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1. 发明申请

US20080031919A1 ADDING MICROSCOPIC POROSITY TO THE SURFACE OF A MICROCOIL TO BE USED FOR MEDICAL IMPLANTATION 有权
公开(公告)号：US20080031919A1
公开(公告)日：2008-02-07
申请号：US11875586
申请日：2007-10-19
申请人： Michael Henson , Robert Stern
发明人： Michael Henson , Robert Stern
IPC分类号： A61F2/02 , A61K31/765 , A61K35/64 , A61K38/16 , A61M29/00 , A61P43/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00004 , A61K31/765 , A61K38/1767 , A61K38/39 , A61M31/002
摘要： A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.

2. 发明申请

US20060251700A1 Adding microscopic porosity to the surface of a microcoil to be used for medical implantation 有权
公开(公告)号：US20060251700A1
公开(公告)日：2006-11-09
申请号：US11435363
申请日：2006-05-16
申请人： Michael Henson , Robert Stern
发明人： Michael Henson , Robert Stern
IPC分类号： A61F2/06
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00004 , A61K31/765 , A61K38/1767 , A61K38/39 , A61M31/002
摘要： A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.

3. 发明申请

US20060251695A1 Adding microscopic porosity to the surface of a microcoil to be used for medical implantation 有权
标题翻译：在用于医学植入的微线圈表面添加微孔隙
公开(公告)号：US20060251695A1
公开(公告)日：2006-11-09
申请号：US11340422
申请日：2006-01-26
申请人： Michael Henson , Robert Stern
发明人： Michael Henson , Robert Stern
IPC分类号： A61F2/06 , A61F13/00
CPC分类号： A61B17/1215 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/1219 , A61B2017/00004 , A61K31/765 , A61K38/1767 , A61K38/39 , A61M31/002
摘要： A vasoocclusive microcoil for therapeutic treatment of a patient's vasculature includes a surface with a plurality of voids or pores therein, and a therapeutic or bioactive material disposed within the plurality of voids or pores. The therapeutic or bioactive material within the plurality of voids or pores operates to accelerate a healing process in the patient's vasculature when the microcoil is introduced into the patient's vasculature.
摘要翻译：用于治疗患者脉管系统的血管收缩性微线圈包括其中具有多个空隙或孔的表面，以及设置在多个空隙或孔内的治疗或生物活性材料。多个空隙或孔隙内的治疗或生物活性物质用于在将微线圈引入患者的脉管系统中时加速患者脉管系统中的愈合过程。

4. 发明申请

US20140339840A1 Kebob tongs 审中-公开
标题翻译： Kebob钳子
公开(公告)号：US20140339840A1
公开(公告)日：2014-11-20
申请号：US13986619
申请日：2013-05-20
申请人： Robert Stern
发明人： Robert Stern
IPC分类号： A47J43/28
CPC分类号： A47J43/283
摘要： Tongs for manipulating shish-kebob on a barbeque grill, the tongs having two arms, the two arms being in parallel relationship at an insulated handle end which includes the pivot point at one end, the arms diverging at the opposing end of the handle end, to form two opposing spaced apart arms having kebob engaging ends, each end having an aperture there through, the apertures engaging the ends of the skewer, the tongs then being compressed so that the kebob engaging ends engage the outer food items on the skewer preventing their rotation so that the kebob may be either flipped for even cooking on the opposing side, or removed from the grill for consumption without endangering the fingers of the user.
摘要翻译：用于在烧烤格栅上操作shish-kebob的钳子，钳子具有两个臂，两个臂在绝缘手柄端处平行关系，其包括在一端的枢转点，臂在手柄端的相对端处发散，以形成两个相对的间隔开的臂，其具有接头端部，每个端部具有通孔的孔，所述孔接合扦子的端部，然后钳子被压缩，使得肠壁接合端接合串上的外部食物，从而防止它们旋转，使得可以将小桶翻转以便在相对侧进行烹饪，或者从烤架中取出以消费，而不会危及用户的手指。

5. 发明申请

US20140002075A1 METHOD FOR ASSESSING REPETITIVE HEAD INJURIES WITH TWO-DIMENSIONAL MAGNETIC RESONANCE SPECTROSCOPY 有权
标题翻译：用二维磁共振光谱法评估重复性头部损伤的方法
公开(公告)号：US20140002075A1
公开(公告)日：2014-01-02
申请号：US13988813
申请日：2011-11-28
申请人： Alexander Lin , Carolyn Mountford , Saadallah Ramadan , Robert Stern
发明人： Alexander Lin , Carolyn Mountford , Saadallah Ramadan , Robert Stern
IPC分类号： G01R33/483
CPC分类号： G01R33/483 , A61B5/055 , A61B5/4064 , A61B2503/00 , A61B2503/04 , A61B2503/10 , G01R33/485
摘要： A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.
摘要翻译：提供了使用磁共振成像（MRI）系统来产生指示受试者的重复性头部损伤的生物标志物的方法。使用MRI系统从受试者获取二维光谱数据。从二维光谱数据生成二维光谱。二维光谱包含由第一光谱维度和第二光谱维度指示的光谱信息。这样的二维光谱可以包括对角峰和非对角线或交叉峰。在这种情况下，每个交叉峰值可以表示例如它在对角线上连接的两个质子之间的标量耦合。然而，根据所使用的方法的类型，也可以存在不同类型的耦合。使用二维光谱，鉴定出指示受试者重复性头部损伤的生物标志物，并且可用于产生指示神经功能障碍的状态或消退的报告。

