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1. 发明授权

US10182967B2 Plug and bodily fluid-collecting instrument set 有权
公开(公告)号：US10182967B2
公开(公告)日：2019-01-22
申请号：US13502479
申请日：2011-01-27
申请人： Masatoshi Niunoya , Ryusuke Okamoto
发明人： Masatoshi Niunoya , Ryusuke Okamoto
IPC分类号： A61B5/15 , B65D41/02 , A61J1/14 , B65D51/00 , A61B5/154 , A61J1/20
摘要： A plug that allows the plug body to be easily and reliably pierced through by a hollow bodily fluid collection needle, makes the bodily fluid collection needle difficult to draw back out of the plug body owing to a resilience of a sheath after the start of bodily fluid collection, and enables easy and reliable collection of the bodily fluid. The plug 1 is a plug for closing an opening end of a bodily fluid-collecting container 14 which is to be inserted into a tubular holder 11, and includes: a plug body 2 to be fixed to the opening end of the bodily fluid-collecting container 14; and a cover member 3 sheathed on the plug body 2 to cover an outer surface of the plug body 2, wherein the cover member 3 includes a side part 3c covering the outer surface of the plug body 2, and an outer surface of the side part 3c is provided with a protrusion 3k which protrudes radially outward of the side part 3c of the cover member 3 to come into contact with and give frictional resistance to an inner wall of the holder 11 upon insertion into the holder 11.

2. 发明授权

US08586323B2 Blood coagulation promoter and blood collection tube comprising a polyoxyalkylene glycerin derivative 有权
标题翻译：含有聚氧化烯甘油衍生物的凝血促进剂和采血管
公开(公告)号：US08586323B2
公开(公告)日：2013-11-19
申请号：US10548541
申请日：2004-04-21
申请人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
发明人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
IPC分类号： C12Q1/56 , G01N33/86
CPC分类号： C08L71/02 , A61B5/15003 , A61B5/150755 , A61B5/154 , B01L3/5082 , C08L2666/04
摘要： The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability; and a blood collection tube accommodating the blood coagulation promoter.The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.
摘要翻译：本发明提供能够发挥优异的凝血促进能力和优异的血块分离能力的凝血促进剂; 以及容纳血液凝固促进剂的采血管。本发明提供一种凝血促进剂，其包含难溶于水的聚氧化烯衍生物; 部分皂化聚乙烯醇; 选自吸附性无机物质和能够水解Arg和任意氨基酸之间的键的水解物中的至少一种物质存在于肽链中Lys和任意氨基酸残基之间的和/或之间的键; 聚乙烯吡咯烷酮优选水溶性硅油，以及血液收集管，其中所述血液凝固促进剂容纳在具有底部的管状容器中。

3. 外观设计

USD688796S1 Cap for a blood collection tube 有权
标题翻译：盖上采血管
公开(公告)号：USD688796S1
公开(公告)日：2013-08-27
申请号：US29403130
申请日：2011-09-30
申请人： Masatoshi Niunoya , Ryusuke Okamoto
设计人： Masatoshi Niunoya , Ryusuke Okamoto

4. 发明申请

US20080262385A1 Backflow Preventing Structure of a Blood Sampler, Luer Adapter, Blood Sampling Needle and Blood Sampling Holder 审中-公开
标题翻译：回流防止血液取样器，鲁尔适配器，血液取样针和血液取样架的结构
公开(公告)号：US20080262385A1
公开(公告)日：2008-10-23
申请号：US11596214
申请日：2005-05-16
申请人： Masahiro Nakaizumi , Ryusuke Okamoto
发明人： Masahiro Nakaizumi , Ryusuke Okamoto
IPC分类号： A61B5/153
CPC分类号： A61B5/154 , A61B5/15003 , A61B5/150221 , A61B5/150351 , A61B5/150389 , A61B5/150496 , A61B5/150572 , A61B5/150732
摘要： A backflow preventing structure of a blood sampler capable of preventing backflow of blood positively without causing a significant increase in the number of components and cost. The backflow preventing structure of a blood sampler comprises a hub (3) as a tubular body having an internal channel (3a) extending from a first end part (3b) toward the second end part (3c) side, and a bottomed tubular backflow preventing member (6) which is composed of a material having rubber elasticity and contained in the internal channel (3a), has an opening opened toward the first end part (3b), and is closed on the second end part (3c) side. Outer circumferential wall of the backflow preventing member (6) is secured liquidtightly to the inner wall of the internal channel (3a), and a cut (6c) is made in the backflow preventing member (6) at a part closer to the second end part side than the secured part.
摘要翻译：能够防止血液回流的血液取样器的回流防止结构，而不会导致部件数量的显着增加和成本。血液采样器的防回流结构包括作为管状体的轮毂（3），其具有从第一端部（3b）朝向第二端部（3c）侧延伸的内部通道（3a），底部由具有橡胶弹性并容纳在内部通道（3a）中的材料构成的管状防回流部件（6）具有朝向第一端部（3b）开口的开口，并且在第二端部（ 3 c）侧。防回流部件（6）的外周壁被液密地固定在内部通道（3a）的内壁上，并且在防逆流部件（6）的靠近第二端部侧比固定部分。

