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1. 发明授权

US06299369B1 Dispenser 有权
标题翻译：分配器
公开(公告)号：US06299369B1
公开(公告)日：2001-10-09
申请号：US09684606
申请日：2000-10-06
申请人： Roger Anthony Baines , Martin Christopher Bunce , Robert David James , Russell Jones
发明人： Roger Anthony Baines , Martin Christopher Bunce , Robert David James , Russell Jones
IPC分类号： A45D4004
CPC分类号： A45D40/04
摘要： A dispenser for a solid or soft solid mass has a barrel, a piston within the barrel, and a mechanism for advancing the piston axially within the barrel including a rotor wheel. A boss having an inwardly tapered profile (tear drop) and a sump dimensioned to receive the boss seats the rotor wheel at a predetermined angular position relative to the barrel. The boss is preferably formed on the rotor wheel and the sump in the base of the barrel. The dispenser is provided with a pair of bosses and sumps, symmetrically arranged around the rotor wheel and barrel base.
摘要翻译：用于固体或软固体物料的分配器具有筒体，筒体内的活塞，以及用于在筒体内轴向推进活塞的机构，包括转子轮。具有向内锥形轮廓（撕裂）的凸台和尺寸适于接纳凸台的油槽将转子轮相对于筒体定位在预定的角度位置。凸台优选地形成在转子轮和在筒的底部中的贮槽中。分配器设置有一对凸起和凹槽，对称地布置在转子轮和筒体的周围。

2. 发明授权

US06221397B1 Surface cross-linked particles suitable for controlled delivery 失效
标题翻译：表面交联颗粒适合受控输送
公开(公告)号：US06221397B1
公开(公告)日：2001-04-24
申请号：US09143118
申请日：1998-08-28
申请人： Gregory J. Russell-Jones , Scott M. Starling , John F. McEwan
发明人： Gregory J. Russell-Jones , Scott M. Starling , John F. McEwan
IPC分类号： A61K914
CPC分类号： A61K9/5161 , A61K9/5169 , C08B15/005 , C08L1/286 , C08L5/04 , C08L89/06 , C08L2666/02
摘要： Cross-linked particles are provided that are useful for delivery of pharmaceutical agents. The particles comprise at least one polymeric compound and a spacer compound, where the polymeric compound and the spacer each comprise reactive carboxyl, hydrazidyl, amino and/or thiol groups. The particles are cross-linked via covalent linkage of the reactive groups on the polymer and spacer respectively. Compositions comprising pharmaceutical agents contained within the particles are disclosed. Methods for preparing the particles, for encapsulating pharmaceutical agents within the particles, and for using the particles for controlled release of the pharmaceutical agent within the patient also are provided.
摘要翻译：提供可用于递送药剂的交联颗粒。颗粒包含至少一种聚合化合物和间隔化合物，其中聚合化合物和间隔物各自包含反应性羧基，肼基，氨基和/或硫醇基团。颗粒通过聚合物和间隔物上的反应性基团的共价连接分别交联。公开了包含颗粒内的药剂的组合物。还提供了用于制备颗粒的方法，用于将药剂包封在颗粒内，并且用于使用颗粒来控制药物在患者体内的释放。

