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1. 发明授权

US08663922B2 Systems and methods for detecting multiple optical signals 有权
标题翻译：用于检测多个光信号的系统和方法
公开(公告)号：US08663922B2
公开(公告)日：2014-03-04
申请号：US12791390
申请日：2010-06-01
申请人： Matthew J. Hayes , Byron J. Knight , Haitao Li , Robert F. Scalese
发明人： Matthew J. Hayes , Byron J. Knight , Haitao Li , Robert F. Scalese
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： To minimize cross talk in systems and methods for detecting two or more different optical signals emitted from each of a plurality of reaction receptacles, an excitation signal associated with each of the optical signals has a known excitation frequency, and any detected signal having a frequency that is inconsistent with the excitation frequency is discarded. The receptacles are moved relative to optical sensors configured to detect each unique optical signal from an associated receptacle, and to further minimize cross talk, the optical sensors are arranged so that only one reaction receptacle at a time is in a signal detecting position with respect to one of its associated optical sensors, and the optical sensors are grouped by the optical signal they are configured to detect so that a first optical signal is detected from each of the reaction receptacles before a second optical signal is detected from the reaction receptacles.
摘要翻译：为了最小化用于检测从多个反应容器中的每一个发射的两个或多个不同光信号的系统和方法中的串扰，与每个光信号相关联的激励信号具有已知的激励频率，并且任何检测信号的频率为与激励频率不一致被丢弃。插座相对于被配置为从相关联的容器检测每个唯一的光信号的光学传感器移动，并且进一步最小化串扰，光学传感器被布置成使得一次只有一个反应容器处于信号检测位置其相关联的光学传感器之一，并且光学传感器被配置为被检测的光信号分组，使得在从反应容器检测到第二光信号之前，从每个反应容器检测第一光信号。

2. 发明申请

US20100240063A1 SYSTEMS AND METHODS FOR DETECTING MULTIPLE OPTICAL SIGNALS 有权
标题翻译：用于检测多个光信号的系统和方法
公开(公告)号：US20100240063A1
公开(公告)日：2010-09-23
申请号：US12791390
申请日：2010-06-01
申请人： Matthew J. HAYES , Byron J. KNIGHT , Haitao Li , Robert F. Scalese
发明人： Matthew J. HAYES , Byron J. KNIGHT , Haitao Li , Robert F. Scalese
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： To minimize cross talk in systems and methods for detecting two or more different optical signals emitted from each of a plurality of reaction receptacles, an excitation signal associated with each of the optical signals has a known excitation frequency, and any detected signal having a frequency that is inconsistent with the excitation frequency is discarded. The receptacles are moved relative to optical sensors configured to detect each unique optical signal from an associated receptacle, and to further minimize cross talk, the optical sensors are arranged so that only one reaction receptacle at a time is in a signal detecting position with respect to one of its associated optical sensors, and the optical sensors are grouped by the optical signal they are configured to detect so that a first optical signal is detected from each of the reaction receptacles before a second optical signal is detected from the reaction receptacles.
摘要翻译：为了最小化用于检测从多个反应容器中的每一个发射的两个或多个不同光信号的系统和方法中的串扰，与每个光信号相关联的激励信号具有已知的激励频率，并且任何检测信号的频率为与激励频率不一致被丢弃。插座相对于被配置为从相关联的容器检测每个唯一的光信号的光学传感器移动，并且进一步最小化串扰，光学传感器被布置成使得一次只有一个反应容器处于信号检测位置其相关联的光学传感器之一，并且光学传感器被配置为被检测的光信号分组，使得在从反应容器检测到第二光信号之前，从每个反应容器检测第一光信号。

