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    • 1. 发明授权
    • Closure for a container and method for carrying out a freeze-drying process
    • 容器的封闭和进行冷冻干燥过程的方法
    • US09540154B2
    • 2017-01-10
    • US13697094
    • 2011-05-06
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • B65D41/28B65B7/28B65D51/24A61J1/14B65D47/24
    • B65D51/241A61J1/1406A61J1/1475B65D47/247
    • A closure (1) for a container (9), or for an ampoule (9), in which a medicament is accommodated, having a closure cap (2) and a closure stopper (5) accommodated in the closure (2). Detent moldings (6) are formed on the closure cap (2) for latchingly holding the closure (1) on the ampoule (9), and a sliding part (3) is provided which is movable relative to the closure cap (2) in order to displace the closure stopper (5) into the closed position. In order to advantageously provide, with respect to carrying out a freeze-drying process, a closure for a container, or for an ampoule, in which a medicament is accommodated, the closure stopper (5) is displaceable relative to the cap (2) by means of the sliding part (3) in order to move the closure stopper into the closed position. There is also a method for carrying out a freeze-drying process for a medium, or for a medicament, which is accommodated in a container, or in an ampoule (9).
    • 用于容器(9)或用于安瓿(9)的封闭件(1),其中容纳有药物,具有容纳在所述封闭件(2)中的封闭盖(2)和封闭塞(5)。 在闭合盖(2)上形成止动模制件(6),用于将封闭件(1)闩锁地保持在安瓿(9)上,并且提供滑动部件(3),其相对于封闭盖(2)可移动 以使闭合止动器(5)移动到关闭位置。 为了有利地提供关于进行冷冻干燥过程的用于容纳药物的容器或安瓿的封闭件,闭合止动器(5)可相对于盖子(2)移位, 通过滑动部分(3),以将闭合止动器移动到关闭位置。 还有一种用于对容纳在容器中或安瓿(9)中的介质或药物进行冷冻干燥过程的方法。
    • 2. 发明申请
    • CLOSURE CAP
    • 封闭帽
    • US20140042163A1
    • 2014-02-13
    • US14112198
    • 2012-04-17
    • Reinhard Louis Jozef WaebenRalf DittmerRonny Prosper Elisabeth Vrijens
    • Reinhard Louis Jozef WaebenRalf DittmerRonny Prosper Elisabeth Vrijens
    • A61J1/14
    • A61J1/14A61J1/1406A61J1/1412A61J1/1468A61J1/18B65D51/002
    • The invention relates to a closure cap (1) for a container (2) for receiving a pharmaceutical substance, in particular for an infusion or transfusion bottle, with a flanged cap (4) which is suitable for engagement around a container neck (8) and which has a metal film layer, wherein the flanged cap (4) also has a recess (5) that is covered by a plastic lid (3), the plastic lid (3) is connected to the flanged cap (4) by means of at least one connection element (9) formed on the underside, and the plastic lid (3) is removable at least in part. In order to provide a closure cap for a container for receiving a pharmaceutical substance, which container is safe to handle and meets strict demands regarding its tamper-proofing, it is proposed that the plastic lid (3) is connected to the flanged cap (4) via a plurality of connection elements (9) which are formed on its underside and pass through associated connection openings (11) formed in the flanged cap (4), and that the plastic lid (3), in order to expose the recess (5), has a tear-off tab (12) which extends from a coverage of the recess (5) as far as an edge of the plastic lid (3), wherein no connection between the plastic lid and the flanged cap (4) is formed in the area of the tear-off tab (12).
    • 本发明涉及一种用于容纳(尤其是用于输注或输液瓶)的药物物质的容器(2)的封闭盖(1),其具有适合于围绕容器颈部(8)接合的法兰盖(4) 并且其具有金属膜层,其中所述带凸缘的帽(4)还具有由塑料盖(3)覆盖的凹部(5),所述塑料盖(3)通过装置连接到所述带凸缘的帽(4) 至少一个形成在下侧的连接元件(9),并且塑料盖(3)至少部分地可移除。 为了提供用于接收药物的容器的封闭盖,该容器可以安全地处理并满足关于其防篡改的严格要求,建议将塑料盖(3)连接到法兰盖(4) )通过多个连接元件(9)形成,所述多个连接元件(9)形成在其下侧并且穿过形成在凸缘盖(4)中的相关连接开口(11),并且塑料盖(3)为了露出凹部 具有从凹部(5)的覆盖物延伸到塑料盖(3)的边缘的撕开突片(12),其中塑料盖和法兰盖(4)之间没有连接, 形成在撕开突片(12)的区域中。
    • 3. 发明申请
    • CLOSURE STOPPER FOR PHARMACEUTICAL APPLICATIONS
    • 用于药物应用的封闭式止血药
    • US20130213924A1
    • 2013-08-22
    • US13820844
    • 2011-09-01
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • B65D39/00
    • B65D39/0005B65D51/002B65D51/241
    • A closure stopper for pharmaceutical applications has a sealing flange seating in a sealing manner on an end face of the container's closure mouth. The sealing flange has a lower sealing surface and a boundary plane contacting an area protruding farthest downwardly and extending perpendicularly to the closure stopper's center axis. An engagement portion extending below the sealing flange is formed with a smaller radial extent than the sealing flange. Preferably a handling portion extends above the sealing flange. A circumferential sealing projection also is formed on the engagement portion and protrudes by a radial dimension with respect to an axial portion of the engagement portion initially adjoining the sealing flange from underneath and having a portion-radius. The sealing projection, at least with respect to its base portion, vertically overlaps a set-back region formed on the sealing flange and set back with respect to the contact plane.
