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1. 发明授权

US09664694B2 Neural proteins as biomarkers for nervous system injury and other neural disorders 有权
公开(公告)号：US09664694B2
公开(公告)日：2017-05-30
申请号：US12950142
申请日：2010-11-19
申请人： Ka-Wang (Kevin) Wang , Ming-Cheng Liu , Monika Oli
发明人： Ka-Wang (Kevin) Wang , Ming-Cheng Liu , Monika Oli
IPC分类号： G01N33/53 , G01N33/542 , G01N33/537 , C12Q1/00 , G01N33/68 , C07K16/18 , C12Q1/68
CPC分类号： G01N33/6896 , C07K16/18 , C12Q1/6883 , G01N2800/28 , G01N2800/52
摘要： The present invention identities biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.

2. 发明授权

US08697070B2 1D05 PCSK9 antagonists 失效
标题翻译： 1D05 PCSK9拮抗剂
公开(公告)号：US08697070B2
公开(公告)日：2014-04-15
申请号：US13466439
申请日：2012-05-08
申请人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
发明人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC分类号： A61K38/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

3. 发明授权

US08557526B2 Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury 有权
标题翻译： Synaptotagmin和collapsin应答介质蛋白作为创伤性脑损伤的生物标志物
公开(公告)号：US08557526B2
公开(公告)日：2013-10-15
申请号：US12535960
申请日：2009-08-05
申请人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
发明人： Andrew K. Ottens , Firas H. Kobaissy , Ka-Wang (Kevin) Wang , Ronald L. Hayes , Zhiqun Zhang , Ming Chen Liu , Monika Oli
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/6896 , G01N2800/28
摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
摘要翻译：在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。

4. 发明授权

US08492107B2 Neural proteins as biomarkers for nervous system injury and other neural disorders 有权
标题翻译：神经蛋白作为神经系统损伤和其他神经障碍的生物标志物
公开(公告)号：US08492107B2
公开(公告)日：2013-07-23
申请号：US12822560
申请日：2010-06-24
申请人： Ka-Wang (Kevin) Wang , Ming-Cheng Liu , Monika Oli
发明人： Ka-Wang (Kevin) Wang , Ming-Cheng Liu , Monika Oli
IPC分类号： G01N33/53 , G01N33/542 , G01N33/537 , G01N33/566 , G01N33/567 , C12Q1/00
CPC分类号： G01N33/6896 , C07K16/18 , C12Q1/6883 , G01N2800/28 , G01N2800/52
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译：本发明鉴定诊断神经细胞损伤和/或神经元疾病的生物标志物。本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。

5. 发明申请

US20110028349A1 Endothelial monocyte activation polypeptide II, a biomarker for use in diagnosis and treatment of brain injury 审中-公开
标题翻译：内皮单核细胞活化多肽II，用于诊断和治疗脑损伤的生物标志物
公开(公告)号：US20110028349A1
公开(公告)日：2011-02-03
申请号：US12806725
申请日：2010-08-19
申请人： Jitendra Ramanlal Dave , Changping Yao , Anthony Joseph Williams , Xi-Chun May , Frank Casper Tortella , Ka-Wang Kevin Wang , Ronald Lawrence Hayes
发明人： Jitendra Ramanlal Dave , Changping Yao , Anthony Joseph Williams , Xi-Chun May , Frank Casper Tortella , Ka-Wang Kevin Wang , Ronald Lawrence Hayes
IPC分类号： C40B40/10 , C40B40/00
CPC分类号： G01N33/6896 , G01N33/6863 , G01N33/6893 , G01N2333/52 , G01N2800/28 , G01N2800/2871
摘要： A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates the presence of ischemic brain injury. Detection of EMAP-II can be done in brain tissue, biofluids such as cerebrospinal fluid or blood (including plasma and serum)
摘要翻译：通过检测内皮单核细胞激活多肽II（EMAP-II）的表达水平并与对照进行比较，诊断脑损伤和脑损伤类型（创伤性与缺血性）的诊断工具和方法。 EMAP-II的增加表明存在创伤性脑损伤，EMAP-II的降低表明存在缺血性脑损伤。 EMAP-II的检测可以在脑组织，生物流体如脑脊液或血液（包括血浆和血清）中进行，

6. 发明申请

US20090317805A1 Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining 有权
标题翻译：蛋白水解标记作为癌症，器官损伤和肌肉康复/运动超调的诊断性生物标志物
公开(公告)号：US20090317805A1
公开(公告)日：2009-12-24
申请号：US12137156
申请日：2008-06-11
申请人： Ka-Wang (Kevin) Wang , Ming Chen Liu
发明人： Ka-Wang (Kevin) Wang , Ming Chen Liu
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/536 , G01N33/567
CPC分类号： G01N33/6896 , C12Q1/37 , Y10T436/118339 , Y10T436/25375
摘要： The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
摘要翻译：本发明鉴定诊断神经细胞损伤，器官损伤和/或神经元障碍的生物标志物。本发明的不同生物标志物的检测也可以诊断神经损伤的严重程度，损伤中涉及的细胞以及损伤的亚细胞定位。

