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1. 发明授权

US10123380B2 Instantaneous in-line heating of samples on a monolithic microwave integrated circuit microfluidic device 有权
公开(公告)号：US10123380B2
公开(公告)日：2018-11-06
申请号：US12433721
申请日：2009-04-30
申请人： Neil Reginald Beer , Benjamin Fasenfest , John Chang
发明人： Neil Reginald Beer , Benjamin Fasenfest , John Chang
IPC分类号： H05B6/80
摘要： A micro-electro-mechanical system for heating a sample including a substrate, a micro-channel flow channel in the substrate, a carrier fluid within the micro-channel flow channel for moving the sample in the micro-channel flow channel, and a microwave source that directs microwaves onto the sample in the micro-channel flow channel for heating the sample. The carrier fluid and the substrate are made of materials that are not appreciably heated by the microwaves. The microwave source includes conductive traces or strips and a microwave power source connected to the conductive traces or strips.

2. 发明授权

US08969767B2 Microwave heating of aqueous samples on a micro-optical-electro-mechanical system 有权
标题翻译：在微光机电系统上微波加热水样
公开(公告)号：US08969767B2
公开(公告)日：2015-03-03
申请号：US12326594
申请日：2008-12-02
申请人： Neil Reginald Beer
发明人： Neil Reginald Beer
IPC分类号： H05B6/64 , H05B6/80
CPC分类号： H05B6/802 , H05B6/80
摘要： Apparatus for heating a sample includes a microchip; a microchannel flow channel in the microchip, the microchannel flow channel containing the sample; a microwave source that directs microwaves onto the sample for heating the sample; a wall section of the microchannel flow channel that receives the microwaves and enables the microwaves to pass through wall section of the microchannel flow channel, the wall section the microchannel flow channel being made of a material that is not appreciably heated by the microwaves; a carrier fluid within the microchannel flow channel for moving the sample in the microchannel flow channel, the carrier fluid being made of a material that is not appreciably heated by the microwaves; wherein the microwaves pass through wall section of the microchannel flow channel and heat the sample.
摘要翻译：用于加热样品的装置包括微芯片; 微芯片中的微通道流动通道，含有样品的微通道流动通道; 将微波引导到样品上用于加热样品的微波源; 所述微通道流动通道的壁部分接收所述微波并使所述微波能够通过所述微通道流动通道的壁部分，所述壁部分所述微通道流动通道由微波不被明显加热的材料制成; 微通道流动通道内的载体流体，用于将样品移动到微通道流动通道中，载体流体由不受微波加热的材料制成; 其中微波通过微通道流动通道的壁部分并加热样品。

3. 发明授权

US08969071B2 Passive chip-based droplet sorting 有权
公开(公告)号：US08969071B2
公开(公告)日：2015-03-03
申请号：US12938715
申请日：2010-11-03
申请人： Neil Reginald Beer , Abraham P. Lee , Andrew C. Hatch , Jeffrey S. Fisher
发明人： Neil Reginald Beer , Abraham P. Lee , Andrew C. Hatch , Jeffrey S. Fisher
IPC分类号： C12M3/00 , C12M1/00 , B01L3/00 , B01L7/00
CPC分类号： B01L3/502761 , B01L7/52 , B01L2200/0652 , B01L2300/0864 , B01L2300/0877 , B01L2300/168 , B01L2400/084 , C12M47/04 , G01N15/10 , G01N2015/1081 , Y10T137/0324
摘要： An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.

4. 发明授权

US08854248B2 Real-time system for imaging and object detection with a multistatic GPR array 有权
标题翻译：使用多级GPR阵列进行成像和物体检测的实时系统
公开(公告)号：US08854248B2
公开(公告)日：2014-10-07
申请号：US13219410
申请日：2011-08-26
申请人： David W. Paglieroni , N. Reginald Beer , Steven W. Bond , Philip L. Top , David H. Chambers , Jeffrey E. Mast , John G. Donetti , Blake C. Mason , Steven M. Jones
发明人： David W. Paglieroni , N. Reginald Beer , Steven W. Bond , Philip L. Top , David H. Chambers , Jeffrey E. Mast , John G. Donetti , Blake C. Mason , Steven M. Jones
IPC分类号： G01S13/00 , G01V3/12 , G01S13/90 , G01S13/88 , G01V3/15 , G01S13/89
CPC分类号： G01S13/89 , G01S13/003 , G01S13/885 , G01S13/90 , G01V3/12 , G01V3/15 , G06N99/00
摘要： A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.
摘要翻译：提供一种用于检测介质内的地下物体的存在的方法和系统。在一些实施例中，成像和检测系统以多状态模式操作，以收集由跨越表面定位并沿着表面行进的收发器天线对阵列产生的雷达返回信号。成像和检测系统预处理返回信号以抑制某些不良影响。成像和检测系统然后从由预处理的返回信号产生的实际孔径雷达图像中生成合成孔径雷达图像。成像和检测系统然后对合成孔径雷达图像进行后处理，以改善地下物体的检测。成像和检测系统识别后处理图像帧的能级中的峰值，其指示地下物体的存在。

