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1. 发明授权

US08864701B2 Implantable MEMS device and method 有权
标题翻译：可植入MEMS器件及方法
公开(公告)号：US08864701B2
公开(公告)日：2014-10-21
申请号：US13584435
申请日：2012-08-13
申请人： Cesario P. Dos Santos , Nicholas M. Gunn , Robert J. Sanchez, Jr. , Leslie A. Field , Chen Ning
发明人： Cesario P. Dos Santos , Nicholas M. Gunn , Robert J. Sanchez, Jr. , Leslie A. Field , Chen Ning
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61B3/16 , A61B2562/028 , A61F2210/0076
摘要： An implantable MEMS package for the treatment of an ocular condition is provided. The MEMS package includes an outer portion; an active portion attached to the outer portion, the active portion including a fluid regulating element having a moving element; and a fluidic channel at an interface of the outer portion and the active portion. The fluidic channel is formed in at least one of the outer and active portions and permits fluid communication from the MEMS package to the fluid regulating element. A method for forming a MEMS package as above is also provided. An ocular implant for treating glaucoma including an inlet tube for receiving aqueous humor; a MEMS package as above, coupled to the inlet tube; a control system to control the MEMS package; and an outlet tube for draining aqueous humor at a drainage location, is provided.
摘要翻译：提供了一种用于治疗眼睛病症的植入式MEMS封装。 MEMS封装包括外部部分; 活动部分附接到外部部分，活动部分包括具有移动元件的流体调节元件; 以及在外部部分和活动部分的界面处的流体通道。流体通道形成在外部和活动部分中的至少一个中，并且允许从MEMS封装到流体调节元件的流体连通。还提供了如上形成MEMS封装的方法。一种用于治疗青光眼的眼部植入物，包括用于接收房水的入口管; 如上所述的MEMS封装，耦合到入口管; 控制系统来控制MEMS封装; 并且提供用于在排水位置排出房水的出口管。

2. 发明申请

US20120022505A1 Closed loop glaucoma drug delivery system 审中-公开
标题翻译：闭环青光眼药物输送系统
公开(公告)号：US20120022505A1
公开(公告)日：2012-01-26
申请号：US13109155
申请日：2011-05-17
申请人： Bruno Dacquay , Robert J. Sanchez, JR. , Matthew J.A. Rickard
发明人： Bruno Dacquay , Robert J. Sanchez, JR. , Matthew J.A. Rickard
IPC分类号： A61M5/00
CPC分类号： A61M5/1723 , A61B3/16 , A61M5/14276 , A61M2005/1726 , A61M2205/3523 , A61M2205/3569 , A61M2205/52 , A61M2205/8243 , A61M2210/0612
摘要： A device implantable into an eye of a patient for treatment of glaucoma. The device has an implantable sensor configured to measure at least one characteristic of the eye. The implantable sensor is sized for implantation into the eye. The device also has an implantable processor coupled to the sensor and configured to receive the measurement of the at least one characteristic of the eye and generate a signal based on the received measurement. Additionally, the device has an implantable actuator coupled to the processor and operable to release a dosage of a therapeutic agent into the eye in response to the signal from the implantable processor.
摘要翻译：可植入患者眼睛的用于治疗青光眼的装置。该装置具有被配置为测量眼睛的至少一种特征的可植入传感器。该植入式传感器的尺寸适于植入眼睛。该装置还具有耦合到传感器的可植入处理器，并且被配置为接收眼睛的至少一个特性的测量并且基于所接收的测量产生信号。另外，该装置具有耦合到处理器的可植入致动器，并且可操作以响应于来自可植入处理器的信号将治疗剂的剂量释放到眼睛中。

3. 发明授权

US09782541B2 Temperature control device and thermal sensor assembly for medical device 有权
公开(公告)号：US09782541B2
公开(公告)日：2017-10-10
申请号：US12444000
申请日：2007-10-01
申请人： Cesario Dos Santos , Robert J. Sanchez, Jr.
发明人： Cesario Dos Santos , Robert J. Sanchez, Jr.
IPC分类号： A61M5/145 , A61M5/142 , A61M5/20 , A61F9/00 , A61M5/31 , A61M5/44 , A61M5/315 , A61M5/14
CPC分类号： A61M5/20 , A61F9/0017 , A61M5/1413 , A61M5/14244 , A61M5/14526 , A61M5/14546 , A61M5/14566 , A61M5/3129 , A61M5/31511 , A61M5/445 , A61M2005/14268 , A61M2205/3368 , A61M2205/3653 , A61M2205/50 , A61M2205/6027 , A61M2205/8206 , A61M2210/0612
摘要： A dispensing assembly has a dispensing chamber housing, a temperature control device, a thermal sensor, and an interface. The dispensing chamber housing has an inner surface, an outer surface, and a wall thickness. The inner surface partially defines a dispensing chamber for receiving a quantity of a substance. The temperature control device at least partially surrounds the dispensing chamber housing. The temperature control device alters a temperature of a substance in the dispensing chamber. The temperature control device and the thermal sensor are located on a substrate. The substrate is wrapped around an exterior surface of the dispensing chamber housing. The interface is connected to the temperature control device and the thermal sensor. An interface connector is connected to the interface. The distance between the temperature control device and the thermal sensor is approximately equal to the wall thickness of the dispensing chamber housing.

