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1. 发明申请

US20090209623A1 Anti-sense nucleic acid derived from organism 审中-公开
标题翻译：来自生物体的反义核酸
公开(公告)号：US20090209623A1
公开(公告)日：2009-08-20
申请号：US11989301
申请日：2006-07-24
申请人： Jon Tomono , Souichi Morikawa , Takahisa Nakai
发明人： Jon Tomono , Souichi Morikawa , Takahisa Nakai
IPC分类号： A61K31/7088 , C07H21/04 , A61K48/00
CPC分类号： A61K8/606 , A61K31/7088 , A61K48/00 , A61Q5/00 , A61Q19/02 , A61Q19/08 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2330/30
摘要： Disclosed are: a method for producing an anti-sense nucleic acid which has a wide variation in nucleotide sequences and excellent anti-sense properties at a low cost in a simple manner and in a large scale; and a cosmetic composition or pharmaceutical composition comprising the anti-sense nucleic acid. A method is discovered which can produce a low molecular weight nucleic acid having anti-sense properties from a nucleic acid starting material derived from an organism at a high yield by using a probe nucleic acid having at least a part of the nucleotide sequence of a target gene. An anti-sense nucleic acid produced by using a nucleic acid derived from an organism as a starting material; and a method for producing the anti-sense nucleic acid.
摘要翻译：本发明公开了以简单的方式和大规模生产具有较低成本的核苷酸序列变异性和抗反应性优异的反义核酸的方法。以及包含所述反义核酸的化妆品组合物或药物组合物。通过使用具有目标的核苷酸序列的至少一部分的探针核酸，发现能够以高产率从来自生物体的核酸起始物质产生具有反义性的低分子量核酸的方法基因。通过使用来自生物体的核酸作为起始原料而产生的反义核酸; 和反义核酸的制造方法。

2. 发明授权

US07906618B2 Peptide capable of binding to insulin-binding protein and adsorbent 有权
标题翻译：能结合胰岛素结合蛋白和吸附剂的肽
公开(公告)号：US07906618B2
公开(公告)日：2011-03-15
申请号：US11573834
申请日：2005-08-09
申请人： Ai Yonezawa , Souichi Morikawa , Eiji Ogino
发明人： Ai Yonezawa , Souichi Morikawa , Eiji Ogino
IPC分类号： A61K38/00 , A61K51/00
CPC分类号： C07K14/62 , A61K47/585 , A61K47/6957 , C07K7/06
摘要： The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber.The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.
摘要翻译：本发明涉及能够结合能够结合胰岛素（IBP）的蛋白质的肽，包含上述固定在载体上的肽的吸附剂，包含上述吸附剂的吸附剂，以及使用上述吸附剂吸附IBP的方法上述吸附剂或吸附剂。本发明提供的肽，吸附剂，吸附剂和方法可以有效吸附和去除IBP，因此可用于例如治疗这种IBP作为加重因素的疾病，通常为糖尿病。

3. 发明授权

US07794993B2 Carbonyl reductase, gene thereof and method of using the same 有权
标题翻译：羰基还原酶，其基因及其使用方法
公开(公告)号：US07794993B2
公开(公告)日：2010-09-14
申请号：US11659481
申请日：2005-08-01
申请人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
发明人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
IPC分类号： C07H21/00 , C12N15/00 , C12N5/10 , C12N1/21 , C12P7/16 , C12P21/00 , C12N9/02 , C07K14/00
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant. Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称还原（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

4. 发明授权

US06613780B2 Heat shock factor activity inhibitor 失效
标题翻译：热休克因子活性抑制剂
公开(公告)号：US06613780B2
公开(公告)日：2003-09-02
申请号：US09939901
申请日：2001-08-27
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： A61K31445
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

5. 发明授权

US06184255B2 Pharmaceutical composition comprising coenzyme Q10 有权
标题翻译：包含辅酶Q10的药物组合物
公开(公告)号：US06184255B2
公开(公告)日：2001-02-06
申请号：US09242327
申请日：1999-05-26
申请人： Tatsumasa Mae , Yoshitomo Sakamoto , Souichi Morikawa , Takayoshi Hidaka
发明人： Tatsumasa Mae , Yoshitomo Sakamoto , Souichi Morikawa , Takayoshi Hidaka
IPC分类号： A61K31075
CPC分类号： A61K31/122 , Y10S514/824 , Y10S514/878 , Y10S514/879
摘要： The present invention has for its object to provide a medicinal composition comprising coenzyme Q10 as an active ingredient, which composition features an enhanced absorption after oral administration. The present invention is directed to a medicinal composition comprising coenzyme Q10 as an active ingredient with the reduced form of coenzyme Q10 accounting for more than 20 weight % of said coenzyme Q10.
摘要翻译：本发明的目的是提供一种包含辅酶Q10作为活性成分的药物组合物，该组合物在口服给药后具有增强的吸收。本发明涉及一种药用组合物，其包含辅酶Q10作为活性成分，还原形式的辅酶Q10占所述辅酶Q10的20重量％以上。

