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1. 发明申请

US20170058343A1 SYSTEMS AND METHODS FOR COLOR DETECTION IN HIGH-THROUGHPUT NUCLEIC ACID SEQUENCING SYSTEMS 审中-公开
标题翻译：用于高通量核酸序列系统中颜色检测的系统和方法
公开(公告)号：US20170058343A1
公开(公告)日：2017-03-02
申请号：US15253015
申请日：2016-08-31
申请人： QIAGEN Instruments AG
发明人： Harald Quintel , Konstantin Lutze
IPC分类号： C12Q1/68 , H04N5/33 , G02B5/20 , G02B27/14 , G02B26/08 , H04N9/04 , H04N5/225
CPC分类号： C12Q1/6874 , C12Q1/6869 , G01J3/10 , G01J3/2823 , G01J3/36 , G01J3/4406 , G01J3/513 , G01J2003/2826 , G01N21/645 , G01N2021/1776 , G01N2021/6419 , G01N2021/6441 , G01N2021/6471 , G02B5/201 , G02B26/0875 , G02B26/0883 , G02B27/141 , H04N5/2254 , H04N5/2256 , H04N5/332 , H04N9/045 , C12Q2523/313 , C12Q2535/122 , C12Q2537/143 , C12Q2563/107 , C12Q2565/102
摘要： A sequencing instrument optical system having a combined light source with multiple collinear excitation beams having different respective excitation wavelengths, a sequencing surface having DNA templates and nucleobase labels configured to emit a respective emission light at a different respective emission wavelength upon excitation by one or more of the excitation beams, a color camera configured to detect the emission light of each of the nucleobase labels, a first optical pathway configured to direct the collinear excitation beams from the combined light source to the sequencing surface, and a second optical pathway configured to direct the emission light from the sequencing surface to the color camera.
摘要翻译：一种测序仪器光学系统，其具有具有不同相应激发波长的多个共线激发光束的组合光源，具有DNA模板和核碱基标记的测序表面被配置为在激发时以不同的相应发射波长发射相应的发射光，激发光束，被配置为检测每个核碱基标记的发射光的彩色照相机，被配置为将来自组合光源的共线激发光束引导到测序表面的第一光学路径，以及被配置为引导发射光从测序表面到彩色摄像机。

2. 发明申请

US20190071722A1 Modular Flow Cells And Methods Of Sequencing 审中-公开
公开(公告)号：US20190071722A1
公开(公告)日：2019-03-07
申请号：US16181918
申请日：2018-11-06
申请人： QIAGEN WALTHAM, Inc , QIAGEN INSTRUMENTS AG
发明人： Jerzy Olejnik , Dirk Zimmermann
IPC分类号： C12Q1/6869
摘要： Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow cells, are described, permitting sequencing wherein less than the full capacity for sequencing is desired.

3. 发明授权

US10150994B2 Modular flow cells and methods of sequencing 有权
公开(公告)号：US10150994B2
公开(公告)日：2018-12-11
申请号：US15215234
申请日：2016-07-20
申请人： INTELLIGENT BIO-SYSTEMS, Inc. , QIAGEN INSTRUMENTS AG
发明人： Jerzy Olejnik , Dirk Zimmermann
IPC分类号： C12Q1/68 , C12Q1/6869
摘要： Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow cells, are described, permitting sequencing wherein less than the full capacity for sequencing is desired.

4. 发明申请

US20160030938A1 CLOSING ARRANGEMENT AND METHOD OF CLOSING TUBE 审中-公开
标题翻译：关闭安装和关闭管的方法
公开(公告)号：US20160030938A1
公开(公告)日：2016-02-04
申请号：US14782010
申请日：2014-04-09
申请人： QIAGEN GMBH , QIAGEN INSTRUMENTS AG
发明人： Bruno WALDER , Sasa LAZEVSKI , Kurt STARK
IPC分类号： B01L3/00 , B65B7/28
CPC分类号： B01L3/50825 , B01L9/06 , B01L2200/025 , B01L2300/041 , B01L2300/042 , B01L2300/043 , B65B7/28 , G01N35/04 , G01N2035/0405
摘要： Closing arrangement for a cap of a tube in a carrier, wherein the arrangement comprises at least a first, a second and a third moveable engagement member, the first member being adapted to induce a first part of the cap rotation and the second member being adapted to induce a second part of the cap rotation and the third member being adapted to induce a third part of the cap rotation for closure.
摘要翻译：一种在载体中的管盖的封闭装置，其中所述装置包括至少第一，第二和第三可移动接合构件，所述第一构件适于引起所述盖旋转的第一部分，并且所述第二构件适于以引起盖旋转的第二部分，并且第三构件适于引起盖旋转的第三部分以关闭。

