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1. 发明授权

US5661029A Biological culture growth and observation device 失效
标题翻译：生物培养生长观察装置
公开(公告)号：US5661029A
公开(公告)日：1997-08-26
申请号：US242014
申请日：1994-05-12
申请人： Jim Self , Robert D. Hall , R. Daniel Webster
发明人： Jim Self , Robert D. Hall , R. Daniel Webster
IPC分类号： C12M1/16 , G02B21/34 , C12M3/00
CPC分类号： C12M23/46 , C12M23/04 , C12M23/12 , C12M23/22 , C12M23/34 , C12M23/38 , G02B21/34
摘要： A biological culture growth and observation system provides for the growth of a biological sample in a growth medium, and the observation of the grown sample (organism) through a microscope objective once growth is sufficient as to permit discrimination of the biological sample. Observation and growth is achieved in a single device. The system includes a tray with a top, and a sealable section on the top. Included within the tray is a depression, or well, that receives the growth medium to grow the biological organism in the well. A lid is sealable and resealable around the sealable section on the top of the tray. An interior side of the lid, that faces the growth medium, does not fog up in the presence of the growth medium. Optionally included is a barrier layer that is positioned over the well. The barrier layer minimizes evaporation from the growth medium and permits the biological culture growth and observation system to have a long shelf life.
摘要翻译：生物培养生长和观察系统提供了生长培养基中生物样品的生长，并且一旦生长足以允许鉴别生物样品，则通过显微镜物镜观察生长的样品（生物体）。在单个设备中实现观察和增长。该系统包括具有顶部的托盘和顶部的可密封部分。包括在托盘内的是凹陷或井，其接收生长培养基以在井中生长生物体。盖可以在托盘顶部的可密封部分周围可密封和重新密封。面向生长介质的盖的内侧在生长培养基的存在下不会起雾。可选地包括位于井上的阻挡层。阻隔层使生长培养基的蒸发最小化，并允许生物培养生长和观察系统具有长的保质期。

2. 发明授权

US4210686A Multi-layered plastic sheeting having high clarity, strength, and resistance to water vapor transmission 失效
标题翻译：具有高透明度，强度和耐水蒸气透过性的多层塑料薄板
公开(公告)号：US4210686A
公开(公告)日：1980-07-01
申请号：US917122
申请日：1978-06-19
申请人： Henry Gajewski , Dean G. Laurin , Paul Measells , R. Daniel Webster
发明人： Henry Gajewski , Dean G. Laurin , Paul Measells , R. Daniel Webster
IPC分类号： A61J1/00 , A61J1/05 , B32B27/08 , B32B27/28 , B32B27/32 , B65D65/40 , C08L23/02 , C09D153/00 , B32B1/02 , B65D65/38
CPC分类号： C09D153/00 , B32B27/08 , B32B27/32 , C08L23/02 , A61J1/10 , Y10T428/1334 , Y10T428/24967 , Y10T428/26 , Y10T428/31913
摘要： A multiple-layered, autoclavable, flexible plastic sheet comprises (a) at least one first layer consisting essentially of 30 to 90 percent by weight of a block copolymer having thermoplastic rubbery characteristics and having rubbery olefin blocks and blocks of a polystyrene; and from 10 to 70 percent by weight of a polyolefin derived principally from at least one of propylene, ethylene and 4-methylpentene-1, said polyolefin having a Vicat Softening Temperature of about 120.degree. C.; and (b) at least one second layer consisting essentially of a polyolefin derived principally by from at least one of propylene, ethylene, and 4-methylpentene-1 and being of semi-crystalline characteristics to exhibit low permeability to water vapor, the first and second layers being bonded together in alternating arrangement.
摘要翻译：多层可高压灭菌的柔性塑料片包括（a）至少一个第一层，其基本上由30至90重量％的具有热塑性橡胶特性的嵌段共聚物组成，并具有橡胶烯烃嵌段和聚苯乙烯嵌段; 和10至70重量％的主要由丙烯，乙烯和4-甲基戊烯-1中的至少一种衍生的聚烯烃，所述聚烯烃的维卡软化温度为约120℃。和（b）至少一个第二层，其基本上由主要由丙烯，乙烯和4-甲基戊烯-1中的至少一种衍生并具有半水性特征的聚烯烃组成，其表现出对水蒸汽的低渗透性，第一和第二层交替排列地结合在一起。

