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1. 发明公开

US20230215575A1 SYSTEM AND METHOD FOR CHRONIC KIDNEY DISEASE 审中-公开
公开(公告)号：US20230215575A1
公开(公告)日：2023-07-06
申请号：US18000406
申请日：2021-06-01
申请人： Richard BRADLEY , MARS, INCORPORATED
发明人： Richard Bradley , llias Tagkopoulos
IPC分类号： G16H50/30 , G16H50/20 , G16H10/40
CPC分类号： G16H50/30 , G16H10/40 , G16H50/20
摘要： The presently disclosed subject matter relates to methods or systems for identifying susceptibility of a dog to develop chronic kidney disease (CKD). The method, for example, can include receiving at least one of one or more biomarkers or demographic information of a dog. The method can also include processing at least one of the one or more biomarkers or demographic information of the dog using a prediction model. The prediction model can include a recurrent neural network. In addition, the method can determine a probability risk score of the dog for developing CKD based on the processed one or more biomarkers or demographic information.

2. 发明授权

US08845108B2 High dynamic range scenographic image projection 有权
标题翻译：高动态范围场景图像投影
公开(公告)号：US08845108B2
公开(公告)日：2014-09-30
申请号：US13385551
申请日：2012-02-24
申请人： Thomas F. LaDuke , Richard Bradley Turner , Steven T. Kosakura , Bryan Lee Jolley
发明人： Thomas F. LaDuke , Richard Bradley Turner , Steven T. Kosakura , Bryan Lee Jolley
IPC分类号： G03B21/14
CPC分类号： G03B21/14 , G03B17/54 , G03B21/606 , H04N9/3147 , H04N9/3182 , H04N9/3194
摘要： A high dynamic range scenographic image and video projection system and method involving the projection of an image of an object or collection of objects onto the object, 2D or 3D, in such a manner than projected image elements are positioned substantially on the actual image of the object. The projection enhances or otherwise alters the hue, contrast, brightness, saturation, luminance, and/or other visible features of the object. Visual and not-visual features may be projected onto the object or the area around the object to enhance or disguise the object as well as the surroundings of the object.
摘要翻译：涉及将物体或物体集合的图像以投影图像元素的方式投影到对象2D或3D上的高动态范围场景图像和视频投影系统和方法基本上位于实际图像上目的。投影增强或改变对象的色调，对比度，亮度，饱和度，亮度和/或其他可见特征。视觉和非视觉特征可以被投影到对象或物体周围的区域上，以增强或伪装对象以及对象的周围环境。

3. 发明申请

US20130231904A1 DYNAMIC OUTLIER BIAS REDUCTION SYSTEM AND METHOD 有权
公开(公告)号：US20130231904A1
公开(公告)日：2013-09-05
申请号：US13772212
申请日：2013-02-20
申请人： Richard Bradley JONES
发明人： Richard Bradley JONES
IPC分类号： G06N7/00
CPC分类号： G06F17/18 , G06F17/5009 , G06K9/6284 , G06N7/00
摘要： A system and method is described herein for data filtering to reduce functional, and trend line outlier bias. Outliers are removed from the data set through an objective statistical method. Bias is determined based on absolute, relative error, or both. Error values are computed from the data, model coefficients, or trend line calculations. Outlier data records are removed when the error values are greater than or equal to the user-supplied criteria. For optimization methods or other iterative calculations, the removed data are re-applied each iteration to the model computing new results. Using model values for the complete dataset, new error values are computed and the outlier bias reduction procedure is re-applied. Overall error is minimized for model coefficients and outlier removed data in an iterative fashion until user defined error improvement limits are reached. The filtered data may be used for validation, outlier bias reduction and data quality operations.

4. 发明申请

US20130046727A1 DYNAMIC OUTLIER BIAS REDUCTION SYSTEM AND METHOD 有权
公开(公告)号：US20130046727A1
公开(公告)日：2013-02-21
申请号：US13213780
申请日：2011-08-19
申请人： Richard Bradley Jones
发明人： Richard Bradley Jones
IPC分类号： G06N5/02
CPC分类号： G06F17/18 , G01N33/0004 , G06N5/04
摘要： A system and method is described herein for data filtering to reduce functional, and trend line outlier bias. Outliers are removed from the data set through an objective statistical method. Bias is determined based on absolute, relative error, or both. Error values are computed from the data, model coefficients, or trend line calculations. Outlier data records are removed when the error values are greater than or equal to the user-supplied criteria. For optimization methods or other iterative calculations, the removed data are re-applied each iteration to the model computing new results. Using model values for the complete dataset, new error values are computed and the outlier bias reduction procedure is re-applied. Overall error is minimized for model coefficients and outlier removed data in an iterative fashion until user defined error improvement limits are reached. The filtered data may be used for validation, outlier bias reduction and data quality operations.