3. 发明授权

US5548064A Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions 失效
标题翻译：维生素B12与EPO的缀合物，其类似物和药物组合物
公开(公告)号：US5548064A
公开(公告)日：1996-08-20
申请号：US64873
申请日：1993-05-24
申请人： Gregory J. Russell-Jones , Steven W. Westwood
发明人： Gregory J. Russell-Jones , Steven W. Westwood
IPC分类号： A61K31/714 , A61K38/00 , A61K47/48 , C07K1/113 , C07K14/505 , C07K14/535 , C07K17/02 , C07K17/08 , C07K17/10 , C07H23/00 , C07K2/00
CPC分类号： A61K47/48169 , A61K47/48023 , A61K47/48176 , C07K14/505 , C07K14/535 , C07K17/02 , A61K38/00
摘要： The invention describes complexes between VB.sub.12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB.sub.12 portion of the complex and significant bioactivity of the GCSF or EPO portion of the complex. The invention also concerns a process for the synthesis of these complexes. This is achieved at least in part, by using a spacer compound, which is linked covalantly between the VB.sub.12 portion and the GCSF or EPO. The complexes preferably have the formulaV--X--A--Y--ZwhereinV is vitamin B.sub.12 or a vitamin B.sub.12 analogue, or derivative, bonded to X either through a carboxylate group pendant to the corrin nucleus of VB.sub.12 or through the central cobalt atom or to a functional group introduced onto the VB.sub.12 molecule, X is selected from: --NHNH--, --NH--, --O--, --S--, --SS--or --CH.sub.2 --, and A is an optionally substituted, saturated or unsaturated, branched or linear, C.sub.1-50 alkylene, cycloalkylene or aromatic group, optionally with one or more carbons within the linear chain being replaced with N, O or S, and wherein the optional substituents are selected from carbonyl, carboxy, hydroxy, amino and other groups, and Y is the covalent linkage between A and Z where Y is selected from --NHCO--, --CONH--, --CONHNHCO--, --N.dbd.N--, --N.dbd.CH--, --NHCH.sub.2 --, --NHN.dbd.CH--, --NHNHCH.sub.2 --, --SS--, --SCH.sub.2 --, --CH.sub.2 S--, --NHCRNH--, --COO--, --OCO--, and R is O, S or NH.sub.2, and Z is GCSF or EPO. The invention also describes reagents that can be used as probes for the detection of buried thiol groups of a protein or peptide, said reagent comprising a complex of either vitamin B.sub.12 (or an analogue thereof) or more generally of any instrumentally or visually detectable label, covalently linked to a diradical spacer, said spacer having a terminal reactive group capable of forming a disulphide bond with a free thiol in said protein or peptides.
摘要翻译：本发明描述了VB12类似物和GCSF或EPO之间的复合物，其在复合物的VB12部分中保留对内在因子（IF）的显着亲和力，并且复合物的GCSF或EPO部分具有显着的生物活性。本发明还涉及合成这些络合物的方法。这通过使用在VB12部分和GCSF或EPO之间共价连接的间隔化合物至少部分地实现。络合物优选具有式V-XAY-Z，其中V是维生素B12或维生素B12类似物或衍生物，其通过悬浮于VB12的corrin核的羧酸酯基团或通过中心钴原子或引入的官能团在VB12分子上，X选自：-NHN - ， - NH - ， - O - ， - S - ， - S - 或-CH 2 - ，A是任选取代的饱和或不饱和的支链或直链C1 -50个亚烷基，亚环烷基或芳基，任选与一个或多个直链内的碳被N，O或S取代，其中任选的取代基选自羰基，羧基，羟基，氨基和其它基团，Y是其中Y选自-NHCO - ， - CONH - ， - CONHNHCO - ， - N = N - ， - N = CH - ， - NHCH 2 - ， - NHN = CH - ， - NHNHCH 2 - ， - -SS - ， - CH 2 - ， - CH 2 S - ， - NHCRNH-，-COO-，-OCO-，R是O，S或NH 2，Z是GCSF或EPO。本发明还描述了可用作检测蛋白质或肽的掩埋硫醇基团的探针的试剂，所述试剂包含维生素B12（或其类似物）或更通常的任何仪器上或视觉上可检测的标记物的复合物，共价连接到双基间隔物上，所述间隔物具有能与所述蛋白质或肽中的游离硫醇形成二硫键的末端反应基团。

4. 发明申请

US20150122849A1 AQUATIC EQUIPMENT-MOUNTING HEADGEAR 审中-公开
标题翻译：水电设备安装头
公开(公告)号：US20150122849A1
公开(公告)日：2015-05-07
申请号：US14070500
申请日：2013-11-02
申请人： Russell Jones
发明人： Russell Jones
IPC分类号： B63C11/02
CPC分类号： B63C11/02 , F16M13/04
摘要： A framework assembly for mounting accessories to the head of an underwater diver is disclosed. The assembly generally includes an equipment mounting rig connected by a post to a low-profile head-engaging base, wherein the base is adapted to fit snugly to the top part of a diver's head and under a diving hood such that the base is securely held in place by said diving hood. Waterproof equipment, including flashlights, cameras, and the like, may be mounted onto the rig.
摘要翻译：公开了一种用于将附件安装到水下潜水员的头部的框架组件。组件通常包括通过柱连接到低轮廓头部接合底座的设备安装台，其中基座适于紧贴地配合到潜水员头部的顶部并且在潜水罩下方，使得底座被牢固地保持潜水罩就位。防水设备，包括手电筒，照相机等可以安装在钻机上。

