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1. 发明申请

US20090124512A1 DNA ARRAY ANALYSIS AS A DIAGNOSTIC FOR CURRENT AND EMERGING STRAINS OF INFLUENZA 审中-公开
标题翻译： DNA阵列分析作为流感和新生应激菌株的诊断
公开(公告)号：US20090124512A1
公开(公告)日：2009-05-14
申请号：US12160784
申请日：2007-01-18
申请人： Kathy L. Rowlen , Robert Kuchta , Michael Townsend , James Smagala , Chad L. Moore , Erica Dawson , Martin Mehlmann , Nancy Cox , Catherine B. Smith , Daniela Mehlmann
发明人： Kathy L. Rowlen , Robert Kuchta , Michael Townsend , James Smagala , Chad L. Moore , Erica Dawson , Martin Mehlmann , Nancy Cox , Catherine B. Smith , Daniela Mehlmann
IPC分类号： C40B40/06 , C40B50/00 , C40B30/04
CPC分类号： C12Q1/701 , C12Q2565/501
摘要： Embodiments herein provide for methods, compositions and apparati for detection and/or diagnosis of virus types, subtypes and/or strains. In particular embodiments, the virus is an influenza virus. The apparatus may include a microarray with attached capture probes, designed to bind to oligonucleotides capable of binding at least a portion of a nucleic acid sequence of one or more target genes in a broad array of influenza types, subtypes or strains. The compositions may include isolated nucleic acids as capture probes, target sequences and/or tagged label probes, of use for diagnosis and/or detection of influenza virus.
摘要翻译：本文的实施方案提供了用于病毒类型，亚型和/或毒株的检测和/或诊断的方法，组合物和装置。在具体实施方案中，病毒是流感病毒。该装置可以包括具有连接的捕获探针的微阵列，设计成与能够结合广泛的流感类型，亚型或毒株的一个或多个目标基因的核酸序列的至少一部分的寡核苷酸结合。组合物可以包括用于诊断和/或检测流感病毒的分离的核酸作为捕获探针，靶序列和/或标记的标记探针。

2. 发明授权

US07354706B2 Use of photopolymerization for amplification and detection of a molecular recognition event 失效
标题翻译：使用光聚合进行扩增和检测分子识别事件
公开(公告)号：US07354706B2
公开(公告)日：2008-04-08
申请号：US11372485
申请日：2006-03-09
申请人： Kathy L. Rowlen , John W. Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
发明人： Kathy L. Rowlen , John W. Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53
CPC分类号： C12Q1/6816 , C12Q2565/401
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一个实施方案中，足够的聚合物形式可通过目视检查来检测。

3. 发明申请

US20060286570A1 Use of photopolymerization for amplification and detection of a molecular recognition event 失效
标题翻译：使用光聚合扩增和检测分子识别事件
公开(公告)号：US20060286570A1
公开(公告)日：2006-12-21
申请号：US11372485
申请日：2006-03-09
申请人： Kathy Rowlen , John Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
发明人： Kathy Rowlen , John Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/401
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一个实施方案中，足够的聚合物形式可通过目视检查来检测。

4. 发明申请

US20100273670A1 DETECTION OF ANTIVIRAL RESISTANCE IN INFLUENZA A USING DNA MICROARRAY 审中-公开
标题翻译：检测使用DNA微阵列的流感病毒抗性
公开(公告)号：US20100273670A1
公开(公告)日：2010-10-28
申请号：US12438271
申请日：2007-08-21
申请人： Kathy L. Rowlen , Robert Kuchta , Michael Townsend , James Smagala , Erica Dawson
发明人： Kathy L. Rowlen , Robert Kuchta , Michael Townsend , James Smagala , Erica Dawson
IPC分类号： C40B30/04 , C40B40/06 , C40B50/14
CPC分类号： C12Q1/70
摘要： Embodiments of the present invention relate to compositions, methods and apparatus for detection of antiviral agent resistance or sensitivity of a virus. In some embodiments, antiviral agent resistance or sensitivity of influenza types, such as A, B and C may be identified. In more embodiments, sub-types such as the hemagglutinin (HA) and neuraminidase (NA) of influenza A may be analyzed for antiviral agent resistance or sensitivity. In a particular embodiment, the various strains of influenza virus may be analyzed for resistance or sensitivity using DNA microarray analysis designed to target a gene segment. In various embodiments, a microarray-based assay system with capture and detection (label) probes may be utilized to identify a change in a gene segment that confers resistance or sensitivity to an antiviral agent of an influenza strain.
摘要翻译：本发明的实施方案涉及用于检测抗病毒剂抗性或病毒敏感性的组合物，方法和装置。在一些实施方案中，可以鉴定抗病毒剂抗性或流感类型如A，B和C的敏感性。在更多实施方案中，可以分析甲型流感病毒的血细胞凝集素（HA）和神经氨酸酶（NA）等亚类的抗病毒药物抗性或敏感性。在一个具体实施方案中，可以使用设计用于靶向基因片段的DNA微阵列分析来分析各种流感病毒株的抗性或敏感性。在各种实施方案中，具有捕获和检测（标记）探针的基于微阵列的测定系统可用于鉴定赋予对流感病毒株抗病毒药物的抗性或敏感性的基因区段的变化。

5. 发明申请

US20100130378A1 MICROARRAY-BASED LINEAGE ANALYSIS AS A DIAGNOSTIC FOR CURRENT AND EMERGING STRAINS OF INFLUENZA B 审中-公开
标题翻译：基于微阵列的线性分析作为流感和流感菌株B的流感和新生应变的诊断
公开(公告)号：US20100130378A1
公开(公告)日：2010-05-27
申请号：US12522146
申请日：2008-01-03
申请人： Kathy L. Rowlen , Daniela M. Mehlmann , Robert Kuchta , Martin Mehlmann , James Smagala , Chad Moore , Erica Dawson-Tenet , Nancy Cox , Michael W. Shaw
发明人： Kathy L. Rowlen , Daniela M. Mehlmann , Robert Kuchta , Martin Mehlmann , James Smagala , Chad Moore , Erica Dawson-Tenet , Nancy Cox , Michael W. Shaw
IPC分类号： C40B30/04 , C40B40/06 , C40B50/14
CPC分类号： C12Q1/701
摘要： Embodiments herein provide for methods, compositions and apparatus for detection and/or diagnosis of pathogenic virus lineage and/or strains. In some embodiments, the virus is influenza Type B virus. In other embodiments, an apparatus may include a microarray with attached capture probes, designed to bind to nucleic acid sequences from a single gene in a broad array of influenza strains. In some embodiments, compositions may include isolated nucleic acid sequences of use as capture probes, target sequences and/or label probe sequences, for diagnosis of and/or detection of influenza virus.
摘要翻译：本文的实施方案提供了用于检测和/或诊断致病性病毒谱系和/或菌株的方法，组合物和装置。在一些实施方案中，病毒是B型流感病毒。在其他实施方案中，装置可以包括具有连接的捕获探针的微阵列，其被设计为结合来自广泛流感病毒株中的单个基因的核酸序列。在一些实施方案中，组合物可以包括用作诊断和/或检测流感病毒的分离的核酸序列，其用作捕获探针，靶序列和/或标记探针序列。

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