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1. 发明授权

US08652778B2 Use of photopolymerization for amplification and detection of a Molecular Recognition Event 有权
标题翻译：使用光聚合进行扩增和检测分子识别事件
公开(公告)号：US08652778B2
公开(公告)日：2014-02-18
申请号：US13082814
申请日：2011-04-08
申请人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
发明人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
IPC分类号： C12Q1/68 , C40B30/04 , B82Y30/00
CPC分类号： C12Q1/6816 , C12Q2565/401 , C12Q2523/313
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。一方面，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。另一方面，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一方面，所形成的聚合物中可以包括可检测的颗粒。另一方面，足够的聚合物形式可通过视觉检查来检测。

2. 发明申请

US20110251092A1 Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event 有权
标题翻译：使用光聚合扩增和检测分子识别事件
公开(公告)号：US20110251092A1
公开(公告)日：2011-10-13
申请号：US13082814
申请日：2011-04-08
申请人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
发明人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
IPC分类号： C40B30/04 , G01N21/75 , B82Y15/00
CPC分类号： C12Q1/6816 , C12Q2565/401 , C12Q2523/313
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。一方面，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。另一方面，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一方面，所形成的聚合物中可以包括可检测的颗粒。另一方面，足够的聚合物形式可通过视觉检查来检测。

3. 发明申请

US20120070818A1 Flow Measurement and Control for Improved Quantification of Particles in Flow Cytometry 审中-公开
标题翻译：流量测量与控制用于改进流式细胞术中颗粒的定量
公开(公告)号：US20120070818A1
公开(公告)日：2012-03-22
申请号：US13319662
申请日：2009-05-13
申请人： Kathy Rowlen , Matthew Ferris
发明人： Kathy Rowlen , Matthew Ferris
IPC分类号： C12Q3/00 , C12M1/36
CPC分类号： G01N15/14 , G01N15/1404
摘要： The present invention relates to methods that enable improved accuracy for quantitative particle counting in a flowing liquid stream. The methods of the present invention utilize the real-time measurement of flow rates and flow rate control through feedback mechanisms to improve quantification, and this improved quantification translates to more accurate particle counting. In certain embodiments, particles being counted are biological particles in a liquid sample, such as viruses.
摘要翻译：本发明涉及能够提高流动液体流中定量颗粒计数的精度的方法。本发明的方法利用反馈机制的流量和流速控制的实时测量来改进定量，并且这种改进的定量转化为更准确的粒子计数。在某些实施方案中，被计数的颗粒是液体样品中的生物颗粒，例如病毒。

4. 发明申请

US20090163375A1 Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event 审中-公开
标题翻译：使用光聚合扩增和检测分子识别事件
公开(公告)号：US20090163375A1
公开(公告)日：2009-06-25
申请号：US12099560
申请日：2008-04-08
申请人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
发明人： Christopher N. Bowman , Kathy Rowlen , Hadley Sikes , Ryan Hansen , Heather Jean Avens
IPC分类号： C40B30/04
CPC分类号： C12Q1/6816 , C12Q2565/401 , C12Q2523/313
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In one aspect, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another aspect, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another aspect, detectable particles can be included in the polymer formed. In another aspect, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。一方面，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。另一方面，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一方面，所形成的聚合物中可以包括可检测的颗粒。另一方面，足够的聚合物形式可通过视觉检查来检测。

5. 发明申请

US20060286570A1 Use of photopolymerization for amplification and detection of a molecular recognition event 失效
标题翻译：使用光聚合扩增和检测分子识别事件
公开(公告)号：US20060286570A1
公开(公告)日：2006-12-21
申请号：US11372485
申请日：2006-03-09
申请人： Kathy Rowlen , John Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
发明人： Kathy Rowlen , John Birks , Christopher Bowman , Hadley Sikes , Ryan Hansen , Robert Kuchta
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/401
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。在另一个实施方案中，足够的聚合物形式可通过目视检查来检测。

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