5. 发明申请

US20070243132A1 Transdermal delivery of pharmaceutical agents 审中-公开
标题翻译：透皮给药药剂
公开(公告)号：US20070243132A1
公开(公告)日：2007-10-18
申请号：US11645122
申请日：2006-12-22
申请人： Gregory Russell-Jones , Michael Luke , Stewart Himes
发明人： Gregory Russell-Jones , Michael Luke , Stewart Himes
IPC分类号： A61K51/12 , A61K31/56 , A61K31/60 , A61K31/7052 , A61K35/32 , A61K35/36 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/22 , A61K38/28 , A61K38/43 , A61K39/00 , A61K39/395
CPC分类号： A61K38/385 , A61K9/0014 , A61K9/1075 , A61K31/714 , A61K33/34 , A61K38/08 , A61K38/1793 , A61K38/1808 , A61K38/28 , A61K38/30 , A61K39/39 , A61K49/0041 , A61K49/0056 , A61K49/0082 , A61K51/122 , A61K2039/54 , A61K2039/55544 , A61K2039/55566 , Y02A50/484 , A61K2300/00
摘要： The present invention generally relates to a vehicle useful for delivering a pharmaceutically active compound including a genetic molecule or composition. More particularly, the present invention provides microemulsions for transdermal delivery of pharmaceutically active agents to a subject.
摘要翻译：本发明一般涉及可用于递送包含遗传分子或组合物的药物活性化合物的载体。更具体地，本发明提供了用于将药物活性剂透皮递送给受试者的微乳液。

6. 发明申请

US20060085831A1 System and method for vision-based security 审中-公开
标题翻译：基于视觉的安全系统和方法
公开(公告)号：US20060085831A1
公开(公告)日：2006-04-20
申请号：US11254295
申请日：2005-10-19
申请人： Russell Jones , Mark West , George Miller
发明人： Russell Jones , Mark West , George Miller
IPC分类号： H04N7/173 , H04N7/18
CPC分类号： G08B25/008 , G08B13/19656 , G08B13/19684 , G08B13/19697 , H04N7/181
摘要： A system and method for arming and disarming a network camera, limiting the number of e-mails sent by the network camera to a user, enabling the network camera to initiate phone calls, transmitting and/or recording video and audio, connecting the network camera to other detection devices, activating a siren, and allowing users to identify themselves within a fixed period of time before taking notification actions.
摘要翻译：一种用于布防和解除网络摄像机的系统和方法，将由网络摄像机发送的电子邮件的数量限制到用户，使得网络摄像机能够发起电话呼叫，发送和/或记录视频和音频，连接网络摄像机到其他检测设备，激活警报器，并允许用户在采取通知操作之前在一段固定的时间内识别自己。

7. 发明申请

US20050220754A1 Vitamin directed targeting therapy 审中-公开
标题翻译：维生素定向治疗
公开(公告)号：US20050220754A1
公开(公告)日：2005-10-06
申请号：US11127285
申请日：2005-05-12
申请人： Gregory Russell-Jones , John McEwan
发明人： Gregory Russell-Jones , John McEwan
IPC分类号： A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/16 , A61K38/17 , A61K47/48
CPC分类号： A61K38/07 , A61K38/05 , A61K38/06 , A61K38/08 , A61K47/551 , A61K47/64 , A61K2300/00
摘要： The invention relates to vitamin-mediated targeting for the delivery of agents and active substances in the therapy of disease. Targeting using vitamins essential for cancer growth are used in complexes for amplified delivery of cytotoxic drugs to tumors and cancer cells, with a concomitant reduction in toxicity to the subject being treated.
摘要翻译：本发明涉及用于在疾病治疗中递送药剂和活性物质的维生素介导靶向。使用用于癌症生长所必需的维生素的靶向用于将肿瘤和癌细胞扩增递送细胞毒性药物的复合物，同时对被治疗的受试者毒性降低。