4. 发明授权

US08876751B2 Phacoemulsification handpiece pressure booster 有权
标题翻译：超声乳化手机加压器
公开(公告)号：US08876751B2
公开(公告)日：2014-11-04
申请号：US12536539
申请日：2009-08-06
申请人： Bruno Dacquay , Robert J. Sanchez, Jr.
发明人： Bruno Dacquay , Robert J. Sanchez, Jr.
IPC分类号： A61M1/00
CPC分类号： A61M1/0031 , A61M1/0064 , A61M3/0283 , A61M2210/0612
摘要： In various embodiments, a handpiece may include an irrigation line coupled to an adjacent line reservoir with a piston configured to move within the adjacent line reservoir to increase an irrigation pressure in the irrigation line near a surgical site. In some embodiments, a sensor may be used to detect an occlusion break in the aspiration line and information from the sensor may result in signaling an actuator to move the piston in response to the occlusion break detection to compensate for a vacuum pressure drop associated with the occlusion break. The handpiece may further include a purge bypass line between the irrigation line and the adjacent line reservoir to allow flow from the irrigation line to travel through the adjacent line reservoir to purge the adjacent line reservoir.
摘要翻译：在各种实施例中，手持件可以包括连接到相邻的线容器的冲洗管线，其中活塞构造成在相邻管线容器内移动以增加在外科手术部位附近的灌溉管线中的冲洗压力。在一些实施例中，可以使用传感器来检测抽吸管线中的堵塞断裂，并且来自传感器的信息可以导致致动器响应于闭塞断裂检测而使活塞移动以补偿与...相关联的真空压降闭塞断裂所述手持件还可以包括在所述冲洗管线和所述相邻的管线容器之间的净化旁通管线，以允许从所述灌溉管线流出以通过所述相邻的管线储存器以净化所述相邻的管路储存器。

5. 发明申请

US20130317412A1 Flow Control For Treating A Medical Condition 审中-公开
标题翻译：治疗病情的流量控制
公开(公告)号：US20130317412A1
公开(公告)日：2013-11-28
申请号：US13478145
申请日：2012-05-23
申请人： Bruno Dacquay , Cesario P. Dos Santos , Casey J. Lind , Robert J. Sanchez, JR. , Mathew J.A. Rickard
发明人： Bruno Dacquay , Cesario P. Dos Santos , Casey J. Lind , Robert J. Sanchez, JR. , Mathew J.A. Rickard
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61B5/0031 , A61B5/03
摘要： An apparatus for treatment of a medical condition of a patient to provide drainage from a region of a patient to a drainage location includes a memory having a plurality of different selectable treatment algorithms stored therein for treating a medical condition, and may include a processor associated with the memory and configured to execute one of the different treatment algorithms. It also may include a flow system controllable by the processor to regulate drainage of fluid from a body portion having a medical condition, the flow system being controllable according to a selected algorithm of said different selectable treatment algorithms. In one aspect, the apparatus further comprises an implantable medical device for treating an ocular condition, and the processor is carried on the implantable medical device.
摘要翻译：一种用于治疗患者的医疗状况以提供从患者区域到排水位置的排泄的装置包括：存储器，其存储有用于治疗医疗状况的多种不同的可选择的治疗算法，并且可以包括与存储器并且被配置为执行不同处理算法之一。它还可以包括可由处理器控制的流动系统，以调节来自具有医疗状况的身体部分的流体的排出，所述流动系统可根据所述不同的可选择治疗算法的所选择的算法来控制。在一个方面，所述装置还包括用于治疗眼睛状况的可植入医疗装置，并且所述处理器承载在所述可植入医疗装置上。

