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1. 发明授权

US12154779B2 Systems and methods for separating ions at about or above atmospheric pressure 有权
公开(公告)号：US12154779B2
公开(公告)日：2024-11-26
申请号：US18108222
申请日：2023-02-10
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder , Amar S. Basu , Wen-Ping Peng
IPC分类号： H01J49/00 , G01N27/623 , H01J49/16 , H01J49/42
CPC分类号： H01J49/4225 , G01N27/623 , H01J49/0013 , H01J49/165 , H01J49/4205 , H01J49/429 , H01J49/4295
摘要： The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.

2. 发明授权

US12040173B2 Quadrupole devices 有权
公开(公告)号：US12040173B2
公开(公告)日：2024-07-16
申请号：US17437717
申请日：2020-03-11
申请人： Micromass UK Limited
发明人： David J. Langridge , Martin Raymond Green
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/429
摘要： A method of operating a quadrupole device (10) is disclosed. The quadrupole device (10) is operated in a mode of operation by applying a repeating voltage waveform comprising a main drive voltage and at least one auxiliary drive voltage is applied to the quadrupole device to the quadrupole device (10). The intensity of ions passing into the quadrupole device is varied with time in synchronisation with the repeating voltage waveform. This may be done such that the number of ions per unit phase which initially experience a phase within a first range of phases of the repeating voltage waveform is greater than the number of ions per unit phase which initially experience a phase within a second range of phases of the repeating voltage waveform.

3. 发明公开

US20240071742A1 TWO FREQUENCY ION TRAP PERFORMANCE 审中-公开
公开(公告)号：US20240071742A1
公开(公告)日：2024-02-29
申请号：US18455356
申请日：2023-08-24
申请人： Thermo Finnigan LLC
发明人： Christopher Mullen , John Syka
IPC分类号： H01J49/42 , H01J49/02
CPC分类号： H01J49/429 , H01J49/025 , H01J49/4225
摘要： This system and method disclosed herein are configured to improve high mass range ion trap performance by use of a multi-directional segmented scan approach. In some embodiments of the system and method disclosed herein, the mass range of conventional ion trap technology may be extended/increased without changing the hardware or compromising lower range mass/charge efficiency. Specifically, the system and methods disclosed herein use a segmented, bi-directional scan that increases the mass range of an ion trap mass spectrometer and circumvents the problem of mass discrimination during mass analysis in the high Thompson value range.

4. 发明授权

US10840074B2 Systems and methods for conducting neutral loss scans in a single ion trap 有权
公开(公告)号：US10840074B2
公开(公告)日：2020-11-17
申请号：US16751265
申请日：2020-01-24
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/0036 , H01J49/0081 , H01J49/429 , H01J49/422
摘要： The invention generally relates to systems and methods for conducting neutral loss scans in a single ion trap. In certain aspects, the invention provides systems that include a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a scan function that excites a precursor ion, rejects the precursor ion after its excitation, and ejects a product ion in the single ion trap.

5. 发明授权

US10622202B2 Ion traps that apply an inverse Mathieu q scan 有权
公开(公告)号：US10622202B2
公开(公告)日：2020-04-14
申请号：US15789688
申请日：2017-10-20
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/422 , H01J49/0013 , H01J49/0031 , H01J49/429
摘要： The invention generally relates to ion traps that operate by applying an inverse Mathieu q scan. In certain embodiments, the invention provides systems that include a mass spectrometer having an ion trap and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply an inverse Mathieu q scan to the ion trap.

6. 发明授权

US09607820B2 Ion mobility spectrometer with upstream devices at constant potential 有权
公开(公告)号：US09607820B2
公开(公告)日：2017-03-28
申请号：US12306162
申请日：2007-06-25
申请人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/42 , G01N27/62 , H01J49/00
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer includes an ion mobility spectrometer or separator arranged upstream of a collision or fragmentation cell. Ions are separated according to their ion mobility within the ion mobility spectrometer or separator. The kinetic energy of the ions exiting the ion mobility spectrometer or separator is increased substantially linearly with time in order to optimize the fragmentation energy of ions as they enter the collision or fragmentation cell. During the time that the potential of the ion mobility spectrometer or separator is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator such as an ion source, ion guide, quadrupole mass filter, optional second collision or fragmentation cell and an ion trapping device are kept constant.

7. 发明授权

US09548193B2 Quadrupole mass spectrometer with quadrupole mass filter as a mass separator 有权
标题翻译：具有四极质量过滤器的四极质谱仪作为质量分离器
公开(公告)号：US09548193B2
公开(公告)日：2017-01-17
申请号：US12994019
申请日：2008-05-26
申请人： Kazuo Mukaibatake , Shigenobu Nakano , Minoru Fujimoto
发明人： Kazuo Mukaibatake , Shigenobu Nakano , Minoru Fujimoto
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/4215 , H01J49/429
摘要： In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ΔM between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ΔM is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution.
摘要翻译：在其中质量扫描在预定质量范围内重复的扫描测量中，当电压从一次扫描的终止电压返回到下次扫描的起始电压时，会发生下冲或其他缺点，以使电压值不稳定。因此，需要适当的等待时间。通常，无论分析条件如何，该等待时间都被设定为恒定。另一方面，在本发明的四极质谱仪中，基于规定的质量范围来计算扫描终止质量和扫描开始质量之间的质量差ΔM，并根据该设定设定不同的建立时间质量差异当质量差ΔM小时，仅需要短的电压稳定时间时，设定较短的建立时间。这缩短了质量扫描的循环周期，这增加了时间分辨率。