3. 发明授权

US5125919A Wedge-shaped port for flexible containers 失效
标题翻译：用于柔性容器的楔形端口
公开(公告)号：US5125919A
公开(公告)日：1992-06-30
申请号：US604338
申请日：1990-10-24
申请人： Robert A. Miller , R. Daniel Webster , Bradley H. Buchanan
发明人： Robert A. Miller , R. Daniel Webster , Bradley H. Buchanan
IPC分类号： A61J1/05 , A61J1/10 , B65D75/58
CPC分类号： A61J1/10 , B65D75/5811 , B65D75/5872
摘要： A wedge-shaped access port for a flexible container is described. The flexible container is formed of at least one or more sheets of material which are sealed together about the edges to form a cavity. The wedge-shaped port is sealed to the container so that a base of the wedge is exterior to the cavity and a thin edge of the wedge is located inside the cavity. An orifice in the port provides a passageway from the base of the wedge to the cavity. The wedge shape of the port allows sealing of the port to container with minimal stress or thinning of material at the seal between the port and the container.
摘要翻译：描述了一种用于柔性容器的楔形进入口。柔性容器由至少一个或多个材料片形成，其围绕边缘密封在一起以形成空腔。楔形端口被密封到容器，使得楔的基部在空腔的外部，并且楔的薄边缘位于腔内。端口中的孔口提供从楔形物的基部到腔体的通道。端口的楔形允许在端口和容器之间的密封处以最小的应力或材料的薄化使端口密封到容器。

4. 发明授权

US06653096B1 Process challenge device and method 有权
标题翻译：过程挑战设备和方法
公开(公告)号：US06653096B1
公开(公告)日：2003-11-25
申请号：US09379682
申请日：1999-08-24
申请人： Dennis Christensen , R. Daniel Webster , Harvey A. Markinson
发明人： Dennis Christensen , R. Daniel Webster , Harvey A. Markinson
IPC分类号： C12Q122
CPC分类号： C12Q1/22 , Y10S435/808
摘要： A process challenge device tailored to mimic the resistance of a particular product-package combination to a particular biological inactivation, disinfection, or sterilization process. The device is used to challenge the process, thus providing a means to validate the efficacy of the process. In one embodiment, the process indicator includes a biological indicator organism stored on a carrier enclosed within a chamber formed by a barrier film material. The specific indicator organism and carrier substrate are chosen for their appropriateness for a given process. The materials comprising the barrier film material of the process challenge device are chosen for the materials' specific resistance to the given process. The process challenge device may also comprise a separate second chamber filled with an appropriate culture medium or enzyme substrate that is separated from the chamber containing the process indicator by a separation means, such as a valve, a clip, or a frangible separation. The separation means between the two chambers is capable of being removed on demand after completion of the process thus allowing the culture medium or enzyme substrate to contact the process indicator.
摘要翻译：定制的过程挑战装置，以模拟特定产品包装组合对特定生物灭活，消毒或灭菌过程的抵抗力。该装置用于挑战该过程，从而提供了验证该过程的功效的手段。在一个实施例中，过程指示器包括存储在封装在由阻挡膜材料形成的腔室内的载体上的生物指示器生物体。选择具体的指示剂生物体和载体底物适合给定的过程。选择包含过程挑战装置的阻挡膜材料的材料用于材料对给定工艺的特异性抗性。过程攻击装置还可以包括填充有合适的培养基或酶底物的单独的第二室，其通过分离装置（例如阀，夹子或易碎分离）与包含过程指示器的室分离。两个室之间的分离装置能够在完成该过程之后根据要求去除，从而允许培养基或酶底物与过程指示剂接触。

