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1. 发明申请

US20070142480A1 Alleviation of pain in osteoarthritis by means of intra-articular implantation of perfluorodecalin. 审中-公开
标题翻译：通过关节内植入全氟萘烷来减轻骨关节炎疼痛。
公开(公告)号：US20070142480A1
公开(公告)日：2007-06-21
申请号：US11306155
申请日：2005-12-18
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： A61K31/025
CPC分类号： A61K31/025
摘要： Methods of alleviating pain by the intra-articular application of perfluorodecalin are disclosed.
摘要翻译：公开了通过关节内应用全氟萘烷缓解疼痛的方法。

2. 发明申请

US20050013871A1 Pharmaceutical composition for the treatment of itch 审中-公开
标题翻译：用于治疗瘙痒的药物组合物
公开(公告)号：US20050013871A1
公开(公告)日：2005-01-20
申请号：US10604424
申请日：2003-07-20
申请人： Sarfaraz Niazi , Anjum Niazi
发明人： Sarfaraz Niazi , Anjum Niazi
IPC分类号： A61K9/00 , A61K31/19 , A61K31/575 , A61K35/64 , A61K35/644 , A61K36/33 , A61K36/63 , A61K47/12 , A61K47/44 , A61K35/78
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/575 , A61K35/644 , A61K36/33 , A61K36/63 , A61K47/12 , A61K47/44 , A61K2300/00
摘要： Disclosed is a topical preparation for the treatment of topical itch in humans and animals. The said composition consists of Opuntia, Propolis, Stearic Acid, Beeswax, Vegetable Oil and β-sitosterol. Itch includes scratch reaction itch, anal itch, or irritant itch due to plants (e.g., poison ivy), insect bite, sunburn, chemical itch, eczema, pruritis dermatitis, diabetic skin itch, aging skin itch, foot-itch, chickenpox, jock itch, hives, itch of healing burns and wounds, dry winter skin itch, and stress-related scalp itch, etc
摘要翻译：公开了用于治疗人和动物的局部瘙痒的局部制剂。所述组合物由仙妮丹，蜂胶，硬脂酸，蜂蜡，植物油和β-谷甾醇组成。瘙痒包括刮擦反应瘙痒，肛门瘙痒或由于植物（例如毒藤）引起的刺激性瘙痒，昆虫咬伤，晒伤，化学瘙痒，湿疹，瘙痒性皮炎，糖尿病皮肤瘙痒，老化皮肤瘙痒，脚痒，水痘，瘙痒，荨麻疹，愈合灼伤和伤口，干燥冬季皮肤瘙痒和压力相关的头皮瘙痒等

3. 发明授权

US4530936A Composition and method for inhibiting the absorption of nutritional elements from the upper intestinal tract 失效
标题翻译：用于抑制营养元素从上肠道吸收的组合物和方法
公开(公告)号：US4530936A
公开(公告)日：1985-07-23
申请号：US512193
申请日：1983-07-08
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： A61K9/107 , A61K31/025
CPC分类号： A61K31/025 , A61K9/107 , Y10S514/909
摘要： A method of inhibiting the absorption of nutritional elements, principally food, from the gastrointesinal tract is disclosed which comprises ingesting perfluorodecalin in an amount sufficient to form a nutritional element-impermeable film thereof on at least a substantial part of the inner wall of the upper intestine and maintaining the film for a time long enough to inhibit the absorption from the gastrointestinal tract of a significant proportion of the ingested nutritional elements. An emulsion dosage form is preferred for carrying out this method, which emulsion contains perfluorodecalin, water, and a non-toxic emulsifier, preferably Pluronic F-68, and optionally flavoring and/or coloring agents.
摘要翻译：公开了一种抑制营养元素（主要是食物）从胃肠道吸收的方法，其包括以足以在至少大部分上肠内壁上形成营养元件不渗透膜的量摄取全氟萘烷并且将膜保持足够长的时间以抑制大部分摄取的营养元件从胃肠道的吸收。乳液剂型优选用于实施该方法，该乳液含有全氟萘烷，水和无毒乳化剂，优选Pluronic F-68，以及任选的调味剂和/或着色剂。

4. 发明授权

US08852435B2 Purification and separation treatment assembly (PASTA) for biological products 有权
标题翻译：用于生物制品的纯化和分离处理组件（PASTA）
公开(公告)号：US08852435B2
公开(公告)日：2014-10-07
申请号：US13286193
申请日：2011-11-29
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： B01D15/08 , B01D15/22 , C12M1/12 , C07K1/16 , C07K1/22
CPC分类号： B01D15/22 , C07K1/16 , C07K1/22
摘要： An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.
摘要翻译：公开了一种能够在生物反应循环期间或结束时捕获和纯化表达的生物产物的组合物，其中将粘合树脂与生物反应器的内容物保持分离，从而允许在生物反应器中捕获，收获和纯化生物产物; 本发明另外提供了去除不需要的代谢产物以及提供色谱柱的有效负载的方法。

5. 发明授权

US09101857B2 Gas scrubbed perfusion filter 有权
标题翻译：气体洗刷灌注过滤器
公开(公告)号：US09101857B2
公开(公告)日：2015-08-11
申请号：US13093859
申请日：2011-04-26
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： B01D29/64 , C12M1/12 , C12M1/04 , B01D29/11 , A01N1/02 , C12M1/00
CPC分类号： C12N1/20 , A01N1/0247 , B01D29/114 , B01D29/15 , B01D29/64 , B01D29/66 , C07K1/34 , C07K14/505 , C12M21/00 , C12M23/26 , C12M29/04 , C12M29/10 , C12M47/02 , C12M47/10
摘要： Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters.
摘要翻译：采用以较快速度行进的细小气泡用于擦洗硬表面过滤器，以连续地连续地从包括由营养介质和细胞培养物组成的悬浮液中收集液体而不堵塞过滤器。