8. 发明授权

US06482413B1 Vitamin B12 —biodegradable micro particulate conjugate carrier systems for peroral delivery of drugs, therapeutic peptides/proteins and vaccines 失效
标题翻译：用于口服递送药物，治疗性肽/蛋白质和疫苗的维生素B12-可生物降解的微粒子共轭载体体系
公开(公告)号：US06482413B1
公开(公告)日：2002-11-19
申请号：US09795979
申请日：2001-03-01
申请人： Kishore Babu Chalasani , Vamanrao Diwan , Kondapuram Vijaya Raghavan , Gregory John Russell-Jones , Sanjain Kumar Jain , Kollipara Koteshawar Rao
发明人： Kishore Babu Chalasani , Vamanrao Diwan , Kondapuram Vijaya Raghavan , Gregory John Russell-Jones , Sanjain Kumar Jain , Kollipara Koteshawar Rao
IPC分类号： A61K39385
CPC分类号： A61K9/5153 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/167 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K47/54 , Y02A50/472 , Y02A50/484 , Y10S977/906
摘要： The invention relates to a novel complex for oral delivery of drugs, therapeutic protein/peptides and vaccines which are loaded in a Vitamin B12 (VB12) coupled particulate carrier system with spacers in between, the carrier system with spacers having a formula VB12—R′/R″—N wherein, R′ or R″ is spacer and/or agents for derivatization of VB12 to provide either NH2 or COOH or SH groups, and N is the micro or nano particle carriers for the delivery of injectable drugs, therapeutic protein/peptides and vaccines.
摘要翻译：本发明涉及用于口服递送药物的新型复合物，治疗性蛋白质/肽和疫苗，其被装载在维生素B12（VB12）偶联的颗粒载体系统中，其间具有间隔物，载体系统与具有式VB12-R' / R“ - N，其中R'或R”是间隔基，和/或用于VB12衍生化以提供NH 2或COOH或SH基团的试剂，N是用于递送可注射药物的微粒或纳米颗粒载体，治疗性蛋白质/肽和疫苗。

9. 发明授权

US6159502A Oral delivery systems for microparticles 失效
标题翻译：口服微粒系统
公开(公告)号：US6159502A
公开(公告)日：2000-12-12
申请号：US956003
申请日：1992-11-30
申请人： Gregory John Russell-Jones , Steven William Westwood
发明人： Gregory John Russell-Jones , Steven William Westwood
IPC分类号： A61K9/50 , A61K9/16 , A61K9/51 , A61K9/52 , A61K47/24 , A61K47/42 , A61K47/46 , A61K47/48 , A61K9/14
CPC分类号： A61K9/5138 , A61K47/48892 , A61K9/167 , A61K9/5153 , A61K9/5169 , Y10S977/906
摘要： There are disclosed complexes and compositions for oral delivery of a substance or substances to the circulation or lymphatic drainage system of a host. The complexes of the invention comprise a microparticle coupled to at least one carrier, the carrier being capable of enabling the complex to be transported to the circulation or lymphatic drainage system via the mucosal epithelium of the host, and the microparticle entrapping or encapsulating, or being capable of entrapping or encapsulating, the substance(s). Examples of suitable carriers are mucosal binding proteins, bacterial adhesins, viral adhesins, toxin binding subunits, lectins, Vitamin B.sub.12 and analogues or derivatives of Vitamin B.sub.12 possessing binding activity to Castle's intrinsic factor.
摘要翻译： PCT No.PCT / AU92 / 00141 Sec。 371日期：1992年11月30日 102（e）日期1992年11月30日PCT提交1992年4月2日PCT公布。公开号WO92 / 17167 1992年10月15日的日期公开了将物质或物质口服递送至宿主的循环或淋巴引流系统的复合物和组合物。本发明的复合物包含与至少一种载体偶联的微粒，所述载体能够使复合物经由宿主的粘膜上皮被输送至循环或淋巴引流系统，并且微粒截留或包封或能够捕获或包封物质。合适的载体的实例是粘膜结合蛋白，细菌粘附素，病毒粘附素，毒素结合亚基，凝集素，维生素B12和具有对城堡内在因子的结合活性的维生素B12的类似物或衍生物。

10. 发明授权

US6103243A Oral vaccines 失效
标题翻译：口服疫苗
公开(公告)号：US6103243A
公开(公告)日：2000-08-15
申请号：US458814
申请日：1995-06-02
申请人： Gregory John Russell-Jones , Peter Howe , Henry James de Aizpurua , Keith Norman Rand
发明人： Gregory John Russell-Jones , Peter Howe , Henry James de Aizpurua , Keith Norman Rand
IPC分类号： A61K39/00 , A61K47/48 , A61P37/04 , A61K39/385
CPC分类号： A61K47/4833 , A61K2039/542 , A61K2039/6068 , A61K39/00 , C07K2319/40 , C07K2319/55 , C07K2319/75
摘要： The present invention relates to the specific stimulation of serum and secretory antibodies through mucosal presentation of antigens.
摘要翻译：本发明涉及通过粘膜呈递抗原对血清和分泌抗体的特异性刺激。

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