5. 发明授权

US5942408A Process challenge device and method 失效
标题翻译：过程挑战设备和方法
公开(公告)号：US5942408A
公开(公告)日：1999-08-24
申请号：US887753
申请日：1997-07-03
申请人： Dennis E. Christensen , R. Daniel Webster , Harvey A. Markinson
发明人： Dennis E. Christensen , R. Daniel Webster , Harvey A. Markinson
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , Y10S435/805
摘要： A process challenge device tailored to mimic the resistance of a particular product to a particular biological inactivation, disinfection, or sterilization process, and used to challenge the process, thus providing a means to validate the efficacy of the process. The process challenge device is used by subjecting the device containing indicator organisms to an inactivation or sterilization process, and culturing any surviving indicator organisms as a means to assess the efficacy of procedures for the inactivation of microorganisms. The device includes a biological indicator organism stored on a carrier substrate enclosed within a chamber formed by a barrier film material. The specific indicator organism and carrier substrate are chosen for their appropriateness for a given process. The materials comprising the barrier film material of the process challenge device are chosen for the materials' specific resistance to the given process. The process challenge device may also comprise a separate second chamber filled with an appropriate culture medium that is separated from the chamber containing the biological indicator by a separation means, such as a valve, a clip, or a frangible separation. The separation means between the two chambers is capable of being removed on demand after completion of the process thus allowing the culture medium to contact the biological indicator. This initiates the beginning of the culture phase which confirms non-survivability of the organism population and thus process efficacy. The incorporation of the culture medium into the device permits a level of convenience to the user not available in prior art inventions.
摘要翻译：定制的过程挑战装置，以模拟特定产品对特定生物灭活，消毒或灭菌过程的抵抗力，并用于挑战该过程，从而提供了验证过程效力的手段。通过使含有指示生物体的装置进行灭活或灭菌过程，并培养任何存活的指示生物体，以评估微生物灭活程序的功效的手段来使用过程挑战装置。该装置包括存储在封装在由阻挡膜材料形成的室内的载体基底上的生物指示生物体。选择具体的指示剂生物体和载体底物适合给定的过程。选择包含过程挑战装置的阻挡膜材料的材料用于材料对给定工艺的特异性抗性。过程攻击装置还可以包括填充有适当培养基的单独的第二室，其通过分离装置（例如阀，夹子或易碎分离）从包含生物指示器的室分离。两个室之间的分离装置能够在完成该过程之后根据需要去除，从而允许培养基接触生物指示剂。这启动了培养阶段的开始，这证实了生物群体的非生存性，从而确保了处理效力。将培养基并入装置允许在现有技术发明中不可用的用户的便利水平。

6. 发明授权

US5071686A Films of polypropylene blends and polyethylene blends and articles made therewith 失效
标题翻译：聚丙烯薄膜和聚乙烯共混物及其制品
公开(公告)号：US5071686A
公开(公告)日：1991-12-10
申请号：US802908
申请日：1985-11-29
申请人： Roger P. Genske , Yong J. Kim , Russell P. Gehrke , Richard E. Johnson, Jr. , R. Daniel Webster , Leonard F. Czuba
发明人： Roger P. Genske , Yong J. Kim , Russell P. Gehrke , Richard E. Johnson, Jr. , R. Daniel Webster , Leonard F. Czuba
IPC分类号： B32B27/32 , B65D65/40 , C08L23/06 , C08L23/08 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/16 , C08L23/20 , C08L23/22 , C08L53/02
CPC分类号： C08L23/12 , B32B27/32 , C08L23/06 , C08L23/0815 , C08L23/10 , C08L23/14 , C08L23/142 , C08L23/16 , C08L23/20 , C08L23/22 , C08L53/02 , Y10T428/1352 , Y10T428/2495 , Y10T428/2809 , Y10T428/31913
摘要： Novel films are disclosed which contain blends of ethylene-based copolymers or other elastomers with polypropylene and polyethylene. Typical films have two-five layers wherein at least one layer is a blend of high density polyethylene with an ethylene-based copolymer or another elastomer and has additional layers of polypropylene blended with an ethylene-based copolymer or another elastomer.
摘要翻译：公开了含有乙烯基共聚物或其它弹性体与聚丙烯和聚乙烯的共混物的新型薄膜。典型的膜具有五层，其中至少一层是高密度聚乙烯与乙烯基共聚物或另一种弹性体的共混物，并且具有与乙烯基共聚物或另一种弹性体共混的其它聚丙烯层。

7. 发明申请

US20130230910A1 Apparatus and Method for Process Challenge Devices 审中-公开
标题翻译：过程挑战设备的装置和方法
公开(公告)号：US20130230910A1
公开(公告)日：2013-09-05
申请号：US13783844
申请日：2013-03-04
申请人： Dennis E. Christensen , R. Daniel Webster
发明人： Dennis E. Christensen , R. Daniel Webster
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22 , A61L2/28 , C12M37/06 , Y10T29/49 , Y10T29/49817
摘要： A process challenge device tailored to mimic the resistance of a particular product to a particular biological inactivation, disinfection, or sterilization process, and used to challenge the process, thus providing a means to validate the efficacy of the process. The process challenge device is used by subjecting the device containing indicator organisms to an inactivation or sterilization process, and culturing any surviving indicator organisms as a means to assess the efficacy of procedures for the inactivation of microorganisms. The device uses a self-containing biological indicator (SCBI) with a biological indicator and media ampule located within a plastic vial. By altering the materials and/or configuration of the SCBI a wide range of resistances to sterilant gas processes may be achieved.
摘要翻译：定制的过程挑战装置，以模拟特定产品对特定生物灭活，消毒或灭菌过程的抵抗力，并用于挑战该过程，从而提供了验证过程效力的手段。通过使含有指示生物体的装置进行灭活或灭菌过程，并培养任何存活的指示生物体，以评估微生物灭活程序的功效的手段，来使用过程挑战装置。该装置使用具有生物指示剂的自体生物指示剂（SCBI）和位于塑料小瓶内的培养基安瓿。通过改变SCBI的材料和/或构型，可以实现对杀菌剂气体方法的广泛的阻力。