6. 发明授权

US07539656B2 System and method for providing an intelligent multi-step dialog with a user 有权
标题翻译：用于向用户提供智能多步骤对话的系统和方法
公开(公告)号：US07539656B2
公开(公告)日：2009-05-26
申请号：US09798964
申请日：2001-03-06
申请人： Raya Fratkina , Monica Anderson , Mark A. Angel , Max Copperman , Scott B. Huffman , David Kay , Robert Stern
发明人： Raya Fratkina , Monica Anderson , Mark A. Angel , Max Copperman , Scott B. Huffman , David Kay , Robert Stern
IPC分类号： G06F17/00 , G06F17/30 , G06N5/00
CPC分类号： G06F17/30654 , G06F17/30873 , G06N5/042 , Y10S707/99933 , Y10S707/99945
摘要： A method and system are disclosed for retrieving information through the use of a multi-stage interaction with a client to identify particular knowledge content associated with a knowledge map. The present invention is an application program running on a server accessed via the world-wide web or other data network using standard Internet protocols, a web browser and web server software. In addition to an automated portion, the present invention allows a human dialog designer to model the way the system elicits information, giving a human feel to the dialog and a better customer experience. In operation, users start a dialog by directing their web browser to a designated web page. This web page asks the user some initial questions that are then passed to a dialog engine. The dialog engine then applies its methods and algorithms to a knowledge map, using dialog control information\ and the user's responses to provide feedback to the user. The feedback may include follow-up questions, relevant documents, and instructions to the user (e.g., instructions to contact a human customer service representative). This dialog engine response is rendered as a web page and returned to the user's web browser. The user can then respond further to the follow-up questions he or she is presented, and the cycle repeats. The invention can be implemented so that it can interact with customers through a wide variety of communication channels including the Internet, wireless devices (e.g., telephone, pager, etc.), handheld devices such as a Personal Data Assistant (PDA), email, and via a telephone where the automated system is delivered using an interactive voice response (IVR) and/or speech-recognition system.
摘要翻译：公开了一种用于通过使用与客户端的多阶段交互来检索信息以识别与知识图相关联的特定知识内容的方法和系统。本发明是在通过世界范围的网络或其他数据网络使用标准互联网协议访问的服务器上运行的应用程序，网络浏览器和web服务器软件。除了自动化部分之外，本发明允许人对话设计者对系统引出信息的方式进行建模，给出对人的感觉和更好的客户体验。在操作中，用户通过将其浏览器指向指定的网页来开始对话。该网页向用户询问一些初始问题，然后传递给对话框引擎。然后，对话框引擎将其方法和算法应用于知识图，使用对话控制信息\和用户的响应来向用户提供反馈。反馈可以包括对用户的后续问题，相关文档和指令（例如，联系人类客户服务代表的指令）。此对话框引擎响应呈现为网页并返回到用户的Web浏览器。用户可以进一步响应他或她所呈现的后续问题，循环重复。可以实现本发明，使得其可以通过包括因特网，无线设备（例如，电话，寻呼机等），诸如个人数据助理（PDA），电子邮件等手持设备的各种通信信道与客户进行交互，以及通过使用交互式语音响应（IVR）和/或语音识别系统传送自动系统的电话。

7. 发明授权

US07148201B2 Use of human plasma hyaluronidase in cancer treatment 有权
公开(公告)号：US07148201B2
公开(公告)日：2006-12-12
申请号：US09795914
申请日：2001-02-27
申请人： Robert Stern , Gregory I. Frost , Anthony Csóka , Tim M. Wong
发明人： Robert Stern , Gregory I. Frost , Anthony Csóka , Tim M. Wong
IPC分类号： A61K31/70 , A01N63/00 , C12N15/63 , A61K38/43 , G01N33/53
CPC分类号： C12Y302/01035 , A61K38/00 , C07K16/40 , C12N9/16 , C12N9/2474 , C12Y302/01036 , G01N33/573
摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.