5. 发明授权

US08618976B2 Radar signal pre-processing to suppress surface bounce and multipath 有权
标题翻译：雷达信号预处理以抑制表面反弹和多径
公开(公告)号：US08618976B2
公开(公告)日：2013-12-31
申请号：US13219482
申请日：2011-08-26
申请人： David W. Paglieroni , Jeffrey E. Mast , N. Reginald Beer
发明人： David W. Paglieroni , Jeffrey E. Mast , N. Reginald Beer
IPC分类号： G01S13/00
CPC分类号： G01S13/89 , G01S13/003 , G01S13/885 , G01S13/90 , G01V3/12 , G01V3/15 , G06N99/00
摘要： A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.
摘要翻译：提供一种用于检测介质内的地下物体的存在的方法和系统。在一些实施例中，成像和检测系统以多状态模式操作，以收集由跨越表面定位并沿着表面行进的收发器天线对阵列产生的雷达返回信号。成像和检测系统预处理返回信号以抑制某些不良影响。成像和检测系统然后从由预处理的返回信号产生的实际孔径雷达图像中生成合成孔径雷达图像。成像和检测系统然后对合成孔径雷达图像进行后处理，以改善地下物体的检测。成像和检测系统识别后处理图像帧的能级中的峰值，其指示地下物体的存在。

6. 发明申请

US20130082870A1 SYNTHETIC APERTURE INTEGRATION (SAI) ALGORITHM FOR SAR IMAGING 有权
标题翻译：用于SAR成像的合成孔径积分（SAI）算法
公开(公告)号：US20130082870A1
公开(公告)日：2013-04-04
申请号：US13219475
申请日：2011-08-26
申请人： David H. Chambers , Jeffrey E. Mast , David W. Paglieroni , N. Reginald Beer
发明人： David H. Chambers , Jeffrey E. Mast , David W. Paglieroni , N. Reginald Beer
IPC分类号： G01S13/90
CPC分类号： G01S13/89 , G01S13/003 , G01S13/885 , G01S13/90 , G01V3/12 , G01V3/15 , G06N99/00
摘要： A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.
摘要翻译：提供一种用于检测介质内的地下物体的存在的方法和系统。在一些实施例中，成像和检测系统以多状态模式操作，以收集由跨越表面定位并沿着表面行进的收发器天线对阵列产生的雷达返回信号。成像和检测系统预处理返回信号以抑制某些不良影响。成像和检测系统然后从由预处理的返回信号产生的实际孔径雷达图像中生成合成孔径雷达图像。成像和检测系统然后对合成孔径雷达图像进行后处理，以改善地下物体的检测。成像和检测系统识别后处理图像帧的能级中的峰值，其指示地下物体的存在。

7. 发明申请

US20130082864A1 DETERMINING ROOT CORRESPONDENCE BETWEEN PREVIOUSLY AND NEWLY DETECTED OBJECTS 有权
标题翻译：确定以前和新检测目标之间的根系相关性
公开(公告)号：US20130082864A1
公开(公告)日：2013-04-04
申请号：US13219512
申请日：2011-08-26
申请人： David W. Paglieroni , N. Reginald Beer
发明人： David W. Paglieroni , N. Reginald Beer
IPC分类号： G01S13/00
CPC分类号： G01S13/89 , G01S13/003 , G01S13/885 , G01S13/90 , G01V3/12 , G01V3/15 , G06N99/00
摘要： A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.
摘要翻译：将基于属性和拓扑的变更检测应用于在结构，道路或感兴趣区域的先前扫描中检测到的对象网络的系统。属性捕获先前检测到的对象的属性或特征，例如位置，检测时间，大小，伸长率，取向等。先前检测到的对象的网络的拓扑维护在存储先前检测到的对象的属性的星座数据库中并隐含地捕获网络的几何结构。变化检测系统通过将在最新扫描上检测到的新物体的属性和拓扑结构与先前检测到的对象的星座数据库进行比较来检测变化。