8. 发明授权

US4778697A Polymeric films 失效
标题翻译：聚合物膜
公开(公告)号：US4778697A
公开(公告)日：1988-10-18
申请号：US802877
申请日：1985-11-29
申请人： Roger P. Genske , Yong J. Kim , Russell P. Gehrke , Richard E. Johnson, Jr. , R. Daniel Webster , Leonard F. Czuba
发明人： Roger P. Genske , Yong J. Kim , Russell P. Gehrke , Richard E. Johnson, Jr. , R. Daniel Webster , Leonard F. Czuba
IPC分类号： B65D65/40 , A61J1/00 , A61J1/05 , A61J1/10 , B32B27/32 , C08L23/06 , C08L23/08 , C08L23/12 , C08L23/14 , C08L23/16 , C08L23/20 , C08L23/22 , C08L25/16 , C08L53/00 , C08L53/02 , B32B1/02 , B32B27/08
CPC分类号： C08L23/12 , B29C47/0021 , B29C47/061 , B32B27/32 , C08L23/06 , C08L23/0815 , C08L23/142 , C08L23/16 , C08L53/00 , C08L2205/02 , C08L2205/03 , C08L23/20 , C08L23/22 , C08L25/16 , C08L53/02 , Y10T428/1334 , Y10T428/2826 , Y10T428/2878 , Y10T428/2883 , Y10T428/31913
摘要： This invention pertains to the use of polymer blends in making multiple layer films. In some layers, the elastomer or ethylene-based copolymer is blended with polypropylene, and in some layers, with polyethylene. Typical films have two to five layers. In multilayer films, at least one layer of a blend of polyethylene, preferably high density polyethylene, with elastomer and/or ethylene-based copolymers. Another layer is polypropylene blended with elastomers and/or ethylene-based copolymers. The films may have as few as two layers, one each having polypropylene and polyethylene, preferably high density polyethylene. Additional layers may be added to the two or three layer films taught herein, for variety of purposes.
摘要翻译：本发明涉及聚合物共混物在制备多层膜中的用途。在一些层中，弹性体或乙烯基共聚物与聚丙烯共混，并且在一些层中与聚乙烯共混。典型的电影有两到五层。在多层膜中，至少有一层聚乙烯，优选高密度聚乙烯与弹性体和/或乙烯基共聚物的混合物。另一层是与弹性体和/或乙烯基共聚物共混的聚丙烯。膜可以具有至少两层，每层具有聚丙烯和聚乙烯，优选高密度聚乙烯。为了各种目的，可以将另外的层添加到本文教导的两层或三层膜中。

9. 发明授权

US4322465A Clear, autoclavable, sealed container having good water vapor barrier properties and flex crack resistance 失效
标题翻译：清洁，耐高压灭菌，密封的容器具有良好的水蒸气阻隔性能和抗弯曲性
公开(公告)号：US4322465A
公开(公告)日：1982-03-30
申请号：US176616
申请日：1980-08-08
申请人： R. Daniel Webster
发明人： R. Daniel Webster
IPC分类号： B65D65/40 , A23L3/00 , B32B27/30 , B32B27/32 , B65D75/38 , B32B3/02 , B32B7/04 , B65B47/00
CPC分类号： B32B27/32 , B65D75/38 , Y10S428/91 , Y10T428/24793 , Y10T428/31757 , Y10T428/31797 , Y10T428/31913
摘要： A clear, flexible, sealed container may be made of first and second plastic sheets sealed together at their peripheries. The first plastic sheet defines a bulge to increase the inside volume of the container, and comprises a laminate of a layer of polyolefin and a blended layer of polyolefin and a block copolymer of polyolefin and polystyrene. The second plastic sheet is a bonded laminate of a layer of biaxially oriented polypropylene and nonoriented polypropylene, peripherally bonded to the layer of polyolefin of the first plastic sheet.
摘要翻译：透明，柔性，密封的容器可以由在其周边密封在一起的第一和第二塑料片制成。第一塑料片限定凸起以增加容器的内部体积，并且包括聚烯烃层和聚烯烃的共混层和聚烯烃和聚苯乙烯的嵌段共聚物的层压体。第二塑料片是由双轴取向的聚丙烯层和无取向聚丙烯层的结合层压体，其外围地结合到第一塑料片的聚烯烃层。

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