6. 发明授权

US08668886B2 Separative bioreactor 有权
标题翻译：分离生物反应器
公开(公告)号：US08668886B2
公开(公告)日：2014-03-11
申请号：US13092955
申请日：2011-04-24
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： B01J3/00
CPC分类号： F24F7/06 , C12M23/14 , C12M25/14 , C12M27/16 , C12M29/06 , C12M41/32 , C12M47/10 , C12Q3/00 , Y10T137/0318
摘要： A bioreactor that combines the steps of recombinant expression and separation of a biological product by binding the secreted biological product with a resin, discarding the nutrient medium and eluting the biological product as a concentrated solution, eliminating the steps of sterile filtration and volume reduction. The method also allows loading of resin for column-purification, eliminating all steps of perfusion process and maintaining a sink condition of a toxic product in nutrient medium to optimize productivity of host cells. The instant invention also allows harvesting of solubilized inclusion bodies after the cells have been lysed and refolding of proteins inside the bioreactor.
摘要翻译：一种生物反应器，其通过将分泌的生物产物与树脂结合来重组表达和分离生物产物的步骤，丢弃营养培养基并以生物产物作为浓缩溶液洗脱，消除了无菌过滤和体积减少的步骤。该方法还允许加载用于柱纯化的树脂，消除灌注过程的所有步骤并保持营养培养基中有毒产物的沉淀条件以优化宿主细胞的生产力。本发明还允许在细胞已经裂解并在生物反应器内重新折叠蛋白质之前收获溶解的包涵体。

7. 发明授权

US4639368A Chewing gum containing a medicament and taste maskers 失效
标题翻译：含有药物和口罩的口香糖
公开(公告)号：US4639368A
公开(公告)日：1987-01-27
申请号：US741871
申请日：1985-06-06
申请人： Sarfaraz Niazi , Alvin Shemesh
发明人： Sarfaraz Niazi , Alvin Shemesh
IPC分类号： A61K9/68
CPC分类号： A61K9/0058
摘要： A chewing gum composition adapted to supply a medicament to the oral cavity for local application thereto or for buccal absorption of said medicament which comprises a chewing gum base, an orally administrable medicament, a taste masking generator of carbon dioxide and optionally a taste bud desensitizing composition.
摘要翻译：一种咀嚼型胶基糖组合物，其适于向所述口腔提供药物以局部施用于所述药物或用于所述药物的口腔吸收，所述药物包含口香糖基料，可口服给药的药物，二氧化碳的味道掩蔽产生剂和任选的味蕾脱敏组合物。

8. 发明授权

US09005959B2 Bioreactor exhaust 有权
标题翻译：生物反应器排气
公开(公告)号：US09005959B2
公开(公告)日：2015-04-14
申请号：US13098462
申请日：2011-05-01
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： A01N1/00 , A01N1/02 , C12M1/00 , C12M1/34
CPC分类号： C12M29/20 , C12M23/26 , C12M23/28 , C12M41/40 , Y10T137/0379 , Y10T137/6416
摘要： An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high aeration.
摘要翻译：描述了适用于来自柔性一次性袋的高体积排气的排气系统，其防止营养物质体积损失并防止不使用任何过滤器的交叉污染。这里描述的发明允许使用一次性二维生物反应器来培养细菌和其他生物体，细胞需要高通风。

9. 发明授权

US08932843B2 Buoyant protein harvesting method 有权
标题翻译：浮游蛋白收获方法
公开(公告)号：US08932843B2
公开(公告)日：2015-01-13
申请号：US13245448
申请日：2011-09-26
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： C12N1/00 , C07K1/14 , B01J20/28 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , B01D15/22
CPC分类号： C12M47/10 , B01D15/22 , B01J20/2805 , C07K1/14 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22
摘要： A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.
摘要翻译：含有色谱介质的漂浮装置具有蛋白质收集功能，取代了细胞分离和体积减少的步骤; 该装置可以装入柱中用于进一步净化。

10. 发明授权

US08685245B2 Concentrator filter 有权
标题翻译：集中器过滤器
公开(公告)号：US08685245B2
公开(公告)日：2014-04-01
申请号：US13149856
申请日：2011-05-31
申请人： Sarfaraz Niazi
发明人： Sarfaraz Niazi
IPC分类号： B01D29/54 , B01D29/62 , B01D35/00
CPC分类号： C12N1/20 , A01N1/0247 , B01D29/114 , B01D29/15 , B01D29/64 , B01D29/66 , C07K1/34 , C07K14/505 , C12M21/00 , C12M23/26 , C12M29/04 , C12M29/10 , C12M47/02 , C12M47/10
摘要： A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.
摘要翻译：用于从液体中分离悬浮物的方法和装置包括：浓缩器过滤器，其将液体从悬浮液中抽出，同时过滤器通过鼓泡过滤器保持开启状态，该喷射过滤器允许通过气泡洗涤聚光过滤器。本发明可用于替代生物过程工业中的交叉流过滤和离心，并减少悬浮液的体积以将最终产物的产率集中在化学工业中。

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