8. 发明申请

US20110215798A1 Signal Enhancement Using a Switchable Magnetic Trap 有权
标题翻译：使用可切换磁性阱的信号增强
公开(公告)号：US20110215798A1
公开(公告)日：2011-09-08
申请号：US11965598
申请日：2007-12-27
申请人： Neil Reginald Beer
发明人： Neil Reginald Beer
IPC分类号： G01N27/84
CPC分类号： G01N27/84
摘要： A system for analyzing a sample including providing a microchannel flow channel; associating the sample with magnetic nanoparticles or magnetic polystyrene-coated beads; moving the sample with said magnetic nanoparticles or magnetic polystyrene-coated beads in the microchannel flow channel; holding the sample with the magnetic nanoparticles or magnetic polystyrene-coated beads in a magnetic trap in the microchannel flow channel; and analyzing the sample obtaining an enhanced analysis signal. An apparatus for analysis of a sample includes magnetic particles connected to the sample, a microchip, a flow channel in the microchip, a source of carrier fluid connected to the flow channel for moving the sample in the flow channel, an electromagnet trap connected to the flow line for selectively magnetically trapping the sample and the magnetic particles, and an analyzer for analyzing the sample.
摘要翻译：一种用于分析样本的系统，包括提供微通道流动通道; 将样品与磁性纳米颗粒或磁性聚苯乙烯涂覆的珠粒缔合; 用微通道流动通道中的所述磁性纳米颗粒或磁性聚苯乙烯涂覆的珠移动样品; 将磁性纳米颗粒或磁性聚苯乙烯涂覆的珠保持在微通道流动通道中的磁捕获器中; 并分析样品获得增强的分析信号。用于分析样品的装置包括连接到样品的磁性颗粒，微芯片，微芯片中的流动通道，连接到用于移动流动通道中的样品的流动通道的载体流体源，连接到流体通道的电磁阱用于选择性地磁捕获样品和磁性颗粒的流动线，以及用于分析样品的分析器。

9. 发明授权

US07788523B2 Method and apparatus for relating device name to physical location of device on a network 失效
标题翻译：将设备名称与网络上设备的物理位置相关联的方法和装置
公开(公告)号：US07788523B2
公开(公告)日：2010-08-31
申请号：US12030966
申请日：2008-02-14
申请人： Reginald Beer , Paul Nicholas Cashman , Paul Hooton , Ian David Judd , Robert Frank Maddock , Neil Morris , Robert Bruce Nicholson , Paul Jonathan Quelch , Barry Douglas White
发明人： Reginald Beer , Paul Nicholas Cashman , Paul Hooton , Ian David Judd , Robert Frank Maddock , Neil Morris , Robert Bruce Nicholson , Paul Jonathan Quelch , Barry Douglas White
IPC分类号： G06F11/00
CPC分类号： H04L12/42
摘要： A method and apparatus for relating a device name to a physical location of a device (202) on a network is provided. The network may be a serial loop network, for example a Fibre Channel Arbitrated Loop network. The network includes a plurality of devices (202) on or connected to the network (201) and a control device (205) with control over at least one of the devices (202). Each device (202) has a check output (204) independent of the network (201) with connection means (206) to a control device (205). The method includes the step of sending a device name from the check output (204) of a device (202) to the control device (205). The check output (204) of a device (202) is also connected to an external indication means for indicating the failure of the device (202).
摘要翻译：提供了一种用于将设备名称与网络上的设备（202）的物理位置相关联的方法和装置。网络可以是串行环路网络，例如光纤通道仲裁环路网络。网络包括位于网络（201）上或连接到网络（201）的多个设备（202）和具有对至少一个设备（202）的控制的控制设备（205）。每个设备（202）具有独立于网络（201）的检查输出（204），其具有到控制设备（205）的连接装置（206）。该方法包括从设备（202）的检查输出（204）向控制设备（205）发送设备名称的步骤。设备（202）的检查输出（204）也连接到用于指示设备（202）的故障的外部指示装置。

10. 发明申请

US20100015614A1 Chip-Based Device for Parallel Sorting, Amplification, Detection, and Identification of Nucleic Acid Subsequences 有权
标题翻译：用于并行排序，扩增，检测和鉴定核酸子序列的基于芯片的器件
公开(公告)号：US20100015614A1
公开(公告)日：2010-01-21
申请号：US12401714
申请日：2009-03-11
申请人： Neil Reginald Beer , Billy W. Colston, JR.
发明人： Neil Reginald Beer , Billy W. Colston, JR.
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L7/525 , B01L3/502761 , B01L3/502792 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/1822 , B01L2300/1827 , B01L2400/0415 , B01L2400/0421 , B01L2400/0454 , C12Q1/686
摘要： An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The micro-reactor maker is positioned to deliver the micro-reactors to the planar substrate. A microprocessor is connected to the electrodes for manipulating the micro-reactors on the planar substrate. A detector is positioned to interrogate the sample contained in the micro-reactors.
摘要翻译：用于具有平面基板的样品的基于芯片的分选，放大，检测和识别的装置。将平面基板分成单元。电池以行和列布置在平面基板上。电极位于细胞中。微反应器制造商生产含有样品的微反应堆。微反应器制造商被定位成将微反应器输送到平面基板。微处理器连接到电极，用于操纵平面基板上的微反应器。定位探测器以询问包含在微反应器中的样品。

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