6. 发明申请

US20130211313A1 Corrugated Membrane Actuators 有权
标题翻译：波纹膜驱动器
公开(公告)号：US20130211313A1
公开(公告)日：2013-08-15
申请号：US13396011
申请日：2012-02-14
申请人： Cesario P. Dos Santos , Robert J. Sanchez, JR. , Leslie A. Field
发明人： Cesario P. Dos Santos , Robert J. Sanchez, JR. , Leslie A. Field
IPC分类号： A61F9/00
CPC分类号： A61F9/00781 , A61M2039/2433
摘要： An IOP control valve is disclosed. The IOP control valve comprises a corrugated membrane and a housing including a fluid inlet and a fluid outlet. The corrugated membrane is anchored within the housing to form a reference chamber on a first side of the corrugated membrane and a fluid flow channel on a second opposing side of the membrane. The reference chamber has a reference chamber pressure representative of atmospheric pressure. The fluid flow channel can selectively increase and decrease in size to permit fluid to flow from the fluid inlet to the fluid outlet. The corrugated membrane is configured to affect flow through the fluid flow channel from the fluid inlet to the fluid outlet by deflecting in response to pressure differentials of the reference chamber pressure and the fluid flow channel pressure acting on the opposing sides of the corrugated membrane.
摘要翻译：公开了一种IOP控制阀。 IOP控制阀包括波纹膜和包括流体入口和流体出口的壳体。波纹膜被锚固在壳体内以在波纹膜的第一侧上形成参考室，并且在膜的第二相对侧上形成流体流动通道。参考室具有代表大气压力的参考室压力。流体流动通道可以选择性地增加和减小尺寸，以允许流体从流体入口流到流体出口。波纹膜被配置为响应于参考室压力和作用在波纹膜的相对侧上的流体流动通道压力的压力而通过偏转而影响通过流体流动通道从流体入口到流体出口的流动。

7. 发明申请

US20110034864A1 PHACOEMULSIFICATION HANDPIECE PRESSURE BOOSTER 有权
标题翻译： PHACOEMULSIFICATION HANDPIECE压力增压器
公开(公告)号：US20110034864A1
公开(公告)日：2011-02-10
申请号：US12536539
申请日：2009-08-06
申请人： Bruno Dacquay , Robert J. Sanchez, JR.
发明人： Bruno Dacquay , Robert J. Sanchez, JR.
IPC分类号： A61F9/007 , A61M1/00
CPC分类号： A61M1/0031 , A61M1/0064 , A61M3/0283 , A61M2210/0612
摘要： In various embodiments, a handpiece may include an irrigation line coupled to an adjacent line reservoir with a piston configured to move within the adjacent line reservoir to increase an irrigation pressure in the irrigation line near a surgical site. In some embodiments, a sensor may be used to detect an occlusion break in the aspiration line and information from the sensor may result in signaling an actuator to move the piston in response to the occlusion break detection to compensate for a vacuum pressure drop associated with the occlusion break. The handpiece may further include a purge bypass line between the irrigation line and the adjacent line reservoir to allow flow from the irrigation line to travel through the adjacent line reservoir to purge the adjacent line reservoir.
摘要翻译：在各种实施例中，手持件可以包括连接到相邻的线容器的冲洗管线，其中活塞构造成在相邻管线容器内移动以增加在外科手术部位附近的灌溉管线中的冲洗压力。在一些实施例中，可以使用传感器来检测抽吸管线中的堵塞断裂，并且来自传感器的信息可以导致致动器响应于闭塞断裂检测而使活塞移动以补偿与...相关联的真空压降闭塞断裂所述手持件还可以包括在所述冲洗管线和所述相邻的管线容器之间的净化旁通管线，以允许从所述灌溉管线流出以通过所述相邻的管线储存器以净化所述相邻的管路储存器。

8. 发明申请

US20100030157A1 Drug Retention Cap 审中-公开
标题翻译：药物保留上限
公开(公告)号：US20100030157A1
公开(公告)日：2010-02-04
申请号：US12364004
申请日：2009-02-02
申请人： Cesario Dos Santos , Robert J. Sanchez, JR.
发明人： Cesario Dos Santos , Robert J. Sanchez, JR.
IPC分类号： A61M5/31 , A61B19/02
CPC分类号： A61M5/3202 , A61M2005/311
摘要： A drug retention cap has a cap section and a drug retention pin. The cap section has a generally dome-shaped top end and a cylindrical portion extending downward from the generally dome-shaped top end. The top end of the cap section is closed, and the bottom end is open. The open bottom end is configured to receive a needle of a drug delivery device. The drug retention pin extends from near the apex of the dome-shaped top end downward toward the open bottom end. The drug retention pin is configured to fit inside a hollow needle.
摘要翻译：药物保持帽具有帽部分和药物保持针。盖部分具有大致圆顶形的顶端和从大致圆顶形的顶端向下延伸的圆柱形部分。盖部分的顶端封闭，底端打开。打开的底端构造成接收药物递送装置的针。药物保持销从圆顶状顶端的顶点附近向下朝向开放的底端延伸。药物保持销被配置成装配在中空针内。

