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    • 4. 发明申请
    • Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof
    • 绑定氧固醇结合蛋白的化合物及其使用方法
    • US20110319352A1
    • 2011-12-29
    • US13139196
    • 2009-12-11
    • Matthew D. ShairAnthony BurgettD. Ryan Anderson
    • Matthew D. ShairAnthony BurgettD. Ryan Anderson
    • A61K31/704A61K31/352A61P35/00A61P9/10A61P25/28A61K31/58A61K31/202
    • A61K31/498A61K31/56A61K31/569A61K31/7056
    • The invention relates in part to the discovery that certain CRAMs, such as schweinfurthin A, target OSBPs (a family of oxysterol binding proteins). Because OSBPs have been shown to be integral to atherosclerosis and Alzheimer's disease (AD), one aspect of the invention relates to the use of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, in the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to novel derivatives of CRAMs, or a pharmaceutically acceptable salt, biologically active metabolite, solvate, hydrate, prodrug, enantiomer or stereoisomer thereof, for the treatment and/or prevention of atherosclerosis, Alzheimer's disease and related disorders. Another aspect of the invention relates to the use of an immobilized CRAMs, such as OSW-I, to aid in screening of compounds to identify additional OSBP binders. Other aspects of the invention relate to the use of CRAMs to treat cancer, such as p21-deficient cancers.
    • 本发明部分地涉及某些CRAM,例如施赖福呋丁A,目标OSBP(氧固醇结合蛋白家族)的发现。 由于OSBPs已被证明与动脉粥样硬化和阿尔茨海默氏病(AD)是不可分割的,本发明的一个方面涉及CRAM或其药学上可接受的盐,生物活性代谢物,溶剂合物,水合物,前药,对映体或立体异构体的用途, 在治疗和/或预防动脉粥样硬化,阿尔茨海默病和相关疾病。 本发明的另一方面涉及用于治疗和/或预防动脉粥样硬化,阿尔茨海默病和相关疾病的CRAM或其药学上可接受的盐,生物活性代谢物,溶剂化物,水合物,前药,对映体或立体异构体的新衍生物。 本发明的另一方面涉及固定化CRAM(例如OSW-1)用于帮助筛选化合物以鉴定另外的OSBP结合物的用途。 本发明的其它方面涉及使用CRAM来治疗癌症,例如p21缺陷型癌症。
    • 10. 发明申请
    • Apparatus and method for displaying an item
    • 用于显示物品的装置和方法
    • US20070144050A1
    • 2007-06-28
    • US11407297
    • 2006-04-20
    • Steve JosephsonRyan Anderson
    • Steve JosephsonRyan Anderson
    • A47G1/16
    • A47G1/141A47G2001/0672B42D15/047B42D15/08
    • A display device, comprising a clear-front envelope formed by foldable blank including at least one backing flap folded around a viewing window and leaving an opening for receiving the planar displayed item, such as a photo; postcard; etc. The opening is at least partially closed when a sealing flap integrally formed with said foldable blank is secured to the backing flap. A support flap integral with the sealing flap, the support flap configured to fold at fold line adjacent to the backing flap and having an end for resting on a horizontal surface to support the clear-front envelope at a viewing angle to the horizontal surface. Optional hanging flaps and a hidden magnet may be used to hang or otherwise mount the display device.
    • 一种显示装置,包括由可折叠坯料形成的透明封套,该可折叠坯料包括折叠在观察窗周围的至少一个背板,并留下用于接收诸如照片的平面显示项目的开口; 明信片; 当与所述可折叠坯料一体形成的密封翼片固定到所述背板上时,所述开口至少部分地封闭。 与密封翼片一体的支撑翼片,支撑翼片构造成在靠近背板的折叠线处折叠并具有用于搁置在水平表面上的端部,以以与水平表面成视角的角度支撑透明封套。 可选的悬挂襟翼和隐藏的磁铁可能用于悬挂或以其他方式安装显示设备。