7. 发明授权

US07611858B1 Detection of cannabinoid receptor biomarkers and uses thereof 有权
标题翻译：大麻素受体生物标志物的检测及其用途
公开(公告)号：US07611858B1
公开(公告)日：2009-11-03
申请号：US11738159
申请日：2007-04-20
申请人： Stanislav Svetlov , Ronald L. Hayes , Ka-Wang (Kevin) Wang
发明人： Stanislav Svetlov , Ronald L. Hayes , Ka-Wang (Kevin) Wang
IPC分类号： G01N33/00 , C07K14/00 , C11D15/00
CPC分类号： G01N33/6896 , C07K16/28 , G01N33/948 , G01N2500/00 , G01N2800/28
摘要： Traumatic insult to the brain leads to a degradation of low molecular weight of cannabinoid type 1 receptor (CB1) and generation of high molecular weight complexes in the cortex and hippocampus, as assessed by both N-terminal and C-terminal specific antibodies. The formation and release of CB1 oligomers was dramatically increased into CSF within 1 hour following traumatic brain insult. Novel CB1 receptor-based, prognostic markers of traumatic brain injury and other forms of brain injury are disclosed. A method of repopulating damaged neural cells by proliferation of a subgroup of neural progenitor cells is described. Targeting CB1 receptors for therapeutic neuroprotection in TBI is also disclosed.
摘要翻译：对大脑的创伤性侮辱导致低分子量的大麻素1型受体（CB1）的降解以及由皮质和海马中的高分子量复合物的产生，如N末端和C末端特异性抗体所评估的。创伤性脑损伤后1小时内，CB1寡聚体的形成和释放显着增加到CSF中。公开了基于CB1受体的新型创伤性脑损伤和脑损伤形式的预后标志物。描述了通过神经祖细胞亚群的增殖来补充损伤的神经细胞的方法。还公开了在TBI中靶向用于治疗性神经保护的CB1受体。

8. 发明申请

US20090246192A1 1D05 PCSK9 antagonists 有权
标题翻译： 1D05 PCSK9拮抗剂
公开(公告)号：US20090246192A1
公开(公告)日：2009-10-01
申请号：US12322867
申请日：2009-02-06
申请人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
发明人： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Laura Orsatti , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/16 , C12P21/06
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

9. 发明申请

US20050110550A1 DC offset cancellation in a direct-conversion receiver 审中-公开
标题翻译：直接转换接收机中的直流偏移消除
公开(公告)号：US20050110550A1
公开(公告)日：2005-05-26
申请号：US10719833
申请日：2003-11-24
申请人： Qian Shi , Liang Dai , Kevin Wang
发明人： Qian Shi , Liang Dai , Kevin Wang
IPC分类号： H03D3/00 , H03F3/45 , H03L5/00
CPC分类号： H03F3/45991 , H03D3/008 , H03F3/45973 , H03F2200/294 , H03F2200/372
摘要： The DCOC block is used in ZIF BB to form HPF function to cancel dc offset with a penalty of small silicon area and low power consumption. It is a LPF plus a voltage to current conversion (VIC) resistor, and can hook up with any BB opamp used in signal path, to form a feedback loop, with or without signal gain stages in the loop. The BB opamp is used as a summing point. The summing method is input current summing. The cutoff frequency of the HPF function is thus defined by the integrator, the VIC resistor, and the feedback resistor in the summing opamp. The presence of the VIC resistor can drastically reduce the integrator capacitor and resistor values and thus save silicon area or improve receiver performance.
摘要翻译：在ZIF BB中使用DCOC块形成HPF功能，以小的硅面积和低功耗的损失来消除直流偏移。它是一个LPF加上电压 - 电流转换（VIC）电阻，并且可以连接在信号通路中使用的任何BB运算放大器，形成一个反馈回路，在回路中有或没有信号增益级。 BB运算符用作求和点。求和方法为输入电流求和。因此，HPF功能的截止频率由积分器，VIC电阻和求和运算放大器中的反馈电阻器定义。 VIC电阻的存在可以显着降低积分器电容和电阻值，从而节省硅面积或提高接收机性能。

10. 发明申请

US20050029967A1 Multi-lamp actuating facility 失效
标题翻译：多灯驱动设备
公开(公告)号：US20050029967A1
公开(公告)日：2005-02-10
申请号：US10936328
申请日：2004-09-08
申请人： Mender Chen , Woody Chan , Kevin Wang
发明人： Mender Chen , Woody Chan , Kevin Wang
IPC分类号： H05B41/282 , H05B41/392 , H05B37/00
CPC分类号： H05B41/2824 , H05B41/392
摘要： A lamp actuating device includes a number of lamps each having an output terminal, an inverter circuit coupled to the lamps to energize the lamps, a low frequency control unit coupled to the inverter circuit, to set an average value for the level of the effective lamp current at the output terminals of the lamps and to control the inverter circuit, a number of current detecting devices coupled between the lamps and the low frequency control devices to obtain and send the average current value at the output terminals of the lamps to the low frequency control unit. A number of regulating devices are coupled between the lamps and the low frequency control unit, to maintain each lamp at the predetermined average value of the effective current.
摘要翻译：灯驱动装置包括多个灯，每个灯具有输出端子，反相器电路耦合到灯以激励灯，连接到逆变器电路的低频控制单元，以设置有效灯的电平的平均值在灯的输出端子处的电流并控制逆变器电路，耦合在灯和低频控制装置之间的多个电流检测装置，以获得并将灯的输出端处的平均电流值发送到低频控制单元多个调节装置耦合在灯和低频控制单元之间，以将每个灯保持在有效电流的预定平均值。

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