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1. 发明授权

US5235409A Optical detection system for capillary separation columns 失效
标题翻译：用于毛细分离柱的光学检测系统
公开(公告)号：US5235409A
公开(公告)日：1993-08-10
申请号：US744563
申请日：1991-08-13
申请人： Dean S. Burgi , John C. Helmer , Ring-Ling Chien
发明人： Dean S. Burgi , John C. Helmer , Ring-Ling Chien
IPC分类号： G01N30/74
CPC分类号： G01N30/74
摘要： On-column optical detection apparatus and method for use with capillary separation columns are shown. The apparatus and method minimize the adverse effects of light scattered from the walls of the column, thereby improving detection sensitivity and providing greater dynamic range. Light from a conventional source is focussed onto a column. Spatial filter means are positioned in front of the column to prevent at least some light from striking the column wall. Another spatial filter is positioned in front of a light collecting means which gathers light emanating from the column. In a specific embodiment, a unique monolens design is shown comprising collecting and focussing lens formed as an integral unit with a bore for a capillary column.

2. 发明授权

US5116471A System and method for improving sample concentration in capillary electrophoresis 失效
标题翻译：提高毛细管电泳样品浓度的系统和方法
公开(公告)号：US5116471A
公开(公告)日：1992-05-26
申请号：US771575
申请日：1991-10-04
申请人： Ring-Ling Chien , Dean S. Burgi
发明人： Ring-Ling Chien , Dean S. Burgi
IPC分类号： G01N27/447
CPC分类号： G01N27/44773
摘要： The method for improving sample concentration in capillary electrophoresis by extracting the sample buffer from the capillary column using the electro-osmotic flow while the sample components are stacked into the support buffer utilizes a system for this technique. The system has a separation column 11, sample introduction means 16 for injecting the sample solution, an injection detector means 20 for detecting the volume of injected sample solution, a separation detector means 21 for detecting the sample components, power supply means 17 for applying a high voltage along the separation column 11 for reversing the direction of the electro-osmotic flow thereby causing extraction of the sample buffer from the separation column and afterward providing the separation sample into its components.
摘要翻译：通过使用电渗流从毛细管柱中提取样品缓冲液，同时将样品组分堆叠到支持缓冲液中，从而提高毛细管电泳中的样品浓度的方法利用该技术的系统。该系统具有分离塔11，用于注射样品溶液的样品引入装置16，用于检测注入的样品溶液的体积的注射检测器装置20，用于检测样品组分的分离检测器装置21，沿着分离塔11的高电压，用于反转电渗流的方向，从而导致样品缓冲液从分离塔中提取，然后将分离样品提供到其组分中。

3. 发明授权

US5089099A Field amplified polarity switching sample injection in capillary zone electrophoresis 失效
标题翻译：毛细管区电泳中的场放大极性切换样品注入
公开(公告)号：US5089099A
公开(公告)日：1992-02-18
申请号：US621169
申请日：1990-11-30
申请人： Ring-Ling Chien , Dean S. Burgi
发明人： Ring-Ling Chien , Dean S. Burgi
IPC分类号： G01N1/00 , G01N27/447
CPC分类号： G01N27/44743 , G01N35/1095
摘要： An improved electroinjection method of introducing a sample having positive and negative ions into a capillary column for CE or CZE process by introducing a short plug of a low concentration buffer before introducing the sample into the column which results in increasing amount of charged ions of the sample introduced in the capillary column due to increasing the electric field at the injection point. A method for efficiently introducing both positive and negative ions is also shown.
摘要翻译：一种改进的电注射方法，其将具有正离子和负离子的样品引入用于CE或CZE方法的毛细管柱中，在将样品引入柱之前引入低浓度缓冲液的短塞，导致样品的带电离子量增加由于注入点处的电场增加，导入毛细管柱。还示出了有效地引入正离子和负离子的方法。

4. 发明申请

US20070151852A1 Mixed mode microfluidic systems 审中-公开
标题翻译：混合模式微流体系统
公开(公告)号：US20070151852A1
公开(公告)日：2007-07-05
申请号：US11594705
申请日：2006-11-07
申请人： Ring-Ling Chien , J. Parce , Michael Spaid
发明人： Ring-Ling Chien , J. Parce , Michael Spaid
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.
摘要翻译：采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连的通道段中的流动由其动力流以及随之而来的塞流动分布主导。本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

5. 发明授权

US07001716B2 Continuous flow methods for monitoring time dependent reactions 有权
标题翻译：用于监测时间依赖性反应的连续流动方法
公开(公告)号：US07001716B2
公开(公告)日：2006-02-21
申请号：US10442006
申请日：2003-05-20
申请人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
发明人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
IPC分类号： C12Q1/00
CPC分类号： G01N21/64 , B01J19/0093 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N21/6428 , G01N21/75 , G01N30/02 , G01N2021/6482 , B01D15/3857
摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.
摘要翻译：用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。

6. 发明授权

US06695009B2 Microfluidic methods, devices and systems for in situ material concentration 有权
标题翻译：用于原位浓缩的微流控方法，装置和系统
公开(公告)号：US06695009B2
公开(公告)日：2004-02-24
申请号：US10013847
申请日：2001-10-30
申请人： Ring-Ling Chien , Benjamin N. Wang
发明人： Ring-Ling Chien , Benjamin N. Wang
IPC分类号： G05D706
CPC分类号： G01N27/44791 , B01L3/502753 , B01L2200/0631 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , Y10T137/0391 , Y10T137/2076 , Y10T137/2142 , Y10T137/2191
摘要： Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, devices and systems employ static fluid interfaces to generate the differential velocities, as well as counter-current flow methods, to concentrate materials within microscale channels.
摘要翻译：通过将材料移动到其中材料的总体速度减小的区域中将材料集中在微流体通道网络内的方法，导致材料在那些降低的速度区域内堆叠。这些方法，设备和系统采用静态流体界面来产生差分速度，以及逆流流动方法，以将材料集中在微量通道内。

