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1. 发明授权

US4882484A Method of mass analyzing a sample by use of a quistor 失效
标题翻译：通过使用电阻对样品进行质量分析的方法
公开(公告)号：US4882484A
公开(公告)日：1989-11-21
申请号：US265108
申请日：1988-10-31
申请人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
发明人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/429
摘要： In a quadrupole ion store (QUISTOR), a sample is analyzed by increasing themplitude of the harmonic, or "secular", oscillations of selected stably trapped ions so that they leave the trapping field. In a preferred embodiment, deviations from the ideal electrode geometry are incorporated into the QUISTOR to produce resonance phenomena between the r and z secular oscillations, thereby increasing the amplitude of oscillations in the z direction.

2. 发明授权

US5739530A Method and device for the introduction of ions into quadrupole ion traps 失效
标题翻译：用于将离子引入四极离子阱的方法和装置
公开(公告)号：US5739530A
公开(公告)日：1998-04-14
申请号：US656581
申请日：1996-05-31
申请人： Jochen Franzen , Reemt-Holger Gabling , Yang Wang
发明人： Jochen Franzen , Reemt-Holger Gabling , Yang Wang
IPC分类号： H01J49/04 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/4265 , H01J49/063 , H01J49/067 , H01J49/424 , H01J49/4295
摘要： The invention relates to methods and devices for the effective introduction of ions, which are stored in an RF ion guide into a quadrupole ion trap. The invention consists of arranging a switchable ion lens between the RF ion guide and the quadrupole ion trap, and introducing the ions into the quadrupole ion trap by a suitable connection of the ion lens only during the filling period, while otherwise the ions are reflected back into the RF ion guide. The filling period can be divided up and limited to the capture intervals of the quadrupole ion trap during each RF period. Measurement of the filling rate can be made by switching open the ion lens longer then the admission interval of the quadrupole ion trap, and measuring the flow of the ions passing through on the detector.
摘要翻译：本发明涉及用于有效引入离子的方法和装置，其被存储在RF离子导向器中成四极离子阱。本发明包括在RF离子导向器和四极离子阱之间设置可切换的离子透镜，并且仅在填充期间通过离子透镜的适当连接将离子引入到四极离子阱中，否则离子被反射回进入RF离子导向器。在每个RF周期期间，填充周期可以分开并限于四极离子阱的捕获间隔。填充速率的测量可以通过开启离子透镜比四极离子阱的进入间隔更长，并测量在检测器上通过的离子的流动来进行。

3. 发明授权

US5028777A Method for mass-spectroscopic examination of a gas mixture and mass spectrometer intended for carrying out this method 失效
标题翻译：用于进行该方法的气体混合物和质谱仪的质谱检测方法
公开(公告)号：US5028777A
公开(公告)日：1991-07-02
申请号：US285741
申请日：1988-12-16
申请人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
发明人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
IPC分类号： H01J49/10 , H01J49/42
CPC分类号： H01J49/424 , H01J49/429
摘要： For mass-spectroscopic examinations of gas mixtures a mass spectrometer is used which comprises a quistor in which ions of the gas mixture whose charge-to-mass ratio is located in a predetermined range are stored by generating an electromagnetic field. By varying the field parameters, the ions are forced successively to leave the ion trap. The intensity of the ion flow leaving the ion trap is measured as a function of the variation of the field parameters. For improving the resolution, one uses a quistor of the type where the distance-related ratio Q of the radii of the inscribed vertex circles of the electrodes comply with the condition Q.ltoreq.3.990, wherein ##EQU1## R.sub.e being the radius of the cross-section of the vertex of the end electrodes (3,5);R.sub.r being the radius of the cross-section of the vertex of the annular electrode (4);z.sub.o being the distance between the vertex of each end electrode (3,5) and the center of the quistor; andr.sub.o being the distance between the vertex of the annular electrode (4) and the center of the quistor.
摘要翻译：对于气体混合物的质谱检测，使用质谱仪，其包括电容器，其中电荷质量比位于预定范围内的气体混合物的离子通过产生电磁场而被存储。通过改变场参数，依次迫使离子离开离子阱。离子离子阱的离子强度作为场参数变化的函数进行测量。为了提高分辨率，可以使用类型的电阻，其中电极的内接顶点圆的半径的距离相关比Q符合条件Q <= 3.990，其中， Re是末端电极顶点的横截面（3,5）; Rr是环形电极（4）的顶点的横截面的半径; zo是每个端电极（3,5）的顶点和电阻的中心之间的距离; 并且ro是环形电极（4）的顶点与电阻器的中心之间的距离。