    • 用于药物应用的闭合止动器具有密封法兰,密封方式位于容器的封闭口的端面上。 密封凸缘具有较低的密封表面和边界面接触最远向下突出并垂直于闭合止动器的中心轴线延伸的区域。 在密封凸缘下方延伸的接合部分形成有比密封凸缘更小的径向延伸。 优选地,处理部分在密封凸缘的上方延伸。 周向密封突起也形成在接合部分上并且相对于初始邻接密封凸缘的接合部分的轴向部分的径向尺寸突出并且具有部分半径。 至少相对于其底部部分的密封突起垂直地重叠形成在密封凸缘上的止挡区域并相对于接触平面回放。
    • 7. 发明授权
    • Closure cap
    • 封闭帽
    • US09265696B2
    • 2016-02-23
    • US14112198
    • 2012-04-17
    • Reinhard Louis Jozef WaebenRalf DittmerRonny Prosper Elisabeth Vrijens
    • Reinhard Louis Jozef WaebenRalf DittmerRonny Prosper Elisabeth Vrijens
    • A61J1/00A61J1/06A61J1/14A61J1/18B65D51/00
    • A61J1/14A61J1/1406A61J1/1412A61J1/1468A61J1/18B65D51/002
    • The invention relates to a closure cap (1) for a container (2) for receiving a pharmaceutical substance, in particular for an infusion or transfusion bottle, with a flanged cap (4) which is suitable for engagement around a container neck (8) and which has a metal film layer, wherein the flanged cap (4) also has a recess (5) that is covered by a plastic lid (3), the plastic lid (3) is connected to the flanged cap (4) by means of at least one connection element (9) formed on the underside, and the plastic lid (3) is removable at least in part. In order to provide a closure cap for a container for receiving a pharmaceutical substance, which container is safe to handle and meets strict demands regarding its tamper-proofing, it is proposed that the plastic lid (3) is connected to the flanged cap (4) via a plurality of connection elements (9) which are formed on its underside and pass through associated connection openings (11) formed in the flanged cap (4), and that the plastic lid (3), in order to expose the recess (5), has a tear-off tab (12) which extends from a coverage of the recess (5) as far as an edge of the plastic lid (3), wherein no connection between the plastic lid and the flanged cap (4) is formed in the area of the tear-off tab (12).
    • 本发明涉及一种用于容纳(尤其是用于输注或输液瓶)的药物物质的容器(2)的封闭盖(1),其具有适合于围绕容器颈部(8)接合的法兰盖(4) 并且其具有金属膜层,其中所述带凸缘的帽(4)还具有由塑料盖(3)覆盖的凹部(5),所述塑料盖(3)通过装置连接到所述带凸缘的帽(4) 至少一个形成在下侧的连接元件(9),并且塑料盖(3)至少部分地可移除。 为了提供用于接收药物的容器的封闭盖,该容器可以安全地处理并满足关于其防篡改的严格要求,建议将塑料盖(3)连接到法兰盖(4) )通过多个连接元件(9)形成,所述多个连接元件(9)形成在其下侧并且穿过形成在凸缘盖(4)中的相关连接开口(11),并且塑料盖(3)为了露出凹部 具有从凹部(5)的覆盖物延伸到塑料盖(3)的边缘的撕开突片(12),其中塑料盖和法兰盖(4)之间没有连接, 形成在撕开突片(12)的区域中。
    • 9. 发明申请
    • CLOSURE FOR A CONTAINER AND METHOD FOR CARRYING OUT A FREEZE-DRYING PROCESS
    • 用于集装箱的封闭件和执行冷冻干燥方法的方法
    • US20130055681A1
    • 2013-03-07
    • US13697094
    • 2011-05-06
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • Ronny Prosper Elisabeth VrijensReinhard Louis Jozef Waeben
    • B65D41/28B65B7/28
    • B65D51/241A61J1/1406A61J1/1475B65D47/247
    • The invention relates in first instance to a closure (1) for a container (9), for example an ampoule (9), in which preferably a medicament is accommodated, having a closure cap (2) and a closure stopper (5) accommodated in the closure (2). Detent moldings (6) are formed on the closure cap (2) for latchingly holding the closure (1) on the ampoule (9), and a sliding part (3) is provided which is movable relative to the closure cap (2) in order to displace the closure stopper (5) into the closed position, In order to advantageously provide, with respect to carrying out a freeze-drying process, a closure for a container, in particular an ampoule, in which a medicament is accommodated, it is proposed that the closure stopper (5) is displaceable relative to the cap (2) by means of the sliding part (3) in order to move the closure stopper into the closed position. The invention further relates to a method for carrying out a freeze-drying process for a medium, in particular a medicament, which is accommodated in a container, in particular an ampoule (9).
    • 本发明首先涉及用于容器(9)的封闭件(1),例如安瓿(9),其中优选地容纳药物,其具有容纳有封闭盖(2)和闭合止动器(5) 在封闭(2)。 在闭合盖(2)上形成止动模制件(6),用于将封闭件(1)闩锁地保持在安瓿(9)上,并且提供滑动部件(3),其相对于封闭盖(2)可移动 以使闭合止动器(5)移位到关闭位置。为了有利地提供关于进行冷冻干燥过程的用于容纳药物的容器,特别是安瓿的封闭件,其中容纳药物 提出了闭合止动器(5)可通过滑动部分(3)相对于盖子(2)移位,以将闭合止动器移动到关闭位置。 本发明还涉及一种用于对介质,特别是药物进行冷冻干燥的方法,所述介质容纳在容器中,特别是安瓿(9)中。