represents where R1 and R2 are each H or alkyl, is disclosed. Compounds of formula I are particularly useful as an attractant for cockroaches, namely, Blattella germanica. Synthesis of the compounds, methods of controlling cockroach populations, and of disrupting cockroach mating are also disclosed.
摘要翻译：式I的化合物

10. 发明授权

US5068820A Data transfer system having transfer discrimination circuit 失效
标题翻译：具有传输分辨率电路的数据传输系统
公开(公告)号：US5068820A
公开(公告)日：1991-11-26
申请号：US221908
申请日：1988-06-10
申请人： Satoshi Nojima , Kazuo Sakagawa , Hideo Suzuki
发明人： Satoshi Nojima , Kazuo Sakagawa , Hideo Suzuki
IPC分类号： G06F13/42
CPC分类号： G06F13/4226
摘要： A data transfer system having a transfer discrimination circuit for discriminating the type of data transfer between an input/output channel device and I/O devices for a computer includes a transfer discrimination circuit. This circuit includes a edge detection unit operating in response to a tag signal supplied to the edge detection unit for detecting the trailing edge of the tag signal after a leading edge of the tag signal has passed. The edge detection unit having a leading edge detector, a trailing edge detector, a storage element, and logic gate circuits. A timing unit is included operating in response to the output of the edge detection unit for counting a predetermined time, along with a discrimination storage unit operating in response to the output of the timing unit for delivering an output indicating an interlock data transfer or an output indicating a data streaming feature data transfer.
摘要翻译：具有用于识别输入/输出通道设备和用于计算机的I / O设备之间的数据传输类型的传送鉴别电路的数据传送系统包括传送鉴别电路。该电路包括边缘检测单元，其响应于提供给边缘检测单元的标签信号而工作，用于在标签信号的前沿通过之后检测标签信号的后沿。边缘检测单元具有前沿检测器，后沿检测器，存储元件和逻辑门电路。包括响应于用于计数预定时间的边缘检测单元的输出而操作的定时单元以及响应于用于传送指示互锁数据传送或输出的输出的定时单元的输出而操作的鉴别存储单元指示数据流特征数据传输。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式