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    • 2. 发明授权
    • Cardiac electrode with drug delivery capabilities
    • 心电极具有药物输送能力
    • US4819662A
    • 1989-04-11
    • US112518
    • 1987-10-26
    • Ronald W. Heil, Jr.Robert C. OwensBrian D. Pederson
    • Ronald W. Heil, Jr.Robert C. OwensBrian D. Pederson
    • A61N1/05A61N1/00
    • A61N1/0568
    • An implantable cardiac pacing lead includes a porous, platinum electrode, a flexible electrically conductive coil, and a crimp tube coupling the electrode to the distal end of the coil. A recess in the crimp tube, open to the electrode at the crimp tube distal end, houses a matrix impregnated with a therapeutic drug. The electrode is highly porous and loaded with a therapeutic drug in liquid or solid form. Immediately upon implant of the electrode at a selected myocardial location, the electrode begins dispensing the therapeutic drug. Meanwhile, the matrix begins to elute its drug at a rate more suited to chronic treatment. If desired, the recess can extend through the crimp tube to permit proximal end loading of the drug carrying matrix. A silicone plug, or an additional and proximal crimp tube section, is inserted into the recess after loading of the matrix to provide the required fluid seal. Finally, a variety of different matrices can be housed in the recess, to provide elution of different drugs and at differing rates.
    • 可植入心脏起搏引线包括多孔铂电极,柔性导电线圈和将电极耦合到线圈的远端的压接管。 在压接管远端的电极开口的压接管中的凹部容纳浸有治疗药物的基质。 电极是高度多孔的,并以液体或固体形式装载治疗药物。 在选定的心肌位置植入电极后,电极开始分配治疗药物。 同时,矩阵开始以更适合慢性治疗的速度洗脱药物。 如果需要,凹槽可以延伸穿过压接管以允许携带药物的基质的近端负载。 在加载基质以提供所需的流体密封之后,硅胶塞或附加的和近端的卷边管部分被插入到凹槽中。 最后,可以将许多不同的基质容纳在凹槽中,以提供不同药物和不同速率的洗脱。
    • 3. 发明授权
    • Diagnostic catheter for monitoring cardiac output
    • 用于监测心输出量的诊断导管
    • US4721115A
    • 1988-01-26
    • US833244
    • 1986-02-27
    • Robert C. Owens
    • Robert C. Owens
    • A61B5/026A61B5/028A61B5/029A61B5/0295A61B5/0408A61B5/0478A61B5/0492A61B5/053A61M25/00A61B5/02
    • A61B5/0538A61B5/028A61B5/029A61B5/0535A61M25/0045A61M25/0054A61M25/09033A61M2025/0036
    • A multi-lumen catheter having a balloon-like expander located at the distal end thereof, the interior of the balloon communicating with one of the plural lumens whereby a fluid introduced at the proximal end of the catheter can be made to inflate the balloon. A series of surface electrodes are axially spaced over a zone located near the distal end of the catheter body. Electrical conductors connected to each of the surface electrodes pass through another lumen to an electrical connector at the proximal end of the catheter. A pair of stiffener members, one being co-extensive with the zone of the catheter bearing the axially spaced surface electrodes and the other being spaced a short predetermined distance proximally of the first stiffener member are in another lumen. The gap between the two stiffener members allows the catheter to bend without kinking the lumens so that, when used, the most proximal ring electrode will be disposed near the apex of the right ventricle with the portion distal of the bend extending upward through the outflow tract of the right ventricle. Further lumens and ports communicating therewith may be added to permit the catheter to be used to take thermal dilution measurements of cardiac outputs.
