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1. 发明授权

US07341874B2 Method for detecting post-translation modifications of peptides 失效
标题翻译：检测肽后翻译修饰的方法
公开(公告)号：US07341874B2
公开(公告)日：2008-03-11
申请号：US10792176
申请日：2004-03-02
申请人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
发明人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
IPC分类号： G01N33/00
CPC分类号： G01N33/6842 , C07K1/107 , C07K1/128 , G01N33/6824 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention provides for novel methods of identifying covalent modifications of an amino acid residue in a polypeptide chain by detecting mass differences.
摘要翻译：本发明提供了通过检测质量差异来鉴定多肽链中氨基酸残基的共价修饰的新方法。

2. 发明授权

US06750061B2 Method and product for the sequence determination of peptides using a mass spectrometer 失效
标题翻译：使用质谱仪对肽进行序列测定的方法和产品
公开(公告)号：US06750061B2
公开(公告)日：2004-06-15
申请号：US09828326
申请日：2001-04-05
申请人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
发明人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
IPC分类号： G01N3300
CPC分类号： G01N33/6842 , C07K1/107 , C07K1/128 , G01N33/6824 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
摘要翻译：描述了通过形成包含一系列多肽的肽梯级来测序多肽的方法，其中该序列的相邻成员变化一个氨基酸残基，并通过质谱确定多肽中每个氨基酸的同一性和位置。

3. 发明授权

US07419954B2 Staphylococcus peptides for bacterial interference 有权
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US07419954B2
公开(公告)日：2008-09-02
申请号：US11212020
申请日：2005-08-25
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/00 , A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C07K14/31
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10 和y为1至10.包括环化方案的制备方法和使用环状肽的方法还公开了本发明。

4. 发明申请

US20070185016A1 Novel Staphylococcus peptides for bacterial interference 有权
标题翻译：新型葡萄球菌肽用于细菌干扰
公开(公告)号：US20070185016A1
公开(公告)日：2007-08-09
申请号：US11212020
申请日：2005-08-25
申请人： Tom Muir , Patricia Mayville , Richard Novick , Ronald Beavis , Guangyong Ji
发明人： Tom Muir , Patricia Mayville , Richard Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/12 , A61K31/43 , A61K31/545
CPC分类号： C07K7/06 , A61K38/00 , C07K14/31
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10 和y为1至10.包括环化方案的制备方法和使用环状肽的方法还公开了本发明。

5. 发明授权

US06953833B2 Staphylococcus peptides for bacterial interference 失效
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US06953833B2
公开(公告)日：2005-10-11
申请号：US10032950
申请日：2001-12-27
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/16 , A61K38/12 , A61K38/00 , C07K16/00
CPC分类号： A61K38/164
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，以及 y为1至10.制备方法包括环化方案，以及使用环状肽的方法还公开了本发明。

6. 发明申请

US20050153454A1 Method for detecting post-translational modification of peptides 审中-公开
标题翻译：检测肽的翻译后修饰的方法
公开(公告)号：US20050153454A1
公开(公告)日：2005-07-14
申请号：US11001908
申请日：2004-12-01
申请人： Brian Chait , Ronald Beavis , Rong Wang , Stephen Kent
发明人： Brian Chait , Ronald Beavis , Rong Wang , Stephen Kent
IPC分类号： C07K1/107 , C07K1/12 , G01N33/68 , G01N33/00
CPC分类号： G01N33/6842 , C07K1/107 , C07K1/128 , G01N33/6824 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
摘要翻译：描述了通过形成包含一系列多肽的肽梯级来测序多肽的方法，其中该序列的相邻成员变化一个氨基酸残基，并通过质谱确定多肽中每个氨基酸的同一性和位置。

7. 发明授权

US06337385B1 Staphylococcus peptides for bacterial interference 有权
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US06337385B1
公开(公告)日：2002-01-08
申请号：US09339511
申请日：1999-06-24
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K3812
CPC分类号： A61K38/164
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)—Z—X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH2- X（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中X选自氨基酸，氨基酸类似物，肽模拟物和非 - 酰胺等离子体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，y为1至10.包括环化方案的制备方法和环肽的使用方法也公开了本发明。

8. 发明授权

US06447786B1 Blocking expression of virulence factors in S. aureus 失效
标题翻译：阻断金黄色葡萄球菌中毒力因子的表达
公开(公告)号：US06447786B1
公开(公告)日：2002-09-10
申请号：US08861476
申请日：1997-05-22
申请人： Richard P. Novick , Guangyong Ji , Ronald Beavis
发明人： Richard P. Novick , Guangyong Ji , Ronald Beavis
IPC分类号： A61K39085
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , C07K16/1271
摘要： This invention provides peptides which inhibit agr transcription in S. aureus and thereby block the expression of virulence factors in S. aureus, pharmaceutical compositions comprising these peptides, as well as methods for treating or preventing an infection or disease caused by S. aureus using the peptides of the present invention.
摘要翻译：本发明提供抑制金黄色葡萄球菌agr转录并因此阻断金黄色葡萄球菌中毒力因子的表达的肽，包含这些肽的药物组合物，以及用于治疗或预防由金黄色葡萄球菌引起的感染或疾病的方法本发明的肽。

9. 发明授权

US06271037B1 Method and product for the sequence determination of peptides using a mass spectrometer 失效
标题翻译：使用质谱仪对肽进行序列测定的方法和产品
公开(公告)号：US06271037B1
公开(公告)日：2001-08-07
申请号：US08341555
申请日：1996-06-24
申请人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
发明人： Brian T. Chait , Ronald Beavis , Rong Wang , Stephen B. H. Kent
IPC分类号： G01N3300
CPC分类号： G01N33/6842 , C07K1/107 , C07K1/128 , G01N33/6824 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
摘要翻译：描述了通过形成包含一系列多肽的肽梯级来测序多肽的方法，其中该序列的相邻成员变化一个氨基酸残基，并通过质谱确定多肽中每个氨基酸的同一性和位置。

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