专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080031919A1 ADDING MICROSCOPIC POROSITY TO THE SURFACE OF A MICROCOIL TO BE USED FOR MEDICAL IMPLANTATION 有权
公开(公告)号：US20080031919A1
公开(公告)日：2008-02-07
申请号：US11875586
申请日：2007-10-19
申请人： Michael Henson , Robert Stern
发明人： Michael Henson , Robert Stern
IPC分类号： A61F2/02 , A61K31/765 , A61K35/64 , A61K38/16 , A61M29/00 , A61P43/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00004 , A61K31/765 , A61K38/1767 , A61K38/39 , A61M31/002
摘要： A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.

2. 发明申请

US20070166357A1 Bandage For Facilitating Transdermal Respiration And Healing 有权
标题翻译：用于促进透皮呼吸和治疗的绷带
公开(公告)号：US20070166357A1
公开(公告)日：2007-07-19
申请号：US11278885
申请日：2006-04-06
申请人： Thomas Shaffer , Robert Stern , Marla Wolfson
发明人： Thomas Shaffer , Robert Stern , Marla Wolfson
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61F13/00063 , A61F2013/00246 , A61F2013/00855 , A61L15/20 , A61L15/44 , A61L2300/10 , A61L2300/602
摘要： A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir.
摘要翻译：绷带包括填充有饱和氧的全氟化合物的储存器。氧气通过可渗透膜到皮肤或伤口以促进愈合，并且二氧化碳从皮肤或伤口传播到储存器。

3. 发明申请

US20070134228A1 HUMAN PLASMA HYALURONIDASE 有权
标题翻译：人血浆HYALURONIDASE
公开(公告)号：US20070134228A1
公开(公告)日：2007-06-14
申请号：US11538246
申请日：2006-10-03
申请人： Robert STERN , Gregory FROST , Anthony CSOKA , Tim Wong
发明人： Robert STERN , Gregory FROST , Anthony CSOKA , Tim Wong
IPC分类号： A61K38/47 , G01N33/53 , C12N9/24 , C12N5/06 , A61K9/127 , C07K16/40
CPC分类号： C12Y302/01035 , A61K38/00 , C07K16/40 , C12N9/16 , C12N9/2474 , C12Y302/01036 , G01N33/573
摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.
摘要翻译：本发明基于发现用于纯化在人血浆（hpHA）中发现的酸活性透明质酸酶的方法，包括生物化学和免疫亲和纯化方法本发明的免疫亲和纯化方法是基于发现用于鉴定抗体的方法特异性结合天然hpHAse（抗天然hpHAse抗体）和通过该筛选方法鉴定的抗天然hpHAse抗体。本发明还特征在于使用生物素化透明质酸（bHA）敏感检测HAse活性的测定。 hpHAse的纯化和表征导致发明人进一步发现，hpHAse由LuCa- 1基因编码，该基因存在于人染色体3p21.3，与肿瘤抑制相关的区域。本发明另外具有通过施用hpHA和/或用hpHA编码DNA转化细胞来治疗荷瘤患者的方法。

4. 发明申请

US20070095420A1 PERFLUOROCARBON GAS INSUFFLATION 审中-公开
标题翻译：全氟化碳消毒
公开(公告)号：US20070095420A1
公开(公告)日：2007-05-03
申请号：US11277428
申请日：2006-03-24
申请人： Thomas Shaffer , Robert Stern , Marla Wolfson
发明人： Thomas Shaffer , Robert Stern , Marla Wolfson
IPC分类号： B65B31/00
CPC分类号： B60C5/001
摘要： Vehicle tires are filled with perfluorocarbon gas to extend tire life.
摘要翻译：汽车轮胎充满全氟化碳气体，延长轮胎寿命。

5. 发明授权

US06193963B1 Method of treating tumor-bearing patients with human plasma hyaluronidase 失效
标题翻译：用人血浆透明质酸酶处理肿瘤患者的方法
公开(公告)号：US06193963B1
公开(公告)日：2001-02-27
申请号：US08916935
申请日：1997-08-21
申请人： Robert Stern , Gregory I. Frost , Anthony Csóka , Tim M. Wong
发明人： Robert Stern , Gregory I. Frost , Anthony Csóka , Tim M. Wong
IPC分类号： A61K3800
CPC分类号： C12Y302/01035 , A61K38/00 , C07K16/40 , C12N9/16 , C12N9/2474 , C12Y302/01036 , G01N33/573
摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.
摘要翻译：本发明基于发现用于纯化在人血浆（hpHA）中发现的酸活性透明质酸酶的方法，包括生物化学和免疫亲和纯化方法。本发明的免疫亲和纯化方法基于发现用于鉴定特异性结合天然hpHA（抗天然hpHAse抗体）的抗体的方法，以及通过该筛选方法鉴定的抗天然hpHAse抗体。本发明还特征在于使用生物素化透明质酸（bHA）敏感检测HAse活性的测定。 hpHAse的纯化和表征导致发明人进一步发现，hpHAse由LuCa-1基因编码，该基因存在于3p21.3的人染色体中，该肿瘤与肿瘤抑制有关。本发明另外具有通过施用hpHA和/或用hpHA编码DNA转化细胞来治疗荷瘤患者的方法。