6. 发明授权

US07915022B2 Carbonyl reductase, gene thereof and method of using the same 有权
标题翻译：羰基还原酶，其基因及其使用方法
公开(公告)号：US07915022B2
公开(公告)日：2011-03-29
申请号：US12840026
申请日：2010-07-20
申请人： Noriyuki Kizaki , Miho Yano , Masashiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
发明人： Noriyuki Kizaki , Miho Yano , Masashiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
IPC分类号： C12N9/02 , C07K14/00 , C12P21/00 , C12P7/16 , C12P7/02 , C12Q1/26
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant.Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称降低（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

7. 发明申请

US20080132679A1 Peptide Capable Of Binding To Insulin-Binding Protein And Adsorbent 有权
标题翻译：能与胰岛素结合蛋白和吸附剂结合的肽
公开(公告)号：US20080132679A1
公开(公告)日：2008-06-05
申请号：US11573834
申请日：2005-08-09
申请人： Ai Yonezawa , Souichi Morikawa , Eiji Ogino
发明人： Ai Yonezawa , Souichi Morikawa , Eiji Ogino
IPC分类号： C07K4/12 , B01D15/26 , B01J20/24 , C07K1/14
CPC分类号： C07K14/62 , A61K47/585 , A61K47/6957 , C07K7/06
摘要： The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber.The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.
摘要翻译：本发明涉及能够结合能够结合胰岛素（IBP）的蛋白质的肽，包含上述固定在载体上的肽的吸附剂，包含上述吸附剂的吸附剂，以及使用上述吸附剂吸附IBP的方法上述吸附剂或吸附剂。本发明提供的肽，吸附剂，吸附剂和方法可以有效吸附和去除IBP，因此可用于例如治疗这种IBP作为加重因素的疾病，通常为糖尿病。

8. 发明授权

US06903116B2 Methods of treating cancer using a heat shock factor activity inhibitor 失效
标题翻译：使用热休克因子活性抑制剂治疗癌症的方法
公开(公告)号：US06903116B2
公开(公告)日：2005-06-07
申请号：US10339063
申请日：2003-01-09
申请人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
发明人： Shin-ichi Yokota , Kozo Yamamoto , Souichi Morikawa , Yoshihide Fuse , Mikio Kitahara
IPC分类号： C07D405/06 , A61K31/445 , A61K31/40
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译：通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。

9. 发明申请

US20100317075A1 Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same 有权
标题翻译：新型羰基还原酶，其基因及其使用方法
公开(公告)号：US20100317075A1
公开(公告)日：2010-12-16
申请号：US12840026
申请日：2010-07-20
申请人： NORIYUKI KIZAKI , MIHO YANO , MASAHIRO FUNAKI , TERUAKI TAKESUE , YOSHIHIKO YASOHARA , SOUICHI MORIKAWA , TAKAHISA NAKAI , MICHIHIKO KATAOKA , SAKAYU SHIMIZU
发明人： NORIYUKI KIZAKI , MIHO YANO , MASAHIRO FUNAKI , TERUAKI TAKESUE , YOSHIHIKO YASOHARA , SOUICHI MORIKAWA , TAKAHISA NAKAI , MICHIHIKO KATAOKA , SAKAYU SHIMIZU
IPC分类号： C12P7/22 , C07H21/04 , C12N9/02 , C12N15/63 , C12N1/21 , C12P7/02
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant.Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称还原（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

10. 发明申请

US20080261281A1 Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same 有权
标题翻译：新型羰基还原酶，其基因及其使用方法
公开(公告)号：US20080261281A1
公开(公告)日：2008-10-23
申请号：US11659481
申请日：2005-08-01
申请人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
发明人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
IPC分类号： C12N9/14 , C12N15/52 , C12N1/21 , C12P13/02
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant.Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称还原（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

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