8. 发明授权

US4973775A Process for delaying the formation and/or reducing the agglomeration tendency of hydrates 失效
标题翻译：延缓水合物形成和/或降低凝聚趋势的方法
公开(公告)号：US4973775A
公开(公告)日：1990-11-27
申请号：US292351
申请日：1988-12-30
申请人： Andre Sugier , Paul Bourgmayer , Robert Stern
发明人： Andre Sugier , Paul Bourgmayer , Robert Stern
IPC分类号： B01F17/22 , B01J19/00 , C09K8/52 , F17D1/02
CPC分类号： C09K8/52 , C10L3/107 , F17D1/02 , C09K2208/22 , Y10S585/95
摘要： The invention concerns a process for delaying the formation and/or reducing the agglomeration tendency of hydrates in conditions under which a hydrate may be formed, these hydrates being formed from water and gas. The process according to the invention wherein, in particular, an additive comprising at least one compound from the group of hydroxycarbylamides of substituted carboxylic acids is used. Application of the process according to the invention to processes using gases and water, which form hydrates between them, in particular in the petroleum or gas industry.
摘要翻译：本发明涉及在水合物可能形成的条件下延迟水合物的形成和/或降低的结合方法，这些水合物由水和气体形成。使用根据本发明的方法，其中特别地，使用包含至少一种取代羧酸的羟基氨基甲酰胺化合物的添加剂。将根据本发明的方法应用于使用气体和水的方法，其在它们之间形成水合物，特别是在石油或天然气工业中。

9. 发明授权

US4132745A Process for isomerizing 1-butene to 2-butene 失效
标题翻译：将1-丁烯异构化为2-丁烯的方法
公开(公告)号：US4132745A
公开(公告)日：1979-01-02
申请号：US879579
申请日：1978-02-21
申请人： Pierre Amigues , Jean Gaillard , Jean-Francois Le Page , Robert Stern
发明人： Pierre Amigues , Jean Gaillard , Jean-Francois Le Page , Robert Stern
IPC分类号： B01J23/40 , B01J37/20 , C07C5/22 , C07C5/25 , C07C5/24 , C07C5/30
CPC分类号： C07C5/226 , B01J23/40 , B01J37/20 , C07C5/2556 , C07C2521/04 , C07C2523/40 , C07C2523/44
摘要： Process for isomerizing 1-butene to 2-butene by contacting 1-butene, at a temperature from 50 to 140.degree. C, in the presence of hydrogen, with an isomerization catalyst containing a noble metal from group VIII of the periodic classification of elements, which catalyst was previously contacted with a sulfur compound at a temperature from 50 to 400.degree. C and then with hydrogen at a temperature of at least 50.degree. C.
摘要翻译：通过在氢存在下，在50-140℃的温度下使1-丁烯与包含元素周期分类的VIII族的贵金属的异构化催化剂接触，将1-丁烯异构化为2-丁烯的方法，该催化剂预先在50-400℃的温度下与硫化合物接触，然后在至少50℃的温度下与氢气接触。

10. 发明授权

US07781397B2 Human plasma hyaluronidase 有权
标题翻译：人血浆透明质酸酶
公开(公告)号：US07781397B2
公开(公告)日：2010-08-24
申请号：US11538246
申请日：2006-10-03
申请人： Robert Stern , Gregory I. Frost , Anthony Csoka , Tim M. Wong
发明人： Robert Stern , Gregory I. Frost , Anthony Csoka , Tim M. Wong
IPC分类号： A01N37/18
CPC分类号： C12Y302/01035 , A61K38/00 , C07K16/40 , C12N9/16 , C12N9/2474 , C12Y302/01036 , G01N33/573
摘要： The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is based on the discovery of a method for identifying antibodies that specifically bind native hpHAse (anti-native hpHAse antibodies), and anti-native hpHAse antibodies identified by this screening method. The invention also features an assay for sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Purification and characterization of hpHAse lead to the inventors' additional discovery that hpHAse is encoded by the LuCa-1 gene, which gene is present in the human chromosome at 3p21.3, a region associated with tumor suppression. The invention additionally features methods of treating tumor-bearing patients by administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.
摘要翻译：本发明基于发现用于纯化在人血浆（hpHA）中发现的酸活性透明质酸酶的方法，包括生物化学和免疫亲和纯化方法。本发明的免疫亲和纯化方法基于发现用于鉴定特异性结合天然hpHA（抗天然hpHAse抗体）的抗体的方法，以及通过该筛选方法鉴定的抗天然hpHAse抗体。本发明还特征在于使用生物素化透明质酸（bHA）敏感检测HAse活性的测定。 hpHAse的纯化和表征导致发明人进一步发现，hpHAse由LuCa-1基因编码，该基因存在于3p21.3的人染色体中，该肿瘤与肿瘤抑制有关。本发明另外具有通过施用hpHA和/或用hpHA编码DNA转化细胞来治疗荷瘤患者的方法。

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