5. 发明申请

US20060039436A1 Diode-pumped laser 有权
标题翻译：二极管泵浦激光器
公开(公告)号：US20060039436A1
公开(公告)日：2006-02-23
申请号：US11012362
申请日：2004-12-15
申请人： Gang Lei , Charles Hulse , Vincent Issier , Richard Bradley, , Robert Waarts
发明人： Gang Lei , Charles Hulse , Vincent Issier , Richard Bradley, , Robert Waarts
IPC分类号： H01S3/09
CPC分类号： H01S3/09415 , H01S3/0604 , H01S3/0612 , H01S3/0627 , H01S3/08 , H01S3/08036 , H01S3/08054 , H01S3/109 , H01S3/113
摘要： A diode-pumped laser with a direct edge coupling of a pump beam is provided. The laser includes a microchip laser cavity optically pumped by a laser diode emitting an astigmatic pump beam having a substantially elliptical beam cross-section at an output laser diode facet. The microchip laser cavity is disposed at a substantial distance exceeding 0.001″ from the laser diode pump where the astigmatic pump beam has a greatly reduced ellipticity, providing high laser output efficiency without coupling lens element between the laser cavity and the laser diode pump. The pumping arrangement is favourable for single-mode lasing. In some embodiments, the laser cavity includes nonlinear crystal for intra-cavity SHG, a saturable absorber for passive Q-switching and mode locking, and a polarizing prism.
摘要翻译：提供了具有泵浦光束的直接边缘耦合的二极管泵浦激光器。激光器包括由激光二极管光泵浦的微芯片激光器腔体，该激光二极管在输出激光二极管面处发射具有基本椭圆形光束横截面的像散泵浦光束。微激光器激光腔设置在距离激光二极管泵超过0.001“的实质距离处，其中散光泵浦光束具有大大降低的椭圆率，在激光腔和激光二极管泵之间提供高激光输出效率而不耦合透镜元件。泵浦装置有利于单模激光。在一些实施例中，激光腔包括用于腔内SHG的非线性晶体，用于无源Q开关和模式锁定的可饱和吸收器和偏振棱镜。

6. 再颁专利

USRE38189E1 Medication delivery and monitoring system and methods 有权
标题翻译：药物输送和监测系统及方法
公开(公告)号：USRE38189E1
公开(公告)日：2003-07-15
申请号：US09362839
申请日：1999-07-28
申请人： Richard Bradley Walker , Robert F. Evans , Robert Hanson , Michael F. Burrow
发明人： Richard Bradley Walker , Robert F. Evans , Robert Hanson , Michael F. Burrow
IPC分类号： A61M100
CPC分类号： A61M5/31533 , A61M5/1413 , A61M39/04 , A61M2205/50 , A61M2205/52 , A61M2205/6072 , G06F19/00
摘要： A medication delivery and monitoring system and methods whereby drugs are safely delivered to a patient, monitored in real-time during delivery and crucial events are recorded during delivery to provide real-time, on-line information and detail for an audit trail. A novel safety label cradle unit is disclosed. Safety label cradles (SLC's) are provided in a plurality of sizes to match varying sizes of syringes which are disposed on a cradle of the SLC to provide a constant needle height on the SLC unit independent of syringe volume (barrel diameter). A selected SLC is securely affixed to a syringe by an adhesively backed label wrapping. The label is preprinted to provide drug identification indicia and drug preparation information. The information is automatically read into the system from the label. A novel delivery station of the system monitors drug delivery as a plunger of the syringe is pushed to deliver a drug to a patient. A smart tray in cooperation with a slider portion of the SLC is used to selectively deliver drugs to a port in the IV set. The smart tray comprises a first portion for carrying SLC units, an attachable second portion having a control panel for operating the system and a cover for lockably affixing the SLC units to the tray.
摘要翻译：药物输送和监测系统和方法，其中在递送期间记录药物被安全递送给患者，在递送期间实时监测和关键事件，以便为审计线索提供实时的在线信息和细节。公开了一种新颖的安全标签支架单元。提供多种尺寸的安全标签托架（SLC）以匹配设置在SLC的支架上的不同尺寸的注射器，以在SLC单元上提供恒定的针高度，而与注射器体积（筒直径）无关。所选择的SLC通过粘性支撑的标签包裹牢固地固定在注射器上。该标签被预先印制以提供药物鉴定标记和药物制备信息。信息从标签自动读入系统。该系统的新型分送站监测药物递送，因为推动注射器的柱塞以向患者输送药物。与SLC的滑块部分协作的智能托盘用于选择性地将药物递送到IV组中的端口。智能托盘包括用于承载SLC单元的第一部分，具有用于操作系统的控制面板的可附接第二部分和用于将SLC单元可锁定地附接到托盘的盖子。