    • 具有位于其远端的球状扩张器的多腔导管,所述气囊的内部与所述多个管腔中的一个连通,由此可以使导入所述导管近端的流体膨胀所述气囊。 一系列表面电极在位于导管主体远端附近的区域上轴向隔开。 连接到每个表面电极的电导体在导管的近端处通过另一个内腔到电连接器。 一对加强构件,一个与导管的区域共同延伸的轴承间隔开的表面电极,另一个在第一加强构件的近侧间隔一短的预定距离处于另一内腔中。 两个加强构件之间的间隙允许导管弯曲而不扭曲管腔,使得当使用时,最近端的环形电极将设置在右心室的顶点附近,而弯曲部的远端部分向上延伸穿过流出道 的右心室。 可以添加与其连通的其它流明和端口,以允许导管用于对心输出量进行热稀释测量。
    • 5. 发明授权
    • Implantable tapered spiral endocardial lead for use in internal
defibrillation
    • 植入式锥形螺旋心内膜铅用于内部除颤
    • US5133365A
    • 1992-07-28
    • US779526
    • 1991-10-18
    • Ronald W. Heil, Jr.Robert C. Owens
    • Ronald W. Heil, Jr.Robert C. Owens
    • A61N1/05A61N1/39
    • A61N1/3956A61N1/056
    • An improved electrocardial lead for use with an automatic implantable cardioverter/defibrillator (AICD) comprises an elongated, flexible, plastic tubular catheter body which is preformed so that when unconstrained, it assumes the shape of a tapered spiral or helix. The catheter body supports a defibrillating electrode attached to the exterior wall of the catheter body and is connected by a suitable cable to a proximal connector for mating with the AICD pulse generator. The improved lead also includes a tip electrode for sensing cardiac activity and providing information to the AICD pulse generator for controlling its operation. The lead of the present invention is intended for endocardial emplacement with the electrode structures predominantly in the right ventrical and provides substantially increased electrode surface area in contact with heart tissue as compared to prior art endocardial defibrillating leads and, thus, maximizing the energy delivered to the heart during defibrillation.
    • 用于与自动植入式心律转复除颤器(AICD)一起使用的改进的心电引线包括细长的,柔性的塑料管状导管体,其被预成型,使得当不受限制时,其呈现锥形螺旋或螺旋形的形状。 导管主体支撑附着在导管主体的外壁上的除颤电极,并通过合适的电缆连接到用于与AICD脉冲发生器配合的近端连接器。 改进的引线还包括用于感测心脏活动的尖端电极,并向AICD脉冲发生器提供信息以控制其操作。 本发明的领域旨在用于心电图放置,其中电极结构主要在右侧通气孔中,并且与现有技术的心内膜除纤维引线相比,提供与心脏组织接触的基本上增加的电极表面积,从而最大限度地提供给 除颤期间心脏。
    • 6. 发明授权
    • Implantable tapered spiral endocardial lead for use in internal
defibrillation
    • 植入式锥形螺旋心内膜铅用于内部除颤
    • US5016808A
    • 1991-05-21
    • US461980
    • 1990-01-08
    • Ronald W. Heil, Jr.Robert C. Owens
    • Ronald W. Heil, Jr.Robert C. Owens
    • A61N1/05A61N1/39
    • A61N1/3956A61N1/056
    • An improved electrocardial lead for use with an automatic implantable cardioverter/defibrillator (AICD) comprises an elongated, flexible, plastic tubular catheter body which is preformed so that when unconstrained, it assumes the shape of a tapered spiral or helix. The catheter body supports a defibrillating electrode attached to the exterior wall of the catheter body and is connected by a suitable cable to a proximal connector for mating with the AICD pulse generator. The improved lead also includes a tip electrode for sensing cardiac activity and providing information to the AICD pulse generator for controlling its operation. The lead of the present invention is intended for endocardial emplacement with the electrode structures predominantly in the right ventricle and provides substantially increased electrode surface area in contact with heart tissue as compared to prior art endocardial defibrillating leads and, thus, maximizing the energy delivered to the heart during defibrillation.
    • 用于与自动植入式心律转复除颤器(AICD)一起使用的改进的心电引线包括细长的,柔性的塑料管状导管体,其被预成型,使得当不受限制时,其呈现锥形螺旋或螺旋形的形状。 导管主体支撑附着在导管主体的外壁上的除颤电极,并通过合适的电缆连接到用于与AICD脉冲发生器配合的近端连接器。 改进的引线还包括用于感测心脏活动的尖端电极,并向AICD脉冲发生器提供信息以控制其操作。 本发明的领域旨在用于心电图放置,其中电极结构主要位于右心室,并且与现有技术的心内膜除颤引线相比,提供与心脏组织接触的显着增加的电极表面积,从而最大限度地提供给 除颤期间心脏。