5. 发明申请

US20140254622A1 METHOD FOR VERIFYING A TEMPERATURE MEASUREMENT IN A MICRO-ENVIRONMENT AND SYSTEM FOR VERIFYING A TEMPERATURE MEASUREMENT IN A MICRO-ENVIRONMENT 有权
标题翻译：用于在微环境中验证温度测量的方法和用于在微环境中验证温度测量的系统
公开(公告)号：US20140254622A1
公开(公告)日：2014-09-11
申请号：US14352708
申请日：2012-10-22
申请人： QIAGEN INSTRUMENTS AG
发明人： Dirk Leber , Stephan Baehler , Hansueli Meyer
IPC分类号： G01K15/00
CPC分类号： G01K15/007 , G01K11/165 , G01K11/20 , G01K15/005
摘要： The present invention pertains to a method suitable for analysing the temperature control of a device which is supposed to establish a defined temperature in a micro-environment, said method comprising a first Optical Temperature Verification step which comprises a) providing one or more thermochromatic liquid crystals in a micro-environment, wherein each thermochromatic liquid crystal has a specific event temperature, b) providing one or more temperature dependent luminophores in a micro-environment, c) varying the temperature in the micro-environments and irradiating the micro-environments with light, d) recording the luminescence of the one or more temperature dependent luminophores when the event temperature of the one or more thermochromatic liquid crystals is reached in the micro-environment and wherein said method preferably comprises a second Optical Temperature Verification step, which comprises the following a) providing one or more temperature dependent luminophores that were used in the First Optical Temperature Verification in a micro-environment, b) varying the temperature of the micro-environments and irradiating the micro-environments with light, c) monitoring the luminescence emitted. The respective method is very suitable to analyse the temperature control of a thermal cycler, in particular during a calibration.
摘要翻译：本发明涉及一种适用于分析假定在微环境中建立限定温度的装置的温度控制的方法，所述方法包括第一光学温度验证步骤，该步骤包括：a）提供一个或多个热色液晶在微环境中，其中每个热色液晶具有特定的事件温度，b）在微环境中提供一个或多个与温度相关的发光体，c）改变微环境中的温度并用光照射微环境，d）当在所述微环境中达到所述一种或多种热色液晶的事件温度时记录所述一种或多种温度依赖性发光体的发光，并且其中所述方法优选地包括第二光学温度验证步骤，其包括以下 a）提供一个或多个依赖温度的发光体 e用于微环境中的第一光学温度验证，b）改变微环境的温度并用光照射微环境，c）监测发射的发光。相应的方法非常适合分析热循环仪的温度控制，特别是在校准过程中。

6. 发明授权

US09976917B2 Method for verifying a temperature measurement in a micro-environment and system for verifying a temperature measurement in a micro-environment 有权
公开(公告)号：US09976917B2
公开(公告)日：2018-05-22
申请号：US14352708
申请日：2012-10-22
申请人： QIAGEN INSTRUMENTS AG
发明人： Dirk Leber , Stephan Baehler , Hansueli Meyer
IPC分类号： G01K11/00 , G01K15/00 , G01K11/20 , G01K11/16
CPC分类号： G01K15/007 , G01K11/165 , G01K11/20 , G01K15/005
摘要： The present invention pertains to a method suitable for analyzing the temperature control of a device which is supposed to establish a defined temperature in a micro-environment, said method comprising a first Optical Temperature Verification step which comprises a) providing one or more thermochromatic liquid crystals in a micro-environment, wherein each thermochromatic liquid crystal has a specific event temperature, b) providing one or more temperature dependent luminophores in a micro-environment, c) varying the temperature in the micro-environments and irradiating the micro-environments with light, d) recording the luminescence of the one or more temperature dependent luminophores when the event temperature of the one or more thermochromatic liquid crystals is reached in the micro-environment and wherein said method preferably comprises a second Optical Temperature Verification step, which comprises the following a) providing one or more temperature dependent luminophores that were used in the First Optical Temperature Verification in a micro-environment, b) varying the temperature of the micro-environments and irradiating the micro-environments with light, c) monitoring the luminescence emitted. The respective method is very suitable to analyze the temperature control of a thermal cycler, in particular during a calibration.