7. 发明授权

US5596407A Optical detector for echelle spectrometer 失效
标题翻译：光电探测器
公开(公告)号：US5596407A
公开(公告)日：1997-01-21
申请号：US477169
申请日：1995-06-07
申请人： Andrew T. Zander , Charles B. Cooper, III , Ring-Ling Chien
发明人： Andrew T. Zander , Charles B. Cooper, III , Ring-Ling Chien
IPC分类号： G01J3/18 , G01J3/28 , G01J3/36
CPC分类号： G01J3/2803
摘要： A solid-state detector for use in an atomic spectrometer comprises a plurality of arrays of sensing elements, or pixels, each of the arrays being positioned along and on the locations of spectral signals on a focal plane of an echelle grating spectrometer. The sensing elements are positioned along the many diffraction orders presented on a two-dimensional echelle grating focal plane so that at least one element is located at each and every resolution element regardless of global x-y coordinate positioning of the elements or with reference to each other. The result is a series of skewed lines of sensing elements, those lines being in the same shape as the series of diffraction order lines which comprise an echelle spectrum. The solid-state detector is particularly useful in an atomic spectrometer wherein an echelle grating is used to diffract incident radiation such that the various components of the radiation may be observed.
摘要翻译：用于原子光谱仪的固态检测器包括多个感测元件或像素阵列，每个阵列沿着光谱信号的位置定位在梯形光栅光谱仪的焦平面上。感测元件沿着呈现在二维光栅焦平面上的许多衍射级定位，使得至少一个元件位于每个分辨率元素处，而不管元件的全局x-y坐标定位或彼此参考。结果是传感元件的一系列偏斜线，那些线与包括梯形图的一系列衍射级线具有相同的形状。固态检测器在原子光谱仪中特别有用，其中使用梯形光栅衍射入射辐射，使得可观察到辐射的各种成分。

8. 发明授权

US07233865B2 Method for determining diffusivity and molecular weight in a microfluidic device 有权
标题翻译：用于确定微流体装置中的扩散系数和分子量的方法
公开(公告)号：US07233865B2
公开(公告)日：2007-06-19
申请号：US11482342
申请日：2006-07-06
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01N33/48 , G01N33/00 , G01N15/06 , G01N31/00 , G06F19/00
CPC分类号： G01N30/00 , B01L3/5027 , G01N13/00 , G01N2013/003 , Y10T436/11 , Y10T436/117497 , Y10T436/2575
摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.
摘要翻译：本发明涉及通过在微流体芯片上提供加成形微通道网络来确定样品溶质的分子量和扩散性的方法，所述微流体芯片具有在交叉点处相交的至少四个微通道; 将包含未知扩散系数的样品溶质和来自分离的微通道的空白流的样品流流过交叉点并流出到分离的微通道; 产生样品曲线，其测量在交叉点处从样品流扩散到空白流中的样品溶质的浓度，同时改变空白流或样品流之一的流速; 以及通过从具有与由样品溶质产生的类似条件下产生的已知分子量和/或扩散系数的至少两种溶质的相似曲线外推数据来确定样品溶质的扩散系数。

9. 发明授权

US07171983B2 Multi-reservoir pressure control system 有权
标题翻译：多层压力控制系统
公开(公告)号：US07171983B2
公开(公告)日：2007-02-06
申请号：US10916270
申请日：2004-08-11
申请人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
发明人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
IPC分类号： F15C1/04 , F04B41/06
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/027 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N11/08 , G01N27/44791 , G01N2035/1044 , G05D7/0694 , Y10T137/2076 , Y10T137/218 , Y10T137/86131
摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.
摘要翻译：改进的微流体装置，系统和方法允许通过在多个储存器处施加，控制和改变压力来选择性地输送微流体网络的微流体通道内的流体。将微流体网络建模为通过通道段连接在一起的一系列节点并且确定通道段的流动阻力特性可以允许计算通过在储存器处的给定压力构造导致的通道段的流体流动。为了在特定通道或一系列通道内实现期望的流量，可以使用网络模型来识别储层压力。粘度计或其他流量传感器可以测量通道内的流量特性，并且可以使用测量的流量特性来计算产生期望流量的压力。多储层压力调节器和压力控制器系统可以可选地与电动或其它流体输送机构结合使用。

10. 发明授权

US07038472B1 Methods and systems for measuring internal dimensions of microscale structures 失效
标题翻译：用于测量微观结构内部尺寸的方法和系统
公开(公告)号：US07038472B1
公开(公告)日：2006-05-02
申请号：US10435937
申请日：2003-05-12
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01R27/08
CPC分类号： B01L3/561 , B01L2200/148 , B01L2300/0838 , G01B7/13 , G01N30/6095 , G01N2030/324
摘要： The present invention provides novel devices for measuring internal dimensions of microscale structures. Methods in accordance with the invention use the voltage measured at a midpoint between a reference structure and a sample structure to determine the resistance of the sample structure, and to then calculate an internal dimension of the sample structure.
摘要翻译：本发明提供了用于测量微结构的内部尺寸的新型装置。根据本发明的方法使用在参考结构和样品结构之间的中点处测量的电压来确定样品结构的电阻，然后计算样品结构的内部尺寸。

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