4. 发明授权

US4975577A Method and instrument for mass analyzing samples with a quistor 失效
标题翻译：用电阻质量分析样品的方法和仪器
公开(公告)号：US4975577A
公开(公告)日：1990-12-04
申请号：US459156
申请日：1989-12-29
申请人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
发明人： Jochen Franzen , Reemt-Holger Gabling , Gerhard Heinen , Gerhard Weiss
IPC分类号： H01J49/42 , H01J
CPC分类号： H01J49/424 , H01J49/429
摘要： A method for the measurement of mass spectra by three dimensional quadrup fields (QUISTORs) is presented, in which the ions are mass-to-charge selectively ejected by a selected nonlinear resonance effect in an inharmonic QUISTOR. In order to enhance scan speed and mass resolution, the ejection of a single kind of ions can be confined to a very small time interval, either by the generation of ions within a small volume outside the field center, or by an excitation of the secular amplitudes by an additional RF voltage across the end electrodes, shortly before the ions encounter the sum resonance condition. An instrument for this method is described.

5. 发明授权

US5521379A Method of selecting reaction paths in ion traps 失效
标题翻译：选择离子阱反应路径的方法
公开(公告)号：US5521379A
公开(公告)日：1996-05-28
申请号：US277666
申请日：1994-07-20
申请人： Jochen Franzen , Reemt-Holger Gabling
发明人： Jochen Franzen , Reemt-Holger Gabling
IPC分类号： B01J19/08 , H01J49/42
CPC分类号： H01J49/428 , B01J19/087 , H01J49/145 , H01J49/4295
摘要： A method is disclosed for chemical ionization of the molecules of an analysis gas or analysis gas mixture or for studying ion-molecule reactions in ion traps. Specifically, by superposing a quadrupole field with a dipolar introduced frequency mixture in which there are accurately selected frequency gaps in the ionization phase of the analysis, the only ions which are stored are those which are on the selected reaction path of the reactant gas ions for making the proper reactant ions for the desired ion-molecule reaction. All the other ions are eliminated from storage by excitation of their secular oscillations. In a second phase, by switching off the dipolar introduced frequency mixture, all the ions can be stored in a wide range of mass-to-charge ratios, and therefore also the product ions of the desired ion-molecule reactions of the analysis gas. In a third phase the spectrum of the product ions is scanned.
摘要翻译：公开了用于分析气体或分析气体混合物的分子的化学电离或用于研究离子阱中的离子 - 分子反应的方法。具体地说，通过将具有偶极引入频率混合的四极场叠加在分析的电离阶段中存在准确选择的频率间隙的情况下，存储的唯一离子是在反应物气体离子的选定反应路径上使合适的反应物离子进行所需的离子 - 分子反应。所有其他离子通过其长期振荡的激发从储存中消除。在第二阶段，通过关闭偶极引入的频率混合物，所有离子可以以宽范围的质荷比存储，因此也可以分析气体所需的离子 - 分子反应的产物离子。在第三阶段，扫描产物离子的光谱。

6. 发明授权

US5298746A Method and device for control of the excitation voltage for ion ejection from ion trap mass spectrometers 失效
标题翻译：用于控制从离子阱质谱仪离子喷射的激发电压的方法和装置
公开(公告)号：US5298746A
公开(公告)日：1994-03-29
申请号：US997284
申请日：1992-12-23
申请人： Jochen Franzen , Reemt-Holger Gabling
发明人： Jochen Franzen , Reemt-Holger Gabling
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/429
摘要： An improved scanning method used in an ion trap mass spectrometer comprises controlling the amplitude of the excitation RF during the mass scan to produce a smooth, nonlinear, highly suitable function. A smooth function is a function with a steady derivative. According to one embodiment of the invention, the excitation amplitude is set proportionally to the square root of the storage amplitude, thus making the excitation amplitude proportional to the root of the mass number.
摘要翻译：在离子阱质谱仪中使用的改进的扫描方法包括在质量扫描期间控制激发RF的振幅以产生平滑，非线性，高度适合的功能。平滑函数是具有稳定导数的函数。根据本发明的一个实施例，激励振幅与存储幅度的平方根成比例地设定，从而使激励振幅与质量数的根成正比。