3. 发明授权

US06247246B1 Microwave moisture analyzer: apparatus and method 失效
标题翻译：微波水分仪：仪器和方法
公开(公告)号：US06247246B1
公开(公告)日：2001-06-19
申请号：US09086756
申请日：1998-05-27
申请人： Robert F. Scalese , Thomas B. Taylor , Tim Holzschuh , Douglas E. Harbert , Thomas G. Playen , Martin L. Maple , Jan Claesson
发明人： Robert F. Scalese , Thomas B. Taylor , Tim Holzschuh , Douglas E. Harbert , Thomas G. Playen , Martin L. Maple , Jan Claesson
IPC分类号： F26B334
CPC分类号： G01N22/04 , G01N5/045
摘要： A toploading weighing instrumentality which determines loss on drying by a cylindrical microwave. The cylindrical cavity of the microwave includes a power supply, a magnetron, a power module operatively coupled between said power supply and said magnetron for driving said magnetron, a wave guide communicating with the magnetron and with a microwave containment chamber for delivering energy thereto, at least one microwave energy sensor for sensing microwave energy or magnetic and/or electric field strength within the chamber for controlling, inter alia, the loss on drying process of the sample being assayed and determining when the drying process is complete. A precision electronic balance is operatively disposed within the microwave chamber for allowing a specimen being assayed to be weighed. In addition, a ventilation chamber is provided for venting moisture from the microwave chamber. A processing unit and associated memory allows means for data acquisition, processing and storage of data from the power module driving the magnetron, the microwave energy sensor(s) for sensing magnetic and/or electric fields and the electronic balance for weighing the initial and final weights of the specimen for loss on drying moisture analysis. Both signaling the removal of microwave energy in the chamber.
摘要翻译：确定圆柱形微波炉干燥损失的称重称重工具。微波炉的圆柱形腔包括电源，磁控管，可操作地耦合在所述电源和所述磁控管之间用于驱动所述磁控管的功率模块，与磁控管连通的波导管和用于将能量传递到其的微波容纳室，用于感测室内的微波能量或磁场强度和/或电场强度的至少一个微波能量传感器，用于特别地控制待测样品的干燥过程的损失并确定干燥过程何时完成。精密电子天平可操作地设置在微波室内，用于测量待测样品。此外，设置有通风室用于从微波室排放湿气。处理单元和相关联的存储器允许用于数据采集，处理和存储来自驱动磁控管的功率模块的数据，用于感测磁场和/或电场的微波能量传感器和用于称量初始和最终的电子天平的装置干燥水分损失试样的重量分析。两者都表明在室中去除微波能量。

4. 发明授权

US6092924A Microwave moisture analyzer: apparatus and method 失效
标题翻译：微波水分仪：仪器和方法
公开(公告)号：US6092924A
公开(公告)日：2000-07-25
申请号：US21570
申请日：1998-02-10
申请人： Robert F. Scalese , Thomas B. Taylor , Tim Holzschuh , Douglas E. Harbert , Thomas G. Plaven , Martin L. Maple , Jan Claesson
发明人： Robert F. Scalese , Thomas B. Taylor , Tim Holzschuh , Douglas E. Harbert , Thomas G. Plaven , Martin L. Maple , Jan Claesson
IPC分类号： G01N22/04 , G01N25/00
CPC分类号： G01N22/04
摘要： A toploading weighing apparatus which determines weight loss for a sample by drying the sample in a cylindrical microwave with a specific structure.
摘要翻译：一种称重装置，其通过在具有特定结构的圆柱形微波炉中干燥样品来确定样品的重量损失。

5. 发明授权

US08008066B2 System for performing multi-formatted assays 有权
标题翻译：执行多格式化测定的系统
公开(公告)号：US08008066B2
公开(公告)日：2011-08-30
申请号：US11372221
申请日：2006-03-10
申请人： Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert E. Heinz , Jerzy A. Macioszek , Christopher B. Davis , Robert F. Scalese
发明人： Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert E. Heinz , Jerzy A. Macioszek , Christopher B. Davis , Robert F. Scalese
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

6. 发明申请

US20110147610A1 SYSTEM FOR CONTINUOUS MODE PROCESSING OF THE CONTENTS OF MULTIPLE REACTION RECEPTACLES IN A REAL-TIME AMPLIFICATION ASSAY 有权
标题翻译：用于实时放大测定中多重反应插入物的内容的连续模式处理系统
公开(公告)号：US20110147610A1
公开(公告)日：2011-06-23
申请号：US13031889
申请日：2011-02-22
申请人： Jerzy A. MACIOSZEK , Christopher B. DAVIS , Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence F. LI , Byron J. KNIGHT , Robert F. SCALESE , Robert E. HEINZ
发明人： Jerzy A. MACIOSZEK , Christopher B. DAVIS , Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence F. LI , Byron J. KNIGHT , Robert F. SCALESE , Robert E. HEINZ
IPC分类号： G01N21/01 , G01N23/10
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