7. 发明授权

US10376887B2 Closing arrangement and method of closing tube 有权
公开(公告)号：US10376887B2
公开(公告)日：2019-08-13
申请号：US14782010
申请日：2014-04-09
申请人： QIAGEN GMBH , QIAGEN INSTRUMENTS AG
发明人： Bruno Walder , Sasa Lazevski , Kurt Stark
IPC分类号： B01L3/00 , B65B7/28 , B01L9/06 , G01N35/04
摘要： Closing arrangement for a cap of a tube in a carrier, wherein the arrangement comprises at least a first, a second and a third moveable engagement member, the first member being adapted to induce a first part of the cap rotation and the second member being adapted to induce a second part of the cap rotation and the third member being adapted to induce a third part of the cap rotation for closure.

8. 发明申请

US20170022555A1 MODULAR FLOW CELLS AND METHODS OF SEQUENCING 审中-公开
标题翻译：模块化流动细胞和序列化方法
公开(公告)号：US20170022555A1
公开(公告)日：2017-01-26
申请号：US15215234
申请日：2016-07-20
申请人： INTELLIGENT BIO-SYSTEMS, Inc. , QIAGEN INSTRUMENTS AG
发明人： Jerzy Olejnik , Dirk Zimmerman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2563/107 , C12Q2565/629
摘要： Modular flow cells, devices with modular flow cells, and methods of sequencing using modular flow cells, as well as systems and kits including modular flow cells, are described, permitting sequencing wherein less than the full capacity for sequencing is desired.
摘要翻译：描述了模块化流动池，具有模块化流动池的装置以及使用模块化流动池的排序方法，以及包括模块化流动池的系统和试剂盒，其允许测序，其中需要小于全部测序能力。

9. 发明申请

US20160375441A1 APPARATUS AND METHOD FOR NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：用于核酸放大的装置和方法
公开(公告)号：US20160375441A1
公开(公告)日：2016-12-29
申请号：US15142817
申请日：2016-04-29
申请人： QIAGEN INSTRUMENTS AG
发明人： Keith Stanley , John Corbett
IPC分类号： B01L7/00 , B01L3/00
CPC分类号： B01L7/52 , B01L3/50273 , B01L2200/04 , B01L2200/0605 , B01L2200/141 , B01L2200/16 , B01L2300/0803 , B01L2300/0864 , B01L2300/1822 , B01L2300/1827 , B01L2400/0409 , B01L2400/0677
摘要： The present invention provides apparatus (1) for conducting sequential nucleic acid amplification reactions. The apparatus (1) comprises a platform (2) having a sample compartment (5) and a plurality of reaction compartments (10). The sample compartment (5) is adapted to receive a fluid sample for conducting a first amplification reaction and the platform (2) is adapted to substantially evenly distribute the fluid sample into the plurality of reaction compartments (10) for conducting second amplification reactions. The present invention also extends to a kit, a method and a device for conducting sequential nucleic acid amplification reactions.
摘要翻译：本发明提供了用于进行顺序核酸扩增反应的装置（1）。装置（1）包括具有样品室（5）和多个反应室（10）的平台（2）。样品室（5）适于接收用于进行第一扩增反应的流体样品，并且所述平台（2）适于将流体样本基本上均匀地分布到多个反应室（10）中以进行第二扩增反应。本发明还延伸到用于进行顺序核酸扩增反应的试剂盒，方法和装置。

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