6. 发明授权

US6013817A Process for the production of ethyl esters 失效
标题翻译：生产乙酯的方法
公开(公告)号：US6013817A
公开(公告)日：2000-01-11
申请号：US852737
申请日：1997-05-07
申请人： Robert Stern , Gerard Hillion , Mohammed Neguib Eisa
发明人： Robert Stern , Gerard Hillion , Mohammed Neguib Eisa
IPC分类号： C07C67/03 , C11C3/04 , C11C3/10 , C07C51/00
CPC分类号： C11C3/003 , C07C67/03 , C11C3/04 , C11C3/10
摘要： For the production of ethyl esters of fatty acids from fatty acid glycerides such as vegetable or animal oil or fat or other mixtures of glycerides, the process comprises the following stages: (a) transesterifying fatty acid glycerides with hydrated ethyl alcohol using an alkaline catalyst to form a medium comprising ethyl esters and excess ethyl alcohol; (b) adding a glycerine phase to said medium, and evaporating the excess ethyl alcohol to produce two immiscible phases, an ester phase and a glycerine phase A, and recycling said excess ethyl alcohol to stage (a); (c) separating said glycerine phase A and said ester phase to obtain the desired ethyl esters; (d) neutralizing said glycerine phase A with acid, and separating resultant "fatty acids+esters" phase and a glycerine phase B, and drying the latter phase; (e) subjecting the "fatty acids+esters" phase to glycerolysis with at least a fraction of the dried glycerine phase B in the presence of an alkaline catalyst to form a mixture of glycerides and esters, and passing said mixture into transesterification stage (a).
摘要翻译：为了从脂肪酸甘油酯如植物油或动物油或脂肪或甘油酯的其它混合物生产脂肪酸乙酯，该方法包括以下步骤：（a）使用碱性催化剂将脂肪酸甘油酯与水合乙醇酯交换成形成包含乙酯和过量乙醇的介质; （b）向所述介质中加入甘油相，并蒸发过量的乙醇以产生两个不混溶相，酯相和甘油相A，并将所述过量的乙醇再循环到步骤（a）; （c）分离所述甘油相A和所述酯相以获得所需的乙酯; （d）用酸中和所述甘油相A，分离所得的“脂肪酸+酯”相和甘油相B，并干燥后一相; （e）在碱性催化剂存在下，使至少一部分干燥的甘油相B对“脂肪酸+酯”相进行甘油分解，形成甘油酯和酯的混合物，并将所述混合物通入酯交换反应阶段）。

7. 发明授权

US5594960A Swimming pool cover with drainage and filter 失效
标题翻译：游泳池盖有排水和过滤器
公开(公告)号：US5594960A
公开(公告)日：1997-01-21
申请号：US575736
申请日：1995-12-18
申请人： Robert Stern
发明人： Robert Stern
IPC分类号： E04H4/10
CPC分类号： E04H4/10
摘要： A cover for a water pool comprised of flexible waterproof material having a drainage opening positioned therein and a sleeve defining a passageway secured on the cover and in alignment with and intersecting the drainage opening allowing a filter to be slidably positionable therein for filtering of rain water and melting snow to remove particulate matter, the filter repositionable or removable for cleaning without the need for removing the cover for the water pool.
摘要翻译：一种用于水池的盖子，包括具有定位在其中的排水开口的柔性防水材料，以及限定固定在盖上并与排水口对准并与之相交的通道的套筒，允许过滤器可滑动地定位在其中以过滤雨水，融雪除去颗粒物，过滤器可重新定位或可拆卸清洁，无需拆除水池盖。