7. 发明授权

US06423547B1 Non-covalent bioconjugates useful for diagnosis and therapy 有权
标题翻译：用于诊断和治疗的非共价生物缀合物
公开(公告)号：US06423547B1
公开(公告)日：2002-07-23
申请号：US09646765
申请日：2000-09-21
申请人： Raghavan Rajagopalan , Joseph E. Bugaj , Richard Bradley Dorshow , Samuel I. Achilefu
发明人： Raghavan Rajagopalan , Joseph E. Bugaj , Richard Bradley Dorshow , Samuel I. Achilefu
IPC分类号： G01N33531
CPC分类号： A61K49/0034 , A61K41/0057 , A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/0054 , A61K49/0056
摘要： A composition comprising non-covalent carrier-hapten bioconjugates having the formula: HM-CM wherein HM is a hapten molecule whose molecular weight is generally, but not always, less than 1000 Daltons and is capable of performing specific functions; CM is a carrier molecule, whose molecular weight is generally, but not always, more than 1000 Daltons and is capable of transporting the hapten to a specific site; and the dashed line is a non-covalent bond between the carrier molecule and the hapten molecule. Preferably, the bioconjugates are formed from fluorescent dye haptens such as cyanine, indocyanine, squaraine, porphyrrins, Rose Bengal, and methylene blue dye and carrier molecules such as methylated serum albumin, polyarginine, polyaspartic acid, polyglutamic acid, cyclodextrin, and inulin. The bioconjugates are useful in diagnostic and therapeutic medical procedures because they are stable in vitro before being used and stable in vivo during and after use.
摘要翻译：包含具有下式的非共价载体 - 半抗原生物缀合物的组合物：其中HM是其分子量通常但不总是小于1000道尔顿并且能够执行特定功能的半抗原分子; CM是一种载体分子，其分子量通常但不总是大于1000道尔顿，并且能够将半抗原转运到特定位点; 并且虚线是载体分子和半抗原分子之间的非共价键。优选地，生物缀合物由荧光染料半抗原如花青，吲哚菁，方酸，卟啉，玫瑰红和亚甲基蓝染料以及载体分子形成作为甲基化血清白蛋白，聚精氨酸，聚天冬氨酸，聚谷氨酸，环糊精和菊粉。生物缀合物在诊断和治疗医疗过程中是有用的，因为它们在使用前和使用后和使用后在体内稳定，在体内稳定。

8. 发明授权

US06228344B1 Method of measuring physiological function 失效
标题翻译：测量生理功能的方法
公开(公告)号：US06228344B1
公开(公告)日：2001-05-08
申请号：US09258148
申请日：1999-02-26
申请人： Richard Bradley Dorshow , Samuel Achilefu , Raghavan Rajagopalan , Joseph Edward Bugaj
发明人： Richard Bradley Dorshow , Samuel Achilefu , Raghavan Rajagopalan , Joseph Edward Bugaj
IPC分类号： A61K4900
CPC分类号： A61K49/0034 , A61K49/0021 , A61K49/0043 , A61K49/0054 , A61K49/0056
摘要： A method of measuring physiological function of a group of body cells, includes the step of selecting a detectable agent capable of emitting a measurable electromagnetic emission. The agent is introduced into body fluid wich contacts the group of body cells. The emission is measured, and physiological function is determined based on measurement of the emission.
摘要翻译：测量一组身体细胞的生理功能的方法包括选择能够发射可测量的电磁发射的可检测试剂的步骤。该药剂被引入与身体细胞组接触的体液中。测量发射，并根据发射的测量确定生理功能。

9. 发明授权

US06217848B1 Cyanine and indocyanine dye bioconjugates for biomedical applications 失效
标题翻译：用于生物医学应用的花青和靛蓝染料生物缀合物
公开(公告)号：US06217848B1
公开(公告)日：2001-04-17
申请号：US09325769
申请日：1999-06-04
申请人： Samuel Achilefu , Richard Bradley Dorshow , Joseph Edward Bugaj , Raghavan Rajagopalan
发明人： Samuel Achilefu , Richard Bradley Dorshow , Joseph Edward Bugaj , Raghavan Rajagopalan
IPC分类号： A61K5100
CPC分类号： A61K41/0057 , A61K41/00 , A61K41/0028 , A61K49/0013
摘要： Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译：公开了用于诊断成像和治疗的染料 - 肽缀合物。染料 - 肽缀合物包括具有多种双和四（羧酸）同系物的几种花青染料。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350-1300nm的范围内是有用的，确切的范围取决于特定的染料。使用二甲基亚砜有助于维持化合物的荧光。本发明的分子可用于诊断成像和治疗，用于检测肿瘤和其他异常以及用于局部治疗，用于光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗的内窥镜应用中。

10. 发明授权

US4300988A Polybutylene and conjugated diene butyl polymer blends 失效
标题翻译：聚丁烯和共轭二烯丁基聚合物共混物
公开(公告)号：US4300988A
公开(公告)日：1981-11-17
申请号：US172308
申请日：1980-07-25
申请人： Anthony J. Berejka , Richard Bradley
发明人： Anthony J. Berejka , Richard Bradley
IPC分类号： C08F2/46 , C08L23/20 , C08L23/22 , C08L9/00
CPC分类号： C08L23/20 , C08L23/22
摘要： Blends of polybutylene and a conjugated diene butyl rubber can be cured by ionizing radiation to form products with excellent resistance to set, sufficient melt flow properties to be re-workable as a plastic after curing and which exhibit significant strength characteristics.
摘要翻译：聚丁烯和共轭二烯丁基橡胶的共混物可以通过电离辐射固化以形成具有优异的耐凝集性，足够的熔体流动性能的产品，可以在固化后作为塑料再加工，并且具有显着的强度特性。

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