8. 发明授权

US09177776B2 Mass to charge ratio selective ejection from ion guide having supplemental RF voltage applied thereto 有权
标题翻译：离子导向器的质荷比选择性喷射具有施加到其上的补充RF电压
公开(公告)号：US09177776B2
公开(公告)日：2015-11-03
申请号：US13522888
申请日：2011-01-18
申请人： John Brian Hoyes , Daniel James Kenny , David Langridge
发明人： John Brian Hoyes , Daniel James Kenny , David Langridge
IPC分类号： H01J49/34 , H01J49/06 , H01J49/42
CPC分类号： H01J49/34 , H01J49/065 , H01J49/4235 , H01J49/4275 , H01J49/429
摘要： An ion guide is disclosed wherein an axial DC voltage barrier is created at the exit of the ion guide. A primary RF voltage is applied to the electrodes in order to confine ions radially within the ion guide. A supplemental RF voltage is also applied to the electrodes. The supplemental RF voltage has a greater axial repeat length than that of the primary RF voltage. The amplitude of the supplemental RF voltage is increased with time causing ions to become unstable and gain sufficient axial kinetic energy such that the ions overcome the axial DC voltage barrier. Ions emerge axially from the ion guide in mass to charge ratio order.
摘要翻译：公开了一种离子导向器，其中在离子导向器的出口处产生轴向DC电压屏障。将初级RF电压施加到电极，以便将离子径向限制在离子导向器内。补充的RF电压也被施加到电极。补充RF电压具有比初级RF电压更大的轴向重复长度。补充RF电压的幅度随时间增加，导致离子变得不稳定并获得足够的轴向动能，使得离子克服轴向DC电压屏障。离子以质量与电荷的比例顺序从离子导向器轴向出现。

9. 发明申请

US20140246576A1 Method and Apparatus for Generating Spectral Data 有权
标题翻译：用于生成光谱数据的方法和装置
公开(公告)号：US20140246576A1
公开(公告)日：2014-09-04
申请号：US14128971
申请日：2012-06-22
申请人： Anthony Gilbert , Richard Moulds
发明人： Anthony Gilbert , Richard Moulds
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , H01J49/0031 , H01J49/429
摘要： A method of generating spectral data comprising the steps of deriving a temporally separated sample from a temporal separation device and subjecting the temporally separated sample to an analysis involving scanning at least one spectrally significant parameter, wherein the analysis is performed so that at least two scans in succession are in opposite directions
摘要翻译：一种产生频谱数据的方法，包括以下步骤：从时间分离装置导出时间上分离的样本，并对时间分离的样本进行涉及扫描至少一个光谱有意义的参数的分析，其中进行分析，使得进行至少两次扫描继承是相反的方向

10. 发明申请

US20140151544A1 Exponential Scan Mode for Quadrupole Mass Spectrometers to Generate Super-Resolved Mass Spectra 有权
标题翻译：指数扫描模式用于四极杆质谱仪生成超解析质谱
公开(公告)号：US20140151544A1
公开(公告)日：2014-06-05
申请号：US14014844
申请日：2013-08-30
申请人： Thermo Finnigan LLC
发明人： Robert A. GROTHE, Jr.
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/4225 , H01J49/429
摘要： A novel scanning method of a mass spectrometer apparatus is introduced so as to relate by simple time shifts, rather than time dilations, the component signal (“peak”) from each ion even to an arbitrary reference signal produced by a desired homogeneous population of ions. Such a method and system, as introduced herein, is enabled in a novel fashion by scanning exponentially the RF and DC voltages on a quadrupole mass filter versus time while maintaining the RF and DC in constant proportion to each other. In such a novel mode of operation, ion intensity as a function of time is the convolution of a fixed peak shape response with the underlying (unknown) distribution of discrete mass-to-charge ratios (mass spectrum). As a result, the mass distribution can be reconstructed by deconvolution, producing a mass spectrum with enhanced sensitivity and mass resolving power.
摘要翻译：引入了一种新型的质谱仪装置的扫描方法，以便通过简单的时间偏移而不是时间扩张来描述从每个离子的分量信号（“峰值”）甚至是由期望的同质离子群产生的任意参考信号。如本文所介绍的这样的方法和系统以新颖的方式通过在四极质量滤波器上相对于时间指数地扫描RF和DC电压而使得RF和DC彼此保持不变成比例而实现。在这种新颖的操作模式中，作为时间的函数的离子强度是固定峰形状响应与离散质荷比（质谱）的潜在（未知）分布的卷积。结果，质量分布可以通过去卷积重建，产生具有增强的灵敏度和质量分辨能力的质谱。

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