8. 发明授权

US5434282A Double-branched compounds and processes for their production 失效
标题翻译：双支化合物及其生产方法
公开(公告)号：US5434282A
公开(公告)日：1995-07-18
申请号：US231706
申请日：1994-04-22
申请人： Robert Stern , Gerard Hillion , Abakar Kotoko , Yves Chauvin
发明人： Robert Stern , Gerard Hillion , Abakar Kotoko , Yves Chauvin
IPC分类号： B01J31/22 , B01J31/24 , C07B61/00 , C07C51/353 , C07C51/36 , C07C53/126 , C07C57/03 , C07C67/303 , C07C67/347 , C07C69/24 , C07C69/30 , C07C69/533 , C07C69/587 , C10M105/24 , C10M105/34 , C10M105/38 , C07C67/03
CPC分类号： C07C69/587 , C07C51/353 , C07C53/126 , C07C67/347
摘要： A novel family of chemical compounds derived from fatty compounds has two branches of two carbon atoms on the linear chain and general formula C.sub.21 H.sub.39 COOR where R represents a hydrogen atom, a lower alkyl radical or a glyceryl radical. Particular compounds for consideration have the following formulae:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.29 COOR (I)(C.sub.2 H.sub.5)(C.sub.2 H.sub.4)C.sub.17 H.sub.30 COOR (II)and(C.sub.2 H.sub.5)(C.sub.2 H.sub.3)C.sub.17 H.sub.31 COOR (III)also compounds with the following formulae derived from partial or total hydrogenation of the above:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.31 COOR (IV)(C.sub.2 h.sub.5)(C.sub.2 h.sub.4)C.sub.17 H.sub.32 COOR (V)andti (C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.33 COOR (VI)Compounds with formulae (I), (II) and (III) may be produced by addition of ethylene to compositions comprising mainly diunsaturated C.sub.18 fatty acids; or to lower alkyl or glyceryl esters of these acids, originating in particular from natural oils, in the presence of a catalytic system containing anionic rhodium of the type [RhX.sub.4 ].sup.- YR'.sub.4 where X is preferably a halide anion; Y is a nitrogen N.sup.+ or phosphorous P.sup.+ atom and R.sup.' is preferably a hydrocarbon group.Compositions in accordance with the invention can be used as base compositions for lubricants or emulsifying agents.
摘要翻译：衍生自脂肪族化合物的化学化合物的新型家族在直链上具有两个碳原子的分支，通式为C 21 H 39 COOR，其中R表示氢原子，低级烷基或甘油基。考虑的具体化合物具有下式：（C 2 H 5）2 C 17 H 29 COOR（I）（C 2 H 5）（C 2 H 4）C 17 H 30 COOR（II）和（C 2 H 5）（C 2 H 3）C 17 H 31 COOR 上述:( C2H5）2C17H31COOR（Ⅳ）（C2h5）（C2h4）C17H32COOR（Ⅴ）和（C2H5）2C17H33COOR（VI）式（Ⅰ），（Ⅱ）和（Ⅲ）化合物可以通过加入乙烯主要包含二不饱和C18脂肪酸的组合物; 或者在含有[RhX4] -YR'4类型的阴离子铑的催化体系存在下，将这些酸的烷基或甘油酯特别地衍生自天然油，其中X优选为卤化物阴离子; Y是氮N +或磷P +原子，R'优选为烃基。根据本发明的组合物可用作润滑剂或乳化剂的基础组合物。

9. 发明授权

US5424466A Improved process for the production of esters from fatty substances having a natural origin 失效
标题翻译：用于由具有天然来源的脂肪物质生产酯的改进方法
公开(公告)号：US5424466A
公开(公告)日：1995-06-13
申请号：US125824
申请日：1993-09-24
申请人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel
发明人： Robert Stern , Gerard Hillion , Jean-Jacques Rouxel
IPC分类号： C10L1/02 , C11B13/02 , C11C3/04 , C11C3/06 , C11B3/10
CPC分类号： C11C3/06 , C10L1/026 , C11C3/04 , Y02E50/13
摘要： A description is given of an improved process for the production of esters from fatty substances having a natural origin (animal and vegetable oils) and low molecular weight alcohols, in which the soaps and oily compounds entrained in the alkaline phases are recycled by treating them, following acidification and separation, with a fraction of the glycerol phase produced, in the presence of an alkaline catalyst and for forming preferably a triglyceride or a partly substituted glyceride.This process makes it possible to quantitatively obtain methyl, ethyl, propyl or butyl esters usable as a substitute for gas oil.
摘要翻译：对由天然来源的脂肪物质（动植物油）和低分子量醇生产酯的改进方法进行了说明，其中通过处理它们将带在碱性相中的皂和油性化合物再循环，在酸化和分离之后，在碱性催化剂存在下，产生一部分甘油相，并优选形成甘油三酯或部分取代的甘油酯。该方法使得可以定量地获得可用作瓦斯油替代物的甲基，乙基，丙基或丁基酯。

10. 发明授权

US4533500A Process for manufacturing N-acyliminodiacetic acids 失效
标题翻译：制备N-酰基亚氨基二乙酸的方法
公开(公告)号：US4533500A
公开(公告)日：1985-08-06
申请号：US476295
申请日：1983-03-17
申请人： Yves Chauvin , Dominique Commereuc , Andre Hirschauer , Dominique Reffet , Robert Stern
发明人： Yves Chauvin , Dominique Commereuc , Andre Hirschauer , Dominique Reffet , Robert Stern
IPC分类号： C07C233/46 , C09F5/00 , C09F7/00 , C11C3/00
CPC分类号： C07C233/46
摘要： N-acyliminodiacetic acids are manufactured by reacting formaldehyde or a formaldehyde generator compound with a N-unsubstituted amide or a generator thereof and with carbon monoxide in contact with a carbonylation catalyst, for example, a cobalt compound, the ratio of the aldehyde groups to the amide groups being at least 2:1. The formaldehyde generator can be a polymeric form of formaldehyde and the amide generator can be a carboxylic ester, acid or anhydride.
摘要翻译： N-酰基亚氨基二乙酸是通过使甲醛或甲醛发生剂化合物与N-未取代的酰胺或其发生剂和与羰基化催化剂例如钴化合物接触的一氧化碳反应制备的，醛基与酰胺基团为至少2:1。甲醛发生器可以是甲醛的聚合形式，酰胺发生剂可以是羧酸酯，酸或酸酐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式