9. 发明授权

US09022970B2 Ophthalmic injection device including dosage control device 有权
标题翻译：眼科注射装置包括剂量控制装置
公开(公告)号：US09022970B2
公开(公告)日：2015-05-05
申请号：US12444044
申请日：2007-10-09
申请人： Bruno Dacquay , Casey Lind , Cesario Dos Santos , Robert J Sanchez, Jr.
发明人： Bruno Dacquay , Casey Lind , Cesario Dos Santos , Robert J Sanchez, Jr.
IPC分类号： A61M5/315 , A61F9/00 , A61M5/142 , A61M5/20
CPC分类号： A61F9/0017 , A61M5/14224 , A61M5/20 , A61M5/31525 , A61M5/31546 , A61M2205/0244 , A61M2205/3368 , A61M2205/3606 , A61M2205/3653 , A61M2205/6018 , A61M2210/0612
摘要： An injection device includes a dispensing chamber, a plunger, a controller, a temperature control device, and a memory device. The dispensing chamber has an inner surface and an outer surface. The inner surface defines a cavity for receiving a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber, is capable of sliding in the cavity of the dispensing chamber, and is fluidly sealed to the inner surface of the dispensing chamber. The controller controls the operation of the injection device. The temperature control device at least partially surrounds the dispensing chamber. The memory device has a parameter stored on it. The controller uses the parameter from the memory device to operate the injection device.
摘要翻译：注射装置包括分配室，柱塞，控制器，温度控制装置和存储装置。分配室具有内表面和外表面。内表面限定用于接收一定量的物质的空腔。柱塞与分配室的内表面接合，能够在分配室的空腔中滑动，并且流体地密封到分配室的内表面。控制器控制注射装置的操作。温度控制装置至少部分地围绕分配室。存储器件具有存储在其上的参数。控制器使用来自存储器装置的参数来操作注射装置。

10. 发明授权

US08834169B2 Method and apparatus for automating arm and grasping movement training for rehabilitation of patients with motor impairment 有权
标题翻译：自动化手臂运动训练用于运动障碍患者康复的方法和装置
公开(公告)号：US08834169B2
公开(公告)日：2014-09-16
申请号：US11512670
申请日：2006-08-30
申请人： David Reinkensmeyer , Robert J. Sanchez, Jr. , Punit Shah , Robert F. Smith, Jr.
发明人： David Reinkensmeyer , Robert J. Sanchez, Jr. , Punit Shah , Robert F. Smith, Jr.
IPC分类号： G09B9/00 , A61H1/02 , A61B5/11 , A61B5/00 , B25J9/00 , A61F5/01
CPC分类号： A61H1/0274 , A61B5/11 , A61B5/1116 , A61B5/1124 , A61B5/4519 , A61B5/4528 , A61B5/486 , A61F5/0102 , A61H1/0237 , A61H1/0281 , A61H2201/5007 , A61H2201/5064 , B25J9/0006
摘要： A method and apparatus for upper limb rehabilitation training of coordinated arm/forearm, forearm/forearm and grasping movements of a motor impaired patient comprises a nonrobotic, passive support, an arm/forearm sensor, a gripping device, a grip sensor capable of measuring an impaired grasping force of a grasping of the patient, a computer to process measurements of coordinated and simultaneous impaired arm/forearm, forearm/forearm and grasping movements to control a graphical representation of the arm/forearm and grasping movements in interaction with a virtual environment, and to provide a visual feedback signal to the patient of simulated normal activities of daily living performed with enhanced motor ability relative to the actual impaired motor ability. A visual feedback signal of the simulated activities of daily living is provided to motivate the patient to perform the upper limb rehabilitation movement training despite limited motor ability.
摘要翻译：一种用于协调臂/前臂，前臂/前臂以及运动障碍患者的抓握运动的上肢康复训练的方法和装置包括无脊椎动物，被动支撑，臂/前臂传感器，夹持装置，能够测量抓握患者的抓握力受损，计算机处理协调和同时受损的手臂/前臂，前臂/前臂和抓握运动的测量，以控制臂/前臂的图形表示和与虚拟环境相互作用的抓握运动，并为患者提供视觉反馈信号，使其相对于实际受损的运动能力，具有增强的运动能力而进行的日常生活的模拟正常活动。提供日常生活的模拟活动的视觉反馈信号，以激励患者进行上肢康复运动训练，尽管运动能力有限。

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