7. 发明申请

US20110053169A1 METHOD FOR CONTINUOUS MODE PROCESSING OF THE CONTENTS OF MULTIPLE REACTION RECEPTACLES IN A REAL-TIME AMPLIFICATION ASSAY 有权
标题翻译：连续模式处理实时放大测定中多重反应接收物的内容的方法
公开(公告)号：US20110053169A1
公开(公告)日：2011-03-03
申请号：US12939420
申请日：2010-11-04
申请人： Jerzy A. MACIOSZEK , Christopher B. DAVIS , Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence F. LI , Byron J. KNIGHT , Robert F. SCALESE , Robert E. HEINZ
发明人： Jerzy A. MACIOSZEK , Christopher B. DAVIS , Gary D. LAIR , Thanh N. NGUYEN , Haitao LI , Florence F. LI , Byron J. KNIGHT , Robert F. SCALESE , Robert E. HEINZ
IPC分类号： C12Q1/68
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

8. 发明授权

US07897337B2 Method for performing multi-formatted assays 有权
标题翻译：执行多格式测定的方法
公开(公告)号：US07897337B2
公开(公告)日：2011-03-01
申请号：US11372217
申请日：2006-03-10
申请人： Jerzy A. Macioszek , Christopher B. Davis , Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert F. Scalese , Robert E. Heinz
发明人： Jerzy A. Macioszek , Christopher B. Davis , Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert F. Scalese , Robert E. Heinz
IPC分类号： C12Q1/68
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预处理分析物分离程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

9. 发明授权

US06702134B2 Closure system 有权
标题翻译：封闭系统
公开(公告)号：US06702134B2
公开(公告)日：2004-03-09
申请号：US10259071
申请日：2002-09-27
申请人： Robert F. Scalese , Daniel L. Kacian
发明人： Robert F. Scalese , Daniel L. Kacian
IPC分类号： B65D4100
CPC分类号： B01L3/50825 , B65D41/0414
摘要： A closure system useful for storing fluids under cold storage conditions. The closure system includes cap and container components which combine to form a dual sealing system. The container has a generally cylindrical side wall, a closed bottom end, and an open top end having an inner beveled lip depending from an annular top rim. The cap has a generally circular top wall from which inner and outer skirts depend. The outer skirt is adapted to grip the open top end of the container. The inner skirt includes an outer surface having a lower seal bead and an upper beveled portion mated with the beveled lip. When the cap is fitted onto the container, the seal bead contacts an inner surface of the container and the upper beveled portion and the beveled lip are engaged in an interference fit, thereby impeding the loss of fluid from the closure system under cold storage conditions.
摘要翻译：用于在冷藏条件下储存流体的封闭系统。封闭系统包括盖和容器组件，其组合形成双重密封系统。容器具有大致圆柱形的侧壁，封闭的底端和敞开的顶端，其具有从环形顶部边缘悬垂的内斜面唇缘。盖子具有大致圆形的顶壁，内裙和外裙从该顶壁依赖。外裙部适于夹紧容器的敞开的顶端。内裙部包括具有下密封珠的外表面和与倾斜唇部配合的上斜面部分。当盖安装在容器上时，密封珠接触容器的内表面，并且上斜面部分和斜面唇缘以过盈配合接合，从而在冷藏条件下阻止流体从封闭系统的流失。

10. 发明授权

US08349564B2 Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay 有权
标题翻译：在实时放大测定中连续模式处理多个反应容器内容物的方法
公开(公告)号：US08349564B2
公开(公告)日：2013-01-08
申请号：US12939420
申请日：2010-11-04
申请人： Jerzy A. Macioszek , Christopher B. Davis , Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert F. Scalese , Robert E. Heinz
发明人： Jerzy A. Macioszek , Christopher B. Davis , Gary D. Lair , Thanh N. Nguyen , Haitao Li , Florence F. Li , Byron J. Knight , Robert F. Scalese , Robert E. Heinz
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , G01N35/02 , G01N21/00 , G01N21/03
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预处理分析物分离程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

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