7. 发明授权

US5438195A Method and device for the digital generation of an additional alternating voltage for the resonant excitation of ions in ion traps 失效
标题翻译：用于数字生成用于离子阱中的离子的共振激发的附加交流电压的方法和装置
公开(公告)号：US5438195A
公开(公告)日：1995-08-01
申请号：US245956
申请日：1994-05-19
申请人： Jochen Franzen , Gerhard Heinen , Reemt-Holger Gabling
发明人： Jochen Franzen , Gerhard Heinen , Reemt-Holger Gabling
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/4285
摘要： A method and a device for the mass selective excitation of the secular oscillations of selected ion types in an RF quadrupole ion trap, including the simultaneous excitation of more than one ion type, is disclosed. The secular oscillation frequency is excited by resonances with specific frequencies of the frequency bands of the additional alternating fields, the frequency bands being generated digitally at a basic pulse rate .OMEGA.. Interfering frequency side bands .OMEGA.-.omega., .OMEGA.+.omega., 2.OMEGA.-.omega., 2.OMEGA.+.omega., etc. arise, however, for each frequency .omega. within the frequency bands. These side bands can excite and eliminate other ions, which are not to be eliminated, in an undesired manner. The invention comprises forming the side bands in such a way that they only excite the selected ions. This is done by making the basic pulse rate for digital generation of the frequency bands for the additional alternating voltage identical with the frequency of the drive voltage of the ion trap or with an integral multiple of it and coupling the basic pulse rate to it in locked phase relation.
摘要翻译：公开了一种用于在RF四极离子阱中选择性离子类型的长期振荡的质量选择性激发的方法和装置，包括同时激发多于一种的离子型。通过与附加交变场的频带的特定频率的共振来激发长期振荡频率，频带以基本脉冲速率OMEGA数字地产生。然而，对于频带内的每个频率ω，出现干扰频率边带OMEGA-ω，OMEGA +ω，2 OMEGA-ω，2 OMEGA +ω等。这些边带可以以不期望的方式激发和消除不被消除的其它离子。本发明包括以这样的方式形成侧带，使得它们仅激发所选择的离子。这是通过使附加交流电压的频带的数字生成的基本脉冲频率与离子阱的驱动电压的频率或其整数倍相同，并将基本脉冲频率与其锁定相位关系。

8. 发明授权

US5386113A Method and device for in-phase measuring of ions from ion trap mass spectrometers 失效
标题翻译：离子阱质谱仪离子同相测量的方法和装置
公开(公告)号：US5386113A
公开(公告)日：1995-01-31
申请号：US996008
申请日：1992-12-23
申请人： Jochen Franzen , Gerhard Heinen , Gerhard Weiss , Reemt-Holger Gabling
发明人： Jochen Franzen , Gerhard Heinen , Gerhard Weiss , Reemt-Holger Gabling
IPC分类号： H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/429
摘要： The measuring process for generating mass spectra using a sequentially-scanned quadrupole ion trap mass spectrometer, is improved by controlling the measurement of the ion packages ejected from the ion trap so that measurement takes place starting at the anticipated exit times of the ion packages and measurement continues only as far as possible for a time duration corresponding to the length of the ion packages. Measuring only during ion package ejection enables a measurement for the total number of ejected ions having a selected mass to be obtained by means of digital addition of the individual package measurements. Subsequent processing of the data can be carried out with practically only the fluctuations of normal ion counting statistics.
摘要翻译：使用顺序扫描的四极离子阱质谱仪产生质谱的测量过程通过控制从离子阱排出的离子组件的测量来改进，以便在离子包装的预计出口时间开始测量和测量仅在对应于离子包装的长度的持续时间内继续进行。仅在离子包装喷射期间进行测量，可以通过数字添加单个包装测量值来测量具有所选质量的所排出的离子的总数。数据的后续处理只能在实际上仅进行正常离子计数统计的波动。

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