5. 发明授权

US09028688B2 Instrument for separating blood and apparatus for separating blood 有权
标题翻译：用于分离血液的仪器和用于分离血液的装置
公开(公告)号：US09028688B2
公开(公告)日：2015-05-12
申请号：US11994055
申请日：2006-06-26
申请人： Ryusuke Okamoto , Katsuya Togawa
发明人： Ryusuke Okamoto , Katsuya Togawa
IPC分类号： B01D29/00 , B01L3/00 , G01N33/49
CPC分类号： B01L3/5635 , B01L2300/0681 , G01N33/491
摘要： Blood separation material which separates blood collected in a blood-sampling container, into blood cells and plasma or serum within a short period of time. An apparatus for separating blood with the blood separation material. An instrument for separating blood having a first hollow needle extending toward one end, a second hollow needle extending toward the other end, a tubular container with an inner space in which the blood flows, and a blood separation material. A container with a first channel for supplying blood into an inner space through which blood flows from the needlepoint of the first hollow needle into the inner space, a second channel for blood to flow out from the inner space toward the needlepoint of the second hollow needle, and a third channel which allows air to flow from the outer space toward the needlepoint of the first hollow needle.
摘要翻译：将在血液取样容器中收集的血液在短时间内分离成血细胞和血浆或血清的血液分离材料。一种用血液分离材料分离血液的装置。一种用于分离具有朝向一端延伸的第一中空针的血液的仪器，朝向另一端延伸的第二空心针，具有血液流过的内部空间的管状容器和血液分离材料。一种具有第一通道的容器，用于将血液供应到内部空间中，血液从第一中空针的针尖流到内部空间，血液从内部空间朝向第二中空针的针尖流出的第二通道以及第三通道，其允许空气从外部空间朝向第一中空针的针尖流动。

6. 发明申请

US20110144536A1 BLOOD COLLECTION CONTAINER 有权
标题翻译：血液收集容器
公开(公告)号：US20110144536A1
公开(公告)日：2011-06-16
申请号：US13033120
申请日：2011-02-23
申请人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
发明人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
IPC分类号： A61B5/15
CPC分类号： A61B5/150755 , A61B5/15003 , A61B5/150351 , A61B5/154 , B01L3/5082 , B01L2300/163
摘要： The present invention provides a blood collection container capable of allowing blood to coagulate in a short time and preventing blood from coagulating with bubbles contained therein and thus preventing formation of bubbly clots when used to collect blood therein. A blood collection container 1 stores a blood coagulation promoting agent 4 for promoting blood coagulation and an antifoaming agent 5, which is a polyoxyalkylene or a derivative thereof. The amount of the antifoaming agent 5 is 2.0×10−3 to 0.2 mg per mL of blood to be collected in the blood collection container 1.
摘要翻译：本发明提供一种采血容器，其能够使血液在短时间内凝结，并且防止血液凝结，其中含有气泡，从而防止在用于在其中收集血液时形成气泡凝块。采集容器1存储促凝血用促凝剂4和作为聚氧化烯或其衍生物的消泡剂5。消肿剂5的量在采血容器1中收集的每毫升血液量为2.0×10-3〜0.2mg。

7. 发明授权

US07927810B2 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
标题翻译：血浆或血清分离膜和包括血浆或血清分离膜的过滤装置
公开(公告)号：US07927810B2
公开(公告)日：2011-04-19
申请号：US10533539
申请日：2003-11-18
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.
摘要翻译：能够省略离心分离的血浆或血清分离膜不会因红细胞破坏引起溶血，并能实现血液或血清从血液中的轻松快速分离; 以及包括血浆或血清分离膜的过滤装置。特别地，血浆或血清分离膜是用于从血液中分离血浆或血清并具有30％或更低的空隙率的膜; 以及过滤器装置，其包括能够获得比等离子体更快速移动的过滤器构件，以及与过滤构件的后侧串联连接的血浆或血清分离膜。

8. 发明申请

US20090050553A1 INSTRUMENT FOR SEPARATING BLOOD AND APPARATUS FOR SEPARATING BLOOD 有权
标题翻译：用于分离血液的仪器和用于分离血液的装置
公开(公告)号：US20090050553A1
公开(公告)日：2009-02-26
申请号：US11994055
申请日：2006-06-26
申请人： Ryusuke Okamoto , Katsuya Togawa
发明人： Ryusuke Okamoto , Katsuya Togawa
IPC分类号： G01N33/48 , B01D29/00
CPC分类号： B01L3/5635 , B01L2300/0681 , G01N33/491
摘要： It is intended to provide a material by which blood having been collected into a blood-sampling container can be conveniently separated into blood cells and the plasma or the serum within a short period of time, and an apparatus for separating blood which is provided with this blood separation material. An instrument (1) for separating blood having a first hollow needle (3) extending toward one end, a second hollow needle (4) extending toward the other end, a tubular container (2) having an inner space (2A) in which the blood flows and a blood separation material (9) for separating the blood into blood cells and the plasma or the serum, wherein the container (2) has a first channel (5) for supplying the blood into the inner space (2A) through which the blood flows from the needlepoint (3a) of the first hollow needle (3) into the inner space (2A), a second channel (6) for flowing out the blood from the inner space (2A) through which the blood flows from the inner space (2A) toward the needlepoint (4a) of the second hollow needle (4), and a third channel (7) which allows the air to flow from the outer space toward the needlepoint (3a) of the first hollow needle (3).
摘要翻译：本发明提供一种能够将收集在血液取样容器中的血液在短时间内容易地分离成血细胞和血浆或血清的材料，以及具有该血液的血液分离装置血液分离材料。 1.一种用于分离具有朝向一端延伸的第一中空针（3）的血液的仪器（1），朝向另一端延伸的第二中空针（4），具有内部空间（2A）的管状容器（2）血液流通和用于将血液分离成血细胞和血浆或血清的血液分离材料（9），其中容器（2）具有用于将血液供应到内部空间（2A）中的第一通道（5），通过该第一通道血液从第一中空针（3）的针尖（3a）流入内部空间（2A），从血液从血液流过的内部空间（2A）流出血液的第二通道（6）内部空间（2A）朝向第二中空针（4）的针尖（4a）;以及第三通道（7），其允许空气从外部空间朝向第一空心针（3）的针尖（3a）流动）。

9. 发明申请

US20070105156A1 Plasma or serum separation membrane and filter apparatus including the plasma of serum separation membrane 有权
标题翻译：血浆或血清分离膜和包括血浆分离膜血浆的过滤装置
公开(公告)号：US20070105156A1
公开(公告)日：2007-05-10
申请号：US11635240
申请日：2006-12-07
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： C12M1/34 , G01N33/53
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.
摘要翻译：能够省略离心分离的血浆或血清分离膜不会因红细胞破坏引起溶血，并能实现血液或血清从血液中的轻松快速分离; 以及包括血浆或血清分离膜的过滤装置。特别地，血浆或血清分离膜是用于从血液中分离血浆或血清并具有30％或更低的空隙率的膜; 以及过滤器装置，其包括能够获得比等离子体更快速移动的过滤器构件，以及与过滤构件的后侧串联连接的血浆或血清分离膜。

10. 发明授权

US07090970B2 Composition for blood serum or plasma separation and vessel for blood examination containing the same 有权
标题翻译：用于血清或血浆分离的组合物和含有该血清的血液检查血管
公开(公告)号：US07090970B2
公开(公告)日：2006-08-15
申请号：US10475807
申请日：2002-12-03
申请人： Hideo Anraku , Ryusuke Okamoto
发明人： Hideo Anraku , Ryusuke Okamoto
IPC分类号： A01N1/02 , C09K3/00 , G01N33/48 , B01D21/26
CPC分类号： G01N33/5002 , B01L3/50215 , B01L2300/12
摘要： A composition for blood serum or plasma separation which has improved compatibility between a cyclopentadiene oligomer and a phthalic ester and generates no oily ingredient suspending in the blood serum or plasma after centrifugal separation regardless of the conditions for the centrifugal separation; and a vessel for blood examination which contains the composition. The composition for blood serum or plasma separation comprises: a polycyclic hydrocarbon compound having an unsaturated and/or saturated cyclic structure in the molecule and having a solidifying point or pour point of 0° C. or lower; a cyclopentadiene oligomer; and a phthalic ester.
摘要翻译：一种用于血清或血浆分离的组合物，其具有改善环戊二烯低聚物和邻苯二甲酸酯之间的相容性，并且在离心分离后不产生悬浮在血清或血浆中的油性成分，而与离心分离条件无关; 和含有该组合物的血液检查用血管。用于血清或血浆分离的组合物包括：分子中具有不饱和和/或饱和环状结构并具有0℃或更低的凝固点或倾点的多环烃化合物; 环戊二烯低聚物